{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:23:54Z","timestamp":1748219034760,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MEC-NEU\/31195\/2017"],"award-info":[{"award-number":["PTDC\/MEC-NEU\/31195\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Santa Casa da Miseric\u00f3rdia de Lisboa","award":["Pr\u00e9mio Jo\u00e3o Lobo Antunes 2017"],"award-info":[{"award-number":["Pr\u00e9mio Jo\u00e3o Lobo Antunes 2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00415-020-09818-z","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T13:03:24Z","timestamp":1586178204000},"page":"2123-2129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diaphragmatic CMAP amplitude from phrenic nerve stimulation predicts functional decline in ALS"],"prefix":"10.1007","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4660-6051","authenticated-orcid":false,"given":"Bruno","family":"Miranda","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-4579","authenticated-orcid":false,"given":"Marta","family":"Gromicho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-6476","authenticated-orcid":false,"given":"Mariana","family":"Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-5897","authenticated-orcid":false,"given":"Susana","family":"Pinto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-8914","authenticated-orcid":false,"given":"Michael","family":"Swash","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0158","authenticated-orcid":false,"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"9818_CR1","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","volume":"377","author":"MC Kiernan","year":"2011","unstructured":"Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O et al (2011) Amyotrophic lateral sclerosis. Lancet 377:942\u2013955","journal-title":"Lancet"},{"key":"9818_CR2","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/17482960802566824","volume":"10","author":"A Chi\u00f2","year":"2009","unstructured":"Chi\u00f2 A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E et al (2009) Prognostic factors in ALS: a critical review. Amyotroph Lateral Scler 10:310\u2013323","journal-title":"Amyotroph Lateral Scler"},{"key":"9818_CR3","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00415-014-7564-8","volume":"262","author":"H Creemers","year":"2014","unstructured":"Creemers H, Grupstra H, Nollet F, van den Berg LH, Beelen A (2014) Prognostic factors for the course of functional status of patients with ALS: a systematic review. J Neurol 262:1407\u20131423","journal-title":"J Neurol"},{"key":"9818_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nrneurol.2011.151","volume":"7","author":"R Bowser","year":"2011","unstructured":"Bowser R, Turner MR, Shefner J (2011) Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations. Nat Rev Neurol 7:631\u2013638","journal-title":"Nat Rev Neurol"},{"key":"9818_CR5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/ana.24273","volume":"76","author":"NG Simon","year":"2014","unstructured":"Simon NG, Turner MR, Vucic S, Al-Chalabi A, Shefner J, Lomen-Hoerth C et al (2014) Quantifying disease progression in amyotrophic lateral sclerosis. Ann Neurol 76:643\u2013657","journal-title":"Ann Neurol"},{"key":"9818_CR6","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3109\/21678421.2012.762930","volume":"14","author":"JD Berry","year":"2013","unstructured":"Berry JD, Miller R, Moore DH, Cudkowicz ME, van den Berg LH, Kerr DA et al (2013) The combined assessment of function and survival (CAFS): a new endpoint for ALS clinical trials. Amyotroph Lateral Scler Frontotemporal Degener 14:162\u2013168","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"9818_CR7","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1136\/jnnp-2014-310176","volume":"86","author":"I Tramacere","year":"2015","unstructured":"Tramacere I, Dalla Bella E, Chio A, Mora G, Filippini G, Lauria G et al (2015) The MITOS system predicts long-term survival in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 86:1180\u20131185","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9818_CR8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3109\/21678421.2016.1140786","volume":"17","author":"M Proudfoot","year":"2016","unstructured":"Proudfoot M, Jones A, Talbot K, Al-Chalabi A, Turner MR (2016) The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset. Amyotroph Lateral Scler Frontotemporal Degener 17:414\u2013425","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"9818_CR9","doi-asserted-by":"publisher","first-page":"e1610","DOI":"10.1212\/WNL.0000000000007242","volume":"92","author":"LH van den Berg","year":"2019","unstructured":"van den Berg LH, Sorensen E, Gronseth G et al (2019) Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials. Neurology 92:e1610\u2013e1623","journal-title":"Neurology"},{"key":"9818_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","volume":"169","author":"JM Cedarbaum","year":"1999","unstructured":"Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B et al (1999) The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci 169:13\u201321","journal-title":"J Neurol Sci"},{"key":"9818_CR11","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1002\/mus.10090","volume":"25","author":"T Magnus","year":"2002","unstructured":"Magnus T, Beck M, Giess R, Puls I, Naumann M, Toyka KV (2002) Disease progression in amyotrophic lateral sclerosis: predictors of survival. Muscle Nerve 25:709\u2013714","journal-title":"Muscle Nerve"},{"key":"9818_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1212\/01.WNL.0000148648.38313.64","volume":"64","author":"P Kaufmann","year":"2005","unstructured":"Kaufmann P, Levy G, Thompson JL, Delbene ML, Battista V, Gordon PH et al (2005) The ALSFRS-R predicts survival time in an ALS clinic population. Neurology 64:38\u201343","journal-title":"Neurology"},{"key":"9818_CR13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1212\/01.wnl.0000194316.91908.8a","volume":"66","author":"F Kimura","year":"2006","unstructured":"Kimura F, Fujimura C, Ishida S, Nakajima H, Furutama D, Uehara H et al (2006) Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS. Neurology 66:265\u2013267","journal-title":"Neurology"},{"key":"9818_CR14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/17482960701656940","volume":"9","author":"P Corcia","year":"2008","unstructured":"Corcia P, Pradat PF, Salachas F, Bruneteau G, Le Forestier N, Seilhean D et al (2008) Causes of death in a post-mortem series of ALS patients. Amyotroph Lateral Scler 9:59\u201362","journal-title":"Amyotroph Lateral Scler"},{"key":"9818_CR15","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","volume":"73","author":"RG Miller","year":"2009","unstructured":"Miller RG, Jackson CE, Kasarskis EJ, England JD, Forshew D, Johnston W et al (2009) Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 73:1218\u20131226","journal-title":"Neurology"},{"key":"9818_CR16","doi-asserted-by":"crossref","unstructured":"EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis, Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, Van Damme P et al (2012) EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)\u2014revised report of an EFNS task force. Eur J Neurol 19:360\u2013375","DOI":"10.1111\/j.1468-1331.2011.03501.x"},{"key":"9818_CR17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1001\/archneur.1979.00500380044004","volume":"36","author":"RJ Fallat","year":"1979","unstructured":"Fallat RJ, Jewitt B, Bass M, Kamm B, Norris F (1979) Spirometry in amyotrophic lateral sclerosis. Arch Neurol 36:74\u201380","journal-title":"Arch Neurol"},{"key":"9818_CR18","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1212\/01.WNL.0000144345.49510.4E","volume":"63","author":"BJ Traynor","year":"2004","unstructured":"Traynor BJ, Zhang H, Shefner JM, Schoenfeld D, Cudkowicz ME (2004) Functional outcome measures as clinical trial endpoints in ALS. Neurology 63:1933\u20131935","journal-title":"Neurology"},{"key":"9818_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3109\/17482960902991773","volume":"11","author":"F Baumann","year":"2010","unstructured":"Baumann F, Henderson RD, Morrison SC, Brown M, Hutchinson N, Douglas JA et al (2010) Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 11:194\u2013202","journal-title":"Amyotroph Lateral Scler"},{"key":"9818_CR20","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1378\/chest.103.2.508","volume":"103","author":"PL Schiffman","year":"1993","unstructured":"Schiffman PL, Belsh JM (1993) Pulmonary function at diagnosis of amyotrophic lateral sclerosis: rate of deterioration. Chest 103:508\u2013513","journal-title":"Chest"},{"key":"9818_CR21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1136\/jnnp.2005.072660","volume":"77","author":"A Czaplinski","year":"2006","unstructured":"Czaplinski A, Yen AA, Appel SH (2006) Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population. J Neurol Neurosurg Psychiatry 77:390\u2013392","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9818_CR22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S1474-4422(18)30089-9","volume":"17","author":"HJ Westeneng","year":"2018","unstructured":"Westeneng HJ, Debray TPA, Visser AE et al (2018) Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model. Lancet Neurol 17:423\u2013433","journal-title":"Lancet Neurol"},{"key":"9818_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2217\/nmt.13.74","volume":"4","author":"S Pinto","year":"2014","unstructured":"Pinto S, de Carvalho M (2014) Breathing new life into treatment advances for respiratory failure in amyotrophic lateral sclerosis patients. Neurodegener Dis Manag 4:83\u2013102","journal-title":"Neurodegener Dis Manag"},{"key":"9818_CR24","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1080\/17482960701249340","volume":"8","author":"S Pinto","year":"2007","unstructured":"Pinto S, Pinto A, Atalaia A, Peralta R, De Carvalho M (2007) Respiratory apraxia in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 8:180\u2013184","journal-title":"Amyotroph Lateral Scler"},{"key":"9818_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0022-510X(95)00057-9","volume":"129","author":"T Evangelista","year":"1995","unstructured":"Evangelista T, de Carvalho M, Pinto A, Sales-Luis ML (1995) Phrenic nerve conduction in amyotrophic lateral sclerosis. J Neurol Sci 129:35\u201337","journal-title":"J Neurol Sci"},{"key":"9818_CR26","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.clinph.2017.11.019","volume":"129","author":"M de Carvalho","year":"2018","unstructured":"de Carvalho M, Pinto S, Swash M (2018) Diaphragm motor responses to phrenic nerve stimulation in ALS: surface and needle recordings. Clin Neurophysiol 129:349\u2013353","journal-title":"Clin Neurophysiol"},{"key":"9818_CR27","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1016\/j.clinph.2009.08.025","volume":"120","author":"S Pinto","year":"2009","unstructured":"Pinto S, Geraldes R, Vaz N, Pinto A, de Carvalho M (2009) Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis: longitudinal study. Clin Neurophysiol 120:2082\u20132085","journal-title":"Clin Neurophysiol"},{"key":"9818_CR28","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1016\/j.clinph.2012.05.012","volume":"123","author":"S Pinto","year":"2012","unstructured":"Pinto S, Pinto A, de Carvalho M (2012) Phrenic nerve studies predict survival in amyotrophic lateral sclerosis. Clin Neurophysiol 123:2454\u20132459","journal-title":"Clin Neurophysiol"},{"key":"9818_CR29","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.clinph.2009.02.170","volume":"120","author":"S Pinto","year":"2009","unstructured":"Pinto S, Turkman A, Pinto A, Swash M, de Carvalho M (2009) Predicting respiratory insufficiency in amyotrophic lateral sclerosis: the role of phrenic nerve studies. Clin Neurophysiol 120:941\u2013946","journal-title":"Clin Neurophysiol"},{"key":"9818_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fneur.2019.00143","volume":"10","author":"M de Carvalho","year":"2019","unstructured":"de Carvalho M, Swash M, Pinto S (2019) Diaphragmatic neurophysiology and respiratory markers in ALS. Front Neurol 10:143","journal-title":"Front Neurol"},{"key":"9818_CR31","doi-asserted-by":"crossref","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron Diseases (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:293\u2013299","DOI":"10.1080\/146608200300079536"},{"key":"9818_CR32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","volume":"119","author":"M de Carvalho","year":"2008","unstructured":"de Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura J et al (2008) Electrodiagnostic criteria for diagnosis of ALS. Clin Neurophysiol 119:497\u2013503","journal-title":"Clin Neurophysiol"},{"key":"9818_CR33","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1002\/mus.21816","volume":"42","author":"S Pinto","year":"2010","unstructured":"Pinto S, de Carvalho M (2010) Symmetry of phrenic nerve motor response in amyotrophic lateral sclerosis. Muscle Nerve 42:882\u2013884","journal-title":"Muscle Nerve"},{"key":"9818_CR34","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1080\/21678421.2017.1354995","volume":"18","author":"S Pinto","year":"2017","unstructured":"Pinto S, de Carvalho M (2017) Comparison of slow and forced vital capacities on ability to predict survival in ALS. Amyotroph Lateral Scler Frontotemporal Degener 18:528\u2013533","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"9818_CR35","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","volume":"16","author":"K Abe","year":"2017","unstructured":"Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M et al (2017) Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16:505\u2013512","journal-title":"Lancet Neurol"},{"key":"9818_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09751-1","author":"A Calvo","year":"2020","unstructured":"Calvo A, Vasta R, Moglia C et al (2020) Prognostic role of slow vital capacity in amyotrophic lateral sclerosis. J Neurol. https:\/\/doi.org\/10.1007\/s00415-020-09751-1","journal-title":"J Neurol"},{"key":"9818_CR37","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1093\/brain\/124.10.2000","volume":"124","author":"RA Lyall","year":"2001","unstructured":"Lyall RA, Donaldson N, Polkey MI, Leigh PN, Moxham J (2001) Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis. Brain 124:2000\u20132013","journal-title":"Brain"},{"key":"9818_CR38","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.clinph.2020.02.010","volume":"131","author":"MC Torrieri","year":"2020","unstructured":"Torrieri MC, Miranda B, Gromicho M, Pinto S, de Carvalho M (2020) Reliability of phrenic nerve conduction study: In healthy controls and in patients with primary lateral sclerosis. Clin Neurophysiol 131:994\u2013999","journal-title":"Clin Neurophysiol"},{"key":"9818_CR39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/14660820410020600","volume":"6","author":"M de Carvalho","year":"2005","unstructured":"de Carvalho M, Chio A, Dengler R, Hecht M, Weber M, Swash M (2005) Neurophysiological measures in amyotrophic lateral sclerosis: markers of progression in clinical trials. Amyotroph Lateral Scler 6:17\u201328","journal-title":"Amyotroph Lateral Scler"},{"key":"9818_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.05.012","author":"B Cao","year":"2019","unstructured":"Cao B, Wei Q, Ou R, Zhang L, Hou Y, Chen Y, Shang H (2019) Neurophysiological index is associated with the survival of patients with amyotrophic lateral sclerosis. Clin Neurophysiol. https:\/\/doi.org\/10.1016\/j.clinph.2019.05.012","journal-title":"Clin Neurophysiol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-020-09818-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-020-09818-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-020-09818-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T23:28:52Z","timestamp":1617665332000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-020-09818-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["9818"],"URL":"https:\/\/doi.org\/10.1007\/s00415-020-09818-z","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"type":"print","value":"0340-5354"},{"type":"electronic","value":"1432-1459"}],"subject":[],"published":{"date-parts":[[2020,4,6]]},"assertion":[{"value":"3 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None of the authors has potential conflicts of interest to be disclosed regarding this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Local ethics committee approved the protocol.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All subjects gave informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}