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All participants underwent 3-T hip MRI using 3D dual-echo proton-density-weighted UTE (PD-UTE) and short TR adiabatic inversion recovery UTE (STAIR-UTE) sequences. Measurements were performed in the femoral head and neck by two readers. Interobserver agreement was assessed via intraclass correlation coefficients (ICC). Group differences were analyzed with the Kruskal\u2013Wallis test and Holm-adjusted post hoc tests. Spearman correlation analysis and receiver operating characteristic (ROC) analysis were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PMR increased and MI decreased with worsening bone status. Significant differences were observed between Young Normal and all older groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). PMR from the oblique-coronal total femoral head differentiated Old Normal from Osteoporosis (5.35 vs. 8.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Both PMR (\u03c1\u2009=\u2009\u22120.406\u2009to\u2009\u22120.211) and MI (\u03c1\u2009=\u20090.333\u20130.402) significantly correlated with T-scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The areas under the ROC curve were 0.776 (95% CI, 0.584\u20130.909) for PMR and 0.738 (95% CI, 0.548\u20130.886) for MI. Interobserver reproducibility was substantial to almost perfect (ICC: 0.73\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMR and MI demonstrated measurable differences across age and bone status and may provide complementary information on trabecular bone characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Can ultrashort echo time (UTE) MRI biomarkers address the need for radiation-free assessment of age- and osteoporosis-related trabecular bone changes in the proximal femur?<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>Pore-to-matrix ratio (PMR) increased and matrix index (MI) decreased with aging and worsening bone status, and femoral head PMR differentiated osteoporosis from normal bone.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Clinical relevance<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>UTE-MRI-derived PMR and MI may provide radiation-free, complementary information to dual-energy X-ray absorptiometry for assessing trabecular bone changes associated with aging and osteoporosis.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-026-12923-8","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:09:09Z","timestamp":1791385749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative ultrashort echo time (UTE) magnetic resonance imaging of femoral trabecular bone in aging and osteoporosis"],"prefix":"10.1007","author":[{"given":"Jisook","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arya","family":"Suprana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Jerban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9203-2450","authenticated-orcid":false,"given":"Jiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"12923_CR1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/nbm.1066","volume":"19","author":"FW Wehrli","year":"2006","unstructured":"Wehrli FW, Song HK, Saha PK, Wright AC (2006) Quantitative MRI for the assessment of bone structure and function. 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