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The aim of this systematic review and meta-analysis was to assess the effects of niacin on inflammatory markers and adipokines.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A comprehensive search was conducted across five databases: PubMed, Scopus, Cochrane Library, Embase, and ISI Web of Science. Randomized controlled trials exploring the effects of niacin on inflammatory markers (CRP, IL-6, TNF-\u03b1) and adipokines (Adiponectin, Leptin) were included. Pooled effect sizes were analysed using a random-effects model, and additional procedures including subgroup analyses, sensitivity analysis and dose-response analysis were also performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>From an initial 1279 articles, fifteen randomized controlled trials (RCTs) were included. Niacin administration demonstrated a notable reduction in CRP levels (SMD: -0.88, 95% CI: -1.46 to -0.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Subgroup analyses confirmed CRP reductions in trials with intervention durations\u2009\u2264\u200924 weeks, doses\u2009\u2264\u20091000\u00a0mg\/day, and elevated baseline CRP levels (&gt;\u20093\u00a0mg\/l). The meta-analysis of IL-6 and TNF-\u03b1 revealed significant TNF-\u03b1 reductions, while IL-6 reduction did not reach statistical significance. Niacin administration also substantially elevated Adiponectin (SMD: 3.52, 95% CI: 0.95 to 6.1, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and Leptin (SMD: 1.90, 95% CI: 0.03 to 3.77, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Niacin treatment is associated with significant reductions in CRP and TNF-\u03b1 levels, suggesting potential anti-inflammatory effects. Additionally, niacin positively influences adipokines, increasing Adiponectin and Leptin levels. These findings provide insights for future research and clinical applications targeting inflammation and metabolic dysregulation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-024-03425-8","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T11:01:50Z","timestamp":1716030110000},"page":"2011-2024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of niacin on inflammatory markers and adipokines: a systematic review and meta-analysis of interventional studies"],"prefix":"10.1007","volume":"63","author":[{"given":"Esmaeil Yousefi","family":"Rad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Saboori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Tammam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pariyarath Sangeetha","family":"Thondre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-7507","authenticated-orcid":false,"given":"Shelly","family":"Coe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"issue":"1","key":"3425_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-018-1381-2","volume":"16","author":"AB Kunnumakkara","year":"2018","unstructured":"Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, Bharti AC, Aggarwal BB (2018) Chronic diseases, inflammation, and spices: how are they linked? 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