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This statement is directed at pathology professionals, offering guidance for the safe implementation of digital pathology while emphasizing the necessity of standardization, quality control, and sustainability. Digital pathology involves automating and standardizing laboratory workflows to produce high-quality whole slide images (WSIs), which are crucial for diagnosis, research, and education. A successful digital transformation requires a multidisciplinary approach, significant investment in human, structural, and informatic resources, and progressive adaptation of laboratory workflows. Key components include robust infrastructure; continuous training; and clear policies for hardware renewal, data storage, and interoperability. The transition demands attention to quality and production control, ensuring efficient WSI generation and timely diagnostic reporting. ESP strongly recommends that pathology departments, supported by funding organizations, start to prioritize digital transformation as a step toward improved patient care and in alignment with global healthcare initiatives. 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AP consulted for IndicaLabs for the last 2\u00a0years. AR declares participation at advisory board meetings by Amgen, AstraZeneca, Bayer, BMS, EliLilly, Gilead, Merck, MSD, Roche and Sanofi, invited speaker role at meetings organized by Amgen, BMS, EliLily, Gilead, Sanofi, Pfizer and Bayer, and travel support provided by Gilead and Sanofi. JT declares participation at advisory board meetings by MSD. PvD declares participation at advisory board meetings by Visiopharm, Sectra and Paige AI. XMG declares lectures and associated travel expenses: Roche Pharma, Qiagen, Ferrer Internacional, Novartis, Menarini, Biocartis, Agilent-Dako, Leica, Reig Jofre, Sysmex, MSD, AstraZeneca, BMS, GSK, Clovis; Advisory boards: AstraZeneca, Lilly, Amgen, GSK, Janssen, Illumina, MSD. IZ serves as scientific advisor for Aiforia. Other authors declare no conflicts of interests. The declared interests by the authors are not related to published content.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}