{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:57:18Z","timestamp":1771930638914,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"crossref","award":["UID\/BIO\/04469\/2013 - POCI-01-0145-FEDER-006684"],"award-info":[{"award-number":["UID\/BIO\/04469\/2013 - POCI-01-0145-FEDER-006684"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Regional Development Fund under the scope of Norte2020","award":["BioTecNorte operation (NORTE-01-0145-FEDER-000004)"],"award-info":[{"award-number":["BioTecNorte operation (NORTE-01-0145-FEDER-000004)"]}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"crossref","award":["UID\/ QUI\/50006\/2013 - POCI\/01\/0145\/FEDER\/007265"],"award-info":[{"award-number":["UID\/ QUI\/50006\/2013 - POCI\/01\/0145\/FEDER\/007265"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"crossref","award":["SFRH\/BD\/101452\/2014"],"award-info":[{"award-number":["SFRH\/BD\/101452\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00253-018-8802-2","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T09:14:29Z","timestamp":1518081269000},"page":"2827-2838","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nickel oxide (NiO) nanoparticles disturb physiology and induce cell death in the yeast Saccharomyces cerevisiae"],"prefix":"10.1007","volume":"102","author":[{"given":"C\u00e1tia A.","family":"Sousa","sequence":"first","affiliation":[]},{"given":"Helena M. V. M.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Eduardo V.","family":"Soares","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"issue":"10","key":"8802_CR1","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1016\/j.chemosphere.2013.09.047","volume":"93","author":"M Ahamed","year":"2013","unstructured":"Ahamed M, Ali D, Alhadlaq HA, Akhtar MJ (2013) Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2). Chemosphere 93(10):2514\u20132522. https:\/\/doi.org\/10.1016\/j.chemosphere.2013.09.047","journal-title":"Chemosphere"},{"issue":"3","key":"8802_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11270-016-2771-9","volume":"227","author":"M Ates","year":"2016","unstructured":"Ates M, Demir V, Arslan Z, Camas M, Celik F (2016) Toxicity of engineered nickel oxide and cobalt oxide nanoparticles to Artemia salina in seawater. Water Air Soil Pollut 227(3):1\u20138. https:\/\/doi.org\/10.1007\/s11270-016-2771-9","journal-title":"Water Air Soil Pollut"},{"issue":"8","key":"8802_CR3","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.scitotenv.2011.01.014","volume":"409","author":"Y-W Baek","year":"2011","unstructured":"Baek Y-W, An Y-J (2011) Microbial toxicity of metal oxide nanoparticles (CuO, NiO, ZnO, and Sb2O3) to Escherichia coli, Bacillus subtilis, and Streptococcus aureus. Sci Total Environ 409(8):1603\u20131608. https:\/\/doi.org\/10.1016\/j.scitotenv.2011.01.014","journal-title":"Sci Total Environ"},{"issue":"23","key":"8802_CR4","doi-asserted-by":"publisher","first-page":"8098","DOI":"10.1128\/AEM.02035-15","volume":"81","author":"S Bao","year":"2015","unstructured":"Bao S, Lu Q, Fang T, Dai H, Zhang C (2015) Assessment of the toxicity of CuO nanoparticles by using Saccharomyces cerevisiae mutants with multiple genes deleted. Appl Environ Microbiol 81(23):8098\u20138107. https:\/\/doi.org\/10.1128\/aem.02035-15","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"8802_CR5","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1128\/AEM.61.4.1614-1619.1995","volume":"61","author":"P Breeuwer","year":"1995","unstructured":"Breeuwer P, Drocourt JL, Bunschoten N, Zwietering MH, Rombouts FM, Abee T (1995) Characterization of uptake and hydrolysis of fluorescein diacetate and carboxyfluorescein diacetate by intracellular esterases in Saccharomyces cerevisiae, which result in accumulation of fluorescent product. Appl Environ Microbiol 61(4):1614\u20131619","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"8802_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.toxlet.2014.01.040","volume":"226","author":"L Capasso","year":"2014","unstructured":"Capasso L, Camatini M, Gualtieri M (2014) Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells. Toxicol Lett 226(1):28\u201334. https:\/\/doi.org\/10.1016\/j.toxlet.2014.01.040","journal-title":"Toxicol Lett"},{"issue":"7","key":"8802_CR7","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1073\/pnas.0608582104","volume":"104","author":"T Cedervall","year":"2007","unstructured":"Cedervall T, Lynch I, Lindman S, Berggard T, Thulin E, Nilsson H, Dawson KA, Linse S (2007) Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc Natl Acad Sci U S A 104(7):2050\u20132055. https:\/\/doi.org\/10.1073\/pnas.0608582104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"8802_CR8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.cbi.2013.09.020","volume":"206","author":"CC Chusuei","year":"2013","unstructured":"Chusuei CC, Wu C-H, Mallavarapu S, Hou FYS, Hsu C-M, Winiarz JG, Aronstarn RS, Huang Y-W (2013) Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties. Chem Biol Interact 206(2):319\u2013326. https:\/\/doi.org\/10.1016\/j.cbi.2013.09.020","journal-title":"Chem Biol Interact"},{"issue":"1\u20132","key":"8802_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1023\/A:1007007704657","volume":"201","author":"R Souza Pereira de","year":"1999","unstructured":"de Souza Pereira R, Geibel J (1999) Direct observation of oxidative stress on the cell wall of Saccharomyces cerevisiae strains with atomic force microscopy. Mol Cell Biochem 201(1\u20132):17\u201324. https:\/\/doi.org\/10.1023\/a:1007007704657","journal-title":"Mol Cell Biochem"},{"key":"8802_CR10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.copbio.2015.03.001","volume":"33","author":"SC Santos dos","year":"2015","unstructured":"dos Santos SC, Sa-Correia I (2015) Yeast toxicogenomics: lessons from a eukaryotic cell model and cell factory. Curr Opin Biotechnol 33:183\u2013191. https:\/\/doi.org\/10.1016\/j.copbio.2015.03.001","journal-title":"Curr Opin Biotechnol"},{"issue":"63","key":"8802_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fgene.2012.00063","volume":"3","author":"SC Santos dos","year":"2012","unstructured":"dos Santos SC, Teixeira MC, Cabrito TR, Sa-Correia I (2012) Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology. Front Genet 3(63):1\u201317. https:\/\/doi.org\/10.3389\/fgene.2012.00063","journal-title":"Front Genet"},{"issue":"2","key":"8802_CR12","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.taap.2015.03.024","volume":"286","author":"W-X Duan","year":"2015","unstructured":"Duan W-X, He M-D, Mao L, Qian F-H, Li Y-M, Pi H-F, Liu C, Chen C-H, Lu Y-H, Cao Z-W, Zhang L, Yu Z-P, Zhou Z (2015) NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells. Toxicol Appl Pharmacol 286(2):80\u201391. https:\/\/doi.org\/10.1016\/j.taap.2015.03.024","journal-title":"Toxicol Appl Pharmacol"},{"key":"8802_CR13","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jhazmat.2013.01.063","volume":"250","author":"M Faisal","year":"2013","unstructured":"Faisal M, Saquib Q, Alatar AA, Al-Khedhairy AA, Hegazy AK, Musarrat J (2013) Phytotoxic hazards of NiO-nanoparticles in tomato: a study on mechanism of cell death. J Hazard Mater 250:318\u2013332. https:\/\/doi.org\/10.1016\/j.jhazmat.2013.01.063","journal-title":"J Hazard Mater"},{"issue":"1","key":"8802_CR14","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3109\/17435390903470101","volume":"4","author":"PA Gillespie","year":"2010","unstructured":"Gillespie PA, Kang GS, Elder A, Gelein R, Chen L, Moreira AL, Koberstein J, Tchou-Wong K-M, Gordon T, Chen LC (2010) Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice. Nanotoxicology 4(1):106\u2013119. https:\/\/doi.org\/10.3109\/17435390903470101","journal-title":"Nanotoxicology"},{"issue":"5287","key":"8802_CR15","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1126\/science.274.5287.546","volume":"274","author":"A Goffeau","year":"1996","unstructured":"Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996) Life with 6000 genes. Science 274(5287):546\u2013567. https:\/\/doi.org\/10.1126\/science.274.5287.546","journal-title":"Science"},{"issue":"4","key":"8802_CR16","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.chemosphere.2010.12.059","volume":"83","author":"N Gong","year":"2011","unstructured":"Gong N, Shao K, Feng W, Lin Z, Liang C, Sun Y (2011) Biotoxicity of nickel oxide nanoparticles and bio-remediation by microalgae Chlorella vulgaris. Chemosphere 83(4):510\u2013516. https:\/\/doi.org\/10.1016\/j.chemosphere.2010.12.059","journal-title":"Chemosphere"},{"issue":"1","key":"8802_CR17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jeurceramsoc.2011.08.015","volume":"32","author":"D Hanaor","year":"2012","unstructured":"Hanaor D, Michelazzi M, Leonelli C, Sorrell CC (2012) The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2. J Eur Ceram Soc 32(1):235\u2013244. https:\/\/doi.org\/10.1016\/j.jeurceramsoc.2011.08.015","journal-title":"J Eur Ceram Soc"},{"key":"8802_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-1-4757-9435-9_7","volume-title":"Biochemistry of nickel vol 12","author":"RP Hausinger","year":"1993","unstructured":"Hausinger RP (1993) Microbial nickel metabolism. In: Frieden E (ed) Biochemistry of nickel vol 12. Springer Science, New York, pp 181\u2013201. https:\/\/doi.org\/10.1007\/978-1-4757-9435-9_7"},{"issue":"1\u20132","key":"8802_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.molcata.2010.12.011","volume":"336","author":"K Hayat","year":"2011","unstructured":"Hayat K, Gondal MA, Khaled MM, Ahmed S (2011) Effect of operational key parameters on photocatalytic degradation of phenol using nano nickel oxide synthesized by sol-gel method. J Mol Catal A Chem 336(1\u20132):64\u201371. https:\/\/doi.org\/10.1016\/j.molcata.2010.12.011","journal-title":"J Mol Catal A Chem"},{"issue":"2","key":"8802_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1539\/joh.L10121","volume":"53","author":"M Horie","year":"2011","unstructured":"Horie M, Fukui H, Nishio K, Endoh S, Kato H, Fujita K, Miyauchi A, Nakamura A, Shichiri M, Ishida N, Kinugasa S, Morimoto Y, Niki E, Yoshida Y, Iwahashi H (2011) Evaluation of acute oxidative stress induced by NiO nanoparticles in vivo and in vitro. J Occup Health 53(2):64\u201374. https:\/\/doi.org\/10.1539\/joh.L10121","journal-title":"J Occup Health"},{"issue":"1","key":"8802_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox5010004","volume":"5","author":"M Horie","year":"2016","unstructured":"Horie M, Yoshiura Y, Izumi H, Oyabu T, Tomonaga T, Okada T, Lee B-W, Myojo T, Kubo M, Shimada M, Morimoto Y (2016) Comparison of the pulmonary oxidative stress caused by intratracheal instillation and inhalation of NiO nanoparticles when equivalent amounts of NiO are retained in the lung. Antioxidants 5(1):1\u201312. https:\/\/doi.org\/10.3390\/antiox5010004","journal-title":"Antioxidants"},{"key":"8802_CR22","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.envint.2015.10.014","volume":"87","author":"A Jemec","year":"2016","unstructured":"Jemec A, Kahru A, Potthoff A, Drobne D, Heinlaan M, Bohme S, Geppert M, Novak S, Schirmer K, Rekulapally R, Singh S, Aruoja V, Sihtmae M, Juganson K, Kakinen A, Kuhnel D (2016) An interlaboratory comparison of nanosilver characterisation and hazard identification: harmonising techniques for high quality data. Environ Int 87:20\u201332. https:\/\/doi.org\/10.1016\/j.envint.2015.10.014","journal-title":"Environ Int"},{"issue":"2","key":"8802_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0016015","volume":"6","author":"H Karathia","year":"2011","unstructured":"Karathia H, Vilaprinyo E, Sorribas A, Alves R (2011) Saccharomyces cerevisiae as a model organism: a comparative study. PLoS One 6(2):1\u201310. https:\/\/doi.org\/10.1371\/journal.pone.0016015","journal-title":"PLoS One"},{"issue":"1","key":"8802_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12989-014-0041-9","volume":"11","author":"HL Karlsson","year":"2014","unstructured":"Karlsson HL, Gliga AR, Calleja FMGR, Goncalves CSAG, Wallinder IO, Vrieling H, Fadeel B, Hendriks G (2014) Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines. Part Fibre Toxicol 11(1):1\u201314. https:\/\/doi.org\/10.1186\/s12989-014-0041-9","journal-title":"Part Fibre Toxicol"},{"issue":"3","key":"8802_CR25","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1021\/tx300467d","volume":"26","author":"K Kasemets","year":"2013","unstructured":"Kasemets K, Suppi S, Kuennis-Beres K, Kahru A (2013) Toxicity of CuO nanoparticles to yeast Saccharomyces cerevisiae BY4741 wild-type and its nine isogenic single-gene deletion mutants. Chem Res Toxicol 26(3):356\u2013367. https:\/\/doi.org\/10.1021\/tx300467d","journal-title":"Chem Res Toxicol"},{"key":"8802_CR26","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/978-94-007-5704-2_70","volume-title":"Encyclopedia of aquatic ecotoxicology vol 2","author":"SJ Klaine","year":"2013","unstructured":"Klaine SJ, Edgington A, Seda B (2013) Nanomaterials in the environment. In: F\u00e9rard J-F, Blaise C (eds) Encyclopedia of aquatic ecotoxicology vol 2. Springer Publishers, Dordrecht, pp 767\u2013779"},{"issue":"3","key":"8802_CR27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1574-6976.2002.tb00613.x","volume":"26","author":"FM Klis","year":"2002","unstructured":"Klis FM, Mol P, Hellingwerf K, Brul S (2002) Dynamics of cell wall structure in Saccharomyces cerevisiae. FEMS Microbiol Rev 26(3):239\u2013256. https:\/\/doi.org\/10.1111\/j.1574-6976.2002.tb00613.x","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"8802_CR28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/yea.1349","volume":"23","author":"FM Klis","year":"2006","unstructured":"Klis FM, Boorsma A, De Groot PWJ (2006) Cell wall construction in Saccharomyces cerevisiae. Yeast 23(3):185\u2013202. https:\/\/doi.org\/10.1002\/yea.1349","journal-title":"Yeast"},{"issue":"1","key":"8802_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2478\/intox-2014-0004","volume":"7","author":"JA Kovriznych","year":"2014","unstructured":"Kovriznych JA, Sotnikova R, Zeljenkova D, Rollerova E, Szabova E (2014) Long-term (30 days) toxicity of NiO nanoparticles for adult zebrafish Danio rerio. Interdiscip Toxicol 7(1):23\u201326. https:\/\/doi.org\/10.2478\/intox-2014-0004","journal-title":"Interdiscip Toxicol"},{"issue":"7","key":"8802_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0159684","volume":"11","author":"S Latvala","year":"2016","unstructured":"Latvala S, Hedberg J, Di Bucchianico S, M\u00f6ller L, Wallinder IW, Elihn K, Karlsson HL (2016) Nickel release, ROS generation and toxicity of Ni and NiO micro- and nanoparticles. PLoS One 11(7):1\u201320. https:\/\/doi.org\/10.1371\/journal.pone.0159684","journal-title":"PLoS One"},{"issue":"9\u201310","key":"8802_CR31","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/smll.201202128","volume":"9","author":"S Lin","year":"2013","unstructured":"Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Maedler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE (2013) Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small 9(9\u201310):1776\u20131785. https:\/\/doi.org\/10.1002\/smll.201202128","journal-title":"Small"},{"issue":"4","key":"8802_CR32","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00775-007-0208-z","volume":"12","author":"C-N Lok","year":"2007","unstructured":"Lok C-N, Ho C-M, Chen R, He Q-Y, Yu W-Y, Sun H, Tam PK-H, Chiu J-F, Che C-M (2007) Silver nanoparticles: partial oxidation and antibacterial activities. J Biol Inorg Chem 12(4):527\u2013534. https:\/\/doi.org\/10.1007\/s00775-007-0208-z","journal-title":"J Biol Inorg Chem"},{"key":"8802_CR33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.envpol.2014.06.027","volume":"193","author":"HB Ma","year":"2014","unstructured":"Ma HB, Wallis LK, Diamond S, Li SB, Canas-Carrell J, Parra A (2014) Impact of solar UV radiation on toxicity of ZnO nanoparticles through photocatalytic reactive oxygen species (ROS) generation and photo-induced dissolution. Environ Pollut 193:165\u2013172. https:\/\/doi.org\/10.1016\/j.envpol.2014.06.027","journal-title":"Environ Pollut"},{"issue":"12","key":"8802_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0015196","volume":"5","author":"A-J Miao","year":"2010","unstructured":"Miao A-J, Luo Z, Chen C-S, Chin W-C, Santschi PH, Quigg A (2010) Intracellular uptake: a possible mechanism for silver engineered nanoparticle toxicity to a freshwater alga Ochromonas danica. PLoS One 5(12):1\u20138. https:\/\/doi.org\/10.1371\/journal.pone.0015196","journal-title":"PLoS One"},{"issue":"7","key":"8802_CR35","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1128\/AEM.63.7.2897-2905.1997","volume":"63","author":"PJ Millard","year":"1997","unstructured":"Millard PJ, Roth BL, Thi HPT, Yue ST, Haugland RP (1997) Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts. Appl Environ Microbiol 63(7):2897\u20132905","journal-title":"Appl Environ Microbiol"},{"issue":"5761","key":"8802_CR36","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1126\/science.1114397","volume":"311","author":"A Nel","year":"2006","unstructured":"Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311(5761):622\u2013627. https:\/\/doi.org\/10.1126\/science.1114397","journal-title":"Science"},{"issue":"17","key":"8802_CR37","doi-asserted-by":"publisher","first-page":"13212","DOI":"10.1007\/s11356-015-4581-9","volume":"22","author":"V Nogueira","year":"2015","unstructured":"Nogueira V, Lopes I, Rocha-Santos TAP, Rasteiro MG, Abrantes N, Goncalves F, Soares AMVM, Duarte AC, Pereira R (2015) Assessing the ecotoxicity of metal nano-oxides with potential for wastewater treatment. Environ Sci Pollut Res 22(17):13212\u201313224. https:\/\/doi.org\/10.1007\/s11356-015-4581-9","journal-title":"Environ Sci Pollut Res"},{"key":"8802_CR38","volume-title":"Alga, growth inhibition test (201) OECD guideline for testing of chemicals","author":"OECD","year":"2011","unstructured":"OECD (2011) Alga, growth inhibition test (201) OECD guideline for testing of chemicals. Organization for Economic Co-Operation and Development, Paris"},{"key":"8802_CR39","doi-asserted-by":"publisher","first-page":"501326","DOI":"10.1155\/2015\/501326","volume":"2015","author":"A Oukarroum","year":"2015","unstructured":"Oukarroum A, Barhoumi L, Samadani M, Dewez D (2015) Toxic effects of nickel oxide bulk and nanoparticles on the aquatic plant Lemna gibba L. Biomed Res Int 2015:501326. https:\/\/doi.org\/10.1155\/2015\/501326 7","journal-title":"Biomed Res Int"},{"issue":"7","key":"8802_CR40","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/bit.260340703","volume":"34","author":"RG Protheroe","year":"1989","unstructured":"Protheroe RG, Cumming RH, Matchett A (1989) Medium-induced inhibition of microbial adsorption to nickel and activated-charcoal. Biotechnol Bioeng 34(7):896\u2013901. https:\/\/doi.org\/10.1002\/bit.260340703","journal-title":"Biotechnol Bioeng"},{"issue":"3\u20134","key":"8802_CR41","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.fct.2012.01.017","volume":"50","author":"MA Siddiqui","year":"2012","unstructured":"Siddiqui MA, Ahamed M, Ahmad J, Khan MAM, Musarrat J, Al-Khedhairy AA, Alrokayan SA (2012) Nickel oxide nanoparticles induce cytotoxicity, oxidative stress and apoptosis in cultured human cells that is abrogated by the dietary antioxidant curcumin. Food Chem Toxicol 50(3\u20134):641\u2013647. https:\/\/doi.org\/10.1016\/j.fct.2012.01.017","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"8802_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3184\/095422900782775535","volume":"12","author":"EV Soares","year":"2000","unstructured":"Soares EV, Duarte APRS, Soares HMVM (2000) Study of the suitability of 2-(N-morpholino) ethanesulfonic acid pH buffer for heavy metals accumulation studies using Saccharomyces cerevisiae. Chem Speciat Bioavailab 12(2):59\u201365. https:\/\/doi.org\/10.3184\/095422900782775535","journal-title":"Chem Speciat Bioavailab"},{"issue":"3","key":"8802_CR43","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.toxlet.2010.05.012","volume":"197","author":"AM Studer","year":"2010","unstructured":"Studer AM, Limbach LK, Van Duc L, Krumeich F, Athanassiou EK, Gerber LC, Moch H, Stark WJ (2010) Nanoparticle cytotoxicity depends on intracellular solubility: comparison of stabilized copper metal and degradable copper oxide nanoparticles. Toxicol Lett 197(3):169\u2013174. https:\/\/doi.org\/10.1016\/j.toxlet.2010.05.012","journal-title":"Toxicol Lett"},{"issue":"3","key":"8802_CR44","doi-asserted-by":"publisher","first-page":"R431","DOI":"10.1152\/ajpregu.00361.2003","volume":"286","author":"MM Tarpey","year":"2004","unstructured":"Tarpey MM, Wink DA, Grisham MB (2004) Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am J Physiol Regul Integr Comp Physiol 286(3):R431\u2013R444. https:\/\/doi.org\/10.1152\/ajpregu.00361.2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"8802_CR45","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3109\/17435390.2013.809810","volume":"8","author":"N Moos von","year":"2014","unstructured":"von Moos N, Slaveykova VI (2014) Oxidative stress induced by inorganic nanoparticles in bacteria and aquatic microalgae\u2014state of the art and knowledge gaps. Nanotoxicology 8(6):605\u2013630. https:\/\/doi.org\/10.3109\/17435390.2013.809810","journal-title":"Nanotoxicology"},{"key":"8802_CR46","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jhazmat.2016.01.066","volume":"308","author":"D Wang","year":"2016","unstructured":"Wang D, Lin Z, Wang T, Yao Z, Qin M, Zheng S, Lu W (2016) Where does the toxicity of metal oxide nanoparticles come from: the nanoparticles, the ions, or a combination of both? J Hazard Mater 308:328\u2013334. https:\/\/doi.org\/10.1016\/j.jhazmat.2016.01.066","journal-title":"J Hazard Mater"},{"issue":"1","key":"8802_CR47","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1093\/toxsci\/kfn034","volume":"103","author":"M Zhang","year":"2008","unstructured":"Zhang M, Liang Y, Zhang X, Xu Y, Dai H, Xiao W (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol Sci 103(1):68\u201376. https:\/\/doi.org\/10.1093\/toxsci\/kfn034","journal-title":"Toxicol Sci"},{"issue":"1","key":"8802_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"W Zhang","year":"2016","unstructured":"Zhang W, Bao S, Fang T (2016) The neglected nano-specific toxicity of ZnO nanoparticles in the yeast Saccharomyces cerevisiae. Sci Rep 6(1):1\u201311. https:\/\/doi.org\/10.1038\/srep24839","journal-title":"Sci Rep"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00253-018-8802-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-018-8802-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-018-8802-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T22:25:22Z","timestamp":1603837522000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00253-018-8802-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["8802"],"URL":"https:\/\/doi.org\/10.1007\/s00253-018-8802-2","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]},"assertion":[{"value":"14 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}