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To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twelve male pigs were randomly assigned to 3 different groups of 4 animals each, determined by the type of patch used during thoracoscopic diaphragmatic hernia repair (Gore-Tex<jats:sup>\u00ae<\/jats:sup>, polycaprolactone electrospun membrane-PCLem, and\u00a0decellularized human chorion membrane-dHCM). After 7\u00a0weeks, all animals were euthanized, followed by necropsy for diaphragmatic evaluation and histological analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thoracoscopic defect creation and diaphragmatic repair were performed without any technical difficulty in all groups. However, hernia recurrence rate was 0% in Gore-Tex<jats:sup>\u00ae<\/jats:sup>, 50% in PCLem and 100% in dHCM groups. At euthanasia, Gore-Tex<jats:sup>\u00ae<\/jats:sup> patches appeared virtually unchanged and covered with a fibrotic capsule, while PCLem and dHCM patches were replaced by either floppy connective tissue or vascularized and floppy regenerated membranous tissue, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Gore-Tex<jats:sup>\u00ae<\/jats:sup> was associated with a higher survival rate and lower recurrence. Nevertheless, the proposed biodegradable membranes were associated with better tissue integration when compared with Gore-Tex<jats:sup>\u00ae<\/jats:sup>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00383-023-05584-x","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T16:02:15Z","timestamp":1700841735000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex\u00ae"],"prefix":"10.1007","volume":"40","author":[{"given":"Marianna","family":"Scuglia","sequence":"first","affiliation":[]},{"given":"Laura P.","family":"Fraz\u00e3o","sequence":"additional","affiliation":[]},{"given":"Alice","family":"Miranda","sequence":"additional","affiliation":[]},{"given":"Albino","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Barbosa-Sequeira","sequence":"additional","affiliation":[]},{"given":"Diana","family":"Coimbra","sequence":"additional","affiliation":[]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Nogueira-Silva","sequence":"additional","affiliation":[]},{"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Correia-Pinto","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"5584_CR1","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1016\/j.jpedsurg.2013.08.014","volume":"48","author":"KP Lallya","year":"2013","unstructured":"Lallya KP et al (2013) Standardized reporting for congenital diaphragmatic hernia\u2014an international consensus. 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