{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:14:08Z","timestamp":1776107648644,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1007\/s00253-006-0561-9","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T08:45:58Z","timestamp":1159951558000},"page":"1173-1179","source":"Crossref","is-referenced-by-count":118,"title":["In vitro evaluation of the prebiotic activity of a pectic oligosaccharide-rich extract enzymatically derived from bergamot peel"],"prefix":"10.1007","volume":"73","author":[{"given":"G.","family":"Mandalari","sequence":"first","affiliation":[]},{"given":"C.","family":"Nueno Palop","sequence":"additional","affiliation":[]},{"given":"K.","family":"Tuohy","sequence":"additional","affiliation":[]},{"given":"G. R.","family":"Gibson","sequence":"additional","affiliation":[]},{"given":"R. N.","family":"Bennett","sequence":"additional","affiliation":[]},{"given":"K. W.","family":"Waldron","sequence":"additional","affiliation":[]},{"given":"G.","family":"Bisignano","sequence":"additional","affiliation":[]},{"given":"A.","family":"Narbad","sequence":"additional","affiliation":[]},{"given":"C. B.","family":"Faulds","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"561_CR1","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1046\/j.1440-1746.2002.02709.x","volume":"17","author":"T Bamba","year":"2002","unstructured":"Bamba T, Kanauchi O, Andoh A, Fujiyama Y (2002) A new prebiotic from germinated barley for nutraceutical treatment of ulcerative colitis. J Gastroenterol Hepatol 17:818\u2013824","journal-title":"J Gastroenterol Hepatol"},{"key":"561_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0008-6215(83)88244-5","volume":"113","author":"AB Blakeney","year":"1983","unstructured":"Blakeney AB, Harris PJ, Henry RJ, Stone BA (1983) A simple and rapid preparation of alditol acetates for monosaccharide analysis. Carbohydr Res 113:291\u2013299","journal-title":"Carbohydr Res"},{"key":"561_CR3","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/0003-2697(73)90377-1","volume":"54","author":"N Blumenkrantz","year":"1973","unstructured":"Blumenkrantz N, Asboe-Hansen G (1973) New method for quantitative determination of uronic acids. Anal Biochem 54:484\u2013489","journal-title":"Anal Biochem"},{"key":"561_CR4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantisation of microgram quantities of protein utilising the principle of protein-dyebinding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"561_CR5","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1079\/BJN20041286","volume":"92","author":"L Dauchet","year":"2004","unstructured":"Dauchet L, Ferri\u00e8res J, Arveiler D, Yarnell JW, Gey F, Ducimeti\u00e8re P, Ruidavets J-B, Haas B, Evans A, Bingham A, Amouyel P, Dallongeville J (2004) Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study. Br J Nutr 92:963\u2013972","journal-title":"Br J Nutr"},{"key":"561_CR6","doi-asserted-by":"publisher","first-page":"1467S","DOI":"10.1093\/jn\/129.7.1467S","volume":"129","author":"NM Delzenne","year":"1999","unstructured":"Delzenne NM, Kok NN (1999) Biochemical basis of oligofructose-induced hypolipidemia in animal models. J Nutr 129:1467S\u20131470S","journal-title":"J Nutr"},{"key":"561_CR7","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1128\/AEM.64.9.3336-3345.1998","volume":"64","author":"AH Franks","year":"1998","unstructured":"Franks AH, Harmsen HJM, Raangs GC, Jansen GJ, Schut F, Welling GW (1998) Variations of bacterial populations in human faeces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 64:3336\u20133345","journal-title":"Appl Environ Microbiol"},{"key":"561_CR8","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","volume":"125","author":"GR Gibson","year":"1995","unstructured":"Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concepts of prebiotics. J Nutr 125:1401\u20131412","journal-title":"J Nutr"},{"key":"561_CR9","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/0016-5085(95)90192-2","volume":"108","author":"GR Gibson","year":"1995","unstructured":"Gibson GR, Beatty ER, Wang X, Cummings JH (1995) Selected stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108:975\u2013982","journal-title":"Gastroenterology"},{"key":"561_CR10","doi-asserted-by":"publisher","DOI":"10.1533\/9781855736436","volume-title":"Prebiotics: new developments in functional foods","author":"GR Gibson","year":"2000","unstructured":"Gibson GR, Ottaway PB, Rastall RA (2000) Prebiotics: new developments in functional foods. Chandos, Oxford, UK"},{"key":"561_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/089106099435862","volume":"11","author":"HJM Harmsen","year":"1999","unstructured":"Harmsen HJM, Elferrich P, Schut F, Welling GW (1999) A 16S rRNA-targeted probe for detection of lactobacilli and enterococci in faecal samples by fluorescent in situ hybridization. Microb Ecol Health Dis 11:3\u201312","journal-title":"Microb Ecol Health Dis"},{"key":"561_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0008-6215(84)85017-X","volume":"134","author":"S Hizukuri","year":"1984","unstructured":"Hizukuri S, Takagi T (1984) Estimation of the distribution of molecular weight for amylase by the low-angle laser-light-scattering technique combined with high-performance gel chromatography. Carbohydr Res 134:1\u201310","journal-title":"Carbohydr Res"},{"key":"561_CR13","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1016\/j.procbio.2005.03.026","volume":"40","author":"RS Jayani","year":"2005","unstructured":"Jayani RS, Saxena S, Gupta R (2005) Microbial pectinolytic enzymes: a review. Process Biochem 40:2931\u20132944","journal-title":"Process Biochem"},{"key":"561_CR14","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1128\/AEM.61.8.3069-3075.1995","volume":"61","author":"PS Langendijk","year":"1995","unstructured":"Langendijk PS, Schut F, Jansen GJ, Raangs GC, Kamphuis GR, Wilkinson MHF, Welling GW (1995) Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in faecal samples. Appl Environ Microbiol 61:3069\u20133075","journal-title":"Appl Environ Microbiol"},{"key":"561_CR15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1021\/jf051847n","volume":"54","author":"G Mandalari","year":"2006","unstructured":"Mandalari G, Bennett RN, Bisignano G, Saija A, Dugo G, Lo Curto R, Faulds CB, Waldron KW (2006) Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major by-product of essential oil extraction. J Agric Food Chem 54:197\u2013203","journal-title":"J Agric Food Chem"},{"key":"561_CR16","doi-asserted-by":"publisher","first-page":"8383","DOI":"10.1128\/AEM.71.12.8383-8389.2005","volume":"71","author":"K Manderson","year":"2005","unstructured":"Manderson K, Pinart M, Tuohy KM, Grace WE, Hotchkiss AT, Widmer W, Yadhav MP, Gibson GR, Rastall RA (2005) In vitro determination of prebiotic properties of oligosaccharides derived from an orange juice manufacturing by-product stream. Appl Environ Microbiol 71:8383\u20138389","journal-title":"Appl Environ Microbiol"},{"key":"561_CR17","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1099\/13500872-142-5-1097","volume":"142","author":"W Manz","year":"1996","unstructured":"Manz W, Amann R, Ludwig W, Vancanneyt M, Schleifer KH (1996) Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Microbiology 142:1097\u20131106","journal-title":"Microbiology"},{"key":"561_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0144-8617(90)90105-2","volume":"12","author":"CD May","year":"1990","unstructured":"May CD (1990) Industrial pectins: Sources, production and applications. Carbohydr Polym 12:79\u201399","journal-title":"Carbohydr Polym"},{"key":"561_CR19","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/jn\/130.5.1197","volume":"130","author":"E Menne","year":"2000","unstructured":"Menne E, Guggenbuhl N, Roberfroid M (2000) Fn-type chicory inulin hydrolysate has a prebiotic effect in humans. J Nutr 130:1197\u20131199","journal-title":"J Nutr"},{"key":"561_CR20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1017\/S0007114500000325","volume":"83","author":"E Olano-Martin","year":"2000","unstructured":"Olano-Martin E, Mountzouris KC, Gibson GR, Rastall RA (2000) In vitro fermentability of dextran, oligodextran and maltodextrin by human gut bacteria. Br J Nutr 83:247\u2013255","journal-title":"Br J Nutr"},{"key":"561_CR21","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1046\/j.1365-2672.2002.01719.x","volume":"93","author":"E Olano-Martin","year":"2002","unstructured":"Olano-Martin E, Gibson GR, Rastall RA (2002) Comparison of the in vitro bifidogenic properties of pectins and pectic-oligosaccharides. J Appl Microbiol 93:505\u2013511","journal-title":"J Appl Microbiol"},{"key":"561_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1046\/j.1472-765X.2003.01398.x","volume":"37","author":"R Palframan","year":"2003","unstructured":"Palframan R, Gibson GR, Rastall RA (2003) Development of a quantitative tool for the comparison of the prebiotic effect of dietary oligosaccharides. Lett Appl Microbiol 37:281\u2013284","journal-title":"Lett Appl Microbiol"},{"key":"561_CR23","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/S0271-5317(01)00284-6","volume":"6","author":"VA Rao","year":"2001","unstructured":"Rao VA (2001) The prebiotic properties of oligofructose at low intake levels. Nutr Res 6:843\u2013848","journal-title":"Nutr Res"},{"key":"561_CR24","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1111\/j.1753-4887.1996.tb03817.x","volume":"54","author":"MB Roberfroid","year":"1996","unstructured":"Roberfroid MB (1996) Functional effects of food components and the gastrointestinal system: chicory fructooligosaccharides. Nutr Rev 54:S38\u2013S42","journal-title":"Nutr Rev"},{"key":"561_CR25","doi-asserted-by":"publisher","first-page":"1682s","DOI":"10.1093\/ajcn\/71.6.1682S","volume":"71","author":"MB Roberfroid","year":"2000","unstructured":"Roberfroid MB (2000) Prebiotics and probiotics: are they functional food? Am J Clin Nutr 71:1682s\u20131687s","journal-title":"Am J Clin Nutr"},{"key":"561_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/jn\/128.1.11","volume":"128","author":"MB Roberfroid","year":"1998","unstructured":"Roberfroid MB, Van Loo JAE, Gibson GR (1998) The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr 128:11\u201319","journal-title":"J Nutr"},{"key":"561_CR27","volume-title":"Role of the gut microflora in toxicity and cancer","author":"IR Rowland","year":"1988","unstructured":"Rowland IR (1988) Role of the gut microflora in toxicity and cancer. Academic, London"},{"key":"561_CR28","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1046\/j.1365-2672.2001.01446.x","volume":"91","author":"CE Rycroft","year":"2001","unstructured":"Rycroft CE, Jones MR, Gibson GR, Rastall RA (2001) A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J Appl Microbiol 91:878\u2013887","journal-title":"J Appl Microbiol"},{"key":"561_CR29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1006\/abbi.1995.1473","volume":"2","author":"N Salah","year":"1995","unstructured":"Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP, Rice-Evans C (1995) Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys 2:339\u2013346","journal-title":"Arch Biochem Biophys"},{"key":"561_CR30","doi-asserted-by":"publisher","first-page":"5192","DOI":"10.1021\/jf050276w","volume":"53","author":"ML Sanz","year":"2005","unstructured":"Sanz ML, Gibson GR, Rastall RA (2005) Influence of disaccharide structure on prebiotic selectivity in vitro. J Agric Food Chem 53:5192\u20135199","journal-title":"J Agric Food Chem"},{"key":"561_CR31","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.3168\/jds.S0022-0302(95)76659-0","volume":"78","author":"EJ Schiffrin","year":"1995","unstructured":"Schiffrin EJ, Rochat F, Link-Amster H, Aeschlimann JM, Donnet-Hugues A (1995) Immune system stimulation by probiotics. J Dairy Sci 78:1597\u20131606","journal-title":"J Dairy Sci"},{"key":"561_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/10408399709527767","volume":"37","author":"BR Thakur","year":"1997","unstructured":"Thakur BR, Rakesh KS, Handa AK (1997) Chemistry and uses of pectin\u2014a review. Crit Rev Food Sci Nutr 37:47\u201373","journal-title":"Crit Rev Food Sci Nutr"},{"key":"561_CR33","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1079\/BJN2001394","volume":"86","author":"KM Tuohy","year":"2001","unstructured":"Tuohy KM, Kolida S, Lustenberger AM, Gibson GR (2001) The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructo-oligosaccharides\u2014a human volunteer study. Br J Nutr 86:341\u2013348","journal-title":"Br J Nutr"},{"key":"561_CR34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/089106002320644357","volume":"14","author":"KM Tuohy","year":"2002","unstructured":"Tuohy KM, Ziemer CJ, Klinder A, Kn\u00f6bel Y, Pool-Zobel BL, Gibson GR (2002) A human volunteer study to determine the prebiotic effects of lactulose powder on human colonic microbiota. Microb Ecol Health Dis 14:165\u2013173","journal-title":"Microb Ecol Health Dis"},{"key":"561_CR35","doi-asserted-by":"publisher","first-page":"S293","DOI":"10.1079\/BJN\/2002551","volume":"87","author":"Y Vandenplas","year":"2002","unstructured":"Vandenplas Y (2002) Oligosaccharides in infant formula. Br J Nutr 87:S293\u2013S296","journal-title":"Br J Nutr"},{"key":"561_CR36","doi-asserted-by":"publisher","first-page":"S261","DOI":"10.1079\/BJN\/2002546","volume":"87","author":"CM Williams","year":"2002","unstructured":"Williams CM, Jackson KG (2002) Inulin and oligofructose: effects on lipid metabolism from human studies. Br J Nutr 87:S261\u2013S264","journal-title":"Br J Nutr"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-006-0561-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-006-0561-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-006-0561-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-006-0561-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T01:27:29Z","timestamp":1581038849000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-006-0561-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["561"],"URL":"https:\/\/doi.org\/10.1007\/s00253-006-0561-9","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}