{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:40:49Z","timestamp":1776184849216,"version":"3.50.1"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Virchows Arch"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 2018, the European Society of Gynecological Oncology (ESGO) jointly with the European Society for Radiotherapy and Oncology (ESTRO) and the European Society of Pathology (ESP) published evidence-based guidelines for the management of patients with cervical cancer. Given the large body of new evidence addressing the management of cervical cancer, the three sister societies jointly decided to update these evidence-based guidelines. The update includes new topics to provide comprehensive guidelines on all relevant issues of diagnosis and treatment in cervical cancer.<\/jats:p><jats:p>To serve on the expert panel (27 experts across Europe) ESGO\/ESTRO\/ESP nominated practicing clinicians who are involved in managing patients with cervical cancer and have demonstrated leadership through their expertise in clinical care and research, national and international engagement, profile, and dedication to the topics addressed. To ensure the statements were evidence based, new data identified from a systematic search was reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the professional experience and consensus of the international development group. Before publication, the guidelines were reviewed by 155 independent international practitioners in cancer care delivery and patient representatives.<\/jats:p><jats:p>These updated guidelines are comprehensive and cover staging, management, follow-up, long-term survivorship, quality of life and palliative care. Management includes fertility sparing treatment, early and locally advanced cervical cancer, invasive cervical cancer diagnosed on a simple hysterectomy specimen, cervical cancer in pregnancy, rare tumors, recurrent and metastatic diseases. The management algorithms and the principles of radiotherapy and pathological evaluation are also defined.<\/jats:p>","DOI":"10.1007\/s00428-023-03552-3","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T06:02:29Z","timestamp":1683266549000},"page":"935-966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["ESGO\/ESTRO\/ESP Guidelines for the management of patients with cervical cancer \u2013 Update 2023*"],"prefix":"10.1007","volume":"482","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-9356","authenticated-orcid":false,"given":"David","family":"Cibula","sequence":"first","affiliation":[]},{"given":"Maria Rosaria","family":"Raspollini","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8709-0410","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Planchamp","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Centeno","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3695","authenticated-orcid":false,"given":"Cyrus","family":"Chargari","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Felix","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-3218","authenticated-orcid":false,"given":"Daniela","family":"Fischerov\u00e1","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Jahnn-Kuch","sequence":"additional","affiliation":[]},{"given":"Florence","family":"Joly","sequence":"additional","affiliation":[]},{"given":"Christhardt","family":"Kohler","sequence":"additional","affiliation":[]},{"given":"Sigurd","family":"Lax","sequence":"additional","affiliation":[]},{"given":"Domenica","family":"Lorusso","sequence":"additional","affiliation":[]},{"given":"Umesh","family":"Mahantshetty","sequence":"additional","affiliation":[]},{"given":"Patrice","family":"Mathevet","sequence":"additional","affiliation":[]},{"given":"Raj","family":"Naik","sequence":"additional","affiliation":[]},{"given":"Remi A.","family":"Nout","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-7194","authenticated-orcid":false,"given":"Ana","family":"Oaknin","sequence":"additional","affiliation":[]},{"given":"Fedro","family":"Peccatori","sequence":"additional","affiliation":[]},{"given":"Jan","family":"Persson","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-4812","authenticated-orcid":false,"given":"Denis","family":"Querleu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-5363","authenticated-orcid":false,"given":"Sandra Rubio","family":"Bernab\u00e9","sequence":"additional","affiliation":[]},{"given":"Maximilian P.","family":"Schmid","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-0004","authenticated-orcid":false,"given":"Artem","family":"Stepanyan","sequence":"additional","affiliation":[]},{"given":"Valentyn","family":"Svintsitskyi","sequence":"additional","affiliation":[]},{"given":"Karl","family":"Tamussino","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-7767","authenticated-orcid":false,"given":"Ignacio","family":"Zapardiel","sequence":"additional","affiliation":[]},{"given":"Jacob","family":"Lindegaard","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"3552_CR1","doi-asserted-by":"publisher","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","volume":"8","author":"M Arbyn","year":"2020","unstructured":"Arbyn M, Weiderpass E, Bruni L et al (2020) Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health 8:e191-203","journal-title":"Lancet Glob Health"},{"key":"3552_CR2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ejca.2021.07.039","volume":"157","author":"T Dyba","year":"2021","unstructured":"Dyba T, Randi G, Bray F et al (2021) The european cancer burden in 2020: incidence and mortality estimates for 40 countries and 25 major cancers. Eur J Cancer 157:308\u201347","journal-title":"Eur J Cancer"},{"key":"3552_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S1470-2045(20)30729-4","volume":"22","author":"M Das","year":"2021","unstructured":"Das M (2021) WHO launches strategy to accelerate elimination of cervical cancer. Lancet Oncol 22:20\u20131","journal-title":"Lancet Oncol"},{"key":"3552_CR4","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/IGC.0000000000001216","volume":"28","author":"D Cibula","year":"2018","unstructured":"Cibula D, P\u00f6tter R, Planchamp F et al (2018) The European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology\/European Society of Pathology Guidelines for the management of patients with cervical cancer. Int J Gynecol Cancer 28:641\u201355","journal-title":"Int J Gynecol Cancer"},{"key":"3552_CR5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.radonc.2018.03.003","volume":"127","author":"D Cibula","year":"2018","unstructured":"Cibula D, P\u00f6tter R, Planchamp F et al (2018) The European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology\/European Society of Pathology Guidelines for the management of patients with cervical cancer. Radiother Oncol 127:404\u201316","journal-title":"Radiother Oncol"},{"key":"3552_CR6","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s00428-018-2362-9","volume":"472","author":"D Cibula","year":"2018","unstructured":"Cibula D, P\u00f6tter R, Planchamp F et al (2018) The European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology\/European Society of Pathology guidelines for the management of patients with cervical cancer. Virchows Arch 472:919\u201336","journal-title":"Virchows Arch"},{"key":"3552_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1086\/321805","volume":"33","author":"CA Dykewicz","year":"2001","unstructured":"Dykewicz CA (2001) Summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clinical Infectious Diseases 33:139\u201344","journal-title":"Clinical Infectious Diseases"}],"container-title":["Virchows Archiv"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03552-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00428-023-03552-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00428-023-03552-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:27:40Z","timestamp":1686194860000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00428-023-03552-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["3552"],"URL":"https:\/\/doi.org\/10.1007\/s00428-023-03552-3","relation":{},"ISSN":["0945-6317","1432-2307"],"issn-type":[{"value":"0945-6317","type":"print"},{"value":"1432-2307","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,5]]},"assertion":[{"value":"20 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Initiated through the ESGO the decision to develop multidisciplinary guidelines was made jointly by the ESGO, ESTRO, and ESP. The ESGO provided administrative support. The ESGO, ESTRO and ESP are nonprofit knowledgeable societies. *These guidelines were developed by ESGO, ESTRO and ESP and are published in the Int J Gynecol Cancer, Radiother Oncol and Virchows Archiv.<b>Disclaimer<\/b><b>Map disclaimer<\/b>","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author note"}},{"value":"CCh has reported advisory boards for GSK, MSD and EISAI; SFL has reported advisory boards for MSD, GSK, AstraZeneca and Novartis; DL has reported consultant honoria from AstraZeneca, Clovis Oncology, GSK, MSD, Immunogen, Genmab, Amgen, Seagen and PharmaMar, advisory boards for AstraZeneca, Merck Serono, Seagen, Immunogen, Genmab, Oncoinvest, Corcept and Sutro, research institutional funding from Clovis Oncology, GSK, MSD and PharmaMar, research sponsored by AstraZeneca, Clovis Oncology, Genmab, GSK, Immunogen, Incyte, MSD, Roche, Seagen and Novartis, and speakers\u2019 bureau activities for AstraZeneca, Clovis Oncology, GSK, MSD and PharmaMar; UM has reported advisory boards for AstraZeneca (Steering committee member for CALLA Study); RN has reported research grants from Elekta, Varian, Accuray, Dutch Research Council, and Dutch Cancer Society; AO has reported personal fees for advisory board membersip from Agenus, AstraZeneca, Clovis Oncology, Corcept Therapeutics, Deciphera Pharmaceuticals, Eisai, EMD Serono, F. Hoffmann-La Roche, Genmab\/Seagen, GSK, ImmunoGen, Itheos, Merck Sharp & Dohme de Espana, SA, Mersana Thereapeutics, Novocure, PharmaMar, piIME Oncology, Roche, Sattucklabs, Sutro Biopharma and Tesaro, and personal fees for travel\/accomodation from AstraZeneca, PharmaMar and Roche; DQ has reported advisory boards for Mimark inc; MPS has reported research grants and personal fees for workshops from Elekta AB; DC, MRR, FP, CC, AF, DF, DJK, FJ, CK, PM, RN, FPec, JP, SR, AS, VS, KT, IZ and JCL have reported no conflicts of interest.<b>Patient and public involvement statement<\/b>","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not commissioned; internally peer reviewed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Provenance and peer review"}},{"value":"All data relevant to the study are included in the article or uploaded as supplementary information.<b>Data availability free text<\/b><b>Press Release<\/b>","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"David Cibula, Maria Rosaria Raspollini, Fran\u00e7ois Planchamp, Carlos Centeno, Cyrus Chargari, Ana Felix, Daniela Fischerova, Daniela Jahn-Kuch, Florence Joly, Christhardt Kohler, Sigurd F. Lax, Domenica Lorusso, Umesh Mahantshetty, Patrice Mathevet, Raj Naik, Remi Nout, Ana Oaknin, Fedro Peccatori, Jan Persson, Denis Querleu, Sandra Rubio, Maximilian Paul Schmid, Artem Stepanyan, Valentyn Svintsitskyi, Karl Tamussino, Ignacio Zapardiel, Jacob Christian Lindegaard.<b>Correction notice<\/b><b>Permission<\/b><b>Editor's note<\/b><b>Republishing<\/b><b>Guest Chief Editor<\/b><b>Deceased<\/b><b>Open data<\/b><b>Open material<\/b><b>Pre-registration<\/b><b>Commentary on<\/b><b>Review of<\/b><b>Commentary by<\/b><b>Series Editor<\/b><b>Addendum<\/b>","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Collaborators"}}]}}