{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:20:28Z","timestamp":1770492028216,"version":"3.49.0"},"reference-count":179,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["ERA-IB-2\/0003\/2015"],"award-info":[{"award-number":["ERA-IB-2\/0003\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PD\/BD\/128035\/2016"],"award-info":[{"award-number":["PD\/BD\/128035\/2016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Microbiol Biotechnol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"Abstract<\/jats:title>Pectin-rich agro-industrial residues are feedstocks with potential for sustainable biorefineries. They are generated in high amounts worldwide from the industrial processing of fruits and vegetables. The challenges posed to the industrial implementation of efficient bioprocesses are however manyfold and thoroughly discussed in this review paper, mainly at the biological level. The most important yeast cell factory platform for advanced biorefineries is currently Saccharomyces cerevisiae<\/jats:italic>, but this yeast species cannot naturally catabolise the main sugars present in pectin-rich agro-industrial residues hydrolysates, in particular d<\/jats:sc>-galacturonic acid and l<\/jats:sc>-arabinose. However, there are non-Saccharomyces<\/jats:italic> species (non-conventional yeasts) considered advantageous alternatives whenever they can express highly interesting metabolic pathways, natively assimilate a wider range of carbon sources or exhibit higher tolerance to relevant bioprocess-related stresses. For this reason, the interest in non-conventional yeasts for biomass-based biorefineries is gaining momentum. This review paper focuses on the valorisation of pectin-rich residues by exploring the potential of yeasts that exhibit vast metabolic versatility for the efficient use of the carbon substrates present in their hydrolysates and high robustness to cope with the multiple stresses encountered. The major challenges and the progresses made related with the isolation, selection, sugar catabolism, metabolic engineering and use of non-conventional yeasts and S. cerevisiae<\/jats:italic>-derived strains for the bioconversion of pectin-rich residue hydrolysates are discussed. The reported examples of value-added products synthesised by different yeasts using pectin-rich residues are reviewed.\n\nKey Points<\/jats:bold>\u2022 Review of the challenges and progresses made on the bioconversion of pectin-rich residues by yeasts.<\/jats:italic>\u2022 Catabolic pathways for the main carbon sources present in pectin-rich residues hydrolysates.<\/jats:italic>\u2022 Multiple stresses with potential to affect bioconversion productivity.<\/jats:italic>\u2022 Yeast metabolic engineering to improve pectin-rich residues bioconversion.<\/jats:italic><\/jats:td>\n<\/jats:tr>\n<\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00253-020-10697-7","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T23:06:08Z","timestamp":1590879968000},"page":"6527-6547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Valorisation of pectin-rich agro-industrial residues by yeasts: potential and challenges"],"prefix":"10.1007","volume":"104","author":[{"given":"Lu\u00eds C.","family":"Martins","sequence":"first","affiliation":[]},{"given":"Catarina C.","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"Paula M.","family":"Semedo","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"S\u00e1-Correia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"10697_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3109\/07388551.2012.659172","volume":"32","author":"CM Ajila","year":"2012","unstructured":"Ajila CM, Brar SK, Verma M, Tyagi RD, Godbout S, Val\u00e9ro JR (2012) Bio-processing of agro-byproducts to animal feed. Crit Rev Biotechnol 32:382\u2013400. https:\/\/doi.org\/10.3109\/07388551.2012.659172","journal-title":"Crit Rev Biotechnol"},{"key":"10697_CR2","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1016\/j.procbio.2005.01.011","volume":"40","author":"Z Aksu","year":"2005","unstructured":"Aksu Z, Eren AT (2005) Carotenoids production by the yeast Rhodotorula mucilaginosa: use of agricultural wastes as a carbon source. Process Biochem 40:2985\u20132991. https:\/\/doi.org\/10.1016\/j.procbio.2005.01.011","journal-title":"Process Biochem"},{"key":"10697_CR3","doi-asserted-by":"crossref","unstructured":"Anschau A (2017) Lipids from oleaginous yeasts: production and encapsulation. In: Nutrient Delivery. Elsevier, pp 749\u2013794","DOI":"10.1016\/B978-0-12-804304-2.00020-2"},{"key":"10697_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/elsc.200900027","volume":"9","author":"W Babel","year":"2009","unstructured":"Babel W (2009) The auxiliary substrate concept: from simple considerations to heuristically valuable knowledge. Eng Life Sci 9:285\u2013290. https:\/\/doi.org\/10.1002\/elsc.200900027","journal-title":"Eng Life Sci"},{"key":"10697_CR5","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.enconman.2010.08.013","volume":"52","author":"M Balat","year":"2011","unstructured":"Balat M (2011) Production of bioethanol from lignocellulosic materials via the biochemical pathway: a review. Energy Convers Manag 52:858\u2013875. https:\/\/doi.org\/10.1016\/j.enconman.2010.08.013","journal-title":"Energy Convers Manag"},{"key":"10697_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/jobm.200390021","volume":"43","author":"L Balsalobre","year":"2003","unstructured":"Balsalobre L, De Sil\u00f3niz M-I, Valderrama M-J, Benito T, Larrea M-T, Peinado J-M (2003) Occurrence of yeasts in municipal wastes and their behaviour in presence of cadmium, copper and zinc. J Basic Microbiol 43:185\u2013193. https:\/\/doi.org\/10.1002\/jobm.200390021","journal-title":"J Basic Microbiol"},{"key":"10697_CR7","doi-asserted-by":"publisher","first-page":"4144","DOI":"10.1128\/AEM.69.7.4144-4150.2003","volume":"69","author":"J Becker","year":"2003","unstructured":"Becker J, Boles E (2003) A modified Saccharomyces cerevisiae strain that consumes L-arabinose and produces ethanol. Appl Environ Microbiol 69:4144\u20134150. https:\/\/doi.org\/10.1128\/AEM.69.7.4144-4150.2003","journal-title":"Appl Environ Microbiol"},{"key":"10697_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13068-017-0841-x","volume":"10","author":"T Benocci","year":"2017","unstructured":"Benocci T, Victoria M, Pontes A, Zhou M, Seiboth B, De Vries RP (2017) Biotechnology for biofuels regulators of plant biomass degradation in ascomycetous fungi. Biotechnol Biofuels 10:1\u201325. https:\/\/doi.org\/10.1186\/s13068-017-0841-x","journal-title":"Biotechnol Biofuels"},{"key":"10697_CR9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1754-6834-7-20","volume":"7","author":"J Benz","year":"2014","unstructured":"Benz J, Protzko RJ, Andrich JM, Bauer S, Dueber JE, Somerville CR (2014) Identification and characterization of a galacturonic acid transporter from Neurospora crassa and its application for Saccharomyces cerevisiae fermentation processes. Biotechnol Biofuels 7:20. https:\/\/doi.org\/10.1186\/1754-6834-7-20","journal-title":"Biotechnol Biofuels"},{"key":"10697_CR10","doi-asserted-by":"publisher","unstructured":"Berlowska J, Pielech-Przybylska K, Balcerek M, Cieciura W, Borowski S, Kregiel D (2017) Integrated bioethanol fermentation\/anaerobic digestion for valorization of sugar beet pulp. Energies 10: . https:\/\/doi.org\/10.3390\/en10091255","DOI":"10.3390\/en10091255"},{"key":"10697_CR11","doi-asserted-by":"crossref","unstructured":"Berlowska J, Binczarski M, Dziugan P, Wilkowska A, Kregiel D, Witonska I (2018) Sugar beet pulp as a source of valuable biotechnological products. In: Advances in Biotechnology for Food Industry. Elsevier, pp 359\u2013392","DOI":"10.1016\/B978-0-12-811443-8.00013-X"},{"key":"10697_CR12","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1475-2859-8-40","volume":"8","author":"M Bettiga","year":"2009","unstructured":"Bettiga M, Bengtsson O, Hahn-H\u00e4gerdal B, Gorwa-Grauslund MF (2009) Arabinose and xylose fermentation by recombinant Saccharomyces cerevisiae expressing a fungal pentose utilization pathway. Microb Cell Factories 8:40. https:\/\/doi.org\/10.1186\/1475-2859-8-40","journal-title":"Microb Cell Factories"},{"key":"10697_CR13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/07388550802368895","volume":"28","author":"S Bhushan","year":"2008","unstructured":"Bhushan S, Kalia K, Sharma M, Singh B, Ahuja PS (2008) Processing of apple pomace for bioactive molecules. Crit Rev Biotechnol 28:285\u2013296. https:\/\/doi.org\/10.1080\/07388550802368895","journal-title":"Crit Rev Biotechnol"},{"key":"10697_CR14","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12934-016-0544-1","volume":"15","author":"A Biz","year":"2016","unstructured":"Biz A, Sugai-Gu\u00e9rios MH, Kuivanen J, Maaheimo H, Krieger N, Mitchell DA, Richard P (2016) The introduction of the fungal d-galacturonate pathway enables the consumption of d-galacturonic acid by Saccharomyces cerevisiae. Microb Cell Factories 15:144. https:\/\/doi.org\/10.1186\/s12934-016-0544-1","journal-title":"Microb Cell Factories"},{"key":"10697_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0960-8524(99)00056-5","volume":"71","author":"P Buzzini","year":"2000","unstructured":"Buzzini P, Martini A (2000) Production of carotenoids by strains of Rhodotorula glutinis cultured in raw materials of agro-industrial origin. Bioresour Technol 71:41\u201344. https:\/\/doi.org\/10.1016\/S0960-8524(99)00056-5","journal-title":"Bioresour Technol"},{"key":"10697_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12934-019-1112-2","volume":"18","author":"P Cai","year":"2019","unstructured":"Cai P, Gao J, Zhou Y (2019) CRISPR-mediated genome editing in non-conventional yeasts for biotechnological applications. Microb Cell Factories 18:63. https:\/\/doi.org\/10.1186\/s12934-019-1112-2","journal-title":"Microb Cell Factories"},{"key":"10697_CR17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1039\/c7fd00094d","volume":"202","author":"M C\u00e1rdenas-Fern\u00e1ndez","year":"2017","unstructured":"C\u00e1rdenas-Fern\u00e1ndez M, Bawn M, Hamley-Bennett C, Bharat PKV, Subrizi F, Suhaili N, Ward DP, Bourdin S, Dalby PA, Hailes HC, Hewitson P, Ignatova S, Kontoravdi C, Leak DJ, Shah N, Sheppard TD, Ward JM, Lye GJ (2017) An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates. Faraday Discuss 202:415\u2013431. https:\/\/doi.org\/10.1039\/c7fd00094d","journal-title":"Faraday Discuss"},{"key":"10697_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0005-2736(96)00245-3","volume":"1325","author":"V Carmelo","year":"1997","unstructured":"Carmelo V, Santos H, S\u00e1-Correia I (1997) Effect of extracellular acidification on the activity of plasma membrane ATPase and on the cytosolic and vacuolar pH of Saccharomyces cerevisiae. Biochim Biophys Acta Biomembr 1325:63\u201370. https:\/\/doi.org\/10.1016\/S0005-2736(96)00245-3","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10697_CR19","doi-asserted-by":"publisher","unstructured":"Carota E, Petruccioli M, D\u2019Annibale A, Gallo AM, Crognale S (2020) Orange peel waste\u2013based liquid medium for biodiesel production by oleaginous yeasts. Appl Microbiol Biotechnol 4617\u20134628 . https:\/\/doi.org\/10.1007\/s00253-020-10579-y","DOI":"10.1007\/s00253-020-10579-y"},{"key":"10697_CR20","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.enconman.2010.01.015","volume":"51","author":"F Cherubini","year":"2010","unstructured":"Cherubini F (2010) The biorefinery concept: using biomass instead of oil for producing energy and chemicals. Energy Convers Manag 51:1412\u20131421. https:\/\/doi.org\/10.1016\/j.enconman.2010.01.015","journal-title":"Energy Convers Manag"},{"key":"10697_CR21","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.apenergy.2012.03.066","volume":"102","author":"IS Choi","year":"2013","unstructured":"Choi IS, Kim J-H, Wi SG, Kim KH, Bae H-J (2013) Bioethanol production from mandarin (Citrus unshiu) peel waste using popping pretreatment. Appl Energy 102:204\u2013210. https:\/\/doi.org\/10.1016\/j.apenergy.2012.03.066","journal-title":"Appl Energy"},{"key":"10697_CR22","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.apenergy.2014.11.070","volume":"140","author":"IS Choi","year":"2015","unstructured":"Choi IS, Lee YG, Khanal SK, Park BJ, Bae H-J (2015) A low-energy, cost-effective approach to fruit and citrus peel waste processing for bioethanol production. Appl Energy 140:65\u201374. https:\/\/doi.org\/10.1016\/j.apenergy.2014.11.070","journal-title":"Appl Energy"},{"key":"10697_CR23","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1007\/s12010-011-9507-5","volume":"167","author":"G Christophe","year":"2012","unstructured":"Christophe G, Deo JL, Kumar V, Nouaille R, Fontanille P, Larroche C (2012) Production of oils from acetic acid by the oleaginous yeast Cryptococcus curvatus. Appl Biochem Biotechnol 167:1270\u20131279. https:\/\/doi.org\/10.1007\/s12010-011-9507-5","journal-title":"Appl Biochem Biotechnol"},{"key":"10697_CR24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/1574-6976.12065","volume":"38","author":"M Conrad","year":"2014","unstructured":"Conrad M, Schothorst J, Kankipati HN, Van Zeebroeck G, Rubio-Texeira M, Thevelein JM (2014) Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 38:254\u2013299. https:\/\/doi.org\/10.1111\/1574-6976.12065","journal-title":"FEMS Microbiol Rev"},{"key":"10697_CR25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.15159\/AR.18.066","volume":"16","author":"A Cristobal-Sarramian","year":"2018","unstructured":"Cristobal-Sarramian A, Atzmuller D (2018) Yeast as a production platform in bioreflneries: conversion of agricultural residues into value-added products. Agron Res 16:377\u2013388. https:\/\/doi.org\/10.15159\/AR.18.066","journal-title":"Agron Res"},{"key":"10697_CR26","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00253-018-9478-3","volume":"103","author":"JT Cunha","year":"2019","unstructured":"Cunha JT, Roman\u00ed A, Costa CE, S\u00e1-Correia I, Domingues L (2019) Molecular and physiological basis of Saccharomyces cerevisiae tolerance to adverse lignocellulose-based process conditions. Appl Microbiol Biotechnol 103:159\u2013175. https:\/\/doi.org\/10.1007\/s00253-018-9478-3","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR27","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.biortech.2017.07.176","volume":"248","author":"S Dahiya","year":"2018","unstructured":"Dahiya S, Kumar AN, Shanthi Sravan J, Chatterjee S, Sarkar O, Mohan SV (2018) Food waste biorefinery: sustainable strategy for circular bioeconomy. Bioresour Technol 248:2\u201312. https:\/\/doi.org\/10.1016\/j.biortech.2017.07.176","journal-title":"Bioresour Technol"},{"key":"10697_CR28","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.biortech.2017.05.100","volume":"245","author":"Z Dai","year":"2017","unstructured":"Dai Z, Gu H, Zhang S, Xin F, Zhang W, Dong W, Ma J, Jia H, Jiang M (2017) Metabolic construction strategies for direct methanol utilization in Saccharomyces cerevisiae. Bioresour Technol 245:1407\u20131412. https:\/\/doi.org\/10.1016\/j.biortech.2017.05.100","journal-title":"Bioresour Technol"},{"key":"10697_CR29","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s10482-012-9854-4","volume":"103","author":"ND Dandi","year":"2013","unstructured":"Dandi ND, Dandi BN, Chaudhari AB (2013) Bioprospecting of thermo- and osmo-tolerant fungi from mango pulp\u2013peel compost for bioethanol production. Antonie Van Leeuwenhoek 103:723\u2013736. https:\/\/doi.org\/10.1007\/s10482-012-9854-4","journal-title":"Antonie Van Leeuwenhoek"},{"key":"10697_CR30","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.copbio.2011.11.021","volume":"23","author":"B de Jong","year":"2012","unstructured":"de Jong B, Siewers V, Nielsen J (2012) Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels. Curr Opin Biotechnol 23:624\u2013630. https:\/\/doi.org\/10.1016\/j.copbio.2011.11.021","journal-title":"Curr Opin Biotechnol"},{"key":"10697_CR31","doi-asserted-by":"publisher","unstructured":"de la Torre I, Acedos MG, Esteban J, Santos VE, Ladero M (2019) Utilisation \/ upgrading of orange peel waste from a biological biorefinery perspective. Appl Microbiol Biotechnol 103:5975\u20135991. https:\/\/doi.org\/10.1007\/s00253-019-09929-2","DOI":"10.1007\/s00253-019-09929-2"},{"key":"10697_CR32","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/omi.2009.0134","volume":"14","author":"PJ Dias","year":"2010","unstructured":"Dias PJ, Teixeira MC, Telo JP, S\u00e1-Correia I (2010) Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach. Omi A J Integr Biol 14:211\u2013227. https:\/\/doi.org\/10.1089\/omi.2009.0134","journal-title":"Omi A J Integr Biol"},{"key":"10697_CR33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/BF02941704","volume":"57\u201358","author":"BS Dien","year":"1996","unstructured":"Dien BS, Kurtzman CP, Saha BC, Bothast RJ (1996) Screening forl-arabinose fermenting yeasts. Appl Biochem Biotechnol 57\u201358:233\u2013242. https:\/\/doi.org\/10.1007\/BF02941704","journal-title":"Appl Biochem Biotechnol"},{"key":"10697_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/microorganisms7080229","volume":"7","author":"DTH Do","year":"2019","unstructured":"Do DTH, Theron CW, Fickers P (2019) Organic wastes as feedstocks for non-conventional yeast-based bioprocesses. Microorganisms 7:1\u201322. https:\/\/doi.org\/10.3390\/microorganisms7080229","journal-title":"Microorganisms"},{"key":"10697_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fgene.2012.00063","volume":"3","author":"SC dos Santos","year":"2012","unstructured":"dos Santos SC (2012) Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology. Front Genet 3:1\u201317. https:\/\/doi.org\/10.3389\/fgene.2012.00063","journal-title":"Front Genet"},{"key":"10697_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.copbio.2015.03.001","volume":"33","author":"SC dos Santos","year":"2015","unstructured":"dos Santos SC, S\u00e1-Correia I (2015) Yeast toxicogenomics: lessons from a eukaryotic cell model and cell factory. Curr Opin Biotechnol 33:183\u2013191. https:\/\/doi.org\/10.1016\/j.copbio.2015.03.001","journal-title":"Curr Opin Biotechnol"},{"key":"10697_CR37","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1007\/s00253-019-09625-1","volume":"103","author":"C Du","year":"2019","unstructured":"Du C, Li Y, Zhao X, Pei X, Yuan W, Bai F, Jiang Y (2019) The production of ethanol from lignocellulosic biomass by Kluyveromyces marxianus CICC 1727-5 and Spathaspora passalidarum ATCC MYA-4345. Appl Microbiol Biotechnol 103:2845\u20132855. https:\/\/doi.org\/10.1007\/s00253-019-09625-1","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR38","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00253-012-4173-2","volume":"95","author":"MC Edwards","year":"2012","unstructured":"Edwards MC, Doran-Peterson J (2012) Pectin-rich biomass as feedstock for fuel ethanol production. Appl Microbiol Biotechnol 95:565\u2013575. https:\/\/doi.org\/10.1007\/s00253-012-4173-2","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR39","doi-asserted-by":"publisher","unstructured":"European Parliament (2009) Directive 2009\/128\/EC of the European Parliament and the council of 21 October 2009 establishing a framework for community action to achieve the sustainable use of pesticides. October 309:71\u201386 . https:\/\/doi.org\/10.3000\/17252555.L_2009.309","DOI":"10.3000\/17252555.L_2009.309"},{"key":"10697_CR40","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/bit.25870","volume":"113","author":"E Fletcher","year":"2016","unstructured":"Fletcher E, Krivoruchko A, Nielsen J (2016) Industrial systems biology and its impact on synthetic biology of yeast cell factories. Biotechnol Bioeng 113:1164\u20131170. https:\/\/doi.org\/10.1002\/bit.25870","journal-title":"Biotechnol Bioeng"},{"key":"10697_CR41","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s13205-015-0312-7","volume":"5","author":"R Gama","year":"2015","unstructured":"Gama R, Van Dyk JS, Pletschke BI (2015) Optimisation of enzymatic hydrolysis of apple pomace for production of biofuel and biorefinery chemicals using commercial enzymes. 3 Biotech 5:1075\u20131087. https:\/\/doi.org\/10.1007\/s13205-015-0312-7","journal-title":"3 Biotech"},{"key":"10697_CR42","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1432-1033.1992.tb16928.x","volume":"206","author":"JM Gancedo","year":"1992","unstructured":"Gancedo JM (1992) Carbon catabolite repression in yeast. Eur J Biochem 206:297\u2013313. https:\/\/doi.org\/10.1111\/j.1432-1033.1992.tb16928.x","journal-title":"Eur J Biochem"},{"key":"10697_CR43","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s10295-016-1789-8","volume":"43","author":"S Gao","year":"2016","unstructured":"Gao S, Tong Y, Wen Z, Zhu L, Ge M, Chen D, Jiang Y, Yang S (2016) Multiplex gene editing of the Yarrowia lipolytica genome using the CRISPR-Cas9 system. J Ind Microbiol Biotechnol 43:1085\u20131093. https:\/\/doi.org\/10.1007\/s10295-016-1789-8","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10697_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2018.03264","volume":"9","author":"M Gao","year":"2019","unstructured":"Gao M, Ploessl D, Shao Z (2019) Enhancing the co-utilization of biomass-derived mixed sugars by yeasts. Front Microbiol 9:1\u201321. https:\/\/doi.org\/10.3389\/fmicb.2018.03264","journal-title":"Front Microbiol"},{"key":"10697_CR45","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/1751-7915.12160","volume":"8","author":"MI Gonz\u00e1lez-Siso","year":"2015","unstructured":"Gonz\u00e1lez-Siso MI, Touri\u00f1o A, Vizoso \u00c1, Pereira-Rodr\u00edguez \u00c1, Rodr\u00edguez-Belmonte E, Becerra M, Cerd\u00e1n ME (2015) Improved bioethanol production in an engineered Kluyveromyces lactis strain shifted from respiratory to fermentative metabolism by deletion of NDI 1. Microb Biotechnol 8:319\u2013330. https:\/\/doi.org\/10.1111\/1751-7915.12160","journal-title":"Microb Biotechnol"},{"key":"10697_CR46","doi-asserted-by":"crossref","unstructured":"Grohmann K, Bothast RJ (1994) Pectin-rich residues generated by processing of citrus fruits, apples, and sugar beets. In: Enzymatic Conversion of Biomass for Fuels Production. pp 372\u2013390","DOI":"10.1021\/bk-1994-0566.ch019"},{"key":"10697_CR47","doi-asserted-by":"publisher","first-page":"4859","DOI":"10.1021\/jf9903049","volume":"47","author":"K Grohmann","year":"1999","unstructured":"Grohmann K, Manthey JA, Cameron RG, Buslig BS (1999) Purification of citrus peel juice and molasses. J Agric Food Chem 47:4859\u20134867. https:\/\/doi.org\/10.1021\/jf9903049","journal-title":"J Agric Food Chem"},{"key":"10697_CR48","doi-asserted-by":"publisher","first-page":"65","DOI":"10.15698\/mic2016.02.477","volume":"3","author":"J Guerreiro","year":"2016","unstructured":"Guerreiro J, Sampaio-Marques B, Soares R, Coelho A, Leao C, Ludovico P, Sa-Correia I (2016) Mitochondrial proteomics of the acetic acid - induced programmed cell death response in a highly tolerant Zygosaccharomyces bailii - derived hybrid strain. Microb Cell 3:65\u201378. https:\/\/doi.org\/10.15698\/mic2016.02.477","journal-title":"Microb Cell"},{"key":"10697_CR49","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.fuel.2015.06.016","volume":"158","author":"H G\u00fcnan Y\u00fccel","year":"2015","unstructured":"G\u00fcnan Y\u00fccel H, Aksu Z (2015) Ethanol fermentation characteristics of Pichia stipitis yeast from sugar beet pulp hydrolysate: use of new detoxification methods. Fuel 158:793\u2013799. https:\/\/doi.org\/10.1016\/j.fuel.2015.06.016","journal-title":"Fuel"},{"key":"10697_CR50","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.enzmictec.2009.05.012","volume":"45","author":"G Guo","year":"2009","unstructured":"Guo G, Hsu D, Chen W-H, Chen W, Hwang W (2009) Characterization of enzymatic saccharification for acid-pretreated lignocellulosic materials with different lignin composition. Enzym Microb Technol 45:80\u201387. https:\/\/doi.org\/10.1016\/j.enzmictec.2009.05.012","journal-title":"Enzym Microb Technol"},{"key":"10697_CR51","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/elsc.201800203","volume":"19","author":"M Guo","year":"2019","unstructured":"Guo M, Cheng S, Chen G, Chen J (2019) Improvement of lipid production in oleaginous yeast Rhodosporidium toruloides by ultraviolet mutagenesis. Eng Life Sci 19:548\u2013556. https:\/\/doi.org\/10.1002\/elsc.201800203","journal-title":"Eng Life Sci"},{"key":"10697_CR52","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1080\/07388551.2016.1214557","volume":"37","author":"SK Gupta","year":"2017","unstructured":"Gupta SK, Shukla P (2017) Gene editing for cell engineering: trends and applications. Crit Rev Biotechnol 37:672\u2013684. https:\/\/doi.org\/10.1080\/07388551.2016.1214557","journal-title":"Crit Rev Biotechnol"},{"key":"10697_CR53","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.biortech.2016.02.131","volume":"209","author":"C Hamley-Bennett","year":"2016","unstructured":"Hamley-Bennett C, Lye GJ, Leak DJ (2016) Selective fractionation of sugar beet pulp for release of fermentation and chemical feedstocks; optimisation of thermo-chemical pre-treatment. Bioresour Technol 209:259\u2013264. https:\/\/doi.org\/10.1016\/j.biortech.2016.02.131","journal-title":"Bioresour Technol"},{"key":"10697_CR54","doi-asserted-by":"publisher","unstructured":"Hicks RH, Sze Y, Chuck CJ, Henk DA (2020) Enhanced inhibitor tolerance and increased lipid productivity through adaptive laboratory evolution in the oleaginous yeast Metshnikowia pulcherrima. bioRxiv 2020.02.17.952291 . https:\/\/doi.org\/10.1101\/2020.02.17.952291","DOI":"10.1101\/2020.02.17.952291"},{"key":"10697_CR55","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1007\/s00018-012-0945-1","volume":"69","author":"K-K Hong","year":"2012","unstructured":"Hong K-K, Nielsen J (2012) Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries. Cell Mol Life Sci 69:2671\u20132690. https:\/\/doi.org\/10.1007\/s00018-012-0945-1","journal-title":"Cell Mol Life Sci"},{"key":"10697_CR56","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.biortech.2016.01.073","volume":"206","author":"X-F Huang","year":"2016","unstructured":"Huang X-F, Liu J-N, Lu L-J, Peng K-M, Yang G-X, Liu J (2016) Culture strategies for lipid production using acetic acid as sole carbon source by Rhodosporidium toruloides. Bioresour Technol 206:141\u2013149. https:\/\/doi.org\/10.1016\/j.biortech.2016.01.073","journal-title":"Bioresour Technol"},{"key":"10697_CR57","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1128\/AEM.07617-11","volume":"78","author":"EH Huisjes","year":"2012","unstructured":"Huisjes EH, de Hulster E, van Dam JC, Pronk JT, van Maris AJA (2012) Galacturonic acid inhibits the growth of Saccharomyces cerevisiae on galactose, xylose, and arabinose. Appl Environ Microbiol 78:5052\u20135059. https:\/\/doi.org\/10.1128\/AEM.07617-11","journal-title":"Appl Environ Microbiol"},{"key":"10697_CR58","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1016\/j.procbio.2005.03.026","volume":"40","author":"RS Jayani","year":"2005","unstructured":"Jayani RS, Saxena S, Gupta R (2005) Microbial pectinolytic enzymes: a review. Process Biochem 40:2931\u20132944. https:\/\/doi.org\/10.1016\/j.procbio.2005.03.026","journal-title":"Process Biochem"},{"key":"10697_CR59","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s00449-013-0907-5","volume":"36","author":"WY Jeon","year":"2013","unstructured":"Jeon WY, Shim WY, Lee SH, Choi JH, Kim JH (2013) Effect of heterologous xylose transporter expression in Candida tropicalis on xylitol production rate. Bioprocess Biosyst Eng 36:809\u2013817. https:\/\/doi.org\/10.1007\/s00449-013-0907-5","journal-title":"Bioprocess Biosyst Eng"},{"key":"10697_CR60","doi-asserted-by":"publisher","first-page":"122259","DOI":"10.1016\/j.biortech.2019.122259","volume":"295","author":"D Jeong","year":"2020","unstructured":"Jeong D, Ye S, Park H, Kim SR (2020) Simultaneous fermentation of galacturonic acid and five-carbon sugars by engineered Saccharomyces cerevisiae. Bioresour Technol 295:122259. https:\/\/doi.org\/10.1016\/j.biortech.2019.122259","journal-title":"Bioresour Technol"},{"key":"10697_CR61","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00284-016-1132-7","volume":"73","author":"H Ji","year":"2016","unstructured":"Ji H, Zhuge B, Zong H, Lu X, Fang H, Zhuge J (2016) Role of CgHOG1 in stress responses and glycerol overproduction of Candida glycerinogenes. Curr Microbiol 73:827\u2013833. https:\/\/doi.org\/10.1007\/s00284-016-1132-7","journal-title":"Curr Microbiol"},{"key":"10697_CR62","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1080\/15435075.2017.1307753","volume":"14","author":"I John","year":"2017","unstructured":"John I, Muthukumar K, Arunagiri A (2017) A review on the potential of citrus waste for D-limonene, pectin, and bioethanol production. Int J Green Energy 14:599\u2013612. https:\/\/doi.org\/10.1080\/15435075.2017.1307753","journal-title":"Int J Green Energy"},{"key":"10697_CR63","doi-asserted-by":"publisher","first-page":"7563","DOI":"10.1007\/s00253-013-5046-z","volume":"97","author":"EA Johnson","year":"2013","unstructured":"Johnson EA (2013a) Biotechnology of non-Saccharomyces yeasts\u2014the basidiomycetes. Appl Microbiol Biotechnol 97:7563\u20137577. https:\/\/doi.org\/10.1007\/s00253-013-5046-z","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR64","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00253-012-4497-y","volume":"97","author":"EA Johnson","year":"2013","unstructured":"Johnson EA (2013b) Biotechnology of non-Saccharomyces yeasts\u2014the ascomycetes. Appl Microbiol Biotechnol 97:503\u2013517. https:\/\/doi.org\/10.1007\/s00253-012-4497-y","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR65","doi-asserted-by":"crossref","unstructured":"Johnson EA, Echavarri-Erasun C (2011) Yeast biotechnology. In: The Yeasts. Elsevier, pp 21\u201344","DOI":"10.1016\/B978-0-444-52149-1.00003-3"},{"key":"10697_CR66","doi-asserted-by":"publisher","first-page":"127","DOI":"10.5958\/2277-9396.2014.00340.7","volume":"3","author":"VK Joshi","year":"2013","unstructured":"Joshi VK, Sharma R, Girdher A (2013) Production and evaluation of biocolour (carotenoids) from Rhodotorula using apple pomace: effect of composition of different nitrogen sources and methods of cell disruption. Int J Food Ferment Technol 3:127. https:\/\/doi.org\/10.5958\/2277-9396.2014.00340.7","journal-title":"Int J Food Ferment Technol"},{"key":"10697_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-5511-9","volume-title":"Metabolic engineering for bioactive compounds","author":"VC Kalia","year":"2017","unstructured":"Kalia VC, Saini AK (2017) Metabolic engineering for bioactive compounds. Springer Singapore, Singapore"},{"key":"10697_CR68","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s13213-011-0302-x","volume":"62","author":"S Kaur Sandhu","year":"2012","unstructured":"Kaur Sandhu S, Singh Oberoi H, Singh Dhaliwal S, Babbar N, Kaur U, Nanda D, Kumar D (2012) Ethanol production from Kinnow mandarin (Citrus reticulata) peels via simultaneous saccharification and fermentation using crude enzyme produced by Aspergillus oryzae and the thermotolerant Pichia kudriavzevii strain. Ann Microbiol 62:655\u2013666. https:\/\/doi.org\/10.1007\/s13213-011-0302-x","journal-title":"Ann Microbiol"},{"key":"10697_CR69","doi-asserted-by":"publisher","first-page":"fov068","DOI":"10.1093\/femsyr\/fov068","volume":"15","author":"\u00d6 Kayikci","year":"2015","unstructured":"Kayikci \u00d6, Nielsen J (2015) Glucose repression in Saccharomyces cerevisiae. FEMS Yeast Res 15:fov068. https:\/\/doi.org\/10.1093\/femsyr\/fov068","journal-title":"FEMS Yeast Res"},{"key":"10697_CR70","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/1462-2920.13617","volume":"19","author":"M Klein","year":"2017","unstructured":"Klein M, Swinnen S, Thevelein JM, Nevoigt E (2017) Glycerol metabolism and transport in yeast and fungi: established knowledge and ambiguities. Environ Microbiol 19:878\u2013893. https:\/\/doi.org\/10.1111\/1462-2920.13617","journal-title":"Environ Microbiol"},{"key":"10697_CR71","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/lam.12514","volume":"62","author":"M Koutinas","year":"2016","unstructured":"Koutinas M, Patsalou M, Stavrinou S, Vyrides I (2016) High temperature alcoholic fermentation of orange peel by the newly isolated thermotolerant Pichia kudriavzevii KVMP10. Lett Appl Microbiol 62:75\u201383. https:\/\/doi.org\/10.1111\/lam.12514","journal-title":"Lett Appl Microbiol"},{"key":"10697_CR72","doi-asserted-by":"publisher","unstructured":"Kr\u0119giel D, Pawlikowska E, Antolak H (2017) Non-conventional yeasts in fermentation processes: potentialities and limitations. Old Yeasts - New Quest. https:\/\/doi.org\/10.5772\/intechopen.70404","DOI":"10.5772\/intechopen.70404"},{"key":"10697_CR73","unstructured":"K\u00fchnel S (2011) Characterization of cell wall degrading enzymes from Chrysosporium lucknowense C1 and their use to degrade sugar beet pulp. Wageningen University, NL"},{"key":"10697_CR74","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1567-1364.2010.00625.x","volume":"10","author":"CP Kurtzman","year":"2010","unstructured":"Kurtzman CP, Robnett CJ (2010) Systematics of methanol assimilating yeasts and neighboring taxa from multigene sequence analysis and the proposal of Peterozyma gen. nov., a new member of the Saccharomycetales. FEMS Yeast Res 10:353\u2013361. https:\/\/doi.org\/10.1111\/j.1567-1364.2010.00625.x","journal-title":"FEMS Yeast Res"},{"key":"10697_CR75","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1038\/s41598-018-20804-4","volume":"8","author":"S Lane","year":"2018","unstructured":"Lane S, Xu H, Oh EJ, Kim H, Lesmana A, Jeong D, Zhang G, Tsai C-S, Jin Y-S, Kim SR (2018) Glucose repression can be alleviated by reducing glucose phosphorylation rate in Saccharomyces cerevisiae. Sci Rep 8:2613. https:\/\/doi.org\/10.1038\/s41598-018-20804-4","journal-title":"Sci Rep"},{"key":"10697_CR76","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1042\/BJ20051465","volume":"395","author":"MJ Leandro","year":"2006","unstructured":"Leandro MJ, Gon\u00e7alves P, Spencer-Martins I (2006) Two glucose\/xylose transporter genes from the yeast Candida intermedia: first molecular characterization of a yeast xylose\u2013H+ symporter. Biochem J 395:543\u2013549. https:\/\/doi.org\/10.1042\/BJ20051465","journal-title":"Biochem J"},{"key":"10697_CR77","doi-asserted-by":"publisher","first-page":"7305","DOI":"10.1038\/s41598-018-25366-z","volume":"8","author":"M-H Lee","year":"2018","unstructured":"Lee M-H, Lin J-J, Lin Y-J, Chang J-J, Ke H-M, Fan W-L, Wang T-Y, Li W-H (2018) Genome-wide prediction of CRISPR\/Cas9 targets in Kluyveromyces marxianus and its application to obtain a stable haploid strain. Sci Rep 8:7305. https:\/\/doi.org\/10.1038\/s41598-018-25366-z","journal-title":"Sci Rep"},{"key":"10697_CR78","unstructured":"Legrand G (2005) The correct use of pressed beet pulp. Collect \u201cGuides Tech Irbab\/Kbivb 46"},{"key":"10697_CR79","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.biortech.2012.10.126","volume":"128","author":"AGM Leijdekkers","year":"2013","unstructured":"Leijdekkers AGM, Bink JPM, Geutjes S, Schols HA, Gruppen H (2013) Enzymatic saccharification of sugar beet pulp for the production of galacturonic acid and arabinose; a study on the impact of the formation of recalcitrant oligosaccharides. Bioresour Technol 128:518\u2013525. https:\/\/doi.org\/10.1016\/j.biortech.2012.10.126","journal-title":"Bioresour Technol"},{"key":"10697_CR80","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ymben.2018.04.011","volume":"50","author":"J Lian","year":"2018","unstructured":"Lian J, Mishra S, Zhao H (2018) Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications. Metab Eng 50:85\u2013108. https:\/\/doi.org\/10.1016\/j.ymben.2018.04.011","journal-title":"Metab Eng"},{"key":"10697_CR81","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.biortech.2016.04.054","volume":"215","author":"R Liguori","year":"2016","unstructured":"Liguori R, Faraco V (2016) Biological processes for advancing lignocellulosic waste biorefinery by advocating circular economy. Bioresour Technol 215:13\u201320. https:\/\/doi.org\/10.1016\/j.biortech.2016.04.054","journal-title":"Bioresour Technol"},{"key":"10697_CR82","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.pecs.2012.03.002","volume":"38","author":"A Limayem","year":"2012","unstructured":"Limayem A, Ricke SC (2012) Lignocellulosic biomass for bioethanol production: current perspectives, potential issues and future prospects. Prog Energy Combust Sci 38:449\u2013467. https:\/\/doi.org\/10.1016\/j.pecs.2012.03.002","journal-title":"Prog Energy Combust Sci"},{"key":"10697_CR83","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1099\/ijs.0.65380-0","volume":"58","author":"S Limtong","year":"2008","unstructured":"Limtong S, Srisuk N, Yongmanitchai W, Yurimoto H, Nakase T (2008) Ogataea chonburiensis sp. nov. and Ogataea nakhonphanomensis sp. nov., thermotolerant, methylotrophic yeast species isolated in Thailand, and transfer of Pichia siamensis and Pichia thermomethanolica to the genus Ogataea. Int J Syst Evol Microbiol 58:302\u2013307. https:\/\/doi.org\/10.1099\/ijs.0.65380-0","journal-title":"Int J Syst Evol Microbiol"},{"key":"10697_CR84","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.biortech.2016.03.132","volume":"215","author":"Z Liu","year":"2016","unstructured":"Liu Z, Ho S-H, Hasunuma T, Chang J-S, Ren N-Q, Kondo A (2016) Recent advances in yeast cell-surface display technologies for waste biorefineries. Bioresour Technol 215:324\u2013333. https:\/\/doi.org\/10.1016\/j.biortech.2016.03.132","journal-title":"Bioresour Technol"},{"key":"10697_CR85","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.biombioe.2019.04.025","volume":"126","author":"L Liu","year":"2019","unstructured":"Liu L, You Y, Deng H, Guo Y, Meng Y (2019) Promoting hydrolysis of apple pomace by pectinase and cellulase to produce microbial oils using engineered Yarrowia lipolytica. Biomass Bioenergy 126:62\u201369. https:\/\/doi.org\/10.1016\/j.biombioe.2019.04.025","journal-title":"Biomass Bioenergy"},{"key":"10697_CR86","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.copbio.2019.07.003","volume":"62","author":"N Liu","year":"2020","unstructured":"Liu N, Santala S, Stephanopoulos G (2020) Mixed carbon substrates: a necessary nuisance or a missed opportunity? Curr Opin Biotechnol 62:15\u201321. https:\/\/doi.org\/10.1016\/j.copbio.2019.07.003","journal-title":"Curr Opin Biotechnol"},{"key":"10697_CR87","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.synbio.2017.08.002","volume":"2","author":"A-K L\u00f6bs","year":"2017","unstructured":"L\u00f6bs A-K, Schwartz C, Wheeldon I (2017) Genome and metabolic engineering in non-conventional yeasts: current advances and applications. Synth Syst Biotechnol 2:198\u2013207. https:\/\/doi.org\/10.1016\/j.synbio.2017.08.002","journal-title":"Synth Syst Biotechnol"},{"key":"10697_CR88","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1021\/acssynbio.8b00331","volume":"7","author":"AK L\u00f6bs","year":"2018","unstructured":"L\u00f6bs AK, Schwartz C, Thorwall S, Wheeldon I (2018) Highly multiplexed CRISPRi repression of respiratory functions enhances mitochondrial localized ethyl acetate biosynthesis in Kluyveromyces marxianus. ACS Synth Biol 7:2647\u20132655. https:\/\/doi.org\/10.1021\/acssynbio.8b00331","journal-title":"ACS Synth Biol"},{"key":"10697_CR89","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s00253-017-8626-5","volume":"102","author":"AA Loman","year":"2018","unstructured":"Loman AA, Islam SMM, Ju L-K (2018) Production of arabitol from enzymatic hydrolysate of soybean flour by Debaryomyces hansenii fermentation. Appl Microbiol Biotechnol 102:641\u2013653. https:\/\/doi.org\/10.1007\/s00253-017-8626-5","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR90","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jclepro.2017.04.155","volume":"158","author":"O Mart\u00ednez","year":"2017","unstructured":"Mart\u00ednez O, S\u00e1nchez A, Font X, Barrena R (2017) Valorization of sugarcane bagasse and sugar beet molasses using Kluyveromyces marxianus for producing value-added aroma compounds via solid-state fermentation. J Clean Prod 158:8\u201317. https:\/\/doi.org\/10.1016\/j.jclepro.2017.04.155","journal-title":"J Clean Prod"},{"key":"10697_CR91","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11274-016-2036-1","volume":"32","author":"C Martini","year":"2016","unstructured":"Martini C, Tauk-Tornisielo SM, Codato CB, Bastos RG, Ceccato-Antonini SR (2016) A strain of Meyerozyma guilliermondii isolated from sugarcane juice is able to grow and ferment pentoses in synthetic and bagasse hydrolysate media. World J Microbiol Biotechnol 32:80. https:\/\/doi.org\/10.1007\/s11274-016-2036-1","journal-title":"World J Microbiol Biotechnol"},{"key":"10697_CR92","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.jbiosc.2016.05.002","volume":"122","author":"T Matsubara","year":"2016","unstructured":"Matsubara T, Hamada S, Wakabayashi A, Kishida M (2016) Fermentative production of l-galactonate by using recombinant Saccharomyces cerevisiae containing the endogenous galacturonate reductase gene from Cryptococcus diffluens. J Biosci Bioeng 122:639\u2013644. https:\/\/doi.org\/10.1016\/j.jbiosc.2016.05.002","journal-title":"J Biosci Bioeng"},{"key":"10697_CR93","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s00217-015-2606-8","volume":"242","author":"M Merz","year":"2016","unstructured":"Merz M, Appel D, Berends P, Rabe S, Blank I, Stressler T, Fischer L (2016) Batch-to-batch variation and storage stability of the commercial peptidase preparation Flavourzyme in respect of key enzyme activities and its influence on process reproducibility. Eur Food Res Technol 242:1005\u20131012. https:\/\/doi.org\/10.1007\/s00217-015-2606-8","journal-title":"Eur Food Res Technol"},{"key":"10697_CR94","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/0141-0229(95)00224-3","volume":"19","author":"V Micard","year":"1996","unstructured":"Micard V, Renard CMGC, Thibault J-F (1996) Enzymatic saccharification of sugar-beet pulp. Enzym Microb Technol 19:162\u2013170. https:\/\/doi.org\/10.1016\/0141-0229(95)00224-3","journal-title":"Enzym Microb Technol"},{"key":"10697_CR95","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1475-2859-9-79","volume":"9","author":"NP Mira","year":"2010","unstructured":"Mira NP, Palma M, Guerreiro JF, S\u00e1-Correia I (2010a) Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid. Microb Cell Factories 9:79. https:\/\/doi.org\/10.1186\/1475-2859-9-79","journal-title":"Microb Cell Factories"},{"key":"10697_CR96","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1089\/omi.2010.0072","volume":"14","author":"NP Mira","year":"2010","unstructured":"Mira NP, Teixeira MC, S\u00e1-Correia I (2010b) Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae : a genome-wide view. Omi A J Integr Biol 14:525\u2013540. https:\/\/doi.org\/10.1089\/omi.2010.0072","journal-title":"Omi A J Integr Biol"},{"key":"10697_CR97","doi-asserted-by":"publisher","first-page":"6896","DOI":"10.1093\/nar\/gkr228","volume":"39","author":"NP Mira","year":"2011","unstructured":"Mira NP, Henriques SF, Keller G, Teixeira MC, Matos RG, Arraiano CM, Winge DR, S\u00e1-Correia I (2011) Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress. Nucleic Acids Res 39:6896\u20136907. https:\/\/doi.org\/10.1093\/nar\/gkr228","journal-title":"Nucleic Acids Res"},{"key":"10697_CR98","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/dnares\/dst058","volume":"21","author":"NP Mira","year":"2014","unstructured":"Mira NP, Munsterkotter M, Dias-Valada F, Santos J, Palma M, Roque FC, Guerreiro JF, Rodrigues F, Sousa MJ, Leao C, Guldener U, Sa-Correia I (2014) The genome sequence of the highly acetic acid-tolerant Zygosaccharomyces bailii-derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant. DNA Res 21:299\u2013313. https:\/\/doi.org\/10.1093\/dnares\/dst058","journal-title":"DNA Res"},{"key":"10697_CR99","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.pbi.2008.03.006","volume":"11","author":"D Mohnen","year":"2008","unstructured":"Mohnen D (2008) Pectin structure and biosynthesis. Curr Opin Plant Biol 11:266\u2013277. https:\/\/doi.org\/10.1016\/j.pbi.2008.03.006","journal-title":"Curr Opin Plant Biol"},{"key":"10697_CR100","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/nar\/gkz859","volume":"48","author":"PT Monteiro","year":"2020","unstructured":"Monteiro PT, Oliveira J, Pais P, Antunes M, Palma M, Cavalheiro M, Galocha M, Godinho CP, Martins LC, Bourbon N, Mota MN, Ribeiro RA, Viana R, S\u00e1-Correia I, Teixeira MC (2020) YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts. Nucleic Acids Res 48:642\u2013649. https:\/\/doi.org\/10.1093\/nar\/gkz859","journal-title":"Nucleic Acids Res"},{"key":"10697_CR101","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13068-017-0899-5","volume":"10","author":"V Mukherjee","year":"2017","unstructured":"Mukherjee V, Radecka D, Aerts G, Verstrepen KJ, Lievens B, Thevelein JM (2017) Phenotypic landscape of non-conventional yeast species for different stress tolerance traits desirable in bioethanol fermentation. Biotechnol Biofuels 10:216. https:\/\/doi.org\/10.1186\/s13068-017-0899-5","journal-title":"Biotechnol Biofuels"},{"key":"10697_CR102","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.foodchem.2016.01.012","volume":"201","author":"J M\u00fcller-Maatsch","year":"2016","unstructured":"M\u00fcller-Maatsch J, Bencivenni M, Caligiani A, Tedeschi T, Bruggeman G, Bosch M, Petrusan J, Van Droogenbroeck B, Elst K, Sforza S (2016) Pectin content and composition from different food waste streams. Food Chem 201:37\u201345. https:\/\/doi.org\/10.1016\/j.foodchem.2016.01.012","journal-title":"Food Chem"},{"key":"10697_CR103","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00253-006-0372-z","volume":"72","author":"SI Mussatto","year":"2006","unstructured":"Mussatto SI, Silva CJSM, Roberto IC (2006) Fermentation performance of Candida guilliermondii for xylitol production on single and mixed substrate media. Appl Microbiol Biotechnol 72:681\u2013686. https:\/\/doi.org\/10.1007\/s00253-006-0372-z","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR104","doi-asserted-by":"publisher","first-page":"8993","DOI":"10.1038\/s41598-017-08356-5","volume":"7","author":"Y Nambu-Nishida","year":"2017","unstructured":"Nambu-Nishida Y, Nishida K, Hasunuma T, Kondo A (2017) Development of a comprehensive set of tools for genome engineering in a cold- and thermo-tolerant Kluyveromyces marxianus yeast strain. Sci Rep 7:8993. https:\/\/doi.org\/10.1038\/s41598-017-08356-5","journal-title":"Sci Rep"},{"key":"10697_CR105","doi-asserted-by":"publisher","first-page":"1800421","DOI":"10.1002\/biot.201800421","volume":"14","author":"J Nielsen","year":"2019","unstructured":"Nielsen J (2019) Yeast systems biology: model organism and cell factory. Biotechnol J 14:1800421. https:\/\/doi.org\/10.1002\/biot.201800421","journal-title":"Biotechnol J"},{"key":"10697_CR106","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.cell.2016.02.004","volume":"164","author":"J Nielsen","year":"2016","unstructured":"Nielsen J, Keasling JD (2016) Engineering cellular metabolism. Cell 164:1185\u20131197. https:\/\/doi.org\/10.1016\/j.cell.2016.02.004","journal-title":"Cell"},{"key":"10697_CR107","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0961-9534(91)90014-4","volume":"1","author":"P Nigam","year":"1991","unstructured":"Nigam P, Vogel M (1991) Bioconversion of sugar industry by-products\u2014molasses and sugar beet pulp for single cell protein production by yeasts. Biomass Bioenergy 1:339\u2013345. https:\/\/doi.org\/10.1016\/0961-9534(91)90014-4","journal-title":"Biomass Bioenergy"},{"key":"10697_CR108","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00253-019-10224-3","volume":"104","author":"M Nurcholis","year":"2020","unstructured":"Nurcholis M, Lertwattanasakul N, Rodrussamee N, Kosaka T, Murata M, Yamada M (2020) Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus. Appl Microbiol Biotechnol 104:475\u2013488. https:\/\/doi.org\/10.1007\/s00253-019-10224-3","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR109","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-3-030-13035-0_4","volume":"58","author":"M Palma","year":"2019","unstructured":"Palma M, S\u00e1-Correia I (2019) Physiological genomics of the highly weak-acid-tolerant food spoilage yeasts of Zygosaccharomyces bailii sensu lato. Prog Mol Subcell Biol 58:85\u2013109","journal-title":"Prog Mol Subcell Biol"},{"key":"10697_CR110","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1186\/s12864-015-2278-6","volume":"16","author":"M Palma","year":"2015","unstructured":"Palma M, Roque F d C, Guerreiro JF, Mira NP, Queiroz L, S\u00e1-Correia I (2015) Search for genes responsible for the remarkably high acetic acid tolerance of a Zygosaccharomyces bailii-derived interspecies hybrid strain. BMC Genomics 16:1070. https:\/\/doi.org\/10.1186\/s12864-015-2278-6","journal-title":"BMC Genomics"},{"key":"10697_CR111","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12864-016-3443-2","volume":"18","author":"M Palma","year":"2017","unstructured":"Palma M, Dias PJ, Roque F d C, Luzia L, Guerreiro JF, S\u00e1-Correia I (2017) The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1\/Cup2. BMC Genomics 18:75. https:\/\/doi.org\/10.1186\/s12864-016-3443-2","journal-title":"BMC Genomics"},{"key":"10697_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2018.00274","volume":"9","author":"M Palma","year":"2018","unstructured":"Palma M, Guerreiro JF, S\u00e1-Correia I (2018) Adaptive response and tolerance to acetic acid in Saccharomyces cerevisiae and Zygosaccharomyces bailii: a physiological genomics perspective. Front Microbiol 9:1\u201316. https:\/\/doi.org\/10.3389\/fmicb.2018.00274","journal-title":"Front Microbiol"},{"key":"10697_CR113","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0960-8524(99)00161-3","volume":"74","author":"E Palmqvist","year":"2000","unstructured":"Palmqvist E, Hahn-H\u00e4gerdal B (2000) Fermentation of lignocellulosic hydrolysates. II: inhibitors and mechanisms of inhibition. Bioresour Technol 74:25\u201333. https:\/\/doi.org\/10.1016\/S0960-8524(99)00161-3","journal-title":"Bioresour Technol"},{"key":"10697_CR114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsyr\/foy056","volume":"18","author":"I Papapetridis","year":"2018","unstructured":"Papapetridis I, Verhoeven MD, Wiersma SJ, Goudriaan M, van Maris AJA, Pronk JT (2018) Laboratory evolution for forced glucose-xylose co-consumption enables identification of mutations that improve mixed-sugar fermentation by xylose-fermenting Saccharomyces cerevisiae. FEMS Yeast Res 18:1\u201317. https:\/\/doi.org\/10.1093\/femsyr\/foy056","journal-title":"FEMS Yeast Res"},{"key":"10697_CR115","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.tibtech.2017.10.013","volume":"36","author":"Y-K Park","year":"2018","unstructured":"Park Y-K, Nicaud J-M, Ledesma-Amaro R (2018) The engineering potential of Rhodosporidium toruloides as a workhorse for biotechnological applications. Trends Biotechnol 36:304\u2013317. https:\/\/doi.org\/10.1016\/j.tibtech.2017.10.013","journal-title":"Trends Biotechnol"},{"key":"10697_CR116","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.biortech.2012.07.030","volume":"124","author":"I Parmar","year":"2012","unstructured":"Parmar I, Rupasinghe HPV (2012) Optimization of dilute acid-based pretreatment and application of laccase on apple pomace. Bioresour Technol 124:433\u2013439. https:\/\/doi.org\/10.1016\/j.biortech.2012.07.030","journal-title":"Bioresour Technol"},{"key":"10697_CR117","first-page":"1","volume":"105","author":"D Peters","year":"2006","unstructured":"Peters D (2006) Raw materials. Adv Biochem Eng Biotechnol 105:1\u201330","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"10697_CR118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmolb.2014.00017","volume":"1","author":"T Pfeiffer","year":"2014","unstructured":"Pfeiffer T, Morley A (2014) An evolutionary perspective on the Crabtree effect. Front Mol Biosci 1:1\u20136. https:\/\/doi.org\/10.3389\/fmolb.2014.00017","journal-title":"Front Mol Biosci"},{"key":"10697_CR119","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1038\/s41467-018-07589-w","volume":"9","author":"RJ Protzko","year":"2018","unstructured":"Protzko RJ, Latimer LN, Martinho Z, de Reus E, Seibert T, Benz JP, Dueber JE (2018) Engineering Saccharomyces cerevisiae for co-utilization of d-galacturonic acid and d-glucose from citrus peel waste. Nat Commun 9:5059. https:\/\/doi.org\/10.1038\/s41467-018-07589-w","journal-title":"Nat Commun"},{"key":"10697_CR120","doi-asserted-by":"publisher","unstructured":"Protzko RJ, Hach CA, Coradetti ST, Hackhofer MA, Magosch S, Thieme N, Geiselman GM, Arkin AP, Skerker JM, Dueber JE, Benz JP (2019) Genomewide and Enzymatic Analysis Reveals Efficient D-Galacturonic Acid Metabolism in the Basidiomycete Yeast Rhodosporidium toruloides. mSystems 4: . https:\/\/doi.org\/10.1128\/mSystems.00389-19","DOI":"10.1128\/mSystems.00389-19"},{"key":"10697_CR121","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nbt.3763","volume":"35","author":"K Qiao","year":"2017","unstructured":"Qiao K, Wasylenko TM, Zhou K, Xu P, Stephanopoulos G (2017) Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism. Nat Biotechnol 35:173\u2013177. https:\/\/doi.org\/10.1038\/nbt.3763","journal-title":"Nat Biotechnol"},{"key":"10697_CR122","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0144-8617(93)90082-F","volume":"20","author":"B Quemener","year":"1993","unstructured":"Quemener B, Lahaye M, Thibault JF (1993) Studies on the simultaneous determination of acidic and neutral sugars of plant cell wall materials by HPLC of their methyl glycosides after combined methanolysis and enzymic prehydrolysis. Carbohydr Polym 20:87\u201394. https:\/\/doi.org\/10.1016\/0144-8617(93)90082-F","journal-title":"Carbohydr Polym"},{"key":"10697_CR123","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/femsyr\/fov053","volume":"15","author":"D Radecka","year":"2015","unstructured":"Radecka D, Mukherjee V, Mateo RQ, Stojiljkovic M, Foulqui\u00e9-Moreno MR, Thevelein JM (2015) Looking beyond Saccharomyces: the potential of non-conventional yeast species for desirable traits in bioethanol fermentation. FEMS Yeast Res 15:53","journal-title":"FEMS Yeast Res"},{"key":"10697_CR124","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.biotechadv.2018.01.006","volume":"36","author":"H Raschmanov\u00e1","year":"2018","unstructured":"Raschmanov\u00e1 H, Weninger A, Glieder A, Kovar K, Vogl T (2018) Implementing CRISPR-Cas technologies in conventional and non-conventional yeasts: current state and future prospects. Biotechnol Adv 36:641\u2013665. https:\/\/doi.org\/10.1016\/j.biotechadv.2018.01.006","journal-title":"Biotechnol Adv"},{"key":"10697_CR125","doi-asserted-by":"crossref","unstructured":"Ratledge C (2010) Single cell oils for the 21st century. In: Single Cell Oils, Second Edi. Elsevier, pp 3\u201326","DOI":"10.1016\/B978-1-893997-73-8.50005-0"},{"key":"10697_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsle\/fny222","volume":"365","author":"S Rebello","year":"2018","unstructured":"Rebello S, Abraham A, Madhavan A, Sindhu R, Binod P, Babu AK, Aneesh EM, Pandey A (2018) Non-conventional yeast cell factories for sustainable bioprocesses. FEMS Microbiol Lett 365:1\u201310. https:\/\/doi.org\/10.1093\/femsle\/fny222","journal-title":"FEMS Microbiol Lett"},{"key":"10697_CR127","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00253-009-1870-6","volume":"82","author":"P Richard","year":"2009","unstructured":"Richard P, Hilditch S (2009) D-galacturonic acid catabolism in microorganisms and its biotechnological relevance. Appl Microbiol Biotechnol 82:597\u2013604. https:\/\/doi.org\/10.1007\/s00253-009-1870-6","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR128","doi-asserted-by":"publisher","first-page":"e52402","DOI":"10.1371\/journal.pone.0052402","volume":"7","author":"F Rodrigues","year":"2012","unstructured":"Rodrigues F, Sousa MJ, Ludovico P, Santos H, C\u00f4rte-Real M, Le\u00e3o C (2012) The fate of acetic acid during glucose co-metabolism by the spoilage yeast Zygosaccharomyces bailii. PLoS One 7:e52402. https:\/\/doi.org\/10.1371\/journal.pone.0052402","journal-title":"PLoS One"},{"key":"10697_CR129","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.lwt.2015.07.056","volume":"64","author":"R Rodr\u00edguez Madrera","year":"2015","unstructured":"Rodr\u00edguez Madrera R, Pando Bedri\u00f1ana R, Su\u00e1rez Valles B (2015) Production and characterization of aroma compounds from apple pomace by solid-state fermentation with selected yeasts. LWT Food Sci Technol 64:1342\u20131353. https:\/\/doi.org\/10.1016\/j.lwt.2015.07.056","journal-title":"LWT Food Sci Technol"},{"key":"10697_CR130","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/ncomms1305","volume":"2","author":"E Rozp\u0119dowska","year":"2011","unstructured":"Rozp\u0119dowska E, Hellborg L, Ishchuk OP, Orhan F, Galafassi S, Merico A, Woolfit M, Compagno C, Pi\u0161kur J (2011) Parallel evolution of the make\u2013accumulate\u2013consume strategy in Saccharomyces and Dekkera yeasts. Nat Commun 2:302. https:\/\/doi.org\/10.1038\/ncomms1305","journal-title":"Nat Commun"},{"key":"10697_CR131","first-page":"1220","volume":"3","author":"PP Sahota","year":"2015","unstructured":"Sahota PP, Kaur N (2015) Characterization of enzyme naringinase and the production of debittered low alcoholic kinnow (Citrus raticulata blanco) beverage. Int J Adv Res 3:1220\u20131233","journal-title":"Int J Adv Res"},{"key":"10697_CR132","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1128\/AEM.39.4.908-912.1980","volume":"39","author":"T Sakai","year":"1980","unstructured":"Sakai T, Okushima M (1980) Microbial production of pectin from citrus peel. Appl Environ Microbiol 39:908\u2013912","journal-title":"Appl Environ Microbiol"},{"key":"10697_CR133","doi-asserted-by":"crossref","unstructured":"Sakai T, Sakamoto T, Hallaert J, Vandamme EJ (1993) Pectin, pectinase, and protopectinase: production, properties, and applications. Adv Appl Microbiol 213\u2013294","DOI":"10.1016\/S0065-2164(08)70597-5"},{"key":"10697_CR134","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s10658-008-9355-5","volume":"123","author":"D Saravanakumar","year":"2009","unstructured":"Saravanakumar D, Spadaro D, Garibaldi A, Gullino ML (2009) Detection of enzymatic activity and partial sequence of a chitinase gene in Metschnikowia pulcherrima strain MACH1 used as post-harvest biocontrol agent. Eur J Plant Pathol 123:183\u2013193. https:\/\/doi.org\/10.1007\/s10658-008-9355-5","journal-title":"Eur J Plant Pathol"},{"key":"10697_CR135","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-8292-4","volume-title":"Yeast biotechnology: diversity and applications","author":"T Satyanarayana","year":"2009","unstructured":"Satyanarayana T, Kunze G (2009) Yeast biotechnology: diversity and applications. Springer Netherlands, Dordrecht"},{"key":"10697_CR136","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.biortech.2007.03.060","volume":"99","author":"S Schiewer","year":"2008","unstructured":"Schiewer S, Patil SB (2008) Pectin-rich fruit wastes as biosorbents for heavy metal removal: equilibrium and kinetics. Bioresour Technol 99:1896\u20131903. https:\/\/doi.org\/10.1016\/j.biortech.2007.03.060","journal-title":"Bioresour Technol"},{"key":"10697_CR137","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1016\/j.biortech.2007.06.042","volume":"99","author":"\u00c2C Schirmer-Michel","year":"2008","unstructured":"Schirmer-Michel \u00c2C, Fl\u00f4res SH, Hertz PF, Matos GS, Ayub MAZ (2008) Production of ethanol from soybean hull hydrolysate by osmotolerant Candida guilliermondii NRRL Y-2075. Bioresour Technol 99:2898\u20132904. https:\/\/doi.org\/10.1016\/j.biortech.2007.06.042","journal-title":"Bioresour Technol"},{"key":"10697_CR138","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/jctb.2028","volume":"84","author":"\u00c2C Schirmer-Michel","year":"2009","unstructured":"Schirmer-Michel \u00c2C, Fl\u00f4res SH, Hertz PF, Ayub MAZ (2009) Effect of oxygen transfer rates on alcohols production by Candida guilliermondii cultivated on soybean hull hydrolysate. J Chem Technol Biotechnol 84:223\u2013228. https:\/\/doi.org\/10.1002\/jctb.2028","journal-title":"J Chem Technol Biotechnol"},{"key":"10697_CR139","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1007\/s00253-019-09622-4","volume":"103","author":"K Schmitz","year":"2019","unstructured":"Schmitz K, Protzko R, Zhang L, Benz JP (2019) Spotlight on fungal pectin utilization\u2014from phytopathogenicity to molecular recognition and industrial applications. Appl Microbiol Biotechnol 103:2507\u20132524. https:\/\/doi.org\/10.1007\/s00253-019-09622-4","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR140","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1007\/s00253-010-3071-8","volume":"89","author":"B Seiboth","year":"2011","unstructured":"Seiboth B, Metz B (2011) Fungal arabinan and L-arabinose metabolism. Appl Microbiol Biotechnol 89:1665\u20131673. https:\/\/doi.org\/10.1007\/s00253-010-3071-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"10697_CR141","doi-asserted-by":"crossref","unstructured":"Sellick CA, Campbell RN, Reece RJ (2008) Galactose metabolism in yeast\u2014structure and regulation of the leloir pathway enzymes and the genes encoding them. In: International Review of Cell and Molecular Biology. pp 111\u2013150","DOI":"10.1016\/S1937-6448(08)01003-4"},{"key":"10697_CR142","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1385\/ABAB:117:1:49","volume":"117","author":"M Serrat","year":"2004","unstructured":"Serrat M, Berm\u00fadez RC, Villa TG (2004) Polygalacturonase and ethanol production in Kluyveromyces marxianus: potential use of polygalacturonase in foodstuffs. Appl Biochem Biotechnol 117:49\u201364. https:\/\/doi.org\/10.1385\/ABAB:117:1:49","journal-title":"Appl Biochem Biotechnol"},{"key":"10697_CR143","doi-asserted-by":"publisher","first-page":"6491","DOI":"10.1038\/s41598-019-43032-w","volume":"9","author":"K Simpson-Lavy","year":"2019","unstructured":"Simpson-Lavy K, Kupiec M (2019) Carbon catabolite repression in yeast is not limited to glucose. Sci Rep 9:6491. https:\/\/doi.org\/10.1038\/s41598-019-43032-w","journal-title":"Sci Rep"},{"key":"10697_CR144","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12934-018-1026-4","volume":"17","author":"G Singh","year":"2018","unstructured":"Singh G, Sinha S, Bandyopadhyay KK, Lawrence M, Paul D (2018) Triauxic growth of an oleaginous red yeast Rhodosporidium toruloides on waste \u2018extract\u2019 for enhanced and concomitant lipid and \u03b2-carotene production. Microb Cell Factories 17:182. https:\/\/doi.org\/10.1186\/s12934-018-1026-4","journal-title":"Microb Cell Factories"},{"key":"10697_CR145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13068-017-1003-x","volume":"11","author":"W Siripong","year":"2018","unstructured":"Siripong W, Wolf P, Kusumoputri TP, Downes JJ, Kocharin K, Tanapongpipat S, Runguphan W (2018) Metabolic engineering of Pichia pastoris for production of isobutanol and isobutyl acetate. Biotechnol Biofuels 11:1. https:\/\/doi.org\/10.1186\/s13068-017-1003-x","journal-title":"Biotechnol Biofuels"},{"key":"10697_CR146","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s10295-014-1447-y","volume":"41","author":"I Sitepu","year":"2014","unstructured":"Sitepu I, Selby T, Lin T, Zhu S, Boundy-Mills K (2014) Carbon source utilization and inhibitor tolerance of 45 oleaginous yeast species. J Ind Microbiol Biotechnol 41:1061\u20131070. https:\/\/doi.org\/10.1007\/s10295-014-1447-y","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10697_CR147","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3136\/fstr.16.123","volume":"16","author":"B Skrbic","year":"2010","unstructured":"Skrbic B, Durisic-Mladenovic N, Macvanin N (2010) Determination of metal contents in sugar beet (Beta vulgaris) and its products: empirical and chemometrical approach. Food Sci Technol Res 16:123\u2013134. https:\/\/doi.org\/10.3136\/fstr.16.123","journal-title":"Food Sci Technol Res"},{"key":"10697_CR148","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1016\/j.febslet.2012.06.012","volume":"586","author":"B Souffriau","year":"2012","unstructured":"Souffriau B, Den Abt T, Thevelein JM (2012) Evidence for rapid uptake of d-galacturonic acid in the yeast Saccharomyces cerevisiae by a channel-type transport system. FEBS Lett 586:2494\u20132499. https:\/\/doi.org\/10.1016\/j.febslet.2012.06.012","journal-title":"FEBS Lett"},{"key":"10697_CR149","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.copbio.2019.02.011","volume":"57","author":"M Spagnuolo","year":"2019","unstructured":"Spagnuolo M, Yaguchi A, Blenner M (2019) Oleaginous yeast for biofuel and oleochemical production. Curr Opin Biotechnol 57:73\u201381. https:\/\/doi.org\/10.1016\/j.copbio.2019.02.011","journal-title":"Curr Opin Biotechnol"},{"key":"10697_CR150","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1754-6834-4-38","volume":"4","author":"T Subtil","year":"2011","unstructured":"Subtil T, Boles E (2011) Improving L-arabinose utilization of pentose fermenting Saccharomyces cerevisiae cells by heterologous expression of L-arabinose transporting sugar transporters. Biotechnol Biofuels 4:38. https:\/\/doi.org\/10.1186\/1754-6834-4-38","journal-title":"Biotechnol Biofuels"},{"key":"10697_CR151","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13568-016-0236-6","volume":"6","author":"A Tanimura","year":"2016","unstructured":"Tanimura A, Takashima M, Sugita T, Endoh R, Ohkuma M, Kishino S, Ogawa J, Shima J (2016) Lipid production through simultaneous utilization of glucose, xylose, and l-arabinose by Pseudozyma hubeiensis: a comparative screening study. AMB Express 6:58. https:\/\/doi.org\/10.1186\/s13568-016-0236-6","journal-title":"AMB Express"},{"key":"10697_CR152","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.renene.2016.06.060","volume":"99","author":"M Taskin","year":"2016","unstructured":"Taskin M, Ortucu S, Aydogan MN, Arslan NP (2016) Lipid production from sugar beet molasses under non-aseptic culture conditions using the oleaginous yeast Rhodotorula glutinis TR29. Renew Energy 99:198\u2013204. https:\/\/doi.org\/10.1016\/j.renene.2016.06.060","journal-title":"Renew Energy"},{"key":"10697_CR153","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.tibtech.2007.06.002","volume":"25","author":"MC Teixeira","year":"2007","unstructured":"Teixeira MC, Duque P, S\u00e1-Correia I (2007) Environmental genomics: mechanistic insights into toxicity of and resistance to the herbicide 2,4-D. Trends Biotechnol 25:363\u2013370. https:\/\/doi.org\/10.1016\/j.tibtech.2007.06.002","journal-title":"Trends Biotechnol"},{"key":"10697_CR154","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.copbio.2010.10.011","volume":"22","author":"MC Teixeira","year":"2011","unstructured":"Teixeira MC, Mira NP, S\u00e1-Correia I (2011) A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae. Curr Opin Biotechnol 22:150\u2013156. https:\/\/doi.org\/10.1016\/j.copbio.2010.10.011","journal-title":"Curr Opin Biotechnol"},{"key":"10697_CR155","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.5935\/0103-5053.20130195","volume":"24","author":"J Tsukamoto","year":"2013","unstructured":"Tsukamoto J, Dur\u00e1n N, Tasic L (2013) Nanocellulose and bioethanol production from orange waste using isolated microorganisms. J Braz Chem Soc 24:1537\u20131543. https:\/\/doi.org\/10.5935\/0103-5053.20130195","journal-title":"J Braz Chem Soc"},{"key":"10697_CR156","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/jobm.200510609","volume":"46","author":"R Vadkertiov\u00e1","year":"2006","unstructured":"Vadkertiov\u00e1 R, Sl\u00e1vikov\u00e1 E (2006) Metal tolerance of yeasts isolated from water, soil and plant environments. J Basic Microbiol 46:145\u2013152. https:\/\/doi.org\/10.1002\/jobm.200510609","journal-title":"J Basic Microbiol"},{"key":"10697_CR157","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.bbamcr.2006.07.016","volume":"1763","author":"IJ van der Klei","year":"2006","unstructured":"van der Klei IJ, Yurimoto H, Sakai Y, Veenhuis M (2006) The significance of peroxisomes in methanol metabolism in methylotrophic yeast. Biochim Biophys Acta, Mol Cell Res 1763:1453\u20131462. https:\/\/doi.org\/10.1016\/j.bbamcr.2006.07.016","journal-title":"Biochim Biophys Acta, Mol Cell Res"},{"key":"10697_CR158","doi-asserted-by":"publisher","first-page":"121922","DOI":"10.1016\/j.biortech.2019.121922","volume":"292","author":"M van Dijk","year":"2019","unstructured":"van Dijk M, Erdei B, Galbe M, Nyg\u00e5rd Y, Olsson L (2019) Strain-dependent variance in short-term adaptation effects of two xylose-fermenting strains of Saccharomyces cerevisiae. Bioresour Technol 292:121922. https:\/\/doi.org\/10.1016\/j.biortech.2019.121922","journal-title":"Bioresour Technol"},{"key":"10697_CR159","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07388550801913840","volume":"28","author":"F Vendruscolo","year":"2008","unstructured":"Vendruscolo F, Albuquerque PM, Streit F, Esposito E, Ninow JL (2008) Apple pomace: a versatile substrate for biotechnological applications. Crit Rev Biotechnol 28:1\u201312. https:\/\/doi.org\/10.1080\/07388550801913840","journal-title":"Crit Rev Biotechnol"},{"key":"10697_CR160","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1023\/A:1016350612380","volume":"18","author":"SG Villas-B\u00f4as","year":"2002","unstructured":"Villas-B\u00f4as SG, Esposito E, De Mendon\u00e7a MM (2002) Novel lignocellulolytic ability of Candida utilis during solid-substrate cultivation on apple pomace. World J Microbiol Biotechnol 18:541\u2013545. https:\/\/doi.org\/10.1023\/A:1016350612380","journal-title":"World J Microbiol Biotechnol"},{"key":"10697_CR161","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.fgb.2015.12.001","volume":"89","author":"JM Wagner","year":"2016","unstructured":"Wagner JM, Alper HS (2016) Synthetic biology and molecular genetics in non-conventional yeasts: current tools and future advances. Fungal Genet Biol 89:126\u2013136. https:\/\/doi.org\/10.1016\/j.fgb.2015.12.001","journal-title":"Fungal Genet Biol"},{"key":"10697_CR162","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s10545-008-1015-6","volume":"31","author":"MMC Wamelink","year":"2008","unstructured":"Wamelink MMC, Struys EA, Jakobs C (2008) The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review. J Inherit Metab Dis 31:703\u2013717. https:\/\/doi.org\/10.1007\/s10545-008-1015-6","journal-title":"J Inherit Metab Dis"},{"key":"10697_CR163","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.biortech.2012.08.024","volume":"124","author":"G-Y Wang","year":"2012","unstructured":"Wang G-Y, Chi Z, Song B, Wang Z-P, Chi Z-M (2012) High level lipid production by a novel inulinase-producing yeast Pichia guilliermondii Pcla22. Bioresour Technol 124:77\u201382. https:\/\/doi.org\/10.1016\/j.biortech.2012.08.024","journal-title":"Bioresour Technol"},{"key":"10697_CR164","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.procbio.2015.04.014","volume":"50","author":"Y Wang","year":"2015","unstructured":"Wang Y, Gong Z, Yang X, Shen H, Wang Q, Wang J, Zhao ZK (2015) Microbial lipid production from pectin-derived carbohydrates by oleaginous yeasts. Process Biochem 50:1097\u20131102. https:\/\/doi.org\/10.1016\/j.procbio.2015.04.014","journal-title":"Process Biochem"},{"key":"10697_CR165","doi-asserted-by":"publisher","first-page":"fov082","DOI":"10.1093\/femsyr\/fov082","volume":"15","author":"A Weninger","year":"2015","unstructured":"Weninger A, Glieder A, Vogl T (2015) A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris. FEMS Yeast Res 15:fov082. https:\/\/doi.org\/10.1093\/femsyr\/fov082","journal-title":"FEMS Yeast Res"},{"key":"10697_CR166","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.foodchem.2014.09.132","volume":"172","author":"A Wikiera","year":"2015","unstructured":"Wikiera A, Mika M, Starzy\u0144ska-Janiszewska A, Stodolak B (2015) Development of complete hydrolysis of pectins from apple pomace. Food Chem 172:675\u2013680. https:\/\/doi.org\/10.1016\/j.foodchem.2014.09.132","journal-title":"Food Chem"},{"key":"10697_CR167","doi-asserted-by":"crossref","unstructured":"Williams PA (2011) Natural polymers: introduction and overview. In: RSC Polymer Chemistry Series. pp 1\u201314","DOI":"10.1039\/9781849733519-00001"},{"key":"10697_CR168","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/465717","volume":"2012","author":"F Wirth","year":"2012","unstructured":"Wirth F, Goldani LZ (2012) Epidemiology of Rhodotorula : an emerging pathogen. Interdiscip Perspect Infect Dis 2012:1\u20137. https:\/\/doi.org\/10.1155\/2012\/465717","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"10697_CR169","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1128\/AEM.00177-07","volume":"73","author":"HW Wisselink","year":"2007","unstructured":"Wisselink HW, Toirkens MJ, del Rosario Franco Berriel M, Winkler AA, van Dijken JP, Pronk JT, van Maris AJA (2007) Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of L-arabinose. Appl Environ Microbiol 73:4881\u20134891. https:\/\/doi.org\/10.1128\/AEM.00177-07","journal-title":"Appl Environ Microbiol"},{"key":"10697_CR170","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/bioengineering3010010","volume":"3","author":"Y Wu","year":"2016","unstructured":"Wu Y, Shen X, Yuan Q, Yan Y (2016) Metabolic engineering strategies for co-utilization of carbon sources in microbes. Bioengineering 3:10. https:\/\/doi.org\/10.3390\/bioengineering3010010","journal-title":"Bioengineering"},{"key":"10697_CR171","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.copbio.2017.12.003","volume":"53","author":"A Yaguchi","year":"2018","unstructured":"Yaguchi A, Spagnuolo M, Blenner M (2018) Engineering yeast for utilization of alternative feedstocks. Curr Opin Biotechnol 53:122\u2013129. https:\/\/doi.org\/10.1016\/j.copbio.2017.12.003","journal-title":"Curr Opin Biotechnol"},{"key":"10697_CR172","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.carbpol.2006.12.024","volume":"69","author":"BM Yapo","year":"2007","unstructured":"Yapo BM, Lerouge P, Thibault J-F, Ralet M-C (2007a) Pectins from citrus peel cell walls contain homogalacturonans homogenous with respect to molar mass, rhamnogalacturonan I and rhamnogalacturonan II. Carbohydr Polym 69:426\u2013435. https:\/\/doi.org\/10.1016\/j.carbpol.2006.12.024","journal-title":"Carbohydr Polym"},{"key":"10697_CR173","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.foodchem.2005.12.012","volume":"100","author":"BM Yapo","year":"2007","unstructured":"Yapo BM, Robert C, Etienne I, Wathelet B, Paquot M (2007b) Effect of extraction conditions on the yield, purity and surface properties of sugar beet pulp pectin extracts. Food Chem 100:1356\u20131364. https:\/\/doi.org\/10.1016\/j.foodchem.2005.12.012","journal-title":"Food Chem"},{"key":"10697_CR174","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s12010-009-8684-y","volume":"160","author":"D Yasokawa","year":"2010","unstructured":"Yasokawa D, Murata S, Iwahashi Y, Kitagawa E, Nakagawa R, Hashido T, Iwahashi H (2010) Toxicity of methanol and formaldehyde towards Saccharomyces cerevisiae as assessed by DNA microarray analysis. Appl Biochem Biotechnol 160:1685\u20131698. https:\/\/doi.org\/10.1007\/s12010-009-8684-y","journal-title":"Appl Biochem Biotechnol"},{"key":"10697_CR175","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1007\/s10295-019-02233-y","volume":"46","author":"S Ye","year":"2019","unstructured":"Ye S, Jeong D, Shon JC, Liu KH, Kim KH, Shin M, Kim SR (2019) Deletion of PHO13 improves aerobic l-arabinose fermentation in engineered Saccharomyces cerevisiae. J Ind Microbiol Biotechnol 46:1725\u20131731. https:\/\/doi.org\/10.1007\/s10295-019-02233-y","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10697_CR176","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cbpa.2015.09.008","volume":"29","author":"GC Zhang","year":"2015","unstructured":"Zhang GC, Liu JJ, Kong II, Kwak S, Jin YS (2015) Combining C6 and C5 sugar metabolism for enhancing microbial bioconversion. Curr Opin Chem Biol 29:49\u201357","journal-title":"Curr Opin Chem Biol"},{"key":"10697_CR177","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.biortech.2018.11.053","volume":"273","author":"M Zhao","year":"2019","unstructured":"Zhao M, Shi D, Lu X, Zong H, Zhuge B, Ji H (2019) Ethanol fermentation from non-detoxified lignocellulose hydrolysate by a multi-stress tolerant yeast Candida glycerinogenes mutant. Bioresour Technol 273:634\u2013640. https:\/\/doi.org\/10.1016\/j.biortech.2018.11.053","journal-title":"Bioresour Technol"},{"key":"10697_CR178","unstructured":"Zhou W, Widmer W, Grohmann K (2008) Developments in ethanol production from citrus peel waste. Proc Fla State Hort Soc:307\u2013310"},{"key":"10697_CR179","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cogsc.2017.10.001","volume":"9","author":"VG Zuin","year":"2018","unstructured":"Zuin VG, Segatto ML, Ramin LZ (2018) Plants as resources for organic molecules: facing the green and sustainable future today. Curr Opin Green Sustain Chem 9:1\u20137. https:\/\/doi.org\/10.1016\/j.cogsc.2017.10.001","journal-title":"Curr Opin Green Sustain Chem"}],"container-title":["Applied Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10697-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00253-020-10697-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00253-020-10697-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T23:07:33Z","timestamp":1622416053000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00253-020-10697-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,31]]},"references-count":179,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10697"],"URL":"https:\/\/doi.org\/10.1007\/s00253-020-10697-7","relation":{},"ISSN":["0175-7598","1432-0614"],"issn-type":[{"value":"0175-7598","type":"print"},{"value":"1432-0614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,31]]},"assertion":[{"value":"20 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}