{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:04:31Z","timestamp":1777352671119,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00392-018-1373-5","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T12:07:42Z","timestamp":1538050062000},"page":"1192-1195","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Collagen biomarker bioprofiles predicting the antifibrotic response to eplerenone in myocardial infarction: findings from the REMINDER trial"],"prefix":"10.1007","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-6138","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Ant\u00f3nio","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Bertram","family":"Pitt","sequence":"additional","affiliation":[]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[]},{"given":"Esteban Lopez","family":"de Sa","sequence":"additional","affiliation":[]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[]},{"given":"Marcus","family":"Flather","sequence":"additional","affiliation":[]},{"given":"Freek","family":"Verheugt","sequence":"additional","affiliation":[]},{"given":"Harry","family":"Shi","sequence":"additional","affiliation":[]},{"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[]},{"given":"John","family":"Vincent","sequence":"additional","affiliation":[]},{"given":"Patrick","family":"Rossignol","sequence":"additional","affiliation":[]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"issue":"9","key":"1373_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00392-017-1111-4","volume":"106","author":"S Khoury","year":"2017","unstructured":"Khoury S, Carmon S, Margolis G, Keren G, Shacham Y (2017) Incidence and outcomes of early left ventricular thrombus following ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. Clin Res Cardiol 106(9):695\u2013701","journal-title":"Clin Res Cardiol"},{"issue":"1","key":"1373_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00392-017-1157-3","volume":"107","author":"JP Ferreira","year":"2017","unstructured":"Ferreira JP, Duarte K, Montalescot G, Pitt B, de Sa EL, Hamm CW, Flather M, Verheugt F, Shi H, Turgonyi E, Orri M, Rossignol P, Vincent J, Zannad F (2017) Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study. Clin Res Cardiol 107(1):49\u201359","journal-title":"Clin Res Cardiol"},{"issue":"22","key":"1373_CR3","first-page":"2700","volume":"102","author":"F Zannad","year":"2000","unstructured":"Zannad F, Alla F, Dousset B, Perez A, Pitt B (2000) Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investig Circ 102(22):2700\u20132706","journal-title":"Rales Investig Circ"},{"issue":"11","key":"1373_CR4","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/sj.ijo.0803022","volume":"29","author":"D Quilliot","year":"2005","unstructured":"Quilliot D, Alla F, Bohme P, Bruntz JF, Hammadi M, Dousset B, Ziegler O, Zannad F (2005) Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance. Int J Obes (Lond) 29(11):1321\u20131328","journal-title":"Int J Obes (Lond)"},{"issue":"18","key":"1373_CR5","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1161\/CIRCULATIONAHA.108.809194","volume":"119","author":"W Iraqi","year":"2009","unstructured":"Iraqi W, Rossignol P, Angioi M, Fay R, Nuee J, Ketelslegers JM, Vincent J, Pitt B, Zannad F (2009) Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study. Circulation 119(18):2471\u20132479","journal-title":"Circulation"},{"key":"1373_CR6","doi-asserted-by":"crossref","unstructured":"Montalescot G, Pitt B, Lopez de Sa E, Hamm CW, Flather M, Verheugt F, Shi H, Turgonyi E, Orri M, Vincent J, Zannad F (2014) Early eplerenone treatment in patients with acute ST-elevation myocardial infarction without heart failure: the randomized double-blind reminder study. In: Eur Heart J, Published on behalf of the European Society of Cardiology The Author 2014. For permissions please email: journals.permissions@oup.com.: England, vol 35, pp\u00a02295\u20132302","DOI":"10.1093\/eurheartj\/ehu164"},{"issue":"16","key":"1373_CR7","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1016\/j.jacc.2016.02.033","volume":"67","author":"F Beygui","year":"2016","unstructured":"Beygui F, Cayla G, Roule V, Roubille F, Delarche N, Silvain J, Van Belle E, Belle L, Galinier M, Motreff P, Cornillet L, Collet JP, Furber A, Goldstein P, Ecollan P, Legallois D, Lebon A, Rousseau H, Machecourt J, Zannad F, Vicaut E, Montalescot G (2016) Early Aldosterone blockade in acute myocardial infarction: the ALBATROSS randomized clinical trial. J Am Coll Cardiol 67(16):1917\u20131927","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"1373_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1023\/A:1011119003788","volume":"15","author":"B Pitt","year":"2001","unstructured":"Pitt B, Williams G, Remme W, Martinez F, Lopez-Sendon J, Zannad F, Neaton J, Roniker B, Hurley S, Burns D, Bittman R, Kleiman J (2001) The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone Post-AMI Heart Failure Efficacy and Survival Study. Cardiovasc Drugs Ther 15(1):79\u201387","journal-title":"Cardiovasc Drugs Ther"},{"issue":"8","key":"1373_CR9","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/ejhf.814","volume":"19","author":"JP Ferreira","year":"2017","unstructured":"Ferreira JP, Mentz RJ, Pizard A, Pitt B, Zannad F (2017) Tailoring mineralocorticoid receptor antagonist therapy in heart failure patients: are we moving towards a personalized approach? Eur J Heart Fail 19(8):974\u2013986","journal-title":"Eur J Heart Fail"},{"issue":"22","key":"1373_CR10","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/j.jacc.2015.04.026","volume":"65","author":"Bego\u00f1a L\u00f3pez","year":"2015","unstructured":"Lopez B, Gonzalez A, Ravassa S, Beaumont J, Moreno MU, San Jose G, Querejeta R, Diez J (2015) Circulating biomarkers of myocardial fibrosis: the need for a reappraisal. J Am Coll Cardiol 65(22):2449\u20132456","journal-title":"Journal of the American College of Cardiology"},{"issue":"19","key":"1373_CR11","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1161\/CIRCULATIONAHA.105.571653","volume":"112","author":"H Izawa","year":"2005","unstructured":"Izawa H, Murohara T, Nagata K, Isobe S, Asano H, Amano T, Ichihara S, Kato T, Ohshima S, Murase Y, Iino S, Obata K, Noda A, Okumura K, Yokota M (2005) Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study. Circulation 112(19):2940\u20132945","journal-title":"Circulation"},{"issue":"14","key":"1373_CR12","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0002-9149(99)80686-9","volume":"75","author":"G Klappacher","year":"1995","unstructured":"Klappacher G, Franzen P, Haab D, Mehrabi M, Binder M, Plesch K, Pacher R, Grimm M, Pribill I, Eichler HG et al (1995) Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol 75(14):913\u2013918","journal-title":"Am J Cardiol"},{"issue":"17","key":"1373_CR13","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1016\/j.jacc.2016.02.048","volume":"67","author":"G Condorelli","year":"2016","unstructured":"Condorelli G, Jotti GS, Pagiatakis C (2016) Fibroblast senescence as a therapeutic target of myocardial fibrosis: beyond spironolactone? J Am Coll Cardiol 67(17):2029\u20132031","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1373_CR14","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/S0008-6363(00)00032-8","volume":"46","author":"Y Sun","year":"2000","unstructured":"Sun Y, Weber KT (2000) Infarct scar: a dynamic tissue. Cardiovasc Res 46(2):250\u2013256","journal-title":"Cardiovasc Res"},{"issue":"2","key":"1373_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/ejhf.696","volume":"19","author":"M Gyongyosi","year":"2017","unstructured":"Gyongyosi M, Winkler J, Ramos I, Do QT, Firat H, McDonald K, Gonzalez A, Thum T, Diez J, Jaisser F, Pizard A, Zannad F (2017) Myocardial fibrosis: biomedical research from bench to bedside. Eur J Heart Fail 19(2):177\u2013191","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"1373_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/ehf2.12218","volume":"5","author":"JP Ferreira","year":"2017","unstructured":"Ferreira JP, Machu JL, Girerd N, Jaisser F, Thum T, Butler J, Gonzalez A, Diez J, Heymans S, McDonald K, Gyongyosi M, Firat H, Rossignol P, Pizard A, Zannad F (2017) Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis. ESC Heart Fail 5(1):139\u2013148","journal-title":"ESC Heart Fail"},{"issue":"8","key":"1373_CR17","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/ejhf.312","volume":"17","author":"S Heymans","year":"2015","unstructured":"Heymans S, Gonzalez A, Pizard A, Papageorgiou AP, Lopez-Andres N, Jaisser F, Thum T, Zannad F, Diez J (2015) Searching for new mechanisms of myocardial fibrosis with diagnostic and\/or therapeutic potential. Eur J Heart Fail 17(8):764\u2013771","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"1373_CR18","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1161\/01.CIR.96.8.2565","volume":"96","author":"P Uusimaa","year":"1997","unstructured":"Uusimaa P, Risteli J, Niemela M, Lumme J, Ikaheimo M, Jounela A, Peuhkurinen K (1997) Collagen scar formation after acute myocardial infarction: relationships to infarct size, left ventricular function, and coronary artery patency. Circulation 96(8):2565\u20132572","journal-title":"Circulation"},{"issue":"3","key":"1373_CR19","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1161\/HYPERTENSIONAHA.113.02654","volume":"63","author":"B Lopez","year":"2014","unstructured":"Lopez B, Gonzalez A, Querejeta R, Larman M, Rabago G, Diez J (2014) Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure. Hypertension 63(3):483\u2013489","journal-title":"Hypertension"},{"issue":"20","key":"1373_CR20","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1161\/01.CIR.0000068340.96506.0F","volume":"107","author":"M Hayashi","year":"2003","unstructured":"Hayashi M, Tsutamoto T, Wada A, Tsutsui T, Ishii C, Ohno K, Fujii M, Taniguchi A, Hamatani T, Nozato Y, Kataoka K, Morigami N, Ohnishi M, Kinoshita M, Horie M (2003) Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction. Circulation 107(20):2559\u20132565","journal-title":"Circulation"},{"issue":"15","key":"1373_CR21","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/j.jacc.2018.02.021","volume":"71","author":"G Arantxa","year":"2018","unstructured":"Arantxa G, Schelbert EB, Diez J, Butler J (2018) Myocardial interstitial fibrosis in heart failure. J Am Coll Cardiol 71(15):1696\u20131706","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"1373_CR22","doi-asserted-by":"publisher","first-page":"e95254","DOI":"10.1371\/journal.pone.0095254","volume":"9","author":"YH Lin","year":"2014","unstructured":"Lin YH, Chou CH, Wu XM, Chang YY, Hung CS, Chen YH, Tzeng YL, Wu VC, Ho YL, Hsieh FJ, Wu KD (2014) Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. PLoS One 9(9):e95254","journal-title":"PLoS One"},{"issue":"6","key":"1373_CR23","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1161\/HYPERTENSIONAHA.111.190512","volume":"59","author":"F Azibani","year":"2012","unstructured":"Azibani F, Benard L, Schlossarek S, Merval R, Tournoux F, Fazal L, Polidano E, Launay JM, Carrier L, Chatziantoniou C, Samuel JL, Delcayre C (2012) Aldosterone inhibits antifibrotic factors in mouse hypertensive heart. Hypertension 59(6):1179\u20131187","journal-title":"Hypertension"},{"issue":"4","key":"1373_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/ejhf.246","volume":"17","author":"B Lopez","year":"2015","unstructured":"Lopez B, Gonzalez A, Querejeta R, Zubillaga E, Larman M, Diez J (2015) Galectin-3 and histological, molecular and biochemical aspects of myocardial fibrosis in heart failure of hypertensive origin. Eur J Heart Fail 17(4):385\u2013392","journal-title":"Eur J Heart Fail"},{"issue":"6","key":"1373_CR25","doi-asserted-by":"publisher","first-page":"R1742","DOI":"10.1152\/ajpregu.90995.2008","volume":"297","author":"LC Sturgis","year":"2009","unstructured":"Sturgis LC, Cannon JG, Schreihofer DA, Brands MW (2009) The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6. Am J Physiol Regul Integr Comp Physiol 297(6):R1742\u2013R1748","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-018-1373-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-018-1373-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-018-1373-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T20:01:45Z","timestamp":1569528105000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-018-1373-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1373"],"URL":"https:\/\/doi.org\/10.1007\/s00392-018-1373-5","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"assertion":[{"value":"26 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}