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J.N.M. is a member of the scientific Advisory Board of Alcon. R.S. is a member of the Advisory Board for Bayer, Allergan, Novartis, Alcon, THEA and Alimera. The remaining authors have no conflict of interest to disclose. None of the authors has any financial or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study were in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments and this research project was approved by the institutional research committee of <i>Centro Hospitalar e Universit\u00e1rio de Coimbra<\/i> (CHUC).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Oral and written informed consent was obtained from all individual participants included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}