{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:44:21Z","timestamp":1773035061756,"version":"3.50.1"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100007453","name":"Stiftung VERUM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"Medizinische Fakult\u00e4t, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","award":["9772513"],"award-info":[{"award-number":["9772513"]}],"id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"publisher","award":["16013"],"award-info":[{"award-number":["16013"]}],"id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation Eclosion"},{"name":"Foundation Strauss"},{"name":"Foundation SFNTF"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Neuropathol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00401-018-1929-5","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T13:15:53Z","timestamp":1542114953000},"page":"239-257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["The metalloprotease ADAMTS4 generates N-truncated A\u03b24\u2013x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"137","author":[{"given":"Susanne","family":"Walter","sequence":"first","affiliation":[]},{"given":"Thorsten","family":"Jumpertz","sequence":"additional","affiliation":[]},{"given":"Melanie","family":"H\u00fcttenrauch","sequence":"additional","affiliation":[]},{"given":"Isabella","family":"Ogorek","sequence":"additional","affiliation":[]},{"given":"Hermeto","family":"Gerber","sequence":"additional","affiliation":[]},{"given":"Steffen E.","family":"Storck","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Zampar","sequence":"additional","affiliation":[]},{"given":"Mitko","family":"Dimitrov","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Lehmann","sequence":"additional","affiliation":[]},{"given":"Klaudia","family":"Lepka","sequence":"additional","affiliation":[]},{"given":"Carsten","family":"Berndt","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Christoph","family":"Becker-Pauly","sequence":"additional","affiliation":[]},{"given":"Dirk","family":"Beher","sequence":"additional","affiliation":[]},{"given":"Claus U.","family":"Pietrzik","sequence":"additional","affiliation":[]},{"given":"Patrick C.","family":"Fraering","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4115-0334","authenticated-orcid":false,"given":"Oliver","family":"Wirths","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-1145","authenticated-orcid":false,"given":"Sascha","family":"Weggen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"1929_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.jalz.2016.03.001","volume":"12","author":"Alzheimer\u2019s Association","year":"2016","unstructured":"Association Alzheimer\u2019s (2016) 2016 Alzheimer\u2019s disease facts and figures. Alzheimers Dement 12:459\u2013509","journal-title":"Alzheimers Dement"},{"key":"1929_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/2051-5960-1-56","volume":"1","author":"G Antonios","year":"2013","unstructured":"Antonios G, Saiepour N, Bouter Y, Richard BC, Paetau A, Verkkoniemi-Ahola A et al (2013) N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody. Acta Neuropathol Commun 1:56. https:\/\/doi.org\/10.1186\/2051-5960-1-56","journal-title":"Acta Neuropathol Commun"},{"key":"1929_CR3","doi-asserted-by":"publisher","first-page":"31493","DOI":"10.1074\/jbc.R109.052340","volume":"284","author":"SS Apte","year":"2009","unstructured":"Apte SS (2009) A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J Biol Chem 284:31493\u201331497. https:\/\/doi.org\/10.1074\/jbc.R109.052340","journal-title":"J Biol Chem"},{"key":"1929_CR4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/alzrt59","volume":"2","author":"RJ Bateman","year":"2011","unstructured":"Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM et al (2011) Autosomal-dominant Alzheimer\u2019s disease: a review and proposal for the prevention of Alzheimer\u2019s disease. Alzheimers Res Ther 2:35. https:\/\/doi.org\/10.1186\/alzrt59","journal-title":"Alzheimers Res Ther"},{"key":"1929_CR5","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1152\/physrev.2001.81.2.871","volume":"81","author":"N Baumann","year":"2001","unstructured":"Baumann N, Pham-Dinh D (2001) Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81:871\u2013927","journal-title":"Physiol Rev"},{"key":"1929_CR6","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00401-014-1287-x","volume":"127","author":"TA Bayer","year":"2014","unstructured":"Bayer TA, Wirths O (2014) Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer\u2019s disease. Acta Neuropathol 127:787\u2013801. https:\/\/doi.org\/10.1007\/s00401-014-1287-x","journal-title":"Acta Neuropathol"},{"key":"1929_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00401-013-1129-2","volume":"126","author":"Y Bouter","year":"2013","unstructured":"Bouter Y, Dietrich K, Wittnam JL, Rezaei-Ghaleh N, Pillot T, Papot-Couturier S et al (2013) N-truncated amyloid beta (Abeta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits. Acta Neuropathol 126:189\u2013205. https:\/\/doi.org\/10.1007\/s00401-013-1129-2","journal-title":"Acta Neuropathol"},{"key":"1929_CR8","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1097\/00001756-199805110-00043","volume":"9","author":"M Brockhaus","year":"1998","unstructured":"Brockhaus M, Grunberg J, Rohrig S, Loetscher H, Wittenburg N, Baumeister R et al (1998) Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. NeuroReport 9:1481\u20131486","journal-title":"NeuroReport"},{"key":"1929_CR9","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1515\/cclm-2014-1048","volume":"53","author":"P Bros","year":"2015","unstructured":"Bros P, Delatour V, Vialaret J, Lalere B, Barthelemy N, Gabelle A et al (2015) Quantitative detection of amyloid-beta peptides by mass spectrometry: state of the art and clinical applications. Clin Chem Lab Med 53:1483\u20131493. https:\/\/doi.org\/10.1515\/cclm-2014-1048","journal-title":"Clin Chem Lab Med"},{"key":"1929_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/ana.410190306","volume":"19","author":"A Brun","year":"1986","unstructured":"Brun A, Englund E (1986) A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol 19:253\u2013262. https:\/\/doi.org\/10.1002\/ana.410190306","journal-title":"Ann Neurol"},{"key":"1929_CR11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.bbadis.2017.07.005","volume":"1864","author":"E Cabrera","year":"2018","unstructured":"Cabrera E, Mathews P, Mezhericher E, Beach TG, Deng J, Neubert TA et al (2018) Abeta truncated species: implications for brain clearance mechanisms and amyloid plaque deposition. Biochim Biophys Acta 1864:208\u2013225. https:\/\/doi.org\/10.1016\/j.bbadis.2017.07.005","journal-title":"Biochim Biophys Acta"},{"key":"1929_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s40478-014-0083-010.1186\/preaccept-3091772881321882","volume":"2","author":"LE Collins-Praino","year":"2014","unstructured":"Collins-Praino LE, Francis YI, Griffith EY, Wiegman AF, Urbach J, Lawton A et al (2014) Soluble amyloid beta levels are elevated in the white matter of Alzheimer\u2019s patients, independent of cortical plaque severity. Acta Neuropathol Commun 2:83. https:\/\/doi.org\/10.1186\/s40478-014-0083-010.1186\/preaccept-3091772881321882","journal-title":"Acta Neuropathol Commun"},{"key":"1929_CR13","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","volume":"164","author":"B Strooper De","year":"2016","unstructured":"De Strooper B, Karran E (2016) The Cellular Phase of Alzheimer\u2019s Disease. Cell 164:603\u2013615. https:\/\/doi.org\/10.1016\/j.cell.2015.12.056","journal-title":"Cell"},{"key":"1929_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrneurol.2009.218","volume":"6","author":"B Strooper De","year":"2010","unstructured":"De Strooper B, Vassar R, Golde T (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol 6:99\u2013107. https:\/\/doi.org\/10.1038\/nrneurol.2009.218","journal-title":"Nat Rev Neurol"},{"key":"1929_CR15","doi-asserted-by":"publisher","first-page":"12313","DOI":"10.1523\/JNEUROSCI.2255-14.2014","volume":"34","author":"SR DeBoer","year":"2014","unstructured":"DeBoer SR, Dolios G, Wang R, Sisodia SS (2014) Differential release of beta-amyloid from dendrite- versus axon-targeted APP. J Neurosci 34:12313\u201312327. https:\/\/doi.org\/10.1523\/jneurosci.2255-14.2014","journal-title":"J Neurosci"},{"key":"1929_CR16","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.2353\/ajpath.2010.100087","volume":"177","author":"MK Desai","year":"2010","unstructured":"Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ (2010) Early oligodendrocyte\/myelin pathology in Alzheimer\u2019s disease mice constitutes a novel therapeutic target. Am J Pathol 177:1422\u20131435. https:\/\/doi.org\/10.2353\/ajpath.2010.100087","journal-title":"Am J Pathol"},{"key":"1929_CR17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/glia.20734","volume":"57","author":"MK Desai","year":"2009","unstructured":"Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ (2009) Triple-transgenic Alzheimer\u2019s disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia 57:54\u201365. https:\/\/doi.org\/10.1002\/glia.20734","journal-title":"Glia"},{"key":"1929_CR18","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1038\/ncomms3246","volume":"4","author":"M Dimitrov","year":"2013","unstructured":"Dimitrov M, Alattia JR, Lemmin T, Lehal R, Fligier A, Houacine J et al (2013) Alzheimer\u2019s disease mutations in APP but not gamma-secretase modulators affect epsilon-cleavage-dependent AICD production. Nat Commun 4:2246. https:\/\/doi.org\/10.1038\/ncomms3246","journal-title":"Nat Commun"},{"key":"1929_CR19","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.eplepsyres.2017.02.021","volume":"132","author":"D Dubey","year":"2017","unstructured":"Dubey D, McRae PA, Rankin-Gee EK, Baranov E, Wandrey L, Rogers S et al (2017) Increased metalloproteinase activity in the hippocampus following status epilepticus. Epilepsy Res 132:50\u201358. https:\/\/doi.org\/10.1016\/j.eplepsyres.2017.02.021","journal-title":"Epilepsy Res"},{"key":"1929_CR20","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1128\/JVI.72.11.8463-8471.1998","volume":"72","author":"T Dull","year":"1998","unstructured":"Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D et al (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72:8463\u20138471","journal-title":"J Virol"},{"key":"1929_CR21","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.1074\/jbc.M116.754101","volume":"292","author":"H Gerber","year":"2017","unstructured":"Gerber H, Wu F, Dimitrov M, Garcia Osuna GM, Fraering PC (2017) Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by gamma-Secretase and Amyloid-beta Peptide Production. J Biol Chem 292:3751\u20133767. https:\/\/doi.org\/10.1074\/jbc.M116.754101","journal-title":"J Biol Chem"},{"key":"1929_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.matbio.2015.01.014","volume":"44\u201346","author":"PE Gottschall","year":"2015","unstructured":"Gottschall PE, Howell MD (2015) ADAMTS expression and function in central nervous system injury and disorders. Matrix Biol 44\u201346:70\u201376. https:\/\/doi.org\/10.1016\/j.matbio.2015.01.014","journal-title":"Matrix Biol"},{"key":"1929_CR23","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1191\/135248506ms1300oa","volume":"12","author":"G Haddock","year":"2006","unstructured":"Haddock G, Cross AK, Plumb J, Surr J, Buttle DJ, Bunning RA et al (2006) Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter. Mult Scler 12:386\u2013396","journal-title":"Mult Scler"},{"key":"1929_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1471-4159.2010.07118.x","volume":"116","author":"S Hahn","year":"2011","unstructured":"Hahn S, Bruning T, Ness J, Czirr E, Baches S, Gijsen H et al (2011) Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer\u2019s disease attenuate the response of cultured cells to gamma-secretase modulators regardless of their potency and structure. J Neurochem 116:385\u2013395. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.07118.x","journal-title":"J Neurochem"},{"key":"1929_CR25","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.expneurol.2006.01.002","volume":"199","author":"MP Harms","year":"2006","unstructured":"Harms MP, Kotyk JJ, Merchant KM (2006) Evaluation of white matter integrity in ex vivo brains of amyloid plaque-bearing APPsw transgenic mice using magnetic resonance diffusion tensor imaging. Exp Neurol 199:408\u2013415. https:\/\/doi.org\/10.1016\/j.expneurol.2006.01.002","journal-title":"Exp Neurol"},{"key":"1929_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2174\/156720508783954703","volume":"5","author":"LB Hersh","year":"2008","unstructured":"Hersh LB, Rodgers DW (2008) Neprilysin and amyloid beta peptide degradation. Curr Alzheimer Res 5:225\u2013231","journal-title":"Curr Alzheimer Res"},{"key":"1929_CR27","doi-asserted-by":"publisher","first-page":"11101","DOI":"10.1074\/jbc.M611588200","volume":"282","author":"R Hills","year":"2007","unstructured":"Hills R, Mazzarella R, Fok K, Liu M, Nemirovskiy O, Leone J et al (2007) Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. J Biol Chem 282:11101\u201311109. https:\/\/doi.org\/10.1074\/jbc.M611588200","journal-title":"J Biol Chem"},{"key":"1929_CR28","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/0196-9781(95)00021-B","volume":"16","author":"S Howell","year":"1995","unstructured":"Howell S, Nalbantoglu J, Crine P (1995) Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism. Peptides 16:647\u2013652","journal-title":"Peptides"},{"key":"1929_CR29","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.3233\/JAD-142463","volume":"44","author":"M Huttenrauch","year":"2015","unstructured":"Huttenrauch M, Baches S, Gerth J, Bayer TA, Weggen S, Wirths O (2015) Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer\u2019s disease. J Alzheimers Dis 44:1291\u20131302. https:\/\/doi.org\/10.3233\/JAD-142463","journal-title":"J Alzheimers Dis"},{"key":"1929_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/72237","volume":"6","author":"N Iwata","year":"2000","unstructured":"Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E et al (2000) Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med 6:143\u2013150. https:\/\/doi.org\/10.1038\/72237","journal-title":"Nat Med"},{"key":"1929_CR31","doi-asserted-by":"publisher","unstructured":"Jansen I, Savage J, Watanabe K, Bryois J, Williams D, Steinberg S et al (2018) Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimers disease risk. bioRxiv 258533; doi: https:\/\/doi.org\/10.1101\/258533","DOI":"10.1101\/258533"},{"key":"1929_CR32","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1097\/00001756-200308060-00005","volume":"14","author":"N Jantaratnotai","year":"2003","unstructured":"Jantaratnotai N, Ryu JK, Kim SU, McLarnon JG (2003) Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo. NeuroReport 14:1429\u20131433. https:\/\/doi.org\/10.1097\/01.wnr.0000086097.47480.a0","journal-title":"NeuroReport"},{"key":"1929_CR33","doi-asserted-by":"publisher","first-page":"27741","DOI":"10.1074\/jbc.M111.252718","volume":"286","author":"T Jefferson","year":"2011","unstructured":"Jefferson T, Causevic M, Auf dem Keller U, Schilling O, Isbert S, Geyer R et al (2011) Metalloprotease Meprin beta Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo. J Biol Chem 286:27741\u201327750. https:\/\/doi.org\/10.1074\/jbc.M111.252718","journal-title":"J Biol Chem"},{"key":"1929_CR34","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/nm.2224","volume":"16","author":"M Jucker","year":"2010","unstructured":"Jucker M (2010) The benefits and limitations of animal models for translational research in neurodegenerative diseases. Nat Med 16:1210\u20131214. https:\/\/doi.org\/10.1038\/nm.2224","journal-title":"Nat Med"},{"key":"1929_CR35","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1083\/jcb.200201123","volume":"158","author":"C Kaether","year":"2002","unstructured":"Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A et al (2002) Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol 158:551\u2013561. https:\/\/doi.org\/10.1083\/jcb.200201123","journal-title":"J Cell Biol"},{"key":"1929_CR36","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1021\/bi015685+","volume":"41","author":"W Kalback","year":"2002","unstructured":"Kalback W, Watson MD, Kokjohn TA, Kuo YM, Weiss N, Luehrs DC et al (2002) APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer\u2019s disease senile plaques. Biochemistry 41:922\u2013928","journal-title":"Biochemistry"},{"key":"1929_CR37","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.mri.2013.06.013","volume":"31","author":"MZ Kastyak-Ibrahim","year":"2013","unstructured":"Kastyak-Ibrahim MZ, Di Curzio DL, Buist R, Herrera SL, Albensi BC, Del Bigio MR et al (2013) Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice. Magn Reson Imaging 31:1515\u20131521. https:\/\/doi.org\/10.1016\/j.mri.2013.06.013","journal-title":"Magn Reson Imaging"},{"key":"1929_CR38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13059-015-0676-3","volume":"16","author":"R Kelwick","year":"2015","unstructured":"Kelwick R, Desanlis I, Wheeler GN, Edwards DR (2015) The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family. Genome Biol 16:113. https:\/\/doi.org\/10.1186\/s13059-015-0676-3","journal-title":"Genome Biol"},{"key":"1929_CR39","doi-asserted-by":"publisher","first-page":"e47793","DOI":"10.1371\/journal.pone.0047793","volume":"7","author":"D Krstic","year":"2012","unstructured":"Krstic D, Rodriguez M, Knuesel I (2012) Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE 7:e47793. https:\/\/doi.org\/10.1371\/journal.pone.0047793","journal-title":"PLoS ONE"},{"key":"1929_CR40","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/alzrt258","volume":"6","author":"MP Kummer","year":"2014","unstructured":"Kummer MP, Heneka MT (2014) Truncated and modified amyloid-beta species. Alzheimers Res Ther 6:28. https:\/\/doi.org\/10.1186\/alzrt258","journal-title":"Alzheimers Res Ther"},{"key":"1929_CR41","doi-asserted-by":"publisher","first-page":"12991","DOI":"10.1074\/jbc.M007859200","volume":"276","author":"YM Kuo","year":"2001","unstructured":"Kuo YM, Kokjohn TA, Beach TG, Sue LI, Brune D, Lopez JC et al (2001) Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer\u2019s disease brains. J Biol Chem 276:12991\u201312998. https:\/\/doi.org\/10.1074\/jbc.M007859200","journal-title":"J Biol Chem"},{"key":"1929_CR42","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/ana.24647","volume":"79","author":"S Lee","year":"2016","unstructured":"Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL et al (2016) White matter hyperintensities are a core feature of Alzheimer\u2019s disease: evidence from the dominantly inherited Alzheimer network. Ann Neurol 79:929\u2013939. https:\/\/doi.org\/10.1002\/ana.24647","journal-title":"Ann Neurol"},{"key":"1929_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13024-016-0078-3","volume":"11","author":"S Lemarchant","year":"2016","unstructured":"Lemarchant S, Pomeshchik Y, Kidin I, Karkkainen V, Valonen P, Lehtonen S et al (2016) ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener 11:10. https:\/\/doi.org\/10.1186\/s13024-016-0078-3","journal-title":"Mol Neurodegener"},{"key":"1929_CR44","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/cne.23701","volume":"523","author":"C Levy","year":"2015","unstructured":"Levy C, Brooks JM, Chen J, Su J, Fox MA (2015) Cell-specific and developmental expression of lectican-cleaving proteases in mouse hippocampus and neocortex. J Comp Neurol 523:629\u2013648. https:\/\/doi.org\/10.1002\/cne.23701","journal-title":"J Comp Neurol"},{"key":"1929_CR45","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1365-2990.2006.00696.x","volume":"32","author":"H Lewis","year":"2006","unstructured":"Lewis H, Beher D, Cookson N, Oakley A, Piggott M, Morris CM et al (2006) Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia. Neuropathol Appl Neurobiol 32:103\u2013118. https:\/\/doi.org\/10.1111\/j.1365-2990.2006.00696.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1929_CR46","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/nprot.2007.135","volume":"2","author":"J Luo","year":"2007","unstructured":"Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J et al (2007) A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc 2:1236\u20131247. https:\/\/doi.org\/10.1038\/nprot.2007.135","journal-title":"Nat Protoc"},{"key":"1929_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0150-6","author":"R Marioni","year":"2018","unstructured":"Marioni R, Harris SE, McRae AF, Zhang Q, Hagenaars SP, Hill WD et al (2018) GWAS on family history of Alzheimer\u2019s disease. Transl Psychiatry 8:99. https:\/\/doi.org\/10.1038\/s41398-018-0150-6","journal-title":"Transl Psychiatry"},{"key":"1929_CR48","doi-asserted-by":"publisher","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","volume":"82","author":"CL Masters","year":"1985","unstructured":"Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and down syndrome. Proc Natl Acad Sci U S A 82:4245\u20134249","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1929_CR49","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00401-017-1738-2","volume":"134","author":"KE McAleese","year":"2017","unstructured":"McAleese KE, Walker L, Graham S, Moya ELJ, Johnson M, Erskine D et al (2017) Parietal white matter lesions in Alzheimer\u2019s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease. Acta Neuropathol 134:459\u2013473. https:\/\/doi.org\/10.1007\/s00401-017-1738-2","journal-title":"Acta Neuropathol"},{"key":"1929_CR50","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/abbi.1993.1112","volume":"301","author":"DL Miller","year":"1993","unstructured":"Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Biemann K et al (1993) Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer\u2019s disease. Arch Biochem Biophys 301:41\u201352. https:\/\/doi.org\/10.1006\/abbi.1993.1112","journal-title":"Arch Biochem Biophys"},{"key":"1929_CR51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/alzrt121","volume":"4","author":"BD Moore","year":"2012","unstructured":"Moore BD, Chakrabarty P, Levites Y, Kukar TL, Baine AM, Moroni T et al (2012) Overlapping profiles of Abeta peptides in the Alzheimer\u2019s disease and pathological aging brains. Alzheimers Res Ther 4:18. https:\/\/doi.org\/10.1186\/alzrt121","journal-title":"Alzheimers Res Ther"},{"key":"1929_CR52","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","volume":"6","author":"SE Nasrabady","year":"2018","unstructured":"Nasrabady SE, Rizvi B, Goldman JE, Brickman AM (2018) White matter changes in Alzheimer\u2019s disease: a focus on myelin and oligodendrocytes. Acta Neuropathol Commun 6:22. https:\/\/doi.org\/10.1186\/s40478-018-0515-3","journal-title":"Acta Neuropathol Commun"},{"key":"1929_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-014-1347-2","volume":"129","author":"HS Nhan","year":"2015","unstructured":"Nhan HS, Chiang K, Koo EH (2015) The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol 129:1\u201319. https:\/\/doi.org\/10.1007\/s00401-014-1347-2","journal-title":"Acta Neuropathol"},{"key":"1929_CR54","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","volume":"26","author":"H Oakley","year":"2006","unstructured":"Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J et al (2006) Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation. J Neurosci 26:10129\u201310140","journal-title":"J Neurosci"},{"key":"1929_CR55","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.nbd.2014.08.031","volume":"73","author":"TJ Oberstein","year":"2015","unstructured":"Oberstein TJ, Spitzer P, Klafki HW, Linning P, Neff F, Knolker HJ et al (2015) Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Abeta peptides. Neurobiol Dis 73:24\u201335. https:\/\/doi.org\/10.1016\/j.nbd.2014.08.031","journal-title":"Neurobiol Dis"},{"key":"1929_CR56","doi-asserted-by":"publisher","first-page":"23895","DOI":"10.1074\/jbc.270.41.23895","volume":"270","author":"CJ Pike","year":"1995","unstructured":"Pike CJ, Overman MJ, Cotman CW (1995) Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. J Biol Chem 270:23895\u201323898","journal-title":"J Biol Chem"},{"key":"1929_CR57","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fnmol.2017.00054","volume":"10","author":"T Pohlkamp","year":"2017","unstructured":"Pohlkamp T, Wasser CR, Herz J (2017) Functional Roles of the Interaction of APP and Lipoprotein Receptors. Front Mol Neurosci 10:54. https:\/\/doi.org\/10.3389\/fnmol.2017.00054","journal-title":"Front Mol Neurosci"},{"key":"1929_CR58","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s00401-010-0690-1","volume":"120","author":"E Portelius","year":"2010","unstructured":"Portelius E, Bogdanovic N, Gustavsson MK, Volkmann I, Brinkmalm G, Zetterberg H et al (2010) Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer\u2019s disease. Acta Neuropathol 120:185\u2013193. https:\/\/doi.org\/10.1007\/s00401-010-0690-1","journal-title":"Acta Neuropathol"},{"key":"1929_CR59","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000369465","volume":"15","author":"E Portelius","year":"2015","unstructured":"Portelius E, Lashley T, Westerlund A, Persson R, Fox NC, Blennow K et al (2015) Brain amyloid-beta fragment signatures in pathological ageing and Alzheimer\u2019s disease by hybrid immunoprecipitation mass spectrometry. Neurodegener Dis 15:50\u201357. https:\/\/doi.org\/10.1159\/000369465","journal-title":"Neurodegener Dis"},{"key":"1929_CR60","doi-asserted-by":"publisher","first-page":"45539","DOI":"10.1074\/jbc.M303737200","volume":"278","author":"MA Pratta","year":"2003","unstructured":"Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA et al (2003) Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 278:45539\u201345545. https:\/\/doi.org\/10.1074\/jbc.M303737200","journal-title":"J Biol Chem"},{"key":"1929_CR61","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1002\/glia.23207","volume":"65","author":"M Pruvost","year":"2017","unstructured":"Pruvost M, Lepine M, Leonetti C, Etard O, Naveau M, Agin V et al (2017) ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function. Glia 65:1961\u20131975. https:\/\/doi.org\/10.1002\/glia.23207","journal-title":"Glia"},{"key":"1929_CR62","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40478-016-0294-7","volume":"4","author":"J Reinert","year":"2016","unstructured":"Reinert J, Richard BC, Klafki HW, Friedrich B, Bayer TA, Wiltfang J et al (2016) Deposition of C-terminally truncated Abeta species Abeta37 and Abeta39 in Alzheimer\u2019s disease and transgenic mouse models. Acta Neuropathol Commun 4:24. https:\/\/doi.org\/10.1186\/s40478-016-0294-7","journal-title":"Acta Neuropathol Commun"},{"key":"1929_CR63","doi-asserted-by":"publisher","first-page":"7817","DOI":"10.1523\/JNEUROSCI.1026-07.2007","volume":"27","author":"S Ring","year":"2007","unstructured":"Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA et al (2007) The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817\u20137826. https:\/\/doi.org\/10.1523\/jneurosci.1026-07.2007","journal-title":"J Neurosci"},{"key":"1929_CR64","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/brain\/awm102","volume":"130","author":"JM Ringman","year":"2007","unstructured":"Ringman JM, O\u2019Neill J, Geschwind D, Medina L, Apostolova LG, Rodriguez Y et al (2007) Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer\u2019s disease mutations. Brain 130:1767\u20131776. https:\/\/doi.org\/10.1093\/brain\/awm102","journal-title":"Brain"},{"key":"1929_CR65","doi-asserted-by":"publisher","first-page":"11080","DOI":"10.1021\/bi026173d","volume":"41","author":"AE Roher","year":"2002","unstructured":"Roher AE, Weiss N, Kokjohn TA, Kuo YM, Kalback W, Anthony J et al (2002) Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer\u2019s disease. Biochemistry 41:11080\u201311090","journal-title":"Biochemistry"},{"key":"1929_CR66","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13024-016-0084-5","volume":"11","author":"C Schonherr","year":"2016","unstructured":"Schonherr C, Bien J, Isbert S, Wichert R, Prox J, Altmeppen H et al (2016) Generation of aggregation prone N-terminally truncated amyloid beta peptides by meprin beta depends on the sequence specificity at the cleavage site. Mol Neurodegener 11:19. https:\/\/doi.org\/10.1186\/s13024-016-0084-5","journal-title":"Mol Neurodegener"},{"key":"1929_CR67","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"DJ Selkoe","year":"2016","unstructured":"Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer\u2019s disease at 25 years. EMBO Mol Med 8:595\u2013608. https:\/\/doi.org\/10.15252\/emmm.201606210","journal-title":"EMBO Mol Med"},{"key":"1929_CR68","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1046\/j.1471-4159.2003.01818.x","volume":"85","author":"N Sergeant","year":"2003","unstructured":"Sergeant N, Bombois S, Ghestem A, Drobecq H, Kostanjevecki V, Missiaen C et al (2003) Truncated beta-amyloid peptide species in pre-clinical Alzheimer\u2019s disease as new targets for the vaccination approach. J Neurochem 85:1581\u20131591","journal-title":"J Neurochem"},{"key":"1929_CR69","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1038\/nn.4160","volume":"18","author":"K Sharma","year":"2015","unstructured":"Sharma K, Schmitt S, Bergner CG, Tyanova S, Kannaiyan N, Manrique-Hoyos N et al (2015) Cell type- and brain region-resolved mouse brain proteome. Nat Neurosci 18:1819\u20131831. https:\/\/doi.org\/10.1038\/nn.4160","journal-title":"Nat Neurosci"},{"key":"1929_CR70","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1007\/s11064-009-0022-9","volume":"34","author":"SD Skaper","year":"2009","unstructured":"Skaper SD, Evans NA, Evans NA, Rosin C, Facci L, Richardson JC (2009) Oligodendrocytes are a novel source of amyloid peptide generation. Neurochem Res 34:2243\u20132250. https:\/\/doi.org\/10.1007\/s11064-009-0022-9","journal-title":"Neurochem Res"},{"key":"1929_CR71","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/art.22334","volume":"56","author":"RH Song","year":"2007","unstructured":"Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC et al (2007) Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 56:575\u2013585. https:\/\/doi.org\/10.1002\/art.22334","journal-title":"Arthritis Rheum"},{"key":"1929_CR72","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.expneurol.2004.09.006","volume":"191","author":"SW Sun","year":"2005","unstructured":"Sun SW, Song SK, Harms MP, Lin SJ, Holtzman DM, Merchant KM et al (2005) Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer\u2019s disease using magnetic resonance diffusion tensor imaging. Exp Neurol 191:77\u201385. https:\/\/doi.org\/10.1016\/j.expneurol.2004.09.006","journal-title":"Exp Neurol"},{"key":"1929_CR73","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1126\/science.284.5420.1664","volume":"284","author":"MD Tortorella","year":"1999","unstructured":"Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R et al (1999) Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 284:1664\u20131666","journal-title":"Science"},{"key":"1929_CR74","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.2174\/138161209788682433","volume":"15","author":"MD Tortorella","year":"2009","unstructured":"Tortorella MD, Malfait F, Barve RA, Shieh HS, Malfait AM (2009) A review of the ADAMTS family, pharmaceutical targets of the future. Curr Pharm Des 15:2359\u20132374","journal-title":"Curr Pharm Des"},{"key":"1929_CR75","doi-asserted-by":"publisher","first-page":"18566","DOI":"10.1074\/jbc.M909383199","volume":"275","author":"MD Tortorella","year":"2000","unstructured":"Tortorella MD, Pratta M, Liu RQ, Austin J, Ross OH, Abbaszade I et al (2000) Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4). J Biol Chem 275:18566\u201318573. https:\/\/doi.org\/10.1074\/jbc.M909383199","journal-title":"J Biol Chem"},{"key":"1929_CR76","doi-asserted-by":"publisher","first-page":"15434","DOI":"10.1074\/jbc.M312797200","volume":"279","author":"P Wang","year":"2004","unstructured":"Wang P, Tortorella M, England K, Malfait AM, Thomas G, Arner EC et al (2004) Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem 279:15434\u201315440. https:\/\/doi.org\/10.1074\/jbc.M312797200","journal-title":"J Biol Chem"},{"key":"1929_CR77","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/35102591","volume":"414","author":"S Weggen","year":"2001","unstructured":"Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU et al (2001) A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414:212\u2013216","journal-title":"Nature"},{"key":"1929_CR78","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.semcdb.2009.01.003","volume":"20","author":"M Willem","year":"2009","unstructured":"Willem M, Lammich S, Haass C (2009) Function, regulation and therapeutic properties of beta-secretase (BACE1). Semin Cell Dev Biol 20:175\u2013182. https:\/\/doi.org\/10.1016\/j.semcdb.2009.01.003","journal-title":"Semin Cell Dev Biol"},{"key":"1929_CR79","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13195-017-0309-z","volume":"9","author":"O Wirths","year":"2017","unstructured":"Wirths O, Walter S, Kraus I, Klafki HW, Stazi M, Oberstein TJ et al (2017) N-truncated Abeta4-x peptides in sporadic Alzheimer\u2019s disease cases and transgenic Alzheimer mouse models. Alzheimers Res Ther 9:80. https:\/\/doi.org\/10.1186\/s13195-017-0309-z","journal-title":"Alzheimers Res Ther"},{"key":"1929_CR80","doi-asserted-by":"publisher","first-page":"Rc118","DOI":"10.1523\/JNEUROSCI.21-01-j0001.2001","volume":"21","author":"J Xu","year":"2001","unstructured":"Xu J, Chen S, Ahmed SH, Chen H, Ku G, Goldberg MP et al (2001) Amyloid-beta peptides are cytotoxic to oligodendrocytes. J Neurosci 21:Rc118","journal-title":"J Neurosci"},{"key":"1929_CR81","doi-asserted-by":"publisher","first-page":"6462","DOI":"10.1074\/jbc.M113.545376","volume":"289","author":"K Yamamoto","year":"2014","unstructured":"Yamamoto K, Owen K, Parker AE, Scilabra SD, Dudhia J, Strickland DK et al (2014) Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding. J Biol Chem 289:6462\u20136474. https:\/\/doi.org\/10.1074\/jbc.M113.545376","journal-title":"J Biol Chem"},{"key":"1929_CR82","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O\u2019Keeffe S et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34:11929\u201311947. https:\/\/doi.org\/10.1523\/jneurosci.1860-14.2014","journal-title":"J Neurosci"}],"container-title":["Acta Neuropathologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00401-018-1929-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-018-1929-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00401-018-1929-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T04:46:23Z","timestamp":1605415583000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00401-018-1929-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1929"],"URL":"https:\/\/doi.org\/10.1007\/s00401-018-1929-5","relation":{},"ISSN":["0001-6322","1432-0533"],"issn-type":[{"value":"0001-6322","type":"print"},{"value":"1432-0533","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"6 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"D.B. is the Chief Executive Officer of Asceneuron SA. All other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were carried out in accordance with German guidelines for animal care and have been approved by the local responsible committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}