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The most prevalent factor responsible for aging is the accumulation of damages resulting from oxidative stress and dysbiosis. D-galactose-induced aging has become a hot topic, and extensive research is being conducted in this area. Published literature has reported that the continuous administration of D-galactose leads to the deterioration of motor and cognitive skills, resembling symptoms of aging. Hence, this procedure is employed as a model for accelerated aging. This review aims to emphasize the effect of D-galactose on various bodily organs and underline the role of the<jats:italic>Lactobacillus<\/jats:italic>sp. in the aging process, along with its anti-oxidative potential. A critical consideration to the literature describing animal models that have used the<jats:italic>Lactobacillus<\/jats:italic>sp. in amending D-galactose-induced aging is also given.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:italic>\u2022 D-Galactose induces the aging process via decreasing the respiratory chain enzyme activity as well as ATP synthesis, mitochondrial dysfunction, and increased ROS production.<\/jats:italic><\/jats:p><jats:p><jats:italic>\u2022 D-Galactose induced aging primarily affects the brain, heart, lung, liver, kidney, and skin.<\/jats:italic><\/jats:p><jats:p><jats:italic>\u2022 The anti-oxidative potential of Lactobacillus sp. in improving D-galactose-induced aging in animal models via direct feeding and feeding of Lactobacillus-fermented food.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.1007\/s00253-022-12041-7","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T03:16:35Z","timestamp":1656904595000},"page":"4831-4843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Antioxidative potential of Lactobacillus sp. in ameliorating D-galactose-induced aging"],"prefix":"10.1007","volume":"106","author":[{"given":"Harsh","family":"Kumar","sequence":"first","affiliation":[]},{"given":"Kanchan","family":"Bhardwaj","sequence":"additional","affiliation":[]},{"given":"Marian","family":"Valko","sequence":"additional","affiliation":[]},{"given":"Suliman Y.","family":"Alomar","sequence":"additional","affiliation":[]},{"given":"Saleh H.","family":"Alwasel","sequence":"additional","affiliation":[]},{"given":"Nat\u00e1lia","family":"Cruz-Martins","sequence":"additional","affiliation":[]},{"given":"Daljeet Singh","family":"Dhanjal","sequence":"additional","affiliation":[]},{"given":"Reena","family":"Singh","sequence":"additional","affiliation":[]},{"given":"Kamil","family":"Ku\u010da","sequence":"additional","affiliation":[]},{"given":"Rachna","family":"Verma","sequence":"additional","affiliation":[]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"12041_CR1","first-page":"26","volume":"50","author":"JJ Ahire","year":"2013","unstructured":"Ahire JJ, Mokashe NU, Patil HJ, Chaudhari BL (2013) Antioxidative potential of folate producing probiotic Lactobacillus helveticus CD6. 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