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All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 455 infants were included in the study. The median GA was 29.6\u00a0weeks, and the median birth weight was 1295\u00a0g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), hemoglobin (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), hematocrit (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), mean corpuscular hemoglobin concentration (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), lymphocytes (<jats:italic>p<\/jats:italic>\u2009=\u20090.035), and platelets (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (<jats:italic>p<\/jats:italic>\u2009=\u20090.044), red blood cell distribution width (RDW) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), erythroblasts (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), neutrophils (<jats:italic>p<\/jats:italic>\u2009=\u20090.030), neutrophils-lymphocytes ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.028), and basophils (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-023-06072-7","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T10:02:17Z","timestamp":1683021737000},"page":"2997-3006","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study"],"prefix":"10.1007","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1875-6581","authenticated-orcid":false,"given":"Mariza","family":"Fevereiro-Martins","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-4648","authenticated-orcid":false,"given":"Ana 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Written informed consent was obtained from the parents of all infants included in the study. This article does not contain any studies with animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors (Mariza Fevereiro-Martins, Ana Carolina Santos, Carlos Marques-Neves, Herc\u00edlia Guimar\u00e3es, Manuel Bicho) declare no conflicts of interest. Mariza Fevereiro-Martins received a research fund from the company CUF and the Portuguese Society of Ophthalmology for the conduct of the present study. The funding body did not influence the design, data interpretation, or conclusions of this study. No proprietary interest is involved in any author of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}