{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:06:49Z","timestamp":1761523609626},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T00:00:00Z","timestamp":1247184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chromosoma"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1007\/s00412-009-0227-3","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T08:58:45Z","timestamp":1247129925000},"page":"567-574","source":"Crossref","is-referenced-by-count":24,"title":["At the right place at the right time: novel CENP-A binding proteins shed light on centromere assembly"],"prefix":"10.1007","volume":"118","author":[{"given":"Mariana C. C.","family":"Silva","sequence":"first","affiliation":[]},{"given":"Lars E. T.","family":"Jansen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,7,10]]},"reference":[{"key":"227_CR1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nrg2466","volume":"9","author":"RC Allshire","year":"2008","unstructured":"Allshire RC, Karpen GH (2008) Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nat Rev Genet 9:923\u2013937","journal-title":"Nat Rev Genet"},{"key":"227_CR2","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1073\/pnas.0308637101","volume":"101","author":"DJ Amor","year":"2004","unstructured":"Amor DJ, Bentley K, Ryan J, Perry J, Wong L, Slater H, Choo KH (2004) Human centromere repositioning \"in progress\". Proc Natl Acad Sci USA 101:6542\u20136547","journal-title":"Proc Natl Acad Sci USA"},{"key":"227_CR3","first-page":"2511","volume":"6","author":"L Aravind","year":"2007","unstructured":"Aravind L, Iyer LM, Wu C (2007) Domain architectures of the Scm3p protein provide insights into centromere function and evolution. Cell cycle (Georgetown. Tex 6:2511\u20132515","journal-title":"Tex"},{"key":"227_CR4","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nature02766","volume":"430","author":"BE Black","year":"2004","unstructured":"Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL Jr, Cleveland DW (2004) Structural determinants for generating centromeric chromatin. Nature 430:578\u2013582","journal-title":"Nature"},{"key":"227_CR5","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1073\/pnas.0700390104","volume":"104","author":"BE Black","year":"2007","unstructured":"Black BE, Brock MA, Bedard S, Woods VL Jr, Cleveland DW (2007a) An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci USA 104:5008\u20135013","journal-title":"Proc Natl Acad Sci USA"},{"key":"227_CR6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.molcel.2006.12.018","volume":"25","author":"BE Black","year":"2007","unstructured":"Black BE, Jansen LE, Maddox PS, Foltz DR, Desai AB, Shah JV, Cleveland DW (2007b) Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell 25:309\u2013322","journal-title":"Mol Cell"},{"key":"227_CR7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrm1314","volume":"5","author":"LA Boyer","year":"2004","unstructured":"Boyer LA, Latek RR, Peterson CL (2004) The SANT domain: a unique histone-tail-binding module? Nat Rev Mol Cell Biol 5:158\u2013163","journal-title":"Nat Rev Mol Cell Biol"},{"key":"227_CR8","doi-asserted-by":"crossref","unstructured":"Carroll CW, Silva MCC, Godek KM, Jansen LET, Straight AF (2009) Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Nat Cell Biol. 21 June 2009; doi: 10.1038\/ncb1899","DOI":"10.1038\/ncb1899"},{"key":"227_CR9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrm2310","volume":"9","author":"IM Cheeseman","year":"2008","unstructured":"Cheeseman IM, Desai A (2008) Molecular architecture of the kinetochore-microtubule interface. Nat Rev Mol Cell Biol 9:33\u201346","journal-title":"Nat Rev Mol Cell Biol"},{"key":"227_CR10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.200201052","volume":"157","author":"IM Cheeseman","year":"2002","unstructured":"Cheeseman IM, Drubin DG, Barnes G (2002) Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast. J Cell Biol 157:199\u2013203","journal-title":"J Cell Biol"},{"key":"227_CR11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1097-2765(03)00011-X","volume":"11","author":"ES Chen","year":"2003","unstructured":"Chen ES, Saitoh S, Yanagida M, Takahashi K (2003) A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast. Mol Cell 11:175\u2013187","journal-title":"Mol Cell"},{"key":"227_CR12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0092-8674(03)00115-6","volume":"112","author":"DW Cleveland","year":"2003","unstructured":"Cleveland DW, Mao Y, Sullivan KF (2003) Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112:407\u2013421","journal-title":"Cell"},{"key":"227_CR13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1139\/O08-135","volume":"87","author":"Y Dalal","year":"2009","unstructured":"Dalal Y (2009) Epigenetic specification of centromeres. Biochem Cell Biol 87:273\u2013282","journal-title":"Biochem Cell Biol"},{"key":"227_CR14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.molcel.2007.10.010","volume":"28","author":"EM Dunleavy","year":"2007","unstructured":"Dunleavy EM, Pidoux AL, Monet M, Bonilla C, Richardson W, Hamilton GL, Ekwall K, McLaughlin PJ, Allshire RC (2007) A NASP (N1\/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres. Mol Cell 28:1029\u20131044","journal-title":"Mol Cell"},{"key":"227_CR15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.02.040","volume":"137","author":"EM Dunleavy","year":"2009","unstructured":"Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G (2009) HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell 137:485\u2013497","journal-title":"Cell"},{"key":"227_CR16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1083\/jcb.200806038","volume":"183","author":"S Erhardt","year":"2008","unstructured":"Erhardt S, Mellone BG, Betts CM, Zhang W, Karpen GH, Straight AF (2008) Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation. J Cell Biol 183:805\u2013818","journal-title":"J Cell Biol"},{"key":"227_CR17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncb1397","volume":"8","author":"DR Foltz","year":"2006","unstructured":"Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (2006) The human CENP-A centromeric nucleosome-associated complex. Nat Cell Biol 8:458\u2013469","journal-title":"Nat Cell Biol"},{"key":"227_CR18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cell.2009.02.039","volume":"137","author":"DR Foltz","year":"2009","unstructured":"Foltz DR, Jansen LE, Bailey AO, Yates JR 3rd, Bassett EA, Wood S, Black BE, Cleveland DW (2009) Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell 137:472\u2013484","journal-title":"Cell"},{"key":"227_CR19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.devcel.2006.11.002","volume":"12","author":"Y Fujita","year":"2007","unstructured":"Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (2007) Priming of Centromere for CENP-A Recruitment by Human hMis18alpha, hMis18beta, and M18BP1. Dev Cell 12:17\u201330","journal-title":"Dev Cell"},{"key":"227_CR20","first-page":"133","volume-title":"The Kinetochore: from molecular discoveries to cancer therapy","author":"T Fukagawa","year":"2009","unstructured":"Fukagawa T, De Wulf P (2009) Kinetochore composition, formation and organization. In: De Wulf P, Earnshaw WC (eds) The Kinetochore: from molecular discoveries to cancer therapy. Springer, New York, pp 133\u2013191"},{"key":"227_CR21","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1073\/pnas.0601686103","volume":"103","author":"T Furuyama","year":"2006","unstructured":"Furuyama T, Dalal Y, Henikoff S (2006) Chaperone-mediated assembly of centromeric chromatin in vitro. Proc Natl Acad Sci USA 103:6172\u20136177","journal-title":"Proc Natl Acad Sci USA"},{"key":"227_CR22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cell.2004.09.002","volume":"118","author":"T Hayashi","year":"2004","unstructured":"Hayashi T, Fujita Y, Iwasaki O, Adachi Y, Takahashi K, Yanagida M (2004) Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell 118:715\u2013729","journal-title":"Cell"},{"key":"227_CR23","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1083\/jcb.200710052","volume":"180","author":"P Hemmerich","year":"2008","unstructured":"Hemmerich P, Weidtkamp-Peters S, Hoischen C, Schmiedeberg L, Erliandri I, Diekmann S (2008) Dynamics of inner kinetochore assembly and maintenance in living cells. J Cell Biol 180:1101\u20131114","journal-title":"J Cell Biol"},{"key":"227_CR24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.devcel.2006.01.014","volume":"10","author":"P Heun","year":"2006","unstructured":"Heun P, Erhardt S, Blower MD, Weiss S, Skora AD, Karpen GH (2006) Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores. Dev Cell 10:303\u2013315","journal-title":"Dev Cell"},{"key":"227_CR25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cell.2008.10.019","volume":"135","author":"T Hori","year":"2008","unstructured":"Hori T, Amano M, Suzuki A, Backer CB, Welburn JP, Dong Y, McEwen BF, Shang WH, Suzuki E, Okawa K et al (2008) CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell 135:1039\u20131052","journal-title":"Cell"},{"key":"227_CR26","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1126\/science.1158699","volume":"321","author":"K Ishii","year":"2008","unstructured":"Ishii K, Ogiyama Y, Chikashige Y, Soejima S, Masuda F, Kakuma T, Hiraoka Y, Takahashi K (2008) Heterochromatin integrity affects chromosome reorganization after centromere dysfunction. Science 321:1088\u20131091","journal-title":"Science"},{"key":"227_CR27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2443.2006.00969.x","volume":"11","author":"H Izuta","year":"2006","unstructured":"Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N et al (2006) Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Genes Cells 11:673\u2013684","journal-title":"Genes Cells"},{"key":"227_CR28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200701066","volume":"176","author":"LE Jansen","year":"2007","unstructured":"Jansen LE, Black BE, Foltz DR, Cleveland DW (2007) Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol 176:795\u2013805","journal-title":"J Cell Biol"},{"key":"227_CR29","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1158\/0008-5472.CAN-07-1307","volume":"67","author":"T Kato","year":"2007","unstructured":"Kato T, Sato N, Hayama S, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y, Daigo Y (2007) Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Res 67:8544\u20138553","journal-title":"Cancer Res"},{"key":"227_CR30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1083\/jcb.200509158","volume":"173","author":"SL Kline","year":"2006","unstructured":"Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (2006) The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol 173:9\u201317","journal-title":"J Cell Biol"},{"key":"227_CR31","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1126\/science.282.5395.1900","volume":"282","author":"G LeRoy","year":"1998","unstructured":"LeRoy G, Orphanides G, Lane WS, Reinberg D (1998) Requirement of RSF and FACT for transcription of chromatin templates in vitro. Science 282:1900\u20131904","journal-title":"Science"},{"key":"227_CR32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1083\/jcb.200606020","volume":"175","author":"ST Liu","year":"2006","unstructured":"Liu ST, Rattner JB, Jablonski SA, Yen TJ (2006) Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. J Cell Biol 175:41\u201353","journal-title":"J Cell Biol"},{"key":"227_CR33","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.200701065","volume":"176","author":"PS Maddox","year":"2007","unstructured":"Maddox PS, Hyndman F, Monen J, Oegema K, Desai A (2007) Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J Cell Biol 176:757\u2013763","journal-title":"J Cell Biol"},{"key":"227_CR34","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1038\/sj.emboj.7601927","volume":"26","author":"SE McClelland","year":"2007","unstructured":"McClelland SE, Borusu S, Amaro AC, Winter JR, Belwal M, McAinsh AD, Meraldi P (2007) The CENP-A NAC\/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J 26:5033\u20135047","journal-title":"EMBO J"},{"key":"227_CR35","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.cell.2007.04.026","volume":"129","author":"G Mizuguchi","year":"2007","unstructured":"Mizuguchi G, Xiao H, Wisniewski J, Smith MM, Wu C (2007) Nonhistone Scm3 and histones CenH3\u2013H4 assemble the core of centromere-specific nucleosomes. Cell 129:1153\u20131164","journal-title":"Cell"},{"key":"227_CR36","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/ncb1396","volume":"8","author":"M Okada","year":"2006","unstructured":"Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (2006) The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol 8:446\u2013457","journal-title":"Nat Cell Biol"},{"key":"227_CR37","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1083\/jcb.104.4.805","volume":"104","author":"DK Palmer","year":"1987","unstructured":"Palmer DK, O'Day K, Wener MH, Andrews BS, Margolis RL (1987) A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones. J Cell Biol 104:805\u2013815","journal-title":"J Cell Biol"},{"key":"227_CR38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1083\/jcb.200903088","volume":"185","author":"M Perpelescu","year":"2009","unstructured":"Perpelescu M, Nozaki N, Obuse C, Yang H, Yoda K (2009) Active establishment of centromeric CENP-A chromatin by RSF complex. J Cell Biol 185:397\u2013407","journal-title":"J Cell Biol"},{"key":"227_CR39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1083\/jcb.200212110","volume":"161","author":"AL Pidoux","year":"2003","unstructured":"Pidoux AL, Richardson W, Allshire RC (2003) Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation. J Cell Biol 161:295\u2013307","journal-title":"J Cell Biol"},{"key":"227_CR40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molcel.2009.01.019","volume":"33","author":"AL Pidoux","year":"2009","unstructured":"Pidoux AL, Choi ES, Abbott JK, Liu X, Kagansky A, Castillo AG, Hamilton GL, Richardson W, Rappsilber J, He X et al (2009) Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Molecular cell 33:299\u2013311","journal-title":"Molecular cell"},{"key":"227_CR41","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1128\/MCB.25.10.3967-3981.2005","volume":"25","author":"V Regnier","year":"2005","unstructured":"Regnier V, Vagnarelli P, Fukagawa T, Zerjal T, Burns E, Trouche D, Earnshaw W, Brown W (2005) CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol Cell Biol 25:3967\u20133981","journal-title":"Mol Cell Biol"},{"key":"227_CR42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cub.2006.11.051","volume":"17","author":"M Schuh","year":"2007","unstructured":"Schuh M, Lehner CF, Heidmann S (2007) Incorporation of Drosophila CID\/CENP-A and CENP-C into centromeres during early embryonic anaphase. Curr Biol 17:237\u2013243","journal-title":"Curr Biol"},{"key":"227_CR43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0092-8674(03)01064-X","volume":"116","author":"H Tagami","year":"2004","unstructured":"Tagami H, Ray-Gallet D, Almouzni G, Nakatani Y (2004) Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell 116:51\u201361","journal-title":"Cell"},{"key":"227_CR44","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1126\/science.288.5474.2215","volume":"288","author":"K Takahashi","year":"2000","unstructured":"Takahashi K, Chen ES, Yanagida M (2000) Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast. Science 288:2215\u20132219","journal-title":"Science"},{"key":"227_CR45","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1098\/rstb.2004.1614","volume":"360","author":"K Takahashi","year":"2005","unstructured":"Takahashi K, Takayama Y, Masuda F, Kobayashi Y, Saitoh S (2005) Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle. Philos Trans R Soc Lond 360:595\u2013606 discussion 606\u2013597","journal-title":"Philos Trans R Soc Lond"},{"key":"227_CR46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0092-8674(00)81326-4","volume":"87","author":"A Verreault","year":"1996","unstructured":"Verreault A, Kaufman PD, Kobayashi R, Stillman B (1996) Nucleosome assembly by a complex of CAF-1 and acetylated histones H3\/H4. Cell 87:95\u2013104","journal-title":"Cell"},{"key":"227_CR47","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1093\/nar\/gki579","volume":"33","author":"J Walfridsson","year":"2005","unstructured":"Walfridsson J, Bjerling P, Thalen M, Yoo EJ, Park SD, Ekwall K (2005) The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres. Nucleic Acids Res 33:2868\u20132879","journal-title":"Nucleic Acids Res"},{"key":"227_CR48","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1023\/B:CHRO.0000036585.44138.4b","volume":"12","author":"PE Warburton","year":"2004","unstructured":"Warburton PE (2004) Chromosomal dynamics of human neocentromere formation. Chromosome Res 12:617\u2013626","journal-title":"Chromosome Res"},{"key":"227_CR49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.molcel.2009.01.017","volume":"33","author":"JS Williams","year":"2009","unstructured":"Williams JS, Hayashi T, Yanagida M, Russell P (2009) Fission yeast Scm3 mediates stable assembly of Cnp1\/CENP-A into centromeric chromatin. Molecular cell 33:287\u2013298","journal-title":"Molecular cell"},{"key":"227_CR50","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.1073\/pnas.130189697","volume":"97","author":"K Yoda","year":"2000","unstructured":"Yoda K, Ando S, Morishita S, Houmura K, Hashimoto K, Takeyasu K, Okazaki T (2000) Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro. Proc Natl Acad Sci USA 97:7266\u20137271","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Chromosoma"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00412-009-0227-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00412-009-0227-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00412-009-0227-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:52:22Z","timestamp":1559069542000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00412-009-0227-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,10]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["227"],"URL":"https:\/\/doi.org\/10.1007\/s00412-009-0227-3","relation":{},"ISSN":["0009-5915","1432-0886"],"issn-type":[{"value":"0009-5915","type":"print"},{"value":"1432-0886","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,10]]}}}