{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:59Z","timestamp":1762100459166},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,1,13]],"date-time":"2006-01-13T00:00:00Z","timestamp":1137110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1007\/s00418-005-0125-6","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T11:24:44Z","timestamp":1137065084000},"page":"89-101","source":"Crossref","is-referenced-by-count":17,"title":["Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal and vascular systems"],"prefix":"10.1007","volume":"126","author":[{"given":"J. B.","family":"Ortiz-Delgado","sequence":"first","affiliation":[]},{"given":"D. C.","family":"Simes","sequence":"additional","affiliation":[]},{"given":"C. S. B.","family":"Viegas","sequence":"additional","affiliation":[]},{"given":"B. J.","family":"Schaff","sequence":"additional","affiliation":[]},{"given":"C.","family":"Sarasquete","sequence":"additional","affiliation":[]},{"given":"M. L.","family":"Cancela","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2006,1,13]]},"reference":[{"key":"125_CR1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4081\/1638","volume":"45","author":"JM Arellano","year":"2001","unstructured":"Arellano JM, Storch V, Sarasquete C (2001) A histological and histochemical study of the oesophagus and oesogaster of the senegal sole Solea senegalensis. Eur J Histochem 45:279\u2013294","journal-title":"Eur J Histochem"},{"key":"125_CR2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1182\/blood.V88.7.2585.bloodjournal8872585","volume":"88","author":"JA Bristol","year":"1996","unstructured":"Bristol JA, Ratcliffe JV, Roth DA, Jacobs MA, Furie BC, Furie B (1996) Biosynthesis of prothrombin: intracellular localization of the vitamin K-dependent carboxylase and the sites of gamma-carboxylation. Blood 88:2585\u20132593","journal-title":"Blood"},{"key":"125_CR3","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1359\/jbmr.2001.16.9.1611","volume":"16","author":"ML Cancela","year":"2001","unstructured":"Cancela ML, Williamson MK, Ohresser MCP, Reia JP, Price PA (2001) Matrix Gla Protein in Xenopus laevis: molecular cloning, tissue distribution and evolutionary considerations. J Bone Miner Res 16:1611\u20131621","journal-title":"J Bone Miner Res"},{"key":"125_CR4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1399-3011.1995.tb01076.x","volume":"46","author":"ML Cancela","year":"1995","unstructured":"Cancela ML, Williamson MK, Price PA (1995) Amino-acid sequence of Bone Gla Protein from the African clawed toad Xenopus laevis and the fish Sparus aurata. Int J Peptide Protein Res 46:419\u2013423","journal-title":"Int J Peptide Protein Res"},{"key":"125_CR5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jbmr.5650080110","volume":"8","author":"CS Carlson","year":"1993","unstructured":"Carlson CS, Tracy RP, Mann KG, Adams MR (1993) Immunolocalization of noncollagenous bone matrix proteins in lumbar vertebrae from intact and surgically menopausal cynomolgus monkeys. J Bone Miner Res 8:71\u201381","journal-title":"J Bone Miner Res"},{"key":"125_CR6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N (1987) Single step method of RNA isolation by acid guanidinium thiocyanate\u2013phenol\u2013chloroform extraction. Anal Biochem 162:156\u2013159","journal-title":"Anal Biochem"},{"key":"125_CR7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF02041246","volume":"47","author":"G Dingerkus","year":"1991","unstructured":"Dingerkus G, Seret B, Guilbert E (1991) Multiple prismatic calcium phosphate layers in the jaws of present-day sharks (Chondrichthyes; Selachii). Experientia 47:38\u201340","journal-title":"Experientia"},{"key":"125_CR8","doi-asserted-by":"crossref","first-page":"11033","DOI":"10.1016\/S0021-9258(18)37912-2","volume":"263","author":"JD Fraser","year":"1988","unstructured":"Fraser JD, Price PA (1988) Lung, heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla protein. Implications for the possible functions of matrix Gla protein and for the tissue distribution of the gamma-carboxylase. J Biol Chem 263:11033\u201311036","journal-title":"J Biol Chem"},{"key":"125_CR9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90567-3","volume":"53","author":"B Furie","year":"1988","unstructured":"Furie B, Furie BC (1988) The molecular basis of blood coagulation. Cell 53:505\u2013518","journal-title":"Cell"},{"key":"125_CR10","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1016\/S0021-9258(18)60639-8","volume":"263","author":"JE Hale","year":"1988","unstructured":"Hale JE, Fraser JD, Price PA (1988) The identification of Matrix Gla Protein in cartilage. J Biol Chem 263:5820\u20135824","journal-title":"J Biol Chem"},{"key":"125_CR11","doi-asserted-by":"crossref","first-page":"21145","DOI":"10.1016\/S0021-9258(18)54832-8","volume":"266","author":"JE Hale","year":"1991","unstructured":"Hale JE, Mattew KW, Price PA (1991) Carboxyl-terminal proteolytic processing of matrix Gla protein. J Biol Chem 266:21145\u201321149","journal-title":"J Biol Chem"},{"key":"125_CR12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0003-9969(01)00022-X","volume":"46","author":"F Hashimoto","year":"2001","unstructured":"Hashimoto F, Kobayashi Y, Kobayashi ET, Sakai E, Kobayashi K, Shibata M, Kato Y, Sakai H (2001) Expression and localization of MGP in rat tooth cementum. Arch Oral Biol 46:585\u2013592","journal-title":"Arch Oral Biol"},{"key":"125_CR13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0022-2836(84)90192-X","volume":"173","author":"G Heijne","year":"1984","unstructured":"Heijne G (1984) How signal sequences maintain cleavage specificity. J Mol Biol 173:243\u2013251","journal-title":"J Mol Biol"},{"key":"125_CR14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajmg.a.30680","volume":"135","author":"DJ Hur","year":"2005","unstructured":"Hur DJ, Raymond GV, Kahler SG, Riegert-Johnson DL, Cohen BA, Boyadjiev SA (2005) A novel MGP mutation in a consanguineous family: review of the clinical and molecular characteristics of Keutel syndrome. Am J Med Genet A 135:36\u201340","journal-title":"Am J Med Genet A"},{"key":"125_CR15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jmor.1051600106","volume":"160","author":"NE Kemp","year":"1979","unstructured":"Kemp NE, Westrin SK (1979) Ultrastructure of calcified cartilage in the endoskeletal tissue of sharks. J Morphol 160:75\u2013109","journal-title":"J Morphol"},{"key":"125_CR16","doi-asserted-by":"crossref","first-page":"26659","DOI":"10.1074\/jbc.M500257200","volume":"280","author":"V Laize","year":"2005","unstructured":"Laize V, Martel P, Viegas CS, Price PA, Cancela ML (2005) Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem 280:26659\u201326668","journal-title":"J Biol Chem"},{"key":"125_CR17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/386078a0","volume":"386","author":"G Luo","year":"1997","unstructured":"Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (1997) Spontaneous calcification of arteries and cartilage in mice lacking Matrix Gla Protein. Nature 386:78\u201381","journal-title":"Nature"},{"key":"125_CR18","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1183\/09031936.01.17305660","volume":"17","author":"M Meier","year":"2001","unstructured":"Meier M, Weng LP, Alexandrakis E, Ruschoff J, Goeckenjan G (2001) Tracheobronchial stenosis in Keutel syndrome. Eur Respir J 17:566\u2013569","journal-title":"Eur Respir J"},{"key":"125_CR19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/5102","volume":"21","author":"PB Munroe","year":"1999","unstructured":"Munroe PB, Olgunturk RO, Fryns J-P, Maldergem LV, Ziereisen F, Yuksel B, Gardiner RM, Chung E (1999) Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Nat Genet 21:142\u2013144","journal-title":"Nat Genet"},{"key":"125_CR20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1083\/jcb.200402046","volume":"165","author":"M Murshed","year":"2004","unstructured":"Murshed M, Schinke T, McKee MD, Karsenty G (2004) Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 165:625\u2013630","journal-title":"J Cell Biol"},{"key":"125_CR21","first-page":"73","volume":"292","author":"J Peignoux-Deville","year":"1981","unstructured":"Peignoux-Deville J, Lallier F, Vidal B (1981) Demonstration of bone tissue in the axial skeleton of a chondrichthian: the dogfish (Scyliorhinus canicula). C R Seances Acad Sci III 292:73\u201378","journal-title":"C R Seances Acad Sci III"},{"key":"125_CR22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00213858","volume":"222","author":"J Peignoux-Deville","year":"1982","unstructured":"Peignoux-Deville J, Lallier F, Vidal B (1982) Evidence for the presence of osseous tissue in dogfish vertebrae. Cell Tissue Res 222:605\u2013614","journal-title":"Cell Tissue Res"},{"key":"125_CR23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S8756-3282(02)00981-X","volume":"32","author":"JP Pinto","year":"2003","unstructured":"Pinto JP, Concei\u00e7\u00e3o N, Gavaia P, Cancela ML (2003) Matrix Gla Protein gene expression and protein accumulation co-localized with cartilage distribution during development of the teleost fish Sparus aurata. Bone 32:201\u2013210","journal-title":"Bone"},{"key":"125_CR24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0378-1119(01)00426-7","volume":"270","author":"JP Pinto","year":"2001","unstructured":"Pinto JP, Ohresser MC, Cancela ML (2001) Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man. Gene 270:77\u201391","journal-title":"Gene"},{"key":"125_CR25","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/01.ATV.18.9.1400","volume":"18","author":"PA Price","year":"1998","unstructured":"Price PA, Faus SA, Williamson MK (1998) Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol 18:1400\u20131407","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"125_CR26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.ATV.20.2.317","volume":"20","author":"PA Price","year":"2000","unstructured":"Price PA, Faus SA, Williamson MK (2000) Warfarin-induced artery calcification is accelerated by growth and vitamin D. Arterioscler Thromb Vasc Biol 20:317\u2013327","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"125_CR27","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1073\/pnas.84.23.8335","volume":"84","author":"PA Price","year":"1987","unstructured":"Price PA, Fraser JD, Metz-Virca G (1987) Molecular cloning of Matrix Gla Protein: implications for substrate recognition by the vitamin K-dependent \u03b3-carboxylase. Proc Natl Acad Sci USA 84:8335\u20138339","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR28","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/pro.5560030511","volume":"3","author":"PA Price","year":"1994","unstructured":"Price PA, Rice JS, Williamson MK (1994) Conserved phosphorylation of serine in the Ser-X-Glu\/Ser(P) sequences of the vitamin K-dependent Matrix Gla Protein from shark, lamb, rat, cow and human. Protein Sci 3:822\u2013830","journal-title":"Protein Sci"},{"key":"125_CR29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0006-291X(83)91663-7","volume":"117","author":"PA Price","year":"1983","unstructured":"Price PA, Urist MR, Otawara Y (1983) Matrix Gla protein, a new \u03b3-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Biochem Biophys Res Commun 117:765\u2013771","journal-title":"Biochem Biophys Res Commun"},{"key":"125_CR30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/jbmr.5650090417","volume":"9","author":"JS Rice","year":"1994","unstructured":"Rice JS, Williamson MK, Price PA (1994) Isolation and sequence of the vitamin K-dependent Matrix Gla Protein from the calcified cartilage of the soupfin shark. J Bone Miner Res 9:567\u2013576","journal-title":"J Bone Miner Res"},{"key":"125_CR31","first-page":"407","volume":"14","author":"C Sarasquete","year":"1999","unstructured":"Sarasquete C, Mu\u00f1oz-Cueto JA, Ortiz JB, Rodrigues-G\u00f3mez FJ, Dinis MT, Segner H (1999) Immunocytochemical distribution of cytochrome P4501A (CYP1A). Histol Histophathol 14:407\u2013415","journal-title":"Histol Histophathol"},{"key":"125_CR32","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1172\/JCI117246","volume":"93","author":"CM Shanahan","year":"1994","unstructured":"Shanahan CM, Cary NRB, Metcalfe JC, Weissberg PL (1994) High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest 93:2393\u20132402","journal-title":"J Clin Invest"},{"key":"125_CR33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s003920070101","volume":"89","author":"CM Shanahan","year":"2000","unstructured":"Shanahan CM, Proudfoot D, Tyson KL, Cary NRB, Edmonds M, Weissberg PL (2000) Expression of mineralization-regulating proteins in association with human vascular calcification. Z Kardiol 89:63\u201368","journal-title":"Z Kardiol"},{"key":"125_CR34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1359\/jbmr.2003.18.2.244","volume":"18","author":"DC Simes","year":"2003","unstructured":"Simes DC, Williamson MK, Ortiz-Delgado JB, Viegas CSB, Cancela ML, Price PA (2003) Purification of Matrix Gla Protein (MGP) from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. J Bone Miner Res 18:244\u2013259","journal-title":"J Bone Miner Res"},{"key":"125_CR35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00223-003-0079-4","volume":"74","author":"DC Simes","year":"2004","unstructured":"Simes DC, Williamson MK, Schaff BJ, Gavaia PJ, Ingleton PM, Price PA, Cancela ML (2004) Characterization of osteocalcin (BGP) and matrix gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Calcif Tissue Res 74:170\u2013180","journal-title":"Calcif Tissue Res"},{"key":"125_CR36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.2001.5996","volume":"289","author":"HMH Spronk","year":"2001","unstructured":"Spronk HMH, Soute BAM, Schurgers LJ, Cleutjens JPM, Thijssen HHW, De Mey JGR, Vermeer C (2001) Matrix Gla Protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall. Biochem Biophys Res Commun 289:485\u2013490","journal-title":"Biochem Biophys Res Commun"},{"key":"125_CR37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ar.1092080202","volume":"208","author":"M Takagi","year":"1984","unstructured":"Takagi M, Parmley RT, Denys FR, Yagasaki H, Toda Y (1984) Ultrastructural cytochemistry of proteoglycans associated with calcification of shark cartilage. Anat Rec 208:149\u2013158","journal-title":"Anat Rec"},{"key":"125_CR38","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1055\/s-0037-1614911","volume":"82","author":"R Wallin","year":"1999","unstructured":"Wallin R, Cain D, Sane DC (1999) Matrix Gla Protein synthesis and gamma-carboxylation in the aortic vessel wall and proliferating vascular smooth muscle cells. Thromb Haemost 82:1764\u20131767","journal-title":"Thromb Haemost"},{"key":"125_CR39","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1126\/science.1749935","volume":"254","author":"SM Wu","year":"1991a","unstructured":"Wu SM, Cheung WF, Frazier D, Stafford DW (1991a) Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. Science 254:1634\u20131636","journal-title":"Science"},{"key":"125_CR40","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1073\/pnas.88.6.2236","volume":"88","author":"SM Wu","year":"1991b","unstructured":"Wu SM, Morris DP, Stafford DW (1991b) Identification and purification to near homogeneity of the vitamin K-dependent carboxylase. Proc Natl Acad Sci USA 88:2236\u20132240","journal-title":"Proc Natl Acad Sci USA"},{"key":"125_CR41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1083\/jcb.147.5.1097","volume":"147","author":"K Yagami","year":"1999","unstructured":"Yagami K, Suh J-Y, Enomoto-Iwamoto M, Koyama E, Abrams WR, Shapiro IM, Pacifici M, Iwamoto M (1999) Matrix Gla protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. J Cell Biol 147:1097\u20131108","journal-title":"J Cell Biol"},{"key":"125_CR42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s002400050119","volume":"27","author":"T Yasui","year":"1999","unstructured":"Yasui T, Fujita K, Sasaki S, Sato M, Sugimoto M, Hirota S, Kitamura Y, Nomura S, Kohri K (1999) Expression of bone matrix proteins in urolithiasis model rats. Urol Res 27:255\u2013261","journal-title":"Urol Res"},{"key":"125_CR43","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1073\/pnas.120081897","volume":"97","author":"Z-F Yin","year":"2000","unstructured":"Yin Z-F, Huang Z-F, Cui J, Fiehler R, Iasky N, Ginsburg D, Broze GJJ (2000) Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci USA 97:6734\u20136738","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-005-0125-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00418-005-0125-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-005-0125-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T14:48:32Z","timestamp":1626965312000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00418-005-0125-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,13]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["125"],"URL":"https:\/\/doi.org\/10.1007\/s00418-005-0125-6","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,13]]}}}