{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:48:24Z","timestamp":1762271304010},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"S5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00406-008-5005-3","type":"journal-article","created":{"date-parts":[[2008,11,5]],"date-time":"2008-11-05T02:25:36Z","timestamp":1225851936000},"page":"44-49","source":"Crossref","is-referenced-by-count":9,"title":["Neurochemical dementia diagnostics: assays in CSF and blood"],"prefix":"10.1007","volume":"258","author":[{"given":"Piotr","family":"Lewczuk","sequence":"first","affiliation":[]},{"given":"Joachim","family":"Hornegger","sequence":"additional","affiliation":[]},{"given":"R\u00fcdiger","family":"Zimmermann","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,11,5]]},"reference":[{"key":"5005_CR1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/WNL.53.7.1488","volume":"53","author":"N Andreasen","year":"1999","unstructured":"Andreasen N, Minthon L, Clarberg A, Davidsson P, Gottfries J, Vanmechelen E, Vanderstichele H, Winblad B, Blennow K (1999) Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample. Neurology 53:1488\u20131494","journal-title":"Neurology"},{"key":"5005_CR2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archneur.58.3.373","volume":"58","author":"N Andreasen","year":"2001","unstructured":"Andreasen N, Minthon L, Davidsson P, Vanmechelen E, Vanderstichele H, Winblad B, Blennow K (2001) Evaluation of CSF-tau and CSF-A\u03b242 as diagnostic markers for Alzheimer disease in clinical practice. Arch Neurol 58:373\u2013379","journal-title":"Arch Neurol"},{"key":"5005_CR3","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/brain\/awl063","volume":"129","author":"M Bibl","year":"2006","unstructured":"Bibl M, Mollenhauer B, Esselmann H, Lewczuk P, Klafki HW, Sparbier K, Smirnov A, Cepek L, Trenkwalder C, Ruther E, Kornhuber J, Otto M, Wiltfang J (2006) CSF amyloid-beta-peptides in Alzheimer\u2019s disease, dementia with Lewy bodies and Parkinson\u2019s disease dementia. Brain 129:1177\u20131187","journal-title":"Brain"},{"key":"5005_CR4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.mp.4001967","volume":"12","author":"M Bibl","year":"2007","unstructured":"Bibl M, Mollenhauer B, Lewczuk P, Esselmann H, Wolf S, Trenkwalder C, Otto M, Stiens G, Ruther E, Kornhuber J, Wiltfang J (2007) Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias. Mol Psychiatry 12:671\u2013680","journal-title":"Mol Psychiatry"},{"key":"5005_CR5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00702-006-0618-z","volume":"114","author":"M Bibl","year":"2007","unstructured":"Bibl M, Mollenhauer B, Wolf S, Esselmann H, Lewczuk P, Kornhuber J, Wiltfang J (2007) Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations. J Neural Transm 114:621\u2013628","journal-title":"J Neural Transm"},{"key":"5005_CR6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1474-4422(03)00530-1","volume":"2","author":"K Blennow","year":"2003","unstructured":"Blennow K, Hampel H (2003) CSF markers for incipient Alzheimer\u2019s disease. Lancet Neurol 2:605\u2013613","journal-title":"Lancet Neurol"},{"key":"5005_CR7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1385\/MN:24:1-3:087","volume":"24","author":"K Blennow","year":"2001","unstructured":"Blennow K, Vanmechelen E, Hampel H (2001) CSF total tau, A\u03b242 and phosphorylated tau protein as biomarkers for Alzheimer\u2019s disease. Mol Neurobiol 24:87\u201397","journal-title":"Mol Neurobiol"},{"key":"5005_CR8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-0447.1993.tb03443.x","volume":"88","author":"K Blennow","year":"1993","unstructured":"Blennow K, Wallin A, Hager O (1993) Low frequency of post-lumbar puncture headache in demented patients. Acta Neurol Scand 88:221\u2013223","journal-title":"Acta Neurol Scand"},{"key":"5005_CR9","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1073\/pnas.93.23.13170","volume":"93","author":"M Citron","year":"1996","unstructured":"Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ (1996) Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc Natl Acad Sci USA 93:13170\u201313175","journal-title":"Proc Natl Acad Sci USA"},{"key":"5005_CR10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archneur.55.9.1195","volume":"55","author":"M Di Luca","year":"1998","unstructured":"Di Luca M, Pastorino L, Bianchetti A, Perez J, Vignolo LA, Lenzi GL, Trabucchi M, Cattabeni F, Padovani A (1998) Differential level of platelet amyloid \u03b2 precursor protein isoforms: an early marker for Alzheimer disease. Arch Neurol 55:1195\u20131200","journal-title":"Arch Neurol"},{"key":"5005_CR11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.neurobiolaging.2007.02.016","volume":"29","author":"S Engelborghs","year":"2008","unstructured":"Engelborghs S, De Vreese K, Van de Casteele T, Vanderstichele H, Van Everbroeck B, Cras P, Martin JJ, Vanmechelen E, De Deyn PP (2008) Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia. Neurobiol Aging 29:1143\u20131159","journal-title":"Neurobiol Aging"},{"key":"5005_CR12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.brainresrev.2004.07.018","volume":"47","author":"RA Fuentealba","year":"2004","unstructured":"Fuentealba RA, Farias G, Scheu J, Bronfman M, Marzolo MP, Inestrosa NC (2004) Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease. Brain Res Brain Res Rev 47:275\u2013289","journal-title":"Brain Res Brain Res Rev"},{"key":"5005_CR13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/archneur.55.7.937","volume":"55","author":"D Galasko","year":"1998","unstructured":"Galasko D, Chang L, Motter R, Clark CM, Kaye J, Knopman D, Thomas R, Kholodenko D, Schenk D, Lieberburg I, Miller B, Green R, Basherad R, Kertiles L, Boss MA, Seubert P (1998) High cerebrospinal fluid tau and low amyloid \u03b242 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 55:937\u2013945","journal-title":"Arch Neurol"},{"key":"5005_CR14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archneur.64.3.354","volume":"64","author":"NR Graff-Radford","year":"2007","unstructured":"Graff-Radford NR, Crook JE, Lucas J, Boeve BF, Knopman DS, Ivnik RJ, Smith GE, Younkin LH, Petersen RC, Younkin SG (2007) Association of low plasma abeta42\/abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Arch Neurol 64:354\u2013362","journal-title":"Arch Neurol"},{"key":"5005_CR15","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","volume":"83","author":"I Grundke-Iqbal","year":"1986","unstructured":"Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83:4913\u20134917","journal-title":"Proc Natl Acad Sci USA"},{"key":"5005_CR16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ana.111","volume":"49","author":"H Hampel","year":"2001","unstructured":"Hampel H, Buerger K, Kohnken R, Teipel SJ, Zinkowski R, Moeller HJ, Rapoport SI, Davies P (2001) Tracking of Alzheimer\u2019s disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann Neurol 49:545\u2013546","journal-title":"Ann Neurol"},{"key":"5005_CR17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archpsyc.61.1.95","volume":"61","author":"H Hampel","year":"2004","unstructured":"Hampel H, Buerger K, Zinkowski R, Teipel SJ, Goernitz A, Andreasen N, Sjoegren M, DeBernardis J, Kerkman D, Ishiguro K, Ohno H, Vanmechelen E, Vanderstichele H, McCulloch C, Moller HJ, Davies P, Blennow K (2004) Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. Arch Gen Psychiatry 61:95\u2013102","journal-title":"Arch Gen Psychiatry"},{"key":"5005_CR18","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1474-4422(06)70355-6","volume":"5","author":"O Hansson","year":"2006","unstructured":"Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L (2006) Association between CSF biomarkers and incipient Alzheimer\u2019s disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 5:228\u2013234","journal-title":"Lancet Neurol"},{"key":"5005_CR19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(00)01697-9","volume":"297","author":"C Hesse","year":"2001","unstructured":"Hesse C, Rosengren L, Andreasen N, Davidsson P, Vanderstichele H, Vanmechelen E, Blennow K (2001) Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke. Neurosci Lett 297:187\u2013190","journal-title":"Neurosci Lett"},{"key":"5005_CR20","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1212\/WNL.52.8.1555","volume":"52","author":"F Hulstaert","year":"1999","unstructured":"Hulstaert F, Blennow K, Ivanoiu A, Schoonderwaldt HC, Riemenschneider M, De Deyn PP, Bancher C, Cras P, Wiltfang J, Mehta PD, Iqbal K, Pottel H, Vanmechelen E, Vanderstichele H (1999) Improved discrimination of AD patients using \u03b2-amyloid(1\u201342) and tau levels in CSF. Neurology 52:1555\u20131562","journal-title":"Neurology"},{"key":"5005_CR21","doi-asserted-by":"crossref","first-page":"22908","DOI":"10.1074\/jbc.271.37.22908","volume":"271","author":"N Ida","year":"1996","unstructured":"Ida N, Hartmann T, Pantel J, Schr\u00f6der J, Zerfass R, F\u00f6rstl H, Sandbrink R, Masters CL, Beyreuther K (1996) Analysis of heterogeneous \u03b2A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem 271:22908\u201322914","journal-title":"J Biol Chem"},{"key":"5005_CR22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0140-6736(86)92134-3","volume":"2","author":"K Iqbal","year":"1986","unstructured":"Iqbal K, Grundke-Iqbal I, Zaidi T, Merz PA, Wen GY, Shaikh SS, Wisniewski HM, Alafuzoff I, Winblad B (1986) Defective brain microtubule assembly in Alzheimer\u2019s disease. Lancet 2:421\u2013426","journal-title":"Lancet"},{"key":"5005_CR23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","volume":"325","author":"J Kang","year":"1987","unstructured":"Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733\u2013736","journal-title":"Nature"},{"key":"5005_CR24","doi-asserted-by":"crossref","first-page":"28655","DOI":"10.1074\/jbc.271.45.28655","volume":"271","author":"H Klafki","year":"1996","unstructured":"Klafki H, Abramowski D, Swoboda R, Paganetti PA, Staufenbiel M (1996) The carboxyl termini of beta-amyloid peptides 1\u201340 and 1\u201342 are generated by distinct gamma-secretase activities. J Biol Chem 271:28655\u201328659","journal-title":"J Biol Chem"},{"key":"5005_CR25","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1093\/brain\/awl280","volume":"129","author":"HW Klafki","year":"2006","unstructured":"Klafki HW, Staufenbiel M, Kornhuber J, Wiltfang J (2006) Therapeutic approaches to Alzheimer\u2019s disease. Brain 129:2840\u20132855","journal-title":"Brain"},{"key":"5005_CR26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0002-9440(10)64947-4","volume":"156","author":"YM Kuo","year":"2000","unstructured":"Kuo YM, Kokjohn TA, Watson MD, Woods AS, Cotter RJ, Sue LI, Kalback WM, Emmerling MR, Beach TG, Roher AE (2000) Elevated A\u03b242 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of A\u03b2PP metabolism. Am J Pathol 156:797\u2013805","journal-title":"Am J Pathol"},{"key":"5005_CR27","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1373\/clinchem.2005.058776","volume":"52","author":"P Lewczuk","year":"2006","unstructured":"Lewczuk P, Beck G, Esselmann H, Bruckmoser R, Zimmermann R, Fiszer M, Bibl M, Maler JM, Kornhuber J, Wiltfang J (2006) Effect of sample collection tubes on cerebrospinal fluid concentrations of Tau proteins and amyloid \u03b2 peptides. Clin Chem 52:332\u2013334","journal-title":"Clin Chem"},{"key":"5005_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2006.07.009","volume":"409","author":"P Lewczuk","year":"2006","unstructured":"Lewczuk P, Beck G, Ganslandt O, Esselmann H, Deisenhammer F, Regeniter A, Petereit HF, Tumani H, Gerritzen A, Oschmann P, Schroder J, Schonknecht P, Zimmermann K, Hampel H, Burger K, Otto M, Haustein S, Herzog K, Dannenberg R, Wurster U, Bibl M, Maler JM, Reubach U, Kornhuber J, Wiltfang J (2006) International quality control survey of neurochemical dementia diagnostics. Neurosci Lett 409:1\u20134","journal-title":"Neurosci Lett"},{"key":"5005_CR29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1385\/JMN:23:1-2:115","volume":"23","author":"P Lewczuk","year":"2004","unstructured":"Lewczuk P, Esselmann H, Bibl M, Beck G, Maler JM, Otto M, Kornhuber J, Wiltfang J (2004) Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer\u2019s disease: original data and review of the literature. J Mol Neurosci 23:115\u2013122","journal-title":"J Mol Neurosci"},{"key":"5005_CR30","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1002\/elps.200406068","volume":"25","author":"P Lewczuk","year":"2004","unstructured":"Lewczuk P, Esselmann H, Bibl M, Paul S, Svitek J, Miertschischk J, Meyrer R, Smirnov A, Maler JM, Klein C, Otto M, Bleich S, Sperling W, Kornhuber J, Ruther E, Wiltfang J (2004) Electrophoretic separation of amyloid beta peptides in plasma. Electrophoresis 25:3336\u20133343","journal-title":"Electrophoresis"},{"key":"5005_CR31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0197-4580(03)00086-1","volume":"25","author":"P Lewczuk","year":"2004","unstructured":"Lewczuk P, Esselmann H, Otto M, Maler JM, Henkel AW, Henkel MK, Eikenberg O, Antz C, Krause WR, Reulbach U, Kornhuber J, Wiltfang J (2004) Neurochemical diagnosis of Alzheimer\u2019s dementia by CSF A\u03b242, A\u03b242\/A\u03b240 ratio and total tau. Neurobiol Aging 25:273\u2013281","journal-title":"Neurobiol Aging"},{"key":"5005_CR32","doi-asserted-by":"crossref","unstructured":"Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Burger K, Hampel H, Frolich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hull M, Schroder J, Kessler H, Pantel J, Gertz H-J, Klafki H-W, Kolsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J (2008) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer\u2019s disease: a multicenter study. Mol Psychiatry (in press)","DOI":"10.1038\/mp.2008.84"},{"key":"5005_CR33","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.neurobiolaging.2006.12.010","volume":"29","author":"P Lewczuk","year":"2008","unstructured":"Lewczuk P, Kornhuber J, Vanderstichele H, Vanmechelen E, Esselmann H, Bibl M, Wolf S, Otto M, Reulbach U, Kolsch H, Jessen F, Schroder J, Schonknecht P, Hampel H, Peters O, Weimer E, Perneczky R, Jahn H, Luckhaus C, Lamla U, Supprian T, Maler JM, Wiltfang J (2008) Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study. Neurobiol Aging 29:812\u2013818","journal-title":"Neurobiol Aging"},{"key":"5005_CR34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00702-006-0511-9","volume":"113","author":"P Lewczuk","year":"2006","unstructured":"Lewczuk P, Kornhuber J, Wiltfang J (2006) The german competence net dementias: standard operating procedures for the neurochemical dementia diagnostics. J Neural Transm 113:1075\u20131080","journal-title":"J Neural Transm"},{"key":"5005_CR35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/pmic.200700703","volume":"8","author":"P Lewczuk","year":"2008","unstructured":"Lewczuk P, Wiltfang J (2008) Neurochemical dementia diagnostics: state of the art and research perspectives. Proteomics 8:1292\u20131301","journal-title":"Proteomics"},{"key":"5005_CR36","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1073\/pnas.032395699","volume":"99","author":"SF Lichtenthaler","year":"2002","unstructured":"Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K (2002) The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc Natl Acad Sci USA 99:1365\u20131370","journal-title":"Proc Natl Acad Sci USA"},{"key":"5005_CR37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0197-4580(98)00014-1","volume":"19","author":"R Mayeux","year":"1998","unstructured":"Mayeux R (1998) Evaluation and use of diagnostic tests in Alzheimer\u2019s disease. Neurobiol Aging 19:139\u2013143","journal-title":"Neurobiol Aging"},{"key":"5005_CR38","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1212\/01.WNL.0000091890.32140.8F","volume":"61","author":"R Mayeux","year":"2003","unstructured":"Mayeux R, Honig LS, Tang MX, Manly J, Stern Y, Schupf N, Mehta PD (2003) Plasma A\u03b240 and A\u03b242 and Alzheimer\u2019s disease: relation to age, mortality, and risk. Neurology 61:1185\u20131190","journal-title":"Neurology"},{"key":"5005_CR39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0304-3940(01)01754-2","volume":"304","author":"PD Mehta","year":"2001","unstructured":"Mehta PD, Pirttila T, Patrick BA, Barshatzky M, Mehta SP (2001) Amyloid [beta] protein 1\u201340 and 1\u201342 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci Lett 304:102\u2013106","journal-title":"Neurosci Lett"},{"key":"5005_CR40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0166-2236(00)02031-2","volume":"25","author":"A Mudher","year":"2002","unstructured":"Mudher A, Lovestone S (2002) Alzheimer\u2019s disease-do tauists and baptists finally shake hands? Trends Neurosci 25:22\u201326","journal-title":"Trends Neurosci"},{"key":"5005_CR41","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1212\/WNL.54.5.1099","volume":"54","author":"M Otto","year":"2000","unstructured":"Otto M, Esselmann H, Schulz-Shaeffer W, Neumann M, Schroter A, Ratzka P, Cepek L, Zerr I, Steinacker P, Windl O, Kornhuber J, Kretzschmar HA, Poser S, Wiltfang J (2000) Decreased \u03b2-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurology 54:1099\u20131102","journal-title":"Neurology"},{"key":"5005_CR42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ymeth.2007.06.012","volume":"44","author":"M Otto","year":"2008","unstructured":"Otto M, Lewczuk P, Wiltfang J (2008) Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases. Methods 44:289\u2013298","journal-title":"Methods"},{"key":"5005_CR43","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1212\/WNL.58.2.192","volume":"58","author":"M Otto","year":"2002","unstructured":"Otto M, Wiltfang J, Cepek L, Neumann M, Mollenhauer B, Steinacker P, Ciesielczyk B, Schulz-Schaeffer W, Kretzschmar HA, Poser S (2002) Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology 58:192\u2013197","journal-title":"Neurology"},{"key":"5005_CR44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0304-3940(97)00215-2","volume":"225","author":"M Otto","year":"1997","unstructured":"Otto M, Wiltfang J, Tumani H, Zerr I, Lantsch M, Kornhuber J, Weber T, Kretzschmar HA, Poser S (1997) Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Neurosci Lett 225:210\u2013212","journal-title":"Neurosci Lett"},{"key":"5005_CR45","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","volume":"63","author":"RL Ownby","year":"2006","unstructured":"Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D (2006) Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 63:530\u2013538","journal-title":"Arch Gen Psychiatry"},{"key":"5005_CR46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s100720170055","volume":"22","author":"L Parnetti","year":"2001","unstructured":"Parnetti L, Lanari A, Amici S, Gallai V, Vanmechelen E, Hulstaert F (2001) CSF phosphorylated tau is a possible marker for discriminating Alzheimer\u2019s disease from dementia with Lewy bodies. Phospho-Tau International Study Group. Neurol Sci 22:77\u201378","journal-title":"Neurol Sci"},{"key":"5005_CR47","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm1653","volume":"13","author":"S Ray","year":"2007","unstructured":"Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L, Quinn JF, Rabinovici GD, Robinson WH, Sabbagh MN, So YT, Sparks DL, Tabaton M, Tinklenberg J, Yesavage JA, Tibshirani R, Wyss-Coray T (2007) Classification and prediction of clinical Alzheimer\u2019s diagnosis based on plasma signaling proteins. Nat Med 13:1359\u20131362","journal-title":"Nat Med"},{"key":"5005_CR48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0197-4580(01)00272-X","volume":"23","author":"M Riemenschneider","year":"2002","unstructured":"Riemenschneider M, Schmolke M, Lautenschlager N, Vanderstichele H, Vanmechelen E, Guder WG, Kurz A (2002) Association of CSF apolipoprotein E, A[beta]42 and cognition in Alzheimer\u2019s disease. Neurobiol Aging 23:205\u2013211","journal-title":"Neurobiol Aging"},{"key":"5005_CR49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(01)02285-6","volume":"314","author":"M Sj\u00f6gren","year":"2001","unstructured":"Sj\u00f6gren M, Gisslen M, Vanmechelen E, Blennow K (2001) Low cerebrospinal fluid \u03b2-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment. Neurosci Lett 314:33\u201336","journal-title":"Neurosci Lett"},{"key":"5005_CR50","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/archpsyc.65.5.542","volume":"65","author":"X Sun","year":"2008","unstructured":"Sun X, Steffens DC, Au R, Folstein M, Summergrad P, Yee J, Rosenberg I, Mwamburi DM, Qiu WQ (2008) Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry 65:542\u2013550","journal-title":"Arch Gen Psychiatry"},{"key":"5005_CR51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0197-4580(98)00022-0","volume":"19","author":"The Working Group on: \u201cMolecular and Biochemical Markers of Alzheimer\u2019s Disease\u201d","year":"1998","unstructured":"The Working Group on: \u201cMolecular and Biochemical Markers of Alzheimer\u2019s Disease\u201d (1998) Consensus report of the working group on: \u201cMolecular and Biochemical Markers of Alzheimer\u2019s Disease\u201d. The Ronald and Nancy Reagan Research Institute of the Alzheimer\u2019s Association and the National Institute on Aging Working Group. Neurobiol Aging 19:109\u2013116","journal-title":"Neurobiol Aging"},{"key":"5005_CR52","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1474-4422(06)70501-4","volume":"5","author":"M Oijen van","year":"2006","unstructured":"van Oijen M, Hofman A, Soares HD, Koudstaal PJ, Breteler MM (2006) Plasma Abeta(1\u201340) and Abeta(1\u201342) and the risk of dementia: a prospective case-cohort study. Lancet Neurol 5:655\u2013660","journal-title":"Lancet Neurol"},{"key":"5005_CR53","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/13506120009146438","volume":"7","author":"H Vanderstichele","year":"2000","unstructured":"Vanderstichele H, Van Kerschaver E, Hesse C, Davidsson P, Buyse MA, Andreasen N, Minthon L, Wallin A, Blennow K, Vanmechelen E (2000) Standardization of measurement of beta-amyloid(1\u201342) in cerebrospinal fluid and plasma. Amyloid 7:245\u2013258","journal-title":"Amyloid"},{"key":"5005_CR54","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/0470846453.ch26","volume-title":"Alzheimer\u2019s disease: advances in etiology, pathogenesis and therapeutics","author":"E Vanmechelen","year":"2001","unstructured":"Vanmechelen E, Van Kerschaver E, Blennow K, De Deyn PP, Gartner FH, Parnetti L, Sindic CJM, Arai H, Riemenschneider M, Hampel H, Pottel H, Valgaeren A, Hulstaert F, Vanderstichele H (2001) CSF-Phospho-tau (181P) as a promising marker for discriminating Alzheimer\u2019s disease from dementia with Lewy bodies. In: Iqbal K, Sisodia SS, Winblad B (eds) Alzheimer\u2019s disease: advances in etiology, pathogenesis and therapeutics. Wiley, Chichester, pp 285\u2013291"},{"key":"5005_CR55","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.2006.04404.x","volume":"101","author":"J Wiltfang","year":"2007","unstructured":"Wiltfang J, Esselmann H, Bibl M, Hull M, Hampel H, Kessler H, Frolich L, Schroder J, Peters O, Jessen F, Luckhaus C, Perneczky R, Jahn H, Fiszer M, Maler JM, Zimmermann R, Bruckmoser R, Kornhuber J, Lewczuk P (2007) Amyloid beta peptide ratio 42\/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load. J Neurochem 101:1053\u20131059","journal-title":"J Neurochem"},{"key":"5005_CR56","doi-asserted-by":"crossref","first-page":"42645","DOI":"10.1074\/jbc.M102790200","volume":"276","author":"J Wiltfang","year":"2001","unstructured":"Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, R\u00fcther E, Kornhuber J, Annaert W, De Strooper B, Saftig P (2001) Elevation of \u03b2-amyloid peptide 2\u201342 in sporadic and familial Alzheimer\u2019s disease and its generation in PS1 knockout cells. J Biol Chem 276:42645\u201342657","journal-title":"J Biol Chem"},{"key":"5005_CR57","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ana.10661","volume":"54","author":"J Wiltfang","year":"2003","unstructured":"Wiltfang J, Esselmann H, Smirnov A, Bibl M, Cepek L, Steinacker P, Mollenhauer B, Buerger K, Hampel H, Paul S, Neumann M, Maler M, Zerr I, Kornhuber J, Kretzschmar HA, Poser S, Otto M (2003) \u03b2-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Ann Neurol 54:263\u2013267","journal-title":"Ann Neurol"},{"key":"5005_CR58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ana.410430109","volume":"43","author":"I Zerr","year":"1998","unstructured":"Zerr I, Bodemer M, Gefeller O, Otto M, Poser S, Wiltfang J, Windl O, Kretzschmar HA, Weber T (1998) Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease. Ann Neurol 43:32\u201340","journal-title":"Ann Neurol"},{"key":"5005_CR59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2003.08.011","volume":"352","author":"H Zetterberg","year":"2003","unstructured":"Zetterberg H, Wahlund LO, Blennow K (2003) Cerebrospinal fluid markers for prediction of Alzheimer\u2019s disease. Neurosci Lett 352:67\u201369","journal-title":"Neurosci Lett"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-008-5005-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00406-008-5005-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-008-5005-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:20:10Z","timestamp":1559067610000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00406-008-5005-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":59,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["5005"],"URL":"https:\/\/doi.org\/10.1007\/s00406-008-5005-3","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}