{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:12:47Z","timestamp":1773317567159,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00392-020-01651-8","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T09:02:26Z","timestamp":1587286946000},"page":"72-83","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical outcomes and thrombus resolution in patients with solid left atrial appendage thrombi: results of a single-center real-world registry"],"prefix":"10.1007","volume":"110","author":[{"given":"Dominik","family":"Nelles","sequence":"first","affiliation":[]},{"given":"Moritz","family":"Lambers","sequence":"additional","affiliation":[]},{"given":"Myriam","family":"Schafigh","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Morais","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Schueler","sequence":"additional","affiliation":[]},{"given":"Vivian","family":"Vij","sequence":"additional","affiliation":[]},{"given":"Vedat","family":"Tiyerili","sequence":"additional","affiliation":[]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[]},{"given":"Jan Wilko","family":"Schrickel","sequence":"additional","affiliation":[]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[]},{"given":"Christoph","family":"Hammerstingl","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Sedaghat","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"1651_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40001-016-0235-8","volume":"21","author":"S Reers","year":"2016","unstructured":"Reers S, Agdirlioglu T, Kellner M et al (2016) Incidence of left atrial abnormalities under treatment with dabigatran, rivaroxaban, and vitamin K antagonists. Eur J Med Res 21:41","journal-title":"Eur J Med Res"},{"key":"1651_CR2","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1111\/j.1540-8167.2009.01540.x","volume":"20","author":"D Scherr","year":"2009","unstructured":"Scherr D, Sharma K, Dalal D et al (2009) Incidence and predictors of periprocedural cerebrovascular accident in patients undergoing catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 20:1357\u20131363","journal-title":"J Cardiovasc Electrophysiol"},{"key":"1651_CR3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1540-8167.2010.01729.x","volume":"21","author":"TW Wallace","year":"2010","unstructured":"Wallace TW, Atwater BD, Daubert JP et al (2010) Prevalence and clinical characteristics associated with left atrial appendage thrombus in fully anticoagulated patients undergoing catheter-directed atrial fibrillation ablation. J Cardiovasc Electrophysiol 21:849\u2013852","journal-title":"J Cardiovasc Electrophysiol"},{"key":"1651_CR4","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.4103\/0366-6999.191744","volume":"129","author":"YY Chen","year":"2016","unstructured":"Chen YY, Liu Q, Liu L et al (2016) Effect of metabolic syndrome on risk stratification for left atrial or left atrial appendage thrombus formation in patients with nonvalvular atrial fibrillation. Chin Med J 129:2395\u20132402","journal-title":"Chin Med J"},{"key":"1651_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jjcc.2012.01.002","volume":"59","author":"M Iwama","year":"2012","unstructured":"Iwama M, Kawasaki M, Tanaka R et al (2012) Left atrial appendage emptying fraction assessed by a feature-tracking echocardiographic method is a determinant of thrombus in patients with nonvalvular atrial fibrillation. J Cardiol 59:329\u2013336","journal-title":"J Cardiol"},{"key":"1651_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/europace\/euu347","volume":"17","author":"M Petersen","year":"2015","unstructured":"Petersen M, Roehrich A, Balzer J et al (2015) Left atrial appendage morphology is closely associated with specific echocardiographic flow pattern in patients with atrial fibrillation. Europace: Eur Pacing Arrhythmias Cardiac Electrophysiol 17:539\u2013545","journal-title":"Europace: Eur Pacing Arrhythmias Cardiac Electrophysiol"},{"key":"1651_CR7","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00392-014-0704-4","volume":"103","author":"A Sedaghat","year":"2014","unstructured":"Sedaghat A, Nickenig G, Hammerstingl C (2014) Left atrial appendage closure in a patient with atrial fibrillation after mechanical mitral valve replacement and cardio-embolic stroke despite effective oral anticoagulant therapy: a case report. Clin Res Cardiol 103:587\u2013589","journal-title":"Clin Res Cardiol"},{"key":"1651_CR8","first-page":"547","volume":"82","author":"NM Al-Saady","year":"1999","unstructured":"Al-Saady NM, Obel OA, Camm AJ (1999) Left atrial appendage: structure, function, and role in thromboembolism. Heart (British Cardiac Society) 82:547\u2013554","journal-title":"Heart (British Cardiac Society)"},{"key":"1651_CR9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0140-6736(09)60040-4","volume":"373","author":"T Watson","year":"2009","unstructured":"Watson T, Shantsila E, Lip GY (2009) Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited. Lancet (London, England) 373:155\u2013166","journal-title":"Lancet (London, England)"},{"key":"1651_CR10","doi-asserted-by":"crossref","unstructured":"Corrigendum to: 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 2017;39:1109\u20131109","DOI":"10.1093\/eurheartj\/ehx039"},{"key":"1651_CR11","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1007\/s00392-019-01437-7","volume":"108","author":"SH Hohnloser","year":"2019","unstructured":"Hohnloser SH, Basic E, Nabauer M (2019) Uptake in antithrombotic treatment and its association with stroke incidence in atrial fibrillation: insights from a large German claims database. Clin Res Cardiol 108:1042\u20131052","journal-title":"Clin Res Cardiol"},{"key":"1651_CR12","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1007\/s00392-018-1345-9","volume":"108","author":"K McNamara","year":"2019","unstructured":"McNamara K, Witry M, Bryant G et al (2019) A prospective, multi-center cohort study: investigating the ability of warfarin-treated patients to predict their INR. Clin Res Cardiol 108:212\u2013217","journal-title":"Clin Res Cardiol"},{"key":"1651_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ahj.2016.05.007","volume":"178","author":"GY Lip","year":"2016","unstructured":"Lip GY, Hammerstingl C, Marin F et al (2016) Left atrial thrombus resolution in atrial fibrillation or flutter: results of a prospective study with rivaroxaban (X-TRA) and a retrospective observational registry providing baseline data (CLOT-AF). Am Heart J 178:126\u2013134","journal-title":"Am Heart J"},{"key":"1651_CR14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jacep.2016.05.006","volume":"3","author":"A Sedaghat","year":"2017","unstructured":"Sedaghat A, Schrickel JW, Andrie R, Schueler R, Nickenig G, Hammerstingl C (2017) Thrombus formation after left atrial appendage occlusion with the amplatzer amulet device. JACC Clin Electrophysiol 3:71\u201375","journal-title":"JACC Clin Electrophysiol"},{"issue":"4","key":"1651_CR15","first-page":"465","volume":"21","author":"M Bulic","year":"2020","unstructured":"Bulic M, Nelles D, Luetkens J, Nickenig G, Sedaghat A (2020) 'What you see is what you'll get': giant extra-appendage left atrial thrombus after left atrial appendageocclusion for persisting left atrial appendage thrombus. Eur Heart J Cardiovasc Imaging 21(4):465","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1651_CR16","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1136\/heart.89.12.1447","volume":"89","author":"RW Troughton","year":"2003","unstructured":"Troughton RW, Asher CR, Klein AL (2003) The role of echocardiography in atrial fibrillation and cardioversion. Heart (British Cardiac Society) 89:1447\u20131454","journal-title":"Heart (British Cardiac Society)"},{"key":"1651_CR17","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/S0735-1097(85)80476-9","volume":"6","author":"S Beppu","year":"1985","unstructured":"Beppu S, Nimura Y, Sakakibara H, Nagata S, Park YD, Izumi S (1985) Smoke-like echo in the left atrial cavity in mitral valve disease: its features and significance. J Am Coll Cardiol 6:744\u2013749","journal-title":"J Am Coll Cardiol"},{"key":"1651_CR18","doi-asserted-by":"crossref","unstructured":"Douglas PS, Garcia MJ, Haines DE et al. ACCF\/ASE\/AHA\/ASNC\/HFSA\/HRS\/SCAI\/SCCM\/SCCT\/SCMR (2011) Appropriate use criteria for echocardiography. a report of the american college of cardiology foundation appropriate use criteria task force, American Society of Echocardiography, American Heart Association, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance Endorsed by the American College of Chest Physicians. J Am Coll Cardiol 57:1126\u201366","DOI":"10.1016\/j.jacc.2010.11.002"},{"key":"1651_CR19","first-page":"1086","volume":"17","author":"JS Gottdiener","year":"2004","unstructured":"Gottdiener JS, Bednarz J, Devereux R et al (2004) American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 17:1086\u20131119","journal-title":"J Am Soc Echocardiogr"},{"key":"1651_CR20","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1109\/TMI.2018.2840820","volume":"37","author":"S Queiros","year":"2018","unstructured":"Queiros S, Morais P, Barbosa D, Fonseca JC, Vilaca JL, D'Hooge J (2018) MITT: medical image tracking toolbox. IEEE Trans Med Imaging 37:2547\u20132557","journal-title":"IEEE Trans Med Imaging"},{"key":"1651_CR21","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1111\/jth.13140","volume":"13","author":"S Kaatz","year":"2015","unstructured":"Kaatz S, Ahmad D, Spyropoulos AC, Schulman S (2015) Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH. J Thromb Haemost 13:2119\u20132126","journal-title":"J Thromb Haemost"},{"key":"1651_CR22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12882-019-1403-1","volume":"20","author":"S Kim","year":"2019","unstructured":"Kim S, Hwang S, Jang HR et al (2019) Creatinine- and cystatin C-based estimated glomerular filtration rate slopes for the prediction of kidney outcome: a comparative retrospective study. BMC Nephrol 20:214","journal-title":"BMC Nephrol"},{"key":"1651_CR23","doi-asserted-by":"publisher","first-page":"e000800","DOI":"10.1136\/openhrt-2018-000800","volume":"5","author":"A Avezum","year":"2018","unstructured":"Avezum A, Oliveira GBF, Diaz R et al (2018) Efficacy and safety of dabigatran versus warfarin from the RE-LY trial. Open heart 5:e000800","journal-title":"Open heart"},{"key":"1651_CR24","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1161\/CIRCULATIONAHA.112.115410","volume":"126","author":"F Dentali","year":"2012","unstructured":"Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W (2012) Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation 126:2381\u20132391","journal-title":"Circulation"},{"key":"1651_CR25","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","volume":"369","author":"RP Giugliano","year":"2013","unstructured":"Giugliano RP, Ruff CT, Braunwald E et al (2013) Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 369:2093\u20132104","journal-title":"N Engl J Med"},{"key":"1651_CR26","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1056\/NEJMoa1107039","volume":"365","author":"CB Granger","year":"2011","unstructured":"Granger CB, Alexander JH, McMurray JJ et al (2011) Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365:981\u2013992","journal-title":"N Engl J Med"},{"key":"1651_CR27","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.113.005008","volume":"130","author":"JL Halperin","year":"2014","unstructured":"Halperin JL, Hankey GJ, Wojdyla DM et al (2014) Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF). Circulation 130:138\u2013146","journal-title":"Circulation"},{"key":"1651_CR28","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00392-019-01526-7","volume":"109","author":"K Jobski","year":"2020","unstructured":"Jobski K, Hoffmann F, Herget-Rosenthal S, Dorks M (2020) Drug interactions with oral anticoagulants in German nursing home residents: comparison between vitamin K antagonists and non-vitamin K antagonist oral anticoagulants based on two nested case-control studies. Clin Res Cardiol 109:465\u2013475","journal-title":"Clin Res Cardiol"},{"key":"1651_CR29","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s00392-018-1256-9","volume":"107","author":"KG Haeusler","year":"2018","unstructured":"Haeusler KG, Groschel K, Kohrmann M et al (2018) Expert opinion paper on atrial fibrillation detection after ischemic stroke. Clin Res Cardiol 107:871\u2013880","journal-title":"Clin Res Cardiol"},{"key":"1651_CR30","doi-asserted-by":"publisher","first-page":"154","DOI":"10.5387\/fms.2013-12","volume":"60","author":"T Kumagai","year":"2014","unstructured":"Kumagai T, Matsuura Y, Yamamoto T, Ugawa Y, Fukushima T (2014) Risk factors for left atrial thrombus from transesophageal echocardiography findings in ischemic stroke patients. Fukushima J Med Sci 60:154\u2013158","journal-title":"Fukushima J Med Sci"},{"key":"1651_CR31","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/s41598-018-19385-z","volume":"8","author":"W Dieker","year":"2018","unstructured":"Dieker W, Behnes M, Fastner C et al (2018) Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: assessment with cardiac-computed-tomography. Sci Rep 8:1670","journal-title":"Sci Rep"},{"key":"1651_CR32","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s00508-019-1469-6","volume":"131","author":"M Jankajova","year":"2019","unstructured":"Jankajova M, Kubikova L, Valocik G et al (2019) Left atrial appendage strain rate is associated with documented thromboembolism in nonvalvular atrial fibrillation. Wien Klin Wochenschr 131:156\u2013164","journal-title":"Wien Klin Wochenschr"},{"key":"1651_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00392-015-0883-7","volume":"105","author":"M Ferner","year":"2016","unstructured":"Ferner M, Wachtlin D, Konrad T et al (2016) Rationale and design of the RE-LATED AF\u2013AFNET 7 trial: REsolution of Left atrial-appendage thrombus-effects of dabigatran in patients with atrial fibrillation. Clin Res Cardiol 105:29\u201336","journal-title":"Clin Res Cardiol"},{"key":"1651_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1067\/mhj.2000.106648","volume":"140","author":"WA Jaber","year":"2000","unstructured":"Jaber WA, Prior DL, Thamilarasan M et al (2000) Efficacy of anticoagulation in resolving left atrial and left atrial appendage thrombi: a transesophageal echocardiographic study. Am Heart J 140:150\u2013156","journal-title":"Am Heart J"},{"key":"1651_CR35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.amjcard.2018.09.027","volume":"123","author":"AD Niku","year":"2019","unstructured":"Niku AD, Shiota T, Siegel RJ, Rader F (2019) Prevalence and resolution of left atrial thrombus in patients with nonvalvular atrial fibrillation and flutter with oral anticoagulation. Am J Cardiol 123:63\u201368","journal-title":"Am J Cardiol"},{"key":"1651_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01594-9","author":"M Koziel","year":"2020","unstructured":"Koziel M, Al-Saady N, Hjortshoj SP, Goudev A, Huber K, Cohen A, Lip GYH (2020) Edoxaban versus warfarin in vitamin K antagonist experienced and naive patients from the edoxaban versus warfarin in subjects undergoing cardioversion of atrial fibrillation (ENSURE-AF) randomised trial. Clin Res Cardiol. https:\/\/doi.org\/10.1007\/s00392-019-01594-9","journal-title":"Clin Res Cardiol"},{"key":"1651_CR37","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s11239-019-01876-z","volume":"48","author":"HH Ke","year":"2019","unstructured":"Ke HH, He Y, Lv XW, Zhang EH, Wei Z, Li JY (2019) Efficacy and safety of rivaroxaban on the resolution of left atrial\/left atrial appendage thrombus in nonvalvular atrial fibrillation patients. J Thromb Thrombolysis 48:270\u2013276","journal-title":"J Thromb Thrombolysis"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-020-01651-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-020-01651-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-020-01651-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T08:13:25Z","timestamp":1722759205000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-020-01651-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,19]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["1651"],"URL":"https:\/\/doi.org\/10.1007\/s00392-020-01651-8","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,19]]},"assertion":[{"value":"26 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}