{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:59:39Z","timestamp":1769579979068,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005856","name":"Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa","doi-asserted-by":"publisher","award":["UID\/Multi\/00709\/2013"],"award-info":[{"award-number":["UID\/Multi\/00709\/2013"]}],"id":[{"id":"10.13039\/501100005856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"COMPETE","doi-asserted-by":"crossref","award":["POCI-01-0145-FEDER-007491"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007491"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00430-018-0539-0","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T02:53:43Z","timestamp":1521428023000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Anti-Candida activity of antidepressants sertraline and fluoxetine: effect upon pre-formed biofilms"],"prefix":"10.1007","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-4386","authenticated-orcid":false,"given":"Ana S.","family":"Oliveira","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-0248","authenticated-orcid":false,"given":"Jos\u00e9","family":"Martinez-de-Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-6254","authenticated-orcid":false,"given":"Gilbert G. G.","family":"Donders","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-8355","authenticated-orcid":false,"given":"Rita","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-3769","authenticated-orcid":false,"given":"Ana","family":"Palmeira-de-Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"539_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","volume":"62","author":"JCO Sardi","year":"2013","unstructured":"Sardi JCO, Scorzoni L, Bernardi T et al (2013) Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol 62:10\u201324. https:\/\/doi.org\/10.1099\/jmm.0.045054-0","journal-title":"J Med Microbiol"},{"key":"539_CR2","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jep.2012.01.029","volume":"140","author":"A Palmeira-de-Oliveira","year":"2012","unstructured":"Palmeira-de-Oliveira A, Gaspar C, Palmeira-de-Oliveira R et al (2012) The anti-Candida activity of Thymbra capitata essential oil: effect upon pre-formed biofilm. J Ethnopharmacol 140:379\u2013383. https:\/\/doi.org\/10.1016\/j.jep.2012.01.029","journal-title":"J Ethnopharmacol"},{"key":"539_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.08.018","author":"AA Chavez-Dozal","year":"2013","unstructured":"Chavez-Dozal AA, Jahng M, Rane HS et al (2013) In vitro analysis of flufenamic acid activity against Candida albicans biofilms. Int J Antimicrob Agents. https:\/\/doi.org\/10.1016\/j.ijantimicag.2013.08.018","journal-title":"Int J Antimicrob Agents"},{"key":"539_CR4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.addr.2015.06.008","volume":"92","author":"R Palmeira-de-Oliveira","year":"2015","unstructured":"Palmeira-de-Oliveira R, Palmeira-de-Oliveira A, Martinez-de-Oliveira J (2015) New strategies for local treatment of vaginal infections. Adv Drug Deliv Rev 92:105\u2013122. https:\/\/doi.org\/10.1016\/j.addr.2015.06.008","journal-title":"Adv Drug Deliv Rev"},{"key":"539_CR5","doi-asserted-by":"crossref","unstructured":"Centers for Disease Control and Prevention (2010) Sexually transmitted diseases treatment guidelines, vol 59. Atlanta","DOI":"10.1093\/cid\/cir694"},{"key":"539_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1128\/AAC.00856-07","volume":"52","author":"A Katragkou","year":"2008","unstructured":"Katragkou A, Chatzimoschou A, Simitsopoulou M et al (2008) Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilms. Antimicrob Agents Chemother 52:357\u2013360. https:\/\/doi.org\/10.1128\/AAC.00856-07","journal-title":"Antimicrob Agents Chemother"},{"key":"539_CR7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1439-0507.2008.01550.x","volume":"52","author":"S Boreck\u00e1-Melkusov\u00e1","year":"2009","unstructured":"Boreck\u00e1-Melkusov\u00e1 S, Moran GP, Sullivan DJ et al (2009) The expression of genes involved in the ergosterol biosynthesis pathway in Candida albicans and Candida dubliniensis biofilms exposed to fluconazole. Mycoses 52:118\u2013128. https:\/\/doi.org\/10.1111\/j.1439-0507.2008.01550.x","journal-title":"Mycoses"},{"key":"539_CR8","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1111\/j.1462-5822.2006.00761.x","volume":"8","author":"CJ Nobile","year":"2006","unstructured":"Nobile CJ, Mitchell AP (2006) Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol 8:1382\u20131391. https:\/\/doi.org\/10.1111\/j.1462-5822.2006.00761.x","journal-title":"Cell Microbiol"},{"key":"539_CR9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","volume":"11","author":"LJ Douglas","year":"2003","unstructured":"Douglas LJ (2003) Candida biofilms and their role in infection. Trends Microbiol 11:30\u201336. https:\/\/doi.org\/10.1016\/S0966-842X(02)00002-1","journal-title":"Trends Microbiol"},{"key":"539_CR10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00294-013-0400-3","volume":"59","author":"L Math\u00e9","year":"2013","unstructured":"Math\u00e9 L, Van Dijck P (2013) Recent insights into Candida albicans biofilm resistance mechanisms. Curr Genet 59:251\u2013264. https:\/\/doi.org\/10.1007\/s00294-013-0400-3","journal-title":"Curr Genet"},{"key":"539_CR11","doi-asserted-by":"publisher","first-page":"647","DOI":"10.4155\/fmc.15.7","volume":"7","author":"N Rabin","year":"2015","unstructured":"Rabin N, Zheng Y, Opoku-Temeng C et al (2015) Agents that inhibit bacterial biofilm formation. Future Med Chem 7:647\u2013671. https:\/\/doi.org\/10.4155\/fmc.15.7","journal-title":"Future Med Chem"},{"key":"539_CR12","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1099\/jmm.0.46443-0","volume":"55","author":"E Pinto","year":"2006","unstructured":"Pinto E, Pina-V C, Salgueiro L et al (2006) Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. J Med Microbiol 55:1367\u20131373. https:\/\/doi.org\/10.1099\/jmm.0.46443-0","journal-title":"J Med Microbiol"},{"key":"539_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0924-8579(99)00154-5","volume":"14","author":"J Munoz-Bellido","year":"2000","unstructured":"Munoz-Bellido J, Munoz-Criado S, Garc\u0131\u0300a-Rodr\u0131\u0300guez J (2000) Antimicrobial activity of psychotropic drugs. Int J Antimicrob Agents 14:177\u2013180. https:\/\/doi.org\/10.1016\/S0924-8579(99)00154-5","journal-title":"Int J Antimicrob Agents"},{"key":"539_CR14","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1128\/AAC.02623-13","volume":"58","author":"AS Oliveira","year":"2014","unstructured":"Oliveira AS, Gaspar CA, Palmeira-de-Oliveira R et al (2014) Anti-Candida activity of fluoxetine alone and combined with fluconazole: a synergistic action against fluconazole-resistant strains. Antimicrob Agents Chemother 58:4224\u20134226. https:\/\/doi.org\/10.1128\/AAC.02623-13","journal-title":"Antimicrob Agents Chemother"},{"key":"539_CR15","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/jac\/dkg184","volume":"51","author":"TJ Young","year":"2003","unstructured":"Young TJ, Oliver GP, Pryde D et al (2003) Antifungal activity of selective serotonin reuptake inhibitors attributed to non-specific cytotoxicity. J Antimicrob Chemother 51:1045\u20131047. https:\/\/doi.org\/10.1093\/jac\/dkg184","journal-title":"J Antimicrob Chemother"},{"key":"539_CR16","doi-asserted-by":"publisher","first-page":"E135","DOI":"10.1086\/324589","volume":"33","author":"C Lass-Florl","year":"2001","unstructured":"Lass-Florl C, Dierich MP, Fuchs D et al (2001) Antifungal activity against Candida species of the selective serotonin-reuptake inhibitor, sertraline. Clin Infect Dis 33:E135\u2013E136. https:\/\/doi.org\/10.1086\/324589","journal-title":"Clin Infect Dis"},{"key":"539_CR17","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/jac\/48.6.775","volume":"48","author":"C Lass-Florl","year":"2001","unstructured":"Lass-Florl C, Dierich MP, Fuchs D et al (2001) Antifungal properties of selective serotonin reuptake inhibitors against Aspergillus species in vitro. J Antimicrob Chemother 48:775\u2013779","journal-title":"J Antimicrob Chemother"},{"key":"539_CR18","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1128\/AAC.00212-12","volume":"56","author":"B Zhai","year":"2012","unstructured":"Zhai B, Wu C, Wang L et al (2012) The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections. Antimicrob Agents Chemother 56:3758\u20133766. https:\/\/doi.org\/10.1128\/AAC.00212-12","journal-title":"Antimicrob Agents Chemother"},{"key":"539_CR19","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1128\/AAC.45.9.2475-2479.2001","volume":"45","author":"G Ramage","year":"2001","unstructured":"Ramage G, VandeWalle K, Wickes BL et al (2001) Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob Agents Chemother 45:2475\u20132479. https:\/\/doi.org\/10.1128\/AAC.45.9.2475-2479.2001","journal-title":"Antimicrob Agents Chemother"},{"key":"539_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.mimet.2007.11.010","volume":"72","author":"E Peeters","year":"2008","unstructured":"Peeters E, Nelis HJ, Coenye T (2008) Comparison of multiple methods for quantification of microbial biofilms grown in microtiter plates. J Microbiol Methods 72:157\u2013165. https:\/\/doi.org\/10.1016\/j.mimet.2007.11.010","journal-title":"J Microbiol Methods"},{"key":"539_CR21","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s11046-011-9448-0","volume":"172","author":"RH Pires","year":"2011","unstructured":"Pires RH, Montanari LB, Martins CHG et al (2011) Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosis. Mycopathologia 172:453\u2013464. https:\/\/doi.org\/10.1007\/s11046-011-9448-0","journal-title":"Mycopathologia"},{"key":"539_CR22","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1038\/nprot.2008.141","volume":"3","author":"CG Pierce","year":"2008","unstructured":"Pierce CG, Uppuluri P, Tristan AR et al (2008) A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. Nat Protoc 3:1494\u20131500. https:\/\/doi.org\/10.1038\/nport.2008.141","journal-title":"Nat Protoc"},{"key":"539_CR23","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3109\/13693780802549594","volume":"47","author":"S Silva","year":"2009","unstructured":"Silva S, Henriques M, Martins A et al (2009) Biofilms of non-Candida albicans Candida species: quantification, structure and matrix composition. Med Mycol 47:681\u2013689. https:\/\/doi.org\/10.3109\/13693780802549594","journal-title":"Med Mycol"},{"key":"539_CR24","doi-asserted-by":"publisher","first-page":"6179","DOI":"10.1128\/AAC.03046-15","volume":"60","author":"W Gu","year":"2016","unstructured":"Gu W, Guo D, Zhang L et al (2016) The synergistic effect of azoles and fluoxetine against resistant Candida albicans strains is attributed to attenuating fungal. Antimicrob Agents Chemother 60:6179\u20136188. https:\/\/doi.org\/10.1128\/AAC.03046-15.Address","journal-title":"Antimicrob Agents Chemother"},{"key":"539_CR25","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.micpath.2017.04.008","volume":"107","author":"RA Costa Silva","year":"2017","unstructured":"Costa Silva RA, da Silva CR, de Andrade Neto JB et al (2017) In vitro anti-Candida activity of selective serotonin reuptake inhibitors against fluconazole-resistant strains and their activity against biofilm-forming isolates. Microb Pathog 107:341\u2013348. https:\/\/doi.org\/10.1016\/j.micpath.2017.04.008","journal-title":"Microb Pathog"},{"key":"539_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1590\/S1516-44461999000500006","volume":"21","author":"RA Moreno","year":"1999","unstructured":"Moreno RA, Moreno e Marcia Brito DH, De Macedo Soares MB (1999) Psicofarmacologia de antidepressivos. Rev Bras Psiquiatr 21:24\u201340. https:\/\/doi.org\/10.1590\/S1516-44461999000500006","journal-title":"Rev Bras Psiquiatr"},{"key":"539_CR27","volume-title":"FOYE\u2019S Principles of Medicinal Chemistry","author":"W Foye","year":"2008","unstructured":"Foye W, Lemke T, Williams D (2008) FOYE\u2019S Principles of Medicinal Chemistry, 6th\u00a0edn. Lippincott Williams & Wilkins, Philadelphia","edition":"6"},{"key":"539_CR28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","volume":"11","author":"LJ Douglas","year":"2016","unstructured":"Douglas LJ (2016) Candida biofilms and their role in infection. Trends Microbiol 11:30\u201336. https:\/\/doi.org\/10.1016\/S0966-842X(02)00002-1","journal-title":"Trends Microbiol"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00430-018-0539-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-018-0539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-018-0539-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T23:21:45Z","timestamp":1570922505000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00430-018-0539-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":28,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["539"],"URL":"https:\/\/doi.org\/10.1007\/s00430-018-0539-0","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]},"assertion":[{"value":"27 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}