{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:58:02Z","timestamp":1775159882587,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Jan Wouter ten Cate Prize","award":["2021"],"award-info":[{"award-number":["2021"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The incidence and outcomes of seizures among patients with severe cerebral venous thrombosis treated with decompressive surgery are unknown as are potential predictors of seizures in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We report data from a multicenter, consecutive cohort including patients with cerebral venous thrombosis treated with decompressive surgery from 15 hospitals in 10 different countries between December 2011 and December 2019. We analyzed the cumulative incidence of seizures within one year after decompressive surgery and performed an exploratory analysis of potential factors associated with the incidence of post-surgery seizures, adjusted for competing mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 116 included patients (median age 38 years [IQR 27\u201346], 68% female), 26 (22%) had seizures within one year after decompressive surgery. The mortality-adjusted cumulative one-year incidence of a first seizure after surgery was 23% (95% CI 16\u201331). Only aphasia at presentation predicted post-surgery seizures. Among patients who had a post-surgery seizure, the first seizure occurred despite active treatment with anti-seizure medications in 83% of patients. Recurrent seizures within the first year after surgery were reported in 63% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>Despite extensive use of anti-seizure medications, in patients with cerebral venous thrombosis treated with decompressive surgery the rate of seizures was 23% (95% CI 16\u201331) within one year after surgery. Of the patients who had a seizure after surgery, 63% had a recurrent seizure within the first year post-surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-025-13410-8","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:19:29Z","timestamp":1760098769000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Seizures after decompressive surgery for cerebral venous thrombosis"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5614-9689","authenticated-orcid":false,"given":"Mayte","family":"Sanchez van Kammen","sequence":"first","affiliation":[]},{"given":"Sanjit","family":"Aaron","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-7597","authenticated-orcid":false,"given":"Jorge M.","family":"Ferreira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-0416","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Canh\u00e3o","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-3490","authenticated-orcid":false,"given":"Adriana B.","family":"Conforto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-4138","authenticated-orcid":false,"given":"Antonio","family":"Arauz","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-9287","authenticated-orcid":false,"given":"Marta","family":"Carvalho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-0943","authenticated-orcid":false,"given":"Jaime","family":"Masjuan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-5696","authenticated-orcid":false,"given":"Vijay K.","family":"Sharma","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-6104","authenticated-orcid":false,"given":"Jukka","family":"Putaala","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-4456","authenticated-orcid":false,"given":"Maarten","family":"Uyttenboogaart","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1861","authenticated-orcid":false,"given":"David J.","family":"Werring","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3872-308X","authenticated-orcid":false,"given":"Rodrigo","family":"Bazan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-4900","authenticated-orcid":false,"given":"Sandeep","family":"Mohindra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5891-4688","authenticated-orcid":false,"given":"Jochen","family":"Weber","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-031X","authenticated-orcid":false,"given":"Bert A.","family":"Coert","sequence":"additional","affiliation":[]},{"given":"Prabhu","family":"Kirubakaran","sequence":"additional","affiliation":[]},{"given":"Pankaj","family":"Singh","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-7924","authenticated-orcid":false,"given":"Diana","family":"Aguiar de Sousa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-982X","authenticated-orcid":false,"given":"Jonathan M.","family":"Coutinho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-9097","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Ferro","sequence":"additional","affiliation":[]},{"name":"on behalf of the DECOMPRESS-2 Study Group","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"issue":"10","key":"13410_CR1","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/ene.13381","volume":"24","author":"JM Ferro","year":"2017","unstructured":"Ferro JM, Bousser MG, Canhao P et al (2017) European stroke organization guideline for the diagnosis and treatment of cerebral venous thrombosis\u2014endorsed by the European academy of neurology. 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Dr Werring reports grant funding from the Stroke Association and British Heart Foundation, speaking honoraria from Bayer, speaking and chairing honoraria from Alexion and NovoNordisk, and consultancy fees from Alnylam, Bayer, and NovoNordisk. Dr Aguiar de Sousa reports personal fees for AstraZeneca, Organon, and Johnson & Johnson advisory board participation, DSMB participation for the SECRET trial (University of British Columbia), and speaking fees from Astrazeneca and Bial. Dr Coutinho reports grants paid to his institution from Boehringer Ingelheim and Bayer. Dr Ferro reports personal fees from Bayer. The other authors report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was obtained from the ethics committee of Hospital de Santa Maria in Lisbon, Portugal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent for the use of pseudonymized care data was obtained if required according to local laws and regulations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"685"}}