{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:50:22Z","timestamp":1772308222385,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s00432-014-1645-z","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T01:47:03Z","timestamp":1395625623000},"page":"921-935","source":"Crossref","is-referenced-by-count":15,"title":["Combination of Cl-IB-MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR-dependent autophagy and mitotic catastrophe on human melanoma cells"],"prefix":"10.1007","volume":"140","author":[{"given":"Ana S.","family":"Soares","sequence":"first","affiliation":[]},{"given":"Vera M.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Carmen","family":"Diniz","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Fresco","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"issue":"12","key":"1645_CR1","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.bcp.2013.09.020","volume":"86","author":"S Aliwaini","year":"2013","unstructured":"Aliwaini S, Swarts AJ, Blanckenberg A, Mapolie S, Prince S (2013) A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy. Biochem Pharmacol 86(12):1650\u20131663","journal-title":"Biochem Pharmacol"},{"issue":"56","key":"1645_CR2","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1038\/sj.onc.1207233","volume":"22","author":"KN Bhalla","year":"2003","unstructured":"Bhalla KN (2003) Microtubule-targeted anticancer agents and apoptosis. Oncogene 22(56):9075\u20139086","journal-title":"Oncogene"},{"issue":"1","key":"1645_CR3","first-page":"3","volume":"66","author":"A Biederbick","year":"1995","unstructured":"Biederbick A, Kern HF, Elsasser HP (1995) Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 66(1):3\u201314","journal-title":"Eur J Cell Biol"},{"issue":"16","key":"1645_CR4","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1038\/sj.onc.1207528","volume":"23","author":"M Castedo","year":"2004","unstructured":"Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G (2004a) Cell death by mitotic catastrophe: a molecular definition. Oncogene 23(16):2825\u20132837","journal-title":"Oncogene"},{"issue":"25","key":"1645_CR5","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/sj.onc.1207572","volume":"23","author":"M Castedo","year":"2004","unstructured":"Castedo M, Perfettini JL, Roumier T, Valent A, Raslova H, Yakushijin K, Horne D, Feunteun J, Lenoir G, Medema R, Vainchenker W, Kroemer G (2004b) Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene 23(25):4362\u20134370","journal-title":"Oncogene"},{"issue":"7","key":"1645_CR6","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1200\/JCO.2005.07.168","volume":"23","author":"DL Dai","year":"2005","unstructured":"Dai DL, Martinka M, Li G (2005) Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. J Clin Oncol 23(7):1473\u20131482","journal-title":"J Clin Oncol"},{"key":"1645_CR7","doi-asserted-by":"crossref","first-page":"156068","DOI":"10.1155\/2012\/156068","volume":"2012","author":"CF Souza de","year":"2012","unstructured":"de Souza CF, Morais AS, Jasiulionis MG (2012) Biomarkers as key contributors in treating malignant melanoma metastases. Dermatol Res Pract 2012:156068","journal-title":"Dermatol Res Pract"},{"issue":"4","key":"1645_CR8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495\u2013516","journal-title":"Toxicol Pathol"},{"issue":"34","key":"1645_CR9","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1038\/sj.onc.1209608","volume":"25","author":"S Fulda","year":"2006","unstructured":"Fulda S, Debatin KM (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25(34):4798\u20134811","journal-title":"Oncogene"},{"issue":"1","key":"1645_CR10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.canlet.2012.12.029","volume":"333","author":"S Gao","year":"2013","unstructured":"Gao S, Chen T, Choi MY, Liang Y, Xue J, Wong YS (2013) Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways. Cancer Lett 333(1):36\u201346","journal-title":"Cancer Lett"},{"issue":"5","key":"1645_CR11","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"issue":"6805","key":"1645_CR12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO (2000) The biochemistry of apoptosis. Nature 407(6805):770\u2013776","journal-title":"Nature"},{"key":"1645_CR13","first-page":"828143","volume":"2013","author":"JY Hung","year":"2013","unstructured":"Hung JY, Wen CW, Hsu YL, Lin ES, Huang MS, Chen CY, Kuo PL (2013) Subamolide a induces mitotic catastrophe accompanied by apoptosis in human lung cancer cells. Evid Based Complement Altern Med 2013:828143","journal-title":"Evid Based Complement Altern Med"},{"issue":"1","key":"1645_CR14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/jcmm.12001","volume":"17","author":"MV Jain","year":"2013","unstructured":"Jain MV, Paczulla AM, Klonisch T, Dimgba FN, Rao SB, Roberg K, Schweizer F, Lengerke C, Davoodpour P, Palicharla VR, Maddika S, Los M (2013) Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med 17(1):12\u201329","journal-title":"J Cell Mol Med"},{"issue":"5","key":"1645_CR15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","volume":"60","author":"A Jemal","year":"2010","unstructured":"Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60(5):277\u2013300","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"1645_CR16","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","volume":"584","author":"CH Jung","year":"2010","unstructured":"Jung CH, Ro SH, Cao J, Otto NM, Kim DH (2010) mTOR regulation of autophagy. FEBS Lett 584(7):1287\u20131295","journal-title":"FEBS Lett"},{"issue":"4","key":"1645_CR17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/embo-reports\/kve061","volume":"2","author":"A Kihara","year":"2001","unstructured":"Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T (2001) Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2(4):330\u2013335","journal-title":"EMBO Rep"},{"issue":"6","key":"1645_CR18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.phrs.2012.07.004","volume":"66","author":"M Komatsu","year":"2012","unstructured":"Komatsu M, Kageyama S, Ichimura Y (2012) p62\/SQSTM1\/A170: physiology and pathology. Pharmacol Res 66(6):457\u2013462","journal-title":"Pharmacol Res"},{"issue":"1","key":"1645_CR19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1615\/CritRevEukarGeneExpr.v21.i1.50","volume":"21","author":"CP Kung","year":"2011","unstructured":"Kung CP, Budina A, Balaburski G, Bergenstock MK, Murphy M (2011) Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr 21(1):71\u2013100","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"5","key":"1645_CR20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.semcancer.2013.06.008","volume":"23","author":"H Liu","year":"2013","unstructured":"Liu H, He Z, Simon HU (2013) Targeting autophagy as a potential therapeutic approach for melanoma therapy. Semin Cancer Biol 23(5):352\u2013360","journal-title":"Semin Cancer Biol"},{"issue":"1\u20132","key":"1645_CR21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.drup.2007.11.003","volume":"11","author":"J LoPiccolo","year":"2008","unstructured":"LoPiccolo J, Blumenthal GM, Bernstein WB, Dennis PA (2008) Targeting the PI3K\/Akt\/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updates 11(1\u20132):32\u201350","journal-title":"Drug Resist Updates"},{"issue":"9","key":"1645_CR22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","volume":"8","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8(9):741\u2013752","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1645_CR23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4161\/cc.5.1.2267","volume":"5","author":"S Mansilla","year":"2006","unstructured":"Mansilla S, Priebe W, Portugal J (2006) Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms. Cell Cycle 5(1):53\u201360","journal-title":"Cell Cycle"},{"key":"1645_CR24","doi-asserted-by":"crossref","first-page":"347312","DOI":"10.1155\/2013\/347312","volume":"2013","author":"JB Martins","year":"2013","unstructured":"Martins JB, Bastos Mde L, Carvalho F, Capela JP (2013) Differential effects of methyl-4-phenylpyridinium ion, rotenone, and paraquat on differentiated SH-SY5Y cells. J Toxicol 2013:347312","journal-title":"J Toxicol"},{"issue":"13","key":"1645_CR25","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1200\/JCO.2008.20.0766","volume":"27","author":"F Meric-Bernstam","year":"2009","unstructured":"Meric-Bernstam F, Gonzalez-Angulo AM (2009) Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 27(13):2278\u20132287","journal-title":"J Clin Oncol"},{"issue":"3","key":"1645_CR26","doi-asserted-by":"crossref","first-page":"e32955","DOI":"10.1371\/journal.pone.0032955","volume":"7","author":"L Mervic","year":"2012","unstructured":"Mervic L (2012) Time course and pattern of metastasis of cutaneous melanoma differ between men and women. PLoS ONE 7(3):e32955","journal-title":"PLoS ONE"},{"issue":"1","key":"1645_CR27","doi-asserted-by":"crossref","first-page":"e30376","DOI":"10.1371\/journal.pone.0030376","volume":"7","author":"R Mintzer","year":"2012","unstructured":"Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE (2012) A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A\/C. PLoS ONE 7(1):e30376","journal-title":"PLoS ONE"},{"issue":"22","key":"1645_CR28","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","volume":"21","author":"N Mizushima","year":"2007","unstructured":"Mizushima N (2007) Autophagy: process and function. Genes Dev 21(22):2861\u20132873","journal-title":"Genes Dev"},{"issue":"1\u20132","key":"1645_CR29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1\u20132):55\u201363","journal-title":"J Immunol Methods"},{"issue":"12","key":"1645_CR30","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s10495-011-0640-y","volume":"16","author":"F Nicolau-Galmes","year":"2011","unstructured":"Nicolau-Galmes F, Asumendi A, Alonso-Tejerina E, Perez-Yarza G, Jangi SM, Gardeazabal J, Arroyo-Berdugo Y, Careaga JM, Diaz-Ramon JL, Apraiz A, Boyano MD (2011) Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis 16(12):1253\u20131267","journal-title":"Apoptosis"},{"issue":"4","key":"1645_CR31","first-page":"397","volume":"2","author":"A Puissant","year":"2012","unstructured":"Puissant A, Fenouille N, Auberger P (2012) When autophagy meets cancer through p62\/SQSTM1. Am J Cancer Res 2(4):397\u2013413","journal-title":"Am J Cancer Res"},{"issue":"7","key":"1645_CR32","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1158\/0008-5472.CAN-12-2501","volume":"73","author":"V Quidville","year":"2013","unstructured":"Quidville V, Alsafadi S, Goubar A et al (2013) Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy. Cancer Res 73(7):2247\u20132258","journal-title":"Cancer Res"},{"issue":"7","key":"1645_CR33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nprot.2008.75","volume":"3","author":"G Repetto","year":"2008","unstructured":"Repetto G, del Peso A, Zurita JL (2008) Neutral red uptake assay for the estimation of cell viability\/cytotoxicity. Nat Protoc 3(7):1125\u20131131","journal-title":"Nat Protoc"},{"issue":"17","key":"1645_CR34","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/jssc.201200375","volume":"35","author":"J Rodriguez","year":"2012","unstructured":"Rodriguez J, Contento AM, Castaneda G, Munoz L, Berciano MA (2012) Determination of morphine, codeine, and paclitaxel in human serum and plasma by micellar electrokinetic chromatography. J Sep Sci 35(17):2297\u20132306","journal-title":"J Sep Sci"},{"issue":"2","key":"1645_CR35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/auto.7.2.14074","volume":"7","author":"S Saiki","year":"2011","unstructured":"Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K, Imoto M, Hattori N (2011) Caffeine induces apoptosis by enhancement of autophagy via PI3K\/Akt\/mTOR\/p70S6K inhibition. Autophagy 7(2):176\u2013187","journal-title":"Autophagy"},{"issue":"4","key":"1645_CR36","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/bjc.2013.420","volume":"109","author":"M Santoni","year":"2013","unstructured":"Santoni M, Amantini C, Morelli MB, Liberati S, Farfariello V, Nabissi M, Bonfili L, Eleuteri AM, Mozzicafreddo M, Burattini L, Berardi R, Cascinu S, Santoni G (2013) Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. Br J Cancer 109(4):1040\u20131050","journal-title":"Br J Cancer"},{"issue":"2","key":"1645_CR37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cellsig.2007.10.015","volume":"20","author":"D Selimovic","year":"2008","unstructured":"Selimovic D, Hassan M, Haikel Y, Hengge UR (2008) Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2. Cell Signal 20(2):311\u2013322","journal-title":"Cell Signal"},{"issue":"45","key":"1645_CR38","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1038\/onc.2011.168","volume":"30","author":"S Shen","year":"2011","unstructured":"Shen S, Kepp O, Michaud M, Martins I, Minoux H, Metivier D, Maiuri MC, Kroemer RT, Kroemer G (2011) Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study. Oncogene 30(45):4544\u20134556","journal-title":"Oncogene"},{"issue":"8","key":"1645_CR39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.biopha.2013.08.003","volume":"67","author":"AS Soares","year":"2013","unstructured":"Soares AS, Costa VM, Diniz C, Fresco P (2013) Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: a new possible therapeutic strategy for melanoma. Biomed Pharmacother 67(8):777\u2013789","journal-title":"Biomed Pharmacother"},{"issue":"20","key":"1645_CR40","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1038\/sj.onc.1206454","volume":"22","author":"MS Soengas","year":"2003","unstructured":"Soengas MS, Lowe SW (2003) Apoptosis and melanoma chemoresistance. Oncogene 22(20):3138\u20133151","journal-title":"Oncogene"},{"issue":"7","key":"1645_CR41","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2217\/14622416.8.7.803","volume":"8","author":"H Steed","year":"2007","unstructured":"Steed H, Sawyer MB (2007) Pharmacology, pharmacokinetics and pharmacogenomics of paclitaxel. Pharmacogenomics 8(7):803\u2013815","journal-title":"Pharmacogenomics"},{"issue":"1","key":"1645_CR42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1634\/theoncologist.2012-0211","volume":"18","author":"SM Stemmer","year":"2013","unstructured":"Stemmer SM, Benjaminov O, Medalia G, Ciuraru NB, Silverman MH, Bar-Yehuda S, Fishman S, Harpaz Z, Farbstein M, Cohen S, Patoka R, Singer B, Kerns WD, Fishman P (2013) CF102 for the treatment of hepatocellular carcinoma: a phase I\/II, open-label, dose-escalation study. Oncologist 18(1):25\u201326","journal-title":"Oncologist"},{"issue":"6","key":"1645_CR43","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1053\/j.seminoncol.2007.09.008","volume":"34","author":"HA Tawbi","year":"2007","unstructured":"Tawbi HA, Kirkwood JM (2007) Management of metastatic melanoma. Semin Oncol 34(6):532\u2013545","journal-title":"Semin Oncol"},{"key":"1645_CR44","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1038\/cddis.2011.86","volume":"2","author":"T Tomic","year":"2011","unstructured":"Tomic T, Botton T, Cerezo M, Robert G, Luciano F, Puissant A, Gounon P, Allegra M, Bertolotto C, Bereder JM, Tartare-Deckert S, Bahadoran P, Auberger P, Ballotti R, Rocchi S (2011) Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Cell Death Dis 2:e199","journal-title":"Cell Death Dis"},{"issue":"Suppl 2","key":"1645_CR45","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.cdd.4401777","volume":"12","author":"Y Tsujimoto","year":"2005","unstructured":"Tsujimoto Y, Shimizu S (2005) Another way to die: autophagic programmed cell death. Cell Death Differ 12(Suppl 2):1528\u20131534","journal-title":"Cell Death Differ"},{"issue":"7","key":"1645_CR46","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/cdd.2008.47","volume":"15","author":"H Vakifahmetoglu","year":"2008","unstructured":"Vakifahmetoglu H, Olsson M, Zhivotovsky B (2008) Death through a tragedy: mitotic catastrophe. Cell Death Differ 15(7):1153\u20131162","journal-title":"Cell Death Differ"},{"issue":"2","key":"1645_CR47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1254\/jphs.93.197","volume":"93","author":"F Wang","year":"2003","unstructured":"Wang F, Cao Y, Zhao W, Liu H, Fu Z, Han R (2003) Taxol inhibits melanoma metastases through apoptosis induction, angiogenesis inhibition, and restoration of E-cadherin and nm23 expression. J Pharmacol Sci 93(2):197\u2013203","journal-title":"J Pharmacol Sci"},{"issue":"5","key":"1645_CR48","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.stem.2013.10.005","volume":"13","author":"S Wang","year":"2013","unstructured":"Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z (2013) Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell 13(5):617\u2013625","journal-title":"Cell Stem Cell"},{"issue":"2","key":"1645_CR49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijpharm.2004.09.018","volume":"288","author":"J Weyermann","year":"2005","unstructured":"Weyermann J, Lochmann D, Zimmer A (2005) A practical note on the use of cytotoxicity assays. Int J Pharm 288(2):369\u2013376","journal-title":"Int J Pharm"},{"issue":"17","key":"1645_CR50","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1158\/1078-0432.CCR-07-5023","volume":"15","author":"E White","year":"2009","unstructured":"White E, DiPaola RS (2009) The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 15(17):5308\u20135316","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1645_CR51","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1745-7270.2008.00393.x","volume":"40","author":"C Xing","year":"2008","unstructured":"Xing C, Zhu B, Liu H, Yao H, Zhang L (2008) Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901. Acta Biochim Biophys Sin 40(3):194\u2013201","journal-title":"Acta Biochim Biophys Sin"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-014-1645-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-014-1645-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-014-1645-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T20:49:24Z","timestamp":1565297364000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-014-1645-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["1645"],"URL":"https:\/\/doi.org\/10.1007\/s00432-014-1645-z","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}