{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:20:21Z","timestamp":1770992421587,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,12,11]],"date-time":"2004-12-11T00:00:00Z","timestamp":1102723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1007\/s00428-004-1156-4","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T10:25:50Z","timestamp":1102674350000},"page":"181-184","source":"Crossref","is-referenced-by-count":34,"title":["Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family"],"prefix":"10.1007","volume":"446","author":[{"given":"Carla","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Herculano","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Seruca","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Cardoso de Oliveira","sequence":"additional","affiliation":[]},{"given":"F\ufffdtima","family":"Carneiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2004,12,11]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1136\/jmg.2004.018275","volume":"41","author":"Brooks-Wilson","year":"2004","unstructured":"Brooks-Wilson AR, Kaurah P, Suriano G, Leach S, Senz J, Grehan N, Butterfield YS, Jeyes J, Schinas J, Bacani J, Kelsey M, Ferreira P, MacGillivray B, MacLeod P, Micek M, Ford J, Foulkes W, Australie K, Greenberg C, LaPointe M, Gilpin C, Nikkel S, Gilchrist D, Hughes R, Jackson CE, Monaghan KG, Oliveira MJ, Seruca R, Gallinger S, Caldas C, Huntsman D (2004) Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. J Med Genet 41:508?517","journal-title":"J Med Genet"},{"key":"CR2","first-page":"873","volume":"36","author":"Caldas","year":"1999","unstructured":"Caldas C, Carneiro F, Lynch HT, Yokota J, Wiesner GL, Powell SM, Lewis FR, Huntsman DG, Pharoah PD, Jankowski JA, MacLeod P, Vogelsang H, Keller G, Park KG, Richards FM, Maher ER, Gayther SA, Oliveira C, Grehan N, Wight D, Seruca R, Roviello F, Ponder BA, Jackson CE (1999) Familial gastric cancer: overview and guidelines for management. J Med Genet 36:873?880","journal-title":"J Med Genet"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/path.1564","volume":"203","author":"Carneiro","year":"2004","unstructured":"Carneiro F, Huntsman DG, Smyrk TC, Owen DA, Seruca R, Pharoah P, Caldas C, Sobrinho-Sim\u00f5es M (2004) Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening. J Pathol 203:681?687","journal-title":"J Pathol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/gut.2002.010447","volume":"53","author":"Charlton","year":"2004","unstructured":"Charlton A, Blair V, Shaw D, Parry S, Guilford P, Martin IG (2004) Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut 53:814?820","journal-title":"Gut"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/gut.2003.022061","volume":"53","author":"Fitzgerald","year":"2004","unstructured":"Fitzgerald RC, Caldas C (2004) Clinical implications of E-cadherin associated hereditary diffuse gastric cancer. Gut 53:775?778","journal-title":"Gut"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/32918","volume":"392","author":"Guilford","year":"1998","unstructured":"Guilford P, Hopkins J, Harraway J, McLeod M, McLeod N, Harawira P, Taite H, Scoular R, Miller A, Reeve AE (1998) E-cadherin germline mutations in familial gastric cancer. Nature 392:402?405","journal-title":"Nature"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1056\/NEJM200106213442504","volume":"344","author":"Huntsman","year":"2001","unstructured":"Huntsman DG, Carneiro F, Lewis FR, MacLeod PM, Hayashi A, Monaghan KG, Maung R, Seruca R, Jackson CE, Caldas C (2001) Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. N Engl J Med 344:1904?1909","journal-title":"N Engl J Med"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.ejca.2004.04.027","volume":"40","author":"Oliveira","year":"2004","unstructured":"Oliveira C, Ferreira P, Nabais S, Campos L, Ferreira A, Cirnes L, Castro Alves C, Veiga I, Fragoso M, Regateiro F, Moreira Dias L, Moreira H, Suriano G, Carlos Machado J, Lopes C, Castedo S, Carneiro F, Seruca R (2004) E-cadherin (CDH1) and p53 rather than SMAD4 and caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. Eur J Cancer 40:1897?1903","journal-title":"Eur J Cancer"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1897-4287-2-2-51","volume":"2","author":"Oliveira","year":"2004","unstructured":"Oliveira C, Suriano G, Ferreira P, Canedo P, Kaurah P, Mateus R, Ferreira A, Ferreira AC, Oliveira MJ, Figueiredo C, Carneiro F, Keller G, Huntsman D, Machado JC, Seruca R (2004) Genetic screening for familial gastric cancer. Hereditary Cancer Clin Pract 2:51?64","journal-title":"Hereditary Cancer Clin Pract"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1053\/gast.2001.29611","volume":"121","author":"Pharoah","year":"2001","unstructured":"Pharoah PD, Guilford P, Caldas C, International Gastric Cancer Linkage Consortium (2001) Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology 121:1348?1353","journal-title":"Gastroenterology"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/hmg\/ddg048","volume":"12","author":"Suriano","year":"2003","unstructured":"Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R (2003) Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet 12:575?582","journal-title":"Hum Mol Genet"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1038\/sj.onc.1205577","volume":"21","author":"Vecsey-Semjen","year":"2002","unstructured":"Vecsey-Semjen B, Becker KF, Sinski A, Blennow E, Vietor I, Zatloukal K, Beug H, Wagner E, Huber LA (2002) Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers. Oncogene 21:4646?4662","journal-title":"Oncogene"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-004-1156-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00428-004-1156-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-004-1156-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:33:48Z","timestamp":1559079228000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00428-004-1156-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,11]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["1156"],"URL":"https:\/\/doi.org\/10.1007\/s00428-004-1156-4","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,11]]}}}