{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:32:30Z","timestamp":1776587550657,"version":"3.51.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"crossref","award":["CA16225"],"award-info":[{"award-number":["CA16225"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Duke-National University Singapore Medical School","award":["NMRC\/CSA-SI\/0011\/2017"],"award-info":[{"award-number":["NMRC\/CSA-SI\/0011\/2017"]}]},{"name":"Duke-National University Singapore Medical School","award":["NMRC\/CGAug16C006"],"award-info":[{"award-number":["NMRC\/CGAug16C006"]}]},{"name":"South African Department of Science and Technology and the South African National Research Foundation"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/19\/51\/34493"],"award-info":[{"award-number":["PG\/19\/51\/34493"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/16\/85\/32471"],"award-info":[{"award-number":["PG\/16\/85\/32471"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB 1116 B8"],"award-info":[{"award-number":["SFB 1116 B8"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["Project number 268555672 \u2013 SFB 1213"],"award-info":[{"award-number":["Project number 268555672 \u2013 SFB 1213"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["Project B05"],"award-info":[{"award-number":["Project B05"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Institute of Health Carlos III","award":["FIS PI19\/01196"],"award-info":[{"award-number":["FIS PI19\/01196"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBER-CV"],"award-info":[{"award-number":["CIBER-CV"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research, Development and Innovation Office of Hungary","award":["Research Excellence Program - TKP"],"award-info":[{"award-number":["Research Excellence Program - TKP"]}]},{"name":"National Research, Development and Innovation Office of Hungary","award":["National Heart Program NVKP 16-1-2016-0017"],"award-info":[{"award-number":["National Heart Program NVKP 16-1-2016-0017"]}]},{"name":"Ministry of Human Capacities in Hungary","award":["Higher Education Institutional Excellence Program"],"award-info":[{"award-number":["Higher Education Institutional Excellence Program"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against acute ischemia\/reperfusion injury to reduce myocardial infarct size and prevent the onset of HF in patients presenting with AMI. However, the clinical translation of cardioprotective interventions that have proven to be beneficial in preclinical animal studies, has been challenging. One likely major reason for this failure to translate cardioprotection into patient benefit is the lack of rigorous and systematic in vivo preclinical assessment of the efficacy of promising cardioprotective interventions prior to their clinical evaluation. To address this, we propose an in vivo set of step-by-step criteria for <jats:bold><jats:underline>IM<\/jats:underline><\/jats:bold>proving <jats:bold><jats:underline>P<\/jats:underline><\/jats:bold>reclinical <jats:bold><jats:underline>A<\/jats:underline><\/jats:bold>ssessment of <jats:bold><jats:underline>C<\/jats:underline><\/jats:bold>ardioprotective <jats:bold><jats:underline>T<\/jats:underline><\/jats:bold>herapies (\u2018IMPACT\u2019), for investigators to consider adopting before embarking on clinical studies, the aim of which is to improve the likelihood of translating novel cardioprotective interventions into the clinical setting for patient benefit.<\/jats:p>","DOI":"10.1007\/s00395-021-00893-5","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T13:23:51Z","timestamp":1631539431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action"],"prefix":"10.1007","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-8974","authenticated-orcid":false,"given":"Sandrine","family":"Lecour","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-9942","authenticated-orcid":false,"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-8962","authenticated-orcid":false,"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-4980","authenticated-orcid":false,"given":"Sean M.","family":"Davidson","sequence":"additional","affiliation":[]},{"given":"Gerd","family":"Heusch","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-4638","authenticated-orcid":false,"given":"Marisol","family":"Ruiz-Meana","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-0476","authenticated-orcid":false,"given":"Rainer","family":"Schulz","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8361-2448","authenticated-orcid":false,"given":"Coert J.","family":"Zuurbier","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-6806","authenticated-orcid":false,"given":"P\u00e9ter","family":"Ferdinandy","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-4956","authenticated-orcid":false,"given":"Derek J.","family":"Hausenloy","sequence":"additional","affiliation":[]},{"name":"on behalf of\u00a0the European Union-CARDIOPROTECTION COST ACTION CA16225","sequence":"additional","affiliation":[]},{"given":"Pavle","family":"Adamovski","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-9942","authenticated-orcid":false,"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[]},{"given":"Saime","family":"Batirel","sequence":"additional","affiliation":[]},{"given":"Monika","family":"Bartekov\u00e1","sequence":"additional","affiliation":[]},{"given":"Luc","family":"Bertrand","sequence":"additional","affiliation":[]},{"given":"Christophe","family":"Beauloye","sequence":"additional","affiliation":[]},{"given":"David","family":"Biedermann","sequence":"additional","affiliation":[]},{"given":"Vilmante","family":"Borutaite","sequence":"additional","affiliation":[]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Chlopicki","sequence":"additional","affiliation":[]},{"given":"Maija","family":"Dambrova","sequence":"additional","affiliation":[]},{"given":"Sean","family":"Davidson","sequence":"additional","affiliation":[]},{"given":"Yvan","family":"Devaux","sequence":"additional","affiliation":[]},{"given":"Fabio","family":"Di Lisa","sequence":"additional","affiliation":[]},{"given":"Dragan","family":"Djuric","sequence":"additional","affiliation":[]},{"given":"David","family":"Erlinge","sequence":"additional","affiliation":[]},{"given":"Ines","family":"Falcao-Pires","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-6806","authenticated-orcid":false,"given":"P\u00e9ter","family":"Ferdinandy","sequence":"additional","affiliation":[]},{"given":"Eleftheria","family":"Galatou","sequence":"additional","affiliation":[]},{"given":"Alfonso","family":"Garcia-Sosa","sequence":"additional","affiliation":[]},{"given":"Henrique","family":"Girao","sequence":"additional","affiliation":[]},{"given":"Zoltan","family":"Giricz","sequence":"additional","affiliation":[]},{"given":"Mariann","family":"Gyongyosi","sequence":"additional","affiliation":[]},{"given":"Derek J","family":"Hausenloy","sequence":"additional","affiliation":[]},{"given":"Donagh","family":"Healy","sequence":"additional","affiliation":[]},{"given":"Gerd","family":"Heusch","sequence":"additional","affiliation":[]},{"given":"Vladimir","family":"Jakovljevic","sequence":"additional","affiliation":[]},{"given":"Jelena","family":"Jovanic","sequence":"additional","affiliation":[]},{"given":"George","family":"Kararigas","sequence":"additional","affiliation":[]},{"given":"Risto","family":"Kerkal","sequence":"additional","affiliation":[]},{"given":"Frantisek","family":"Kolar","sequence":"additional","affiliation":[]},{"given":"Brenda","family":"Kwak","sequence":"additional","affiliation":[]},{"given":"Przemys\u0142aw","family":"Leszek","sequence":"additional","affiliation":[]},{"given":"Edgars","family":"Liepinsh","sequence":"additional","affiliation":[]},{"given":"Jacob","family":"Lonborg","sequence":"additional","affiliation":[]},{"given":"Sarah","family":"Longnus","sequence":"additional","affiliation":[]},{"given":"Jasna","family":"Marinovic","sequence":"additional","affiliation":[]},{"given":"Danina Mirela","family":"Muntean","sequence":"additional","affiliation":[]},{"given":"Lana","family":"Nezic","sequence":"additional","affiliation":[]},{"given":"Michel","family":"Ovize","sequence":"additional","affiliation":[]},{"given":"Pasquale","family":"Pagliaro","sequence":"additional","affiliation":[]},{"given":"Clarissa Pedrosa","family":"Da Costa Gomes","sequence":"additional","affiliation":[]},{"given":"John","family":"Pernow","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Persidis","sequence":"additional","affiliation":[]},{"given":"S\u00f8ren Erik","family":"Pischke","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Podesser","sequence":"additional","affiliation":[]},{"given":"Ines","family":"Poto\u010dnjak","sequence":"additional","affiliation":[]},{"given":"Fabrice","family":"Prunier","sequence":"additional","affiliation":[]},{"given":"Tanya","family":"Ravingerova","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-4638","authenticated-orcid":false,"given":"Marisol","family":"Ruiz-Meana","sequence":"additional","affiliation":[]},{"given":"Alina","family":"Serban","sequence":"additional","affiliation":[]},{"given":"Katrine","family":"Slagsvold","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-0476","authenticated-orcid":false,"given":"Rainer","family":"Schulz","sequence":"additional","affiliation":[]},{"given":"Niels","family":"van Royen","sequence":"additional","affiliation":[]},{"given":"Belma","family":"Turan","sequence":"additional","affiliation":[]},{"given":"Marko","family":"Vendelin","sequence":"additional","affiliation":[]},{"given":"Stewart","family":"Walsh","sequence":"additional","affiliation":[]},{"given":"Nace","family":"Zidar","sequence":"additional","affiliation":[]},{"given":"Coert","family":"Zuurbier","sequence":"additional","affiliation":[]},{"given":"Derek","family":"Yellon","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"893_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00395-020-00825-9","volume":"115","author":"MV Basalay","year":"2020","unstructured":"Basalay MV, Yellon DM, Davidson SM (2020) Targeting myocardial ischaemic injury in the absence of reperfusion. Basic Res Cardiol 115:63. https:\/\/doi.org\/10.1007\/s00395-020-00825-9","journal-title":"Basic Res Cardiol"},{"key":"893_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00395-021-00874-8","volume":"116","author":"R Bolli","year":"2021","unstructured":"Bolli R (2021) CAESAR\u2019s legacy: a new era of rigor in preclinical studies of cardioprotection. Basic Res Cardiol 116:33. https:\/\/doi.org\/10.1007\/s00395-021-00874-8","journal-title":"Basic Res Cardiol"},{"key":"893_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-018-0696-8","volume":"113","author":"HE Botker","year":"2018","unstructured":"Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https:\/\/doi.org\/10.1007\/s00395-018-0696-8","journal-title":"Basic Res Cardiol"},{"key":"893_CR4","doi-asserted-by":"publisher","DOI":"10.3791\/61901","author":"GB Brenner","year":"2021","unstructured":"Brenner GB, Giricz Z, Garamvolgyi R, Makkos A, Onodi Z, Sayour NV, Gergely TG, Baranyai T, Petnehazy O, Korosi D, Szabo GP, Vago H, Dohy Z, Czimbalmos C, Merkely B, Boldin-Adamsky S, Feinstein E, Horvath IG, Ferdinandy P (2021) Post-myocardial infarction heart failure in closed-chest coronary occlusion\/reperfusion model in Gottingen Minipigs and landrace pigs. J Vis Exp. https:\/\/doi.org\/10.3791\/61901","journal-title":"J Vis Exp"},{"key":"893_CR5","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41569-019-0296-9","volume":"16","author":"M Cour","year":"2019","unstructured":"Cour M, Lecour S (2019) Remote ischaemic conditioning: in search of a suitable match. Nat Rev Cardiol 16:704\u2013705. https:\/\/doi.org\/10.1038\/s41569-019-0296-9","journal-title":"Nat Rev Cardiol"},{"key":"893_CR6","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/jgm.1472","volume":"12","author":"O Danos","year":"2010","unstructured":"Danos O, Davies K, Lehn P, Mulligan R (2010) The ARRIVE guidelines, a welcome improvement to standards for reporting animal research. J Gene Med 12:559\u2013560. https:\/\/doi.org\/10.1002\/jgm.1472","journal-title":"J Gene Med"},{"key":"893_CR7","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1093\/eurheartj\/ehx414","volume":"38","author":"S de Waha","year":"2017","unstructured":"de Waha S, Patel MR, Granger CB, Ohman EM, Maehara A, Eitel I, Ben-Yehuda O, Jenkins P, Thiele H, Stone GW (2017) Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J 38:3502\u20133510. https:\/\/doi.org\/10.1093\/eurheartj\/ehx414","journal-title":"Eur Heart J"},{"key":"893_CR8","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1093\/eurheartj\/ehy365","volume":"40","author":"P Ferdinandy","year":"2019","unstructured":"Ferdinandy P, Baczko I, Bencsik P, Giricz Z, Gorbe A, Pacher P, Varga ZV, Varro A, Schulz R (2019) Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications. Eur Heart J 40:1771\u20131777. https:\/\/doi.org\/10.1093\/eurheartj\/ehy365","journal-title":"Eur Heart J"},{"key":"893_CR9","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1124\/pr.113.008300","volume":"66","author":"P Ferdinandy","year":"2014","unstructured":"Ferdinandy P, Hausenloy DJ, Heusch G, Baxter GF, Schulz R (2014) Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev 66:1142\u20131174. https:\/\/doi.org\/10.1124\/pr.113.008300","journal-title":"Pharmacol Rev"},{"key":"893_CR10","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1093\/eurheartj\/ehw145","volume":"38","author":"DJ Hausenloy","year":"2017","unstructured":"Hausenloy DJ, Botker HE, Engstrom T, Erlinge D, Heusch G, Ibanez B, Kloner RA, Ovize M, Yellon DM, Garcia-Dorado D (2017) Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations. Eur Heart J 38:935\u2013941. https:\/\/doi.org\/10.1093\/eurheartj\/ehw145","journal-title":"Eur Heart J"},{"key":"893_CR11","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1093\/cvr\/cvy286","volume":"115","author":"DJ Hausenloy","year":"2019","unstructured":"Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G (2019) The coronary circulation in acute myocardial ischaemia\/reperfusion injury: a target for cardioprotection. Cardiovasc Res 115:1143\u20131155. https:\/\/doi.org\/10.1093\/cvr\/cvy286","journal-title":"Cardiovasc Res"},{"key":"893_CR12","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.jacc.2019.03.020","volume":"73","author":"DJ Hausenloy","year":"2019","unstructured":"Hausenloy DJ, Heusch G (2019) Translating cardioprotection for patient benefit: the EU-CARDIOPROTECTION COST Action. J Am Coll Cardiol 73:2001\u20132003. https:\/\/doi.org\/10.1016\/j.jacc.2019.03.020","journal-title":"J Am Coll Cardiol"},{"key":"893_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00395-020-00830-y","volume":"115","author":"Z He","year":"2020","unstructured":"He Z, Davidson SM, Yellon DM (2020) The importance of clinically relevant background therapy in cardioprotective studies. Basic Res Cardiol 115:69. https:\/\/doi.org\/10.1007\/s00395-020-00830-y","journal-title":"Basic Res Cardiol"},{"key":"893_CR14","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1093\/eurheartj\/ehy253","volume":"39","author":"G Heusch","year":"2018","unstructured":"Heusch G (2018) Cardioprotection research must leave its comfort zone. Eur Heart J 39:3393\u20133395. https:\/\/doi.org\/10.1093\/eurheartj\/ehy253","journal-title":"Eur Heart J"},{"key":"893_CR15","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1161\/CIRCRESAHA.116.308640","volume":"118","author":"G Heusch","year":"2016","unstructured":"Heusch G (2016) The coronary circulation as a target of cardioprotection. Circ Res 118:1643\u20131658. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.308640","journal-title":"Circ Res"},{"key":"893_CR16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00395-019-0756-8","volume":"114","author":"G Heusch","year":"2019","unstructured":"Heusch G (2019) Coronary microvascular obstruction: the new frontier in cardioprotection. Basic Res Cardiol 114:45. https:\/\/doi.org\/10.1007\/s00395-019-0756-8","journal-title":"Basic Res Cardiol"},{"key":"893_CR17","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.117.310820","volume":"120","author":"G Heusch","year":"2017","unstructured":"Heusch G (2017) Critical issues for the translation of cardioprotection. Circ Res 120:1477\u20131486. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.310820","journal-title":"Circ Res"},{"key":"893_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773\u2013789. https:\/\/doi.org\/10.1038\/s41569-020-0403-y","journal-title":"Nat Rev Cardiol"},{"key":"893_CR19","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1093\/eurheartj\/ehw224","volume":"38","author":"G Heusch","year":"2017","unstructured":"Heusch G, Gersh BJ (2017) The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J 38:774\u2013784. https:\/\/doi.org\/10.1093\/eurheartj\/ehw224","journal-title":"Eur Heart J"},{"key":"893_CR20","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","volume":"383","author":"G Heusch","year":"2014","unstructured":"Heusch G, Libby P, Gersh B, Yellon D, Bohm M, Lopaschuk G, Opie L (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383:1933\u20131943. https:\/\/doi.org\/10.1016\/S0140-6736(14)60107-0","journal-title":"Lancet"},{"key":"893_CR21","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1161\/CIRCRESAHA.118.313947","volume":"123","author":"G Heusch","year":"2018","unstructured":"Heusch G, Skyschally A, Kleinbongard P (2018) Translation, translation, translation. Circ Res 123:931\u2013933. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313947","journal-title":"Circ Res"},{"key":"893_CR22","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.yjmcc.2011.02.016","volume":"50","author":"G Heusch","year":"2011","unstructured":"Heusch G, Skyschally A, Schulz R (2011) The in-situ pig heart with regional ischemia\/reperfusion\u2014ready for translation. J Mol Cell Cardiol 50:951\u2013963. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.02.016","journal-title":"J Mol Cell Cardiol"},{"key":"893_CR23","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/SHK.0000000000001362","volume":"53","author":"AFW Ho","year":"2020","unstructured":"Ho AFW, Chong J, Ong MEH, Hausenloy DJ (2020) Remote ischemic conditioning in emergency medicine-clinical frontiers and research opportunities. Shock 53:269\u2013276. https:\/\/doi.org\/10.1097\/SHK.0000000000001362","journal-title":"Shock"},{"key":"893_CR24","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/j.1476-5381.2010.01128.x","volume":"162","author":"CR Hooijmans","year":"2011","unstructured":"Hooijmans CR, de Vries R, Leenaars M, Curfs J, Ritskes-Hoitinga M (2011) Improving planning, design, reporting and scientific quality of animal experiments by using the Gold Standard Publication Checklist, in addition to the ARRIVE guidelines. Br J Pharmacol 162:1259\u20131260. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.01128.x","journal-title":"Br J Pharmacol"},{"key":"893_CR25","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/CIRCRESAHA.116.305462","volume":"116","author":"SP Jones","year":"2015","unstructured":"Jones SP, Tang XL, Guo Y, Steenbergen C, Lefer DJ, Kukreja RC, Kong M, Li Q, Bhushan S, Zhu X, Du J, Nong Y, Stowers HL, Kondo K, Hunt GN, Goodchild TT, Orr A, Chang CC, Ockaili R, Salloum FN, Bolli R (2015) The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs. Circ Res 116:572\u2013586. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305462","journal-title":"Circ Res"},{"key":"893_CR26","doi-asserted-by":"publisher","first-page":"5252","DOI":"10.1111\/bph.14839","volume":"177","author":"P Kleinbongard","year":"2020","unstructured":"Kleinbongard P, Botker HE, Ovize M, Hausenloy DJ, Heusch G (2020) Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting? Br J Pharmacol 177:5252\u20135269. https:\/\/doi.org\/10.1111\/bph.14839","journal-title":"Br J Pharmacol"},{"key":"893_CR27","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.28.1_supplement.lb650","author":"R Kukreja","year":"2014","unstructured":"Kukreja R, Tang XL, Lefer D, Steenbergen C, Jones S, Guo Y, Li Q, Kong M, Stowers H, Hunt G, Tokita Y, Wu W, Ockaili R, Salloum F, Book M, Du J, Bhushan S, Goodchild T, Chang C, Bolli R (2014) Administration of sildenafil at reperfusion fails to reduce infarct size: results from the CAESAR Cardioprotection Consortium (LB650). FASEB J. https:\/\/doi.org\/10.1096\/fasebj.28.1_supplement.lb650","journal-title":"FASEB J"},{"key":"893_CR28","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/cvr\/cvu225","volume":"104","author":"S Lecour","year":"2014","unstructured":"Lecour S, Botker HE, Condorelli G, Davidson SM, Garcia-Dorado D, Engel FB, Ferdinandy P, Heusch G, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Sluijter JP, Van Laake LW, Yellon DM, Hausenloy DJ (2014) ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies. Cardiovasc Res 104:399\u2013411. https:\/\/doi.org\/10.1093\/cvr\/cvu225","journal-title":"Cardiovasc Res"},{"key":"893_CR29","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.28.1_supplement.lb645","author":"D Lefer","year":"2014","unstructured":"Lefer D, Jones S, Steenbergen C, Kukreja R, Guo Y, Tang XL, Li Q, Ockaili R, Salloum F, Kong M, Polhemus D, Bhushan S, Goodchild T, Chang C, Book M, Du J, Bolli R (2014) Sodium nitrite fails to limit myocardial infarct size: results from the CAESAR Cardioprotection Consortium (LB645). FASEB J. https:\/\/doi.org\/10.1096\/fasebj.28.1_supplement.lb645","journal-title":"FASEB J"},{"key":"893_CR30","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1177\/1074248411414155","volume":"16","author":"DJ Lefer","year":"2011","unstructured":"Lefer DJ, Bolli R (2011) Development of an NIH consortium for preclinicAl AssESsment of CARdioprotective therapies (CAESAR): a paradigm shift in studies of infarct size limitation. J Cardiovasc Pharmacol Ther 16:332\u2013339. https:\/\/doi.org\/10.1177\/1074248411414155","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"893_CR31","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/cvr\/cvaa155","volume":"117","author":"C Perrino","year":"2021","unstructured":"Perrino C, Ferdinandy P, Botker HE, Brundel B, Collins P, Davidson SM, den Ruijter HM, Engel FB, Gerdts E, Girao H, Gyongyosi M, Hausenloy DJ, Lecour S, Madonna R, Marber M, Murphy E, Pesce M, Regitz-Zagrosek V, Sluijter JPG, Steffens S, Gollmann-Tepekoylu C, Van Laake LW, Van Linthout S, Schulz R, Ytrehus K (2021) Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart. Cardiovasc Res 117:367\u2013385. https:\/\/doi.org\/10.1093\/cvr\/cvaa155","journal-title":"Cardiovasc Res"},{"key":"893_CR32","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1161\/CIRCRESAHA.117.310628","volume":"120","author":"FD Ramirez","year":"2017","unstructured":"Ramirez FD, Motazedian P, Jung RG, Di Santo P, MacDonald ZD, Moreland R, Simard T, Clancy AA, Russo JJ, Welch VA, Wells GA, Hibbert B (2017) Methodological rigor in preclinical cardiovascular studies: targets to enhance reproducibility and promote research translation. Circ Res 120:1916\u20131926. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.310628","journal-title":"Circ Res"},{"key":"893_CR33","doi-asserted-by":"publisher","first-page":"20290","DOI":"10.1038\/s41598-019-56613-6","volume":"9","author":"X Rossello","year":"2019","unstructured":"Rossello X, Rodriguez-Sinovas A, Vilahur G, Crisostomo V, Jorge I, Zaragoza C, Zamorano JL, Bermejo J, Ordonez A, Bosca L, Vazquez J, Badimon L, Sanchez-Margallo FM, Fernandez-Aviles F, Garcia-Dorado D, Ibanez B (2019) CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): a multicenter preclinical network for testing reproducibility in cardiovascular interventions. Sci Rep 9:20290. https:\/\/doi.org\/10.1038\/s41598-019-56613-6","journal-title":"Sci Rep"},{"key":"893_CR34","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1161\/CIRCULATIONAHA.111.032698","volume":"124","author":"L Schwartz Longacre","year":"2011","unstructured":"Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E, Downey J, Gibbons RJ, Gottlieb RA, Heusch G, Jennings RB, Lefer DJ, Mentzer RM, Murphy E, Ovize M, Ping P, Przyklenk K, Sack MN, Vander Heide RS, Vinten-Johansen J, Yellon DM, National Heart L, Institute B, NIoH, (2011) New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. Circulation 124:1172\u20131179. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.032698","journal-title":"Circulation"},{"key":"893_CR35","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1016\/j.jacc.2016.01.069","volume":"67","author":"GW Stone","year":"2016","unstructured":"Stone GW, Selker HP, Thiele H, Patel MR, Udelson JE, Ohman EM, Maehara A, Eitel I, Granger CB, Jenkins PL, Nichols M, Ben-Yehuda O (2016) Relationship between infarct size and outcomes following primary PCI: patient-level analysis from 10 randomized trials. J Am Coll Cardiol 67:1674\u20131683. https:\/\/doi.org\/10.1016\/j.jacc.2016.01.069","journal-title":"J Am Coll Cardiol"},{"key":"893_CR36","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1093\/eurheartj\/ehx515","volume":"38","author":"K Szummer","year":"2017","unstructured":"Szummer K, Wallentin L, Lindhagen L, Alfredsson J, Erlinge D, Held C, James S, Kellerth T, Lindahl B, Ravn-Fischer A, Rydberg E, Yndigegn T, Jernberg T (2017) Improved outcomes in patients with ST-elevation myocardial infarction during the last 20 years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995\u20132014. Eur Heart J 38:3056\u20133065. https:\/\/doi.org\/10.1093\/eurheartj\/ehx515","journal-title":"Eur Heart J"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-021-00893-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-021-00893-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-021-00893-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T18:09:16Z","timestamp":1642615756000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-021-00893-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["893"],"URL":"https:\/\/doi.org\/10.1007\/s00395-021-00893-5","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"assertion":[{"value":"19 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"PF is founder and CEO of Pharmahungary, a group of R&D companies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"52"}}