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All were right-knee dominant and engaged in regular running. Sagittal T\n                      <jats:sub>2<\/jats:sub>\n                      -weighted Multi-Echo Spin-Echo images at 3\u00a0T were used to assess T\n                      <jats:sub>2<\/jats:sub>\n                      values pre-run, post-run, and one week later for global and compartmental KAC. Recovery programme included low-intensity running, strength training and rest. Repeated measures ANOVA or equivalent non-parametric tests with post-hoc comparisons compared T\n                      <jats:sub>2<\/jats:sub>\n                      values over time. Separate analyses were conducted based on laterality, gender and anatomical compartments. Significance was set at\u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post-run T\n                      <jats:sub>2<\/jats:sub>\n                      values decreased significantly by 0.9\u00a0ms (\u2212\u00a02.0%, p\u2009&lt;\u20090.001), with up to 5.3% reductions in medial tibial (MT) and femoral (MF) compartments. Recovery patterns varied by compartment, sex and laterality. Most compartments returned to baseline within one week; the lateral condyle (LatC) showed incomplete recovery (\u2212\u00a04.7%, Proportional Recovery Index (PRI)\u2009=\u2009\u2212\u00a00,1); the right knee\u2019s MT exhibited overcompensation (6.3%, PRI\u2009=\u20092.6). Males showed higher baseline T\n                      <jats:sub>2<\/jats:sub>\n                      values and more efficient recovery in the LatC compared to females (PRI\u2009=\u2009\u2212\u00a00.1 vs. \u2212\u00a00.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Half-marathon running induces reversible reductions in KAC hydration, with most compartments recovering or overcompensating within one week. Dictionary-matching T2 mapping offers a robust approach for monitoring cartilage integrity and guiding individualised recovery strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00421-025-05898-9","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:08:31Z","timestamp":1755936511000},"page":"811-824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of physiological changes in knee cartilage using parametric T2 relaxation maps estimated with a dictionary method"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-3289","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Coelho","sequence":"first","affiliation":[]},{"given":"Tiago T.","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Sandra M.","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Ad\u00e9lio","family":"Vila\u00e7a","sequence":"additional","affiliation":[]},{"given":"Rita G.","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Lu\u00edsa","family":"Nogueira","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"5898_CR1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/mrm.25156","volume":"73","author":"N Ben-Eliezer","year":"2015","unstructured":"Ben-Eliezer N, Sodickson DK, Block KT (2015) Rapid and accurate T2 mapping from multi\u2013spin-echo data using Bloch-simulation-based reconstruction. 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Approval was granted by Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio (CHUdSA), Unidade Local de Sa\u00fade de Santo Ant\u00f3nio Ethics Committee number 2018203 (178-DEFI \/ 177-CES).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participation"}},{"value":"Participants provided written consent for the publication of anonymized data collected as part of this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}