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Hundreds of sRNAs have been found using in silico genome analysis and experimentally based approaches in bacteria of the <jats:italic>Burkholderia cepacia<\/jats:italic> complex (Bcc). However, and despite the hundreds of sRNAs identified so far, the number of functionally characterized sRNAs from these bacteria remains very limited. In this mini-review, we describe the general characteristics of sRNAs and the main mechanisms involved in their action as regulators of post-transcriptional gene expression, as well as the work done so far in the identification and characterization of sRNAs from Bcc. The number of functionally characterized sRNAs from Bcc is expected to increase and to add new knowledge on the biology of these bacteria, leading to novel therapeutic approaches to tackle the infections caused by these opportunistic pathogens, particularly severe among cystic fibrosis patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>\n              <jats:italic>\u2022Hundreds of sRNAs have been identified in Burkholderia cepacia complex bacteria (Bcc).<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022A few sRNAs have been functionally characterized in Bcc.<\/jats:italic>\n            <\/jats:p>\n            <jats:p>\n              <jats:italic>\u2022Functionally characterized Bcc sRNAs play major roles in metabolism, biofilm formation, and virulence.<\/jats:italic>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00253-024-13121-6","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:02:21Z","timestamp":1712048541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Non-coding regulatory sRNAs from bacteria of the Burkholderia cepacia complex"],"prefix":"10.1007","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7845-1141","authenticated-orcid":false,"given":"Gon\u00e7alo R.","family":"Matos","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-676X","authenticated-orcid":false,"given":"Joana R.","family":"Feliciano","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge H.","family":"Leit\u00e3o","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"13121_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.mib.2007.05.003","volume":"10","author":"S Altuvia","year":"2007","unstructured":"Altuvia S (2007) Identification of bacterial small non-coding RNAs: experimental approaches. 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