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Clinical data including demographics, genetic results and best-corrected visual acuity (BCVA) at baseline and follow-up were collected. Horizontal and vertical SD-OCT scans were analyzed by 2 independent graders. Outer nuclear layer (ONL) thickness and ellipsoid zone (EZ) width were manually measured in horizontal and vertical scans. HRF were classified according to location: outer retinal layers within the central 3mm (central-HRF), outer retinal layers beyond the central 3mm (perifoveal-HRF), and choroid (choroidal-HRF). Central macular thickness (CMT), central point thickness (CPT) and choroidal thickness (CT) at baseline and follow-up were also recorded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 175 eyes from 94 RP patients (47.9% female, mean age 50.7\u00b115.5 years) were included, with a mean follow-up of 29.24\u00b17.17 months. Mean ETDRS (early treatment diabetic retinopathy study) BCVA decreased from 61.09\u00b123.54 to 56.09\u00b126.65 (<jats:italic>p<\/jats:italic>=0.082). At baseline, 72 eyes (41.1%) showed central-HRF, 110 eyes (62.9%) had perifoveal-HRF and 149 eyes (85.1%) exhibited choroidal-HRF. Central-HRF and perifoveal-HRF were associated with worse final BCVA, as well as greater BCVA deterioration (all <jats:italic>p<\/jats:italic>&lt;0.0029). Only central-HRF were associated with a worse final CMT (<jats:italic>p<\/jats:italic>&lt;0.001). Shorter EZ widths were associated with all types of HRF (<jats:italic>p<\/jats:italic>&lt;0.05). Perifoveal and choroidal-HRF predicted smaller final EZ areas (<jats:italic>p<\/jats:italic>&lt;0.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>HRF are highly prevalent in RP patients and appear to have a negative prognostic impact in visual function and EZ area.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06474-1","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T08:01:54Z","timestamp":1712304114000},"page":"2851-2858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic impact of hyperreflective foci in nonsyndromic retinitis pigmentosa"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-4252","authenticated-orcid":false,"given":"Raquel","family":"F\u00e9lix","sequence":"first","affiliation":[]},{"given":"Nuno","family":"Gouveia","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-1302","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Bernardes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8676-0833","authenticated-orcid":false,"given":"Rufino","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-5176","authenticated-orcid":false,"given":"Joaquim","family":"Murta","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-0483","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"6474_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","volume":"66","author":"SK Verbakel","year":"2018","unstructured":"Verbakel SK, van Huet RAC, Boon CJF et al (2018) Non-syndromic retinitis pigmentosa. 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