{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:24:22Z","timestamp":1760171062543},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"CORAL","award":["- Norte-01-0145-FEDER-000036"],"award-info":[{"award-number":["- Norte-01-0145-FEDER-000036"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunogenetics"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00251-018-1071-5","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T23:08:20Z","timestamp":1531350500000},"page":"681-687","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cetacea are natural knockouts for IL20"],"prefix":"10.1007","volume":"70","author":[{"given":"M\u00f3nica","family":"Lopes-Marques","sequence":"first","affiliation":[]},{"given":"Andr\u00e9 M.","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"Miguel M.","family":"Fonseca","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Ruivo","sequence":"additional","affiliation":[]},{"given":"L. Filipe C.","family":"Castro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"1071_CR1","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/bies.10192","volume":"24","author":"C Adami","year":"2002","unstructured":"Adami C (2002) What is complexity? BioEssays 24:1085\u20131094. \n                    https:\/\/doi.org\/10.1002\/bies.10192","journal-title":"BioEssays"},{"issue":"3","key":"1071_CR2","doi-asserted-by":"publisher","first-page":"701-721.e70","DOI":"10.1016\/j.jaci.2010.11.050","volume":"127","author":"M\u00fcbeccel Akdis","year":"2011","unstructured":"Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, Klunker S, Meyer N, O\u2019Mahony L, Palomares O, Rhyner C, Quaked N, Schaffartzik A, van de Veen W, Zeller S, Zimmermann M, Akdis CA (2011) Interleukins, from 1 to 37, and interferon-\u03b3: receptors, functions, and roles in diseases J Allergy Clin Immunol 127:701\u2013721.e770 doi:\n                    https:\/\/doi.org\/10.1016\/j.jaci.2010.11.050\n                    \n                  , 721.e70","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"7","key":"1071_CR3","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nrg.2016.39","volume":"17","author":"Ricard Albalat","year":"2016","unstructured":"Albalat R, Ca\u00f1estro C (2016) Evolution by gene loss. Nat Rev Genet 17:379\u2013391. \n                    https:\/\/doi.org\/10.1038\/nrg.2016.39\n                    \n                  , https:\/\/www.nature.com\/articles\/nrg.2016.39#supplementary-information","journal-title":"Nature Reviews Genetics"},{"key":"1071_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0092-8674(01)00187-8","volume":"104","author":"H Blumberg","year":"2001","unstructured":"Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA (2001) Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104:9\u201319","journal-title":"Cell"},{"key":"1071_CR5","doi-asserted-by":"publisher","first-page":"8036","DOI":"10.1073\/pnas.1501844112","volume":"112","author":"BA Braun","year":"2015","unstructured":"Braun BA, Marcovitz A, Camp JG, Jia R, Bejerano G (2015) Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales. Proc Natl Acad Sci U S A 112:8036\u20138040. \n                    https:\/\/doi.org\/10.1073\/pnas.1501844112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1071_CR6","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1136\/jmedgenet-2017-104837","volume":"54","author":"CA Emerling","year":"2017","unstructured":"Emerling CA, Widjaja AD, Nguyen NN, Springer MS (2017) Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci. J Med Genet 54:787\u2013794. \n                    https:\/\/doi.org\/10.1136\/jmedgenet-2017-104837","journal-title":"J Med Genet"},{"key":"1071_CR7","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.intimp.2004.01.004","volume":"4","author":"H Fickenscher","year":"2004","unstructured":"Fickenscher H, Pirzer H (2004) Interleukin-26. Int Immunopharmacol 4:609\u2013613. \n                    https:\/\/doi.org\/10.1016\/j.intimp.2004.01.004","journal-title":"Int Immunopharmacol"},{"key":"1071_CR8","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1534\/genetics.104.037523","volume":"170","author":"Y Go","year":"2005","unstructured":"Go Y, Satta Y, Takenaka O, Takahata N (2005) Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Genetics 170:313\u2013326","journal-title":"Genetics"},{"key":"1071_CR9","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.4049\/jimmunol.0901829","volume":"184","author":"M He","year":"2010","unstructured":"He M, Liang P (2010) IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. J Immunol 184:1793\u20131798. \n                    https:\/\/doi.org\/10.4049\/jimmunol.0901829","journal-title":"J Immunol"},{"key":"1071_CR10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/1523-1747.ep12275348","volume":"85","author":"BD Hicks","year":"1985","unstructured":"Hicks BD, St Aubin DJ, Geraci JR, Brown WR (1985) Epidermal growth in the bottlenose dolphin, Tursiops truncatus. J Invest Dermatol 85:60\u201363","journal-title":"J Invest Dermatol"},{"key":"1071_CR11","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.4049\/jimmunol.1102843","volume":"188","author":"YH Hsu","year":"2012","unstructured":"Hsu YH, Hsing CH, Li CF, Chan CH, Chang MC, Yan JJ, Chang MS (2012) Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models. J Immunol 188:1981\u20131991. \n                    https:\/\/doi.org\/10.4049\/jimmunol.1102843","journal-title":"J Immunol"},{"key":"1071_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/srep24339","volume":"6","author":"YH Hsu","year":"2016","unstructured":"Hsu YH, Chiu YS, Chen WY, Huang KY, Jou IM, Wu PT, Wu CH, Chang MS (2016) Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis. Sci Rep 6:24339. \n                    https:\/\/doi.org\/10.1038\/srep24339","journal-title":"Sci Rep"},{"key":"1071_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17782-4","volume":"7","author":"J Lachner","year":"2017","unstructured":"Lachner J, Mlitz V, Tschachler E, Eckhart L (2017) Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes. Sci Rep 7:17446. \n                    https:\/\/doi.org\/10.1038\/s41598-017-17782-4","journal-title":"Sci Rep"},{"key":"1071_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ympev.2017.08.014","volume":"116","author":"M Lopes-Marques","year":"2017","unstructured":"Lopes-Marques M, Ruivo R, Fonseca E, Teixeira A, Castro LFC (2017) Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies. Mol Phylogenet Evol 116:78\u201386. \n                    https:\/\/doi.org\/10.1016\/j.ympev.2017.08.014","journal-title":"Mol Phylogenet Evol"},{"key":"1071_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/9780470619902.ch3","volume-title":"Evolution after Gene Duplication","author":"Steven Maere","year":"2011","unstructured":"Maere S, Van de Peer Y (2010) Duplicate retention after small- and large-scale duplications. In: Evolution after gene duplication. John Wiley & Sons, Inc., pp 31\u201356. doi:\n                    https:\/\/doi.org\/10.1002\/9780470619902.ch3"},{"key":"1071_CR16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.tree.2014.04.001","volume":"29","author":"MR McGowen","year":"2014","unstructured":"McGowen MR, Gatesy J, Wildman DE (2014) Molecular evolution tracks macroevolutionary transitions in Cetacea. Trends Ecol Evol 29:336\u2013346. \n                    https:\/\/doi.org\/10.1016\/j.tree.2014.04.001","journal-title":"Trends Ecol Evol"},{"key":"1071_CR17","doi-asserted-by":"publisher","unstructured":"Morris JJ, Lenski RE, Zinser ER (2012) The Black Queen Hypothesis: evolution of dependencies through adaptive gene loss. mBio 3. \n                    https:\/\/doi.org\/10.1128\/mBio.00036-12","DOI":"10.1128\/mBio.00036-12"},{"key":"1071_CR18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/1753425913486687","volume":"20","author":"F Neves","year":"2014","unstructured":"Neves F, Abrantes J, Steinke JW, Esteves PJ (2014) Maximum-likelihood approaches reveal signatures of positive selection in IL genes in mammals. Innate Immun 20:184\u2013191. \n                    https:\/\/doi.org\/10.1177\/1753425913486687","journal-title":"Innate Immun"},{"key":"1071_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1086\/302219","volume":"64","author":"MV Olson","year":"1999","unstructured":"Olson MV (1999) When less is more: gene loss as an engine of evolutionary change. Am J Hum Genet 64:18\u201323","journal-title":"Am J Hum Genet"},{"key":"1071_CR20","doi-asserted-by":"publisher","first-page":"10564","DOI":"10.1093\/nar\/gku744","volume":"42","author":"GE Parada","year":"2014","unstructured":"Parada GE, Munita R, Cerda CA, Gysling K (2014) A comprehensive survey of non-canonical splice sites in the human transcriptome. Nucleic Acids Res 42:10564\u201310578. \n                    https:\/\/doi.org\/10.1093\/nar\/gku744","journal-title":"Nucleic Acids Res"},{"key":"1071_CR21","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1093\/bioinformatics\/bti320","volume":"21","author":"SL Pond","year":"2005","unstructured":"Pond SL, Frost SD (2005) Datamonkey: rapid detection of selective pressure on individual sites of codon alignments. Bioinformatics (Oxford, England) 21:2531\u20132533. \n                    https:\/\/doi.org\/10.1093\/bioinformatics\/bti320","journal-title":"Bioinformatics (Oxford, England)"},{"key":"1071_CR22","doi-asserted-by":"publisher","first-page":"R558","DOI":"10.1016\/j.cub.2017.05.001","volume":"27","author":"ND Pyenson","year":"2017","unstructured":"Pyenson ND (2017) The ecological rise of whales chronicled by the fossil record. Curr Biol: CB 27:R558\u2013r564. \n                    https:\/\/doi.org\/10.1016\/j.cub.2017.05.001","journal-title":"Curr Biol: CB"},{"key":"1071_CR23","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/j.1523-1747.2003.12626.x","volume":"121","author":"J Romer","year":"2003","unstructured":"Romer J, Hasselager E, Norby PL, Steiniche T, Thorn Clausen J, Kragballe K (2003) Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. J Invest Dermatol 121:1306\u20131311. \n                    https:\/\/doi.org\/10.1111\/j.1523-1747.2003.12626.x","journal-title":"J Invest Dermatol"},{"key":"1071_CR24","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nri3766","volume":"14","author":"S Rutz","year":"2014","unstructured":"Rutz S, Wang X, Ouyang W (2014) The IL-20 subfamily of cytokines\u2014from host defence to tissue homeostasis. Nat Rev Immunol 14:783\u2013795. \n                    https:\/\/doi.org\/10.1038\/nri3766","journal-title":"Nat Rev Immunol"},{"key":"1071_CR25","doi-asserted-by":"publisher","unstructured":"Sadier A et al (2018) Evidence for multifactorial processes underlying phenotypic variation in bat visual opsins bioRxiv. \n                    https:\/\/doi.org\/10.1101\/300301","DOI":"10.1101\/300301"},{"key":"1071_CR26","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1093\/nar\/gkw210","volume":"44","author":"V Sharma","year":"2016","unstructured":"Sharma V, Elghafari A, Hiller M (2016) Coding exon-structure aware realigner (CESAR) utilizes genome alignments for accurate comparative gene annotation. Nucleic Acids Res 44:e103\u2013e103. \n                    https:\/\/doi.org\/10.1093\/nar\/gkw210","journal-title":"Nucleic Acids Res"},{"key":"1071_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03667-1","volume":"9","author":"V Sharma","year":"2018","unstructured":"Sharma V, Hecker N, Roscito JG, Foerster L, Langer BE, Hiller M (2018) A genomics approach reveals insights into the importance of gene losses for mammalian adaptations. Nat Commun 9:1215. \n                    https:\/\/doi.org\/10.1038\/s41467-018-03667-1","journal-title":"Nat Commun"},{"key":"1071_CR28","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nrg.2016.46","volume":"17","author":"CR Sibley","year":"2016","unstructured":"Sibley CR, Blazquez L, Ule J (2016) Lessons from non-canonical splicing. Nat Rev Genet 17:407\u2013421. \n                    https:\/\/doi.org\/10.1038\/nrg.2016.46","journal-title":"Nat Rev Genet"},{"key":"1071_CR29","unstructured":"Sokolov VEE (1982) Mammalian skin. University of California Press, Berkeley and Los Angeles"},{"key":"1071_CR30","first-page":"373","volume":"113","author":"RI Spearman","year":"1972","unstructured":"Spearman RI (1972) The epidermal stratum corneum of the whale. J Anat 113:373\u2013381","journal-title":"J Anat"},{"key":"1071_CR31","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ympev.2017.12.010","volume":"120","author":"MS Springer","year":"2018","unstructured":"Springer MS, Gatesy J (2018) Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands. Mol Phylogenet Evol 120:364\u2013374. \n                    https:\/\/doi.org\/10.1016\/j.ympev.2017.12.010","journal-title":"Mol Phylogenet Evol"},{"key":"1071_CR32","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/exd.12681","volume":"24","author":"B Strasser","year":"2015","unstructured":"Strasser B, Mlitz V, Fischer H, Tschachler E, Eckhart L (2015) Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins. Exp Dermatol 24:365\u2013369. \n                    https:\/\/doi.org\/10.1111\/exd.12681","journal-title":"Exp Dermatol"},{"key":"1071_CR33","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1093\/molbev\/msu400","volume":"32","author":"JO Wertheim","year":"2015","unstructured":"Wertheim JO, Murrell B, Smith MD, Kosakovsky Pond SL, Scheffler K (2015) RELAX: detecting relaxed selection in a phylogenetic framework. Mol Biol Evol 32:820\u2013832. \n                    https:\/\/doi.org\/10.1093\/molbev\/msu400","journal-title":"Mol Biol Evol"},{"key":"1071_CR34","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00109-009-0457-0","volume":"87","author":"K Wolk","year":"2009","unstructured":"Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, vom Baur E, Witte K, Warszawska K, Philipp S, Johnson-Leger C, Volk HD, Sterry W, Sabat R (2009) IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J Mol Med (Berl) 87:523\u2013536. \n                    https:\/\/doi.org\/10.1007\/s00109-009-0457-0","journal-title":"J Mol Med (Berl)"},{"key":"1071_CR35","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/oxfordjournals.molbev.a025957","volume":"15","author":"Z Yang","year":"1998","unstructured":"Yang Z (1998) Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Mol Biol Evol 15:568\u2013573. \n                    https:\/\/doi.org\/10.1093\/oxfordjournals.molbev.a025957","journal-title":"Mol Biol Evol"},{"key":"1071_CR36","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/molbev\/msm088","volume":"24","author":"Z Yang","year":"2007","unstructured":"Yang Z (2007) PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol 24:1586\u20131591. \n                    https:\/\/doi.org\/10.1093\/molbev\/msm088","journal-title":"Mol Biol Evol"},{"key":"1071_CR37","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/PL00006320","volume":"46","author":"Z Yang","year":"1998","unstructured":"Yang Z, Nielsen R (1998) Synonymous and nonsynonymous rate variation in nuclear genes of mammals. J Mol Evol 46:409\u2013418","journal-title":"J Mol Evol"},{"issue":"1","key":"1071_CR38","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ng.2835","volume":"46","author":"Hyung-Soon Yim","year":"2013","unstructured":"Yim H-S et al (2013) Minke whale genome and aquatic adaptation in cetaceans. Nat Genet 46(88). \n                    https:\/\/doi.org\/10.1038\/ng.2835\n                    \n                  , https:\/\/www.nature.com\/articles\/ng.2835#supplementary-information","journal-title":"Nature Genetics"},{"key":"1071_CR39","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1002\/ar.a.10077","volume":"273","author":"TS Zabka","year":"2003","unstructured":"Zabka TS, Romano TA (2003) Distribution of MHC II (+) cells in skin of the Atlantic bottlenose dolphin (Tursiops truncatus): an initial investigation of dolphin dendritic cells. Anat Rec A Discov Mol Cell Evol Biol 273:636\u2013647. \n                    https:\/\/doi.org\/10.1002\/ar.a.10077","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"}],"container-title":["Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00251-018-1071-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-018-1071-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00251-018-1071-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T23:56:18Z","timestamp":1562889378000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00251-018-1071-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["1071"],"URL":"https:\/\/doi.org\/10.1007\/s00251-018-1071-5","relation":{},"ISSN":["0093-7711","1432-1211"],"issn-type":[{"value":"0093-7711","type":"print"},{"value":"1432-1211","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]},"assertion":[{"value":"28 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}