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From these, 81 patients were excluded due to prior or concurrent cholecystectomy. The remaining 653 patients with in situ gallbladder were followed for 12\u00a0months and were clinically screened for symptomatic or complicated cholelithiasis. Clinical and demographic characteristics were compared at baseline and 12\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 653 patients with in situ gallbladder, only 24 (3.3 %) developed symptomatic gallstones and only nine presented complicated disease. None of the patients with asymptomatic disease at the time of surgery progressed to symptomatic or complicated disease. Patients who developed symptomatic disease were not significantly different, although there was a trend toward longer obesity evolution, lower insulin levels, and lower hepatic enzymes level. A multivariate regression analysis revealed that patients with gastric sleeve were more likely to develop symptomatic gallstones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although further studies are required, the management of gallstones in morbidly obese patients should not be different from normal\u2010weight patients. Therefore, performing a laparoscopic cholecystectomy only in symptomatic patients is an effective approach and asymptomatic gallstones should not be treated at the time of bariatric surgery.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-016-3639-2","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T15:47:16Z","timestamp":1468424836000},"page":"2904-2910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Gallstones and Bariatric Surgery: To Treat or Not to Treat?"],"prefix":"10.1002","volume":"40","author":[{"given":"Marina","family":"Morais","sequence":"first","affiliation":[{"name":"General Surgery Department Sao Joao Medical Center Porto Portugal"}]},{"given":"Gil","family":"Faria","sequence":"additional","affiliation":[{"name":"Center for Health Technology and Services Research (CINTESIS) Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar Porto Portugal"}]},{"given":"John","family":"Preto","sequence":"additional","affiliation":[{"name":"General Surgery Department Sao Joao Medical Center Porto Portugal"}]},{"given":"Jos\u00e9","family":"Costa\u2010Maia","sequence":"additional","affiliation":[{"name":"General Surgery Department Sao Joao Medical Center Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"e_1_2_8_2_2","unstructured":"http:\/\/www.who.int\/gho\/ncd\/risk_factors\/obesity_text\/en\/ceJ. 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