{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:07:39Z","timestamp":1770134859017,"version":"3.49.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s00432-016-2278-1","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T17:20:28Z","timestamp":1475688028000},"page":"275-291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["\u03b2-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives"],"prefix":"10.1007","volume":"143","author":[{"given":"Marisa","family":"Coelho","sequence":"first","affiliation":[]},{"given":"C\u00e1tia","family":"Soares-Silva","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"given":"Franca","family":"Marino","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Cosentino","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"2278_CR1","doi-asserted-by":"publisher","first-page":"e29915","DOI":"10.1371\/journal.pone.0029915","volume":"7","author":"HA Al-Wadei","year":"2012","unstructured":"Al-Wadei HA, Al-Wadei MH, Schuller HM (2012a) Cooperative regulation of non-small cell lung carcinoma by nicotinic and \u03b2-adrenergic receptors: a novel target for intervention PloS One 7:e29915. doi: 10.1371\/journal.pone.0029915","journal-title":"Cooperative regulation of non-small cell lung carcinoma by nicotinic and \u03b2-adrenergic receptors: a novel target for intervention PloS One"},{"key":"2278_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.phrs.2012.03.014","volume":"66","author":"HA Al-Wadei","year":"2012","unstructured":"Al-Wadei HA, Ullah MF, Al-Wadei MH (2012b) Intercepting neoplastic progression in lung malignancies via the \u03b2 adrenergic (\u03b2-AR) pathway: implications for anti-cancer drug targets. Pharmacol Res 66:33\u201340. doi: 10.1016\/j.phrs.2012.03.014","journal-title":"Pharmacol Res"},{"key":"2278_CR3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbi.2008.06.007","volume":"23","author":"GN Armaiz-Pena","year":"2009","unstructured":"Armaiz-Pena GN, Lutgendorf SK, Cole SW, Sood AK (2009) Neuroendocrine modulation of cancer progression. Brain Behav Immun 23:10\u201315. doi: 10.1016\/j.bbi.2008.06.007","journal-title":"Brain Behav Immun"},{"key":"2278_CR4","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.18632\/oncotarget.2887","volume":"6","author":"GN Armaiz-Pena","year":"2015","unstructured":"Armaiz-Pena GN et al (2015) Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget 6:4266\u20134273. doi: 10.18632\/oncotarget.2887","journal-title":"Oncotarget"},{"key":"2278_CR5","doi-asserted-by":"publisher","first-page":"11406","DOI":"10.1073\/pnas.1936664100","volume":"100","author":"M Azzi","year":"2003","unstructured":"Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, Pineyro G (2003) \u0392-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci USA 100:11406\u201311411. doi: 10.1073\/pnas.1936664100","journal-title":"Proc Natl Acad Sci USA"},{"key":"2278_CR6","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1124\/mol.64.3.679","volume":"64","author":"JG Baker","year":"2003","unstructured":"Baker JG, Hall IP, Hill SJ (2003) Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses. Mol Pharmacol 64:679\u2013688. doi: 10.1124\/mol.64.3.679","journal-title":"Mol Pharmacol"},{"key":"2278_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.tips.2011.02.010","volume":"32","author":"JG Baker","year":"2011","unstructured":"Baker JG, Hill SJ, Summers RJ (2011) Evolution of \u03b2-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci 32:227\u2013234. doi: 10.1016\/j.tips.2011.02.010","journal-title":"Trends Pharmacol Sci"},{"key":"2278_CR8","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1200\/jco.2010.33.5422","volume":"29","author":"TI Barron","year":"2011","unstructured":"Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K (2011) \u0392 blockers and breast cancer mortality: a population- based study. J Clin Oncol 29:2635\u20132644. doi: 10.1200\/jco.2010.33.5422","journal-title":"J Clin Oncol"},{"key":"2278_CR9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbi.2010.12.012","volume":"25","author":"DG Bernab\u00e9","year":"2011","unstructured":"Bernab\u00e9 DG, Tamae AC, Biasoli ER, Oliveira SH (2011) Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells. Brain Behav Immun 25:574\u2013583","journal-title":"Brain Behav Immun"},{"key":"2278_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3233\/cbm-2012-0228","volume":"10","author":"DM Bravo-Calderon","year":"2011","unstructured":"Bravo-Calderon DM, Oliveira DT, Marana AN, Nonogaki S, Carvalho AL, Kowalski LP (2011) Prognostic significance of \u03b2-2 adrenergic receptor in oral squamous cell carcinoma. Cancer Biomark 10:51\u201359. doi: 10.3233\/cbm-2012-0228","journal-title":"Cancer Biomark"},{"key":"2278_CR11","first-page":"153","volume":"21","author":"Y Cakir","year":"2002","unstructured":"Cakir Y, Plummer HK 3rd, Tithof PK, Schuller HM (2002) \u0392-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. Int J Oncol 21:153\u2013157","journal-title":"Int J Oncol"},{"key":"2278_CR12","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.18632\/oncotarget.2652","volume":"6","author":"M Calvani","year":"2015","unstructured":"Calvani M et al (2015) Norepinephrine promotes tumor microenvironment reactivity through \u03b23-adrenoreceptors during melanoma progression. Oncotarget 6:4615\u20134632. doi: 10.18632\/oncotarget.2652","journal-title":"Oncotarget"},{"key":"2278_CR13","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1158\/0008-5472.can-08-4289","volume":"69","author":"D Chakroborty","year":"2009","unstructured":"Chakroborty D, Sarkar C, Basu B, Dasgupta PS, Basu S (2009) Catecholamines regulate tumor angiogenesis. Cancer Res 69:3727\u20133730. doi: 10.1158\/0008-5472.can-08-4289","journal-title":"Cancer Res"},{"key":"2278_CR14","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/ncponc1134","volume":"5","author":"Y Chida","year":"2008","unstructured":"Chida Y, Hamer M, Wardle J, Steptoe A (2008) Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol 5:466\u2013475. doi: 10.1038\/ncponc1134","journal-title":"Nat Clin Pract Oncol"},{"key":"2278_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.clbc.2015.07.001","volume":"15","author":"WK Childers","year":"2015","unstructured":"Childers WK, Hollenbeak CS, Cheriyath P (2015) \u03b2-Blockers reduce breast cancer recurrence and breast cancer death: a meta-analysis. Clin Breast Cancer 15:426\u2013431. doi: 10.1016\/j.clbc.2015.07.001","journal-title":"Clin Breast Cancer"},{"key":"2278_CR16","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00432-014-1658-7","volume":"140","author":"CH Choi","year":"2014","unstructured":"Choi CH et al (2014) Meta-analysis of the effects of \u03b2 blocker on survival time in cancer patients. J Cancer Res Clin Oncol 140:1179\u20131188. doi: 10.1007\/s00432-014-1658-7","journal-title":"J Cancer Res Clin Oncol"},{"key":"2278_CR17","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.3892\/or.2015.3874","volume":"33","author":"M Coelho","year":"2015","unstructured":"Coelho M, Moz M, Correia G, Teixeira A, Medeiros R, Ribeiro L (2015) Antiproliferative effects of \u03b2-blockers on human colorectal cancer cells. Oncol Rep 33:2513\u20132520. doi: 10.3892\/or.2015.3874","journal-title":"Oncol Rep"},{"key":"2278_CR18","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/1078-0432.ccr-11-0641","volume":"18","author":"SW Cole","year":"2012","unstructured":"Cole SW, Sood AK (2012) Molecular pathways: \u03b2-adrenergic signaling in cancer. Cancer Res 18:1201\u20131206. doi: 10.1158\/1078-0432.ccr-11-0641","journal-title":"Cancer Res"},{"key":"2278_CR19","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc3978","volume":"15","author":"SW Cole","year":"2015","unstructured":"Cole SW, Nagaraja AS, Lutgendorf SK, Green PA, Sood AK (2015) Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer 15:563\u2013572. doi: 10.1038\/nrc3978","journal-title":"Nat Rev Cancer"},{"key":"2278_CR20","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s00432-015-2078-z","volume":"142","author":"R Colucci","year":"2016","unstructured":"Colucci R, Moretti S (2016) The role of stress and \u03b2-adrenergic system in melanoma: current knowledge and possible therapeutic options. J Cancer Res Clin Oncol 142:1021\u20131029. doi: 10.1007\/s00432-015-2078-z","journal-title":"J Cancer Res Clin Oncol"},{"key":"2278_CR21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0024-3205(00)00937-1","volume":"68","author":"M Cosentino","year":"2000","unstructured":"Cosentino M et al (2000) HPLC-ED measurement of endogenous catecholamines in human immune cells and hematopoietic cell lines. Life Sci 68:283\u2013295","journal-title":"Life Sci"},{"key":"2278_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3389\/fncel.2015.00302","volume":"9","author":"M Cosentino","year":"2015","unstructured":"Cosentino M, Marino F, Maestroni GJ (2015) Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives. Front Cell Neurosci 9:302. doi: 10.3389\/fncel.2015.00302","journal-title":"Front Cell Neurosci"},{"key":"2278_CR23","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00210-014-0969-1","volume":"387","author":"M Monte Dal","year":"2014","unstructured":"Dal Monte M, Fornaciari I, Nicchia GP, Svelto M, Casini G, Bagnoli P (2014) \u03b23-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch Pharmaco 387:533\u2013543. doi: 10.1007\/s00210-014-0969-1","journal-title":"Naunyn Schmiedebergs Arch Pharmaco"},{"key":"2278_CR24","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ygyno.2012.07.102","volume":"127","author":"ES Diaz","year":"2012","unstructured":"Diaz ES, Karlan BY, Li AJ (2012) Impact of \u03b2 blockers on epithelial ovarian cancer survival. Gynecol Oncol 127:375\u2013378. doi: 10.1016\/j.ygyno.2012.07.102","journal-title":"Gynecol Oncol"},{"key":"2278_CR25","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s00262-014-1617-9","volume":"63","author":"JW Eng","year":"2014","unstructured":"Eng JW, Kokolus KM, Reed CB, Hylander BL, Ma WW, Repasky EA (2014) A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response. Cancer Immunol Immunother 63:1115\u20131128. doi: 10.1007\/s00262-014-1617-9","journal-title":"Cancer Immunol Immunother"},{"key":"2278_CR26","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/j.1476-5381.2009.00602.x","volume":"159","author":"BA Evans","year":"2010","unstructured":"Evans BA, Sato M, Sarwar M, Hutchinson DS, Summers RJ (2010) Ligand-directed signalling at \u03b2-adrenoceptors. Br J Pharmacol 159:1022\u20131038. doi: 10.1111\/j.1476-5381.2009.00602.x","journal-title":"Br J Pharmacol"},{"key":"2278_CR27","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359\u2013E386. doi: 10.1002\/ijc.29210","journal-title":"Int J Cancer"},{"key":"2278_CR28","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nature06185","volume":"449","author":"MA Flierl","year":"2007","unstructured":"Flierl MA et al (2007) Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 449:721\u2013725. doi: 10.1038\/nature06185","journal-title":"Nature"},{"key":"2278_CR29","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1751-7176.2011.00515.x","volume":"13","author":"WH Frishman","year":"2011","unstructured":"Frishman WH, Saunders E (2011) \u03b2-Adrenergic blockers. J Clin Hypertens (Greenwich) 13:649\u2013653. doi: 10.1111\/j.1751-7176.2011.00515.x","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2278_CR30","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1124\/mol.106.026716","volume":"70","author":"S Galandrin","year":"2006","unstructured":"Galandrin S, Bouvier M (2006) Distinct signaling profiles of \u03b21 and \u03b22 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 70:1575\u20131584. doi: 10.1124\/mol.106.026716","journal-title":"Mol Pharmacol"},{"key":"2278_CR31","doi-asserted-by":"publisher","first-page":"10058","DOI":"10.18632\/oncotarget.2460","volume":"5","author":"L Gargiulo","year":"2014","unstructured":"Gargiulo L et al (2014) Differential \u03b22-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines. Oncotarget 5:10058\u201310069. doi: 10.18632\/oncotarget.2460","journal-title":"Oncotarget"},{"key":"2278_CR32","first-page":"69","volume":"37","author":"DS Goldstein","year":"2003","unstructured":"Goldstein DS (2003) Catecholamines and stress. Endocr Regul 37:69\u201380","journal-title":"Endocr Regul"},{"key":"2278_CR33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/b978-0-12-381298-8.00011-3","volume":"484","author":"M Grazia Perrone","year":"2010","unstructured":"Grazia Perrone M, Scilimati A (2010) \u03b2(3)-Adrenoceptor agonists and (antagonists as) inverse agonists history, perspective, constitutive activity, and stereospecific binding. Methods Enzymol 484:197\u2013230. doi: 10.1016\/b978-0-12-381298-8.00011-3","journal-title":"Methods Enzymol"},{"key":"2278_CR34","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.eururo.2013.01.007","volume":"65","author":"HH Grytli","year":"2014","unstructured":"Grytli HH, Fagerland MW, Fossa SD, Tasken KA (2014) Association between use of \u03b2-blockers and prostate cancer-specific survival: a cohort study of 3561 prostate cancer patients with high-risk or metastatic disease. Eur Urol 65:635\u2013641. doi: 10.1016\/j.eururo.2013.01.007","journal-title":"Eur Urol"},{"key":"2278_CR35","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3892\/or_00001032","volume":"53","author":"S Guimaraes","year":"2001","unstructured":"Guimaraes S, Moura D (2001) Vascular adrenoceptors: an update. Pharmacol Rev 53:319\u2013356. doi: 10.3892\/or_00001032","journal-title":"Pharmacol Rev"},{"key":"2278_CR36","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674. doi: 10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"2278_CR37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ygyno.2013.03.007","volume":"129","author":"F Heitz","year":"2013","unstructured":"Heitz F et al (2013) Impact of \u03b2 blocker medication in patients with platinum sensitive recurrent ovarian cancer-a combined analysis of 2 prospective multicenter trials by the AGO study group NCIC-CTG and EORTC-GCG. Gynecol Oncol 129:463\u2013466. doi: 10.1016\/j.ygyno.2013.03.007","journal-title":"Gynecol Oncol"},{"key":"2278_CR38","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3109\/10408449109017917","volume":"21","author":"D Hoffmann","year":"1991","unstructured":"Hoffmann D, Rivenson A, Chung FL, Hecht SS (1991) Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis. Crit Rev Toxicol 21:305\u2013311. doi: 10.3109\/10408449109017917","journal-title":"Crit Rev Toxicol"},{"key":"2278_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019246","author":"S Inbar","year":"2011","unstructured":"Inbar S, Neeman E, Avraham R, Benish M, Rosenne E, Ben-Eliyahu S (2011) Do stress responses promote leukemia progression? an animal study suggesting a role for epinephrine and prostaglandin-E(2) through reduced NK activity. PLoS One. doi: 10.1371\/journal.pone.0019246","journal-title":"PLoS One"},{"key":"2278_CR40","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2147\/ott.s38403","volume":"5","author":"Y Ji","year":"2012","unstructured":"Ji Y, Chen S, Xiao X, Zheng S, Li K (2012) \u03b2-blockers: a novel class of antitumor agents. Onco Targets Ther 5:391\u2013401. doi: 10.2147\/ott.s38403","journal-title":"Onco Targets Ther"},{"key":"2278_CR41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1471-2407-13-85","volume":"13","author":"SA Johannesdottir","year":"2013","unstructured":"Johannesdottir SA, Schmidt M, Phillips G, Glaser R, Yang EV, Blumenfeld M, Lemeshow S (2013a) Use of \u03b2-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study. BMC Cancer 13:85. doi: 10.1186\/1471-2407-13-85","journal-title":"BMC Cancer"},{"key":"2278_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1471-2407-13-85","volume":"13","author":"SA Johannesdottir","year":"2013","unstructured":"Johannesdottir SA, Schmidt M, Phillips G, Glaser R, Yang EV, Blumenfeld M, Lemeshow S (2013b) Use of ss-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study. BMC Cancer 13:85. doi: 10.1186\/1471-2407-13-85","journal-title":"BMC Cancer"},{"key":"2278_CR43","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbi.2016.07.162","volume":"57","author":"DM Lamkin","year":"2016","unstructured":"Lamkin DM et al (2016) \u03b2-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum. Brain Behav Immun 57:338\u2013346. doi: 10.1016\/j.bbi.2016.07.162","journal-title":"Brain Behav Immun"},{"key":"2278_CR44","doi-asserted-by":"publisher","first-page":"10634","DOI":"10.1038\/ncomms10634","volume":"7","author":"CP Le","year":"2016","unstructured":"Le CP et al (2016) Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination. Nature Commun 7:10634. doi: 10.1038\/ncomms10634","journal-title":"Nature Commun"},{"key":"2278_CR45","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1158\/1055-9965.epi-11-0249","volume":"20","author":"S Lemeshow","year":"2011","unstructured":"Lemeshow S et al (2011) \u03b2-Blockers and survival among Danish patients with malignant melanoma: a population-based cohort study. Cancer Epidemiol Biomarkers Prev 20:2273\u20132279. doi: 10.1158\/1055-9965.epi-11-0249","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2278_CR46","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.3892\/or_00001032","volume":"24","author":"X Liao","year":"2010","unstructured":"Liao X, Che X, Zhao W, Zhang D, Bi T, Wang G (2010) The \u03b2-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor \u03baB signaling. Oncol Rep 24:1669\u20131676. doi: 10.3892\/or_00001032","journal-title":"Oncol Rep"},{"key":"2278_CR47","first-page":"584","volume":"59","author":"X Lin","year":"2012","unstructured":"Lin X, Luo K, Lv Z, Huang J (2012) \u03b2-adrenoceptor action on pancreatic cancer cell proliferation and tumor growth in mice. Hepatogastroenterology 59:584\u2013588","journal-title":"Hepatogastroenterology"},{"key":"2278_CR48","doi-asserted-by":"publisher","first-page":"e61435","DOI":"10.1371\/journal.pone.0061435","volume":"8","author":"Q Lin","year":"2013","unstructured":"Lin Q, Wang F, Yang R, Zheng X, Gao H, Zhang P (2013) Effect of chronic restraint stress on human colorectal carcinoma growth in mice. PLoS One 8:e61435. doi: 10.1371\/journal.pone.0061435","journal-title":"PLoS One"},{"key":"2278_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1124\/jpet.107.134528","volume":"326","author":"X Liu","year":"2008","unstructured":"Liu X, Wu WK, Yu L, Li ZJ, Sung JJ, Zhang ST, Cho CH (2008) Epidermal growth factor-induced esophageal cancer cell proliferation requires transactivation of \u03b2-adrenoceptors. J Pharmacol Exp Ther 326:69\u201375. doi: 10.1124\/jpet.107.134528","journal-title":"J Pharmacol Exp Ther"},{"key":"2278_CR50","doi-asserted-by":"publisher","unstructured":"L\u00f3pez-Send\u00f3n J, Swedberg K, McMurray J, Tamargo J, Maggioni AP, Dargie H, Tendera M, Waagstein F, Kjekshus J, Lechat P, Torp-Pedersen C (2004) Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The task force on ACE-inhibitors of the European Society of Cardiology. Eur Heart J 25:1454\u20131470. doi: 10.1016\/j.ehj.2004.06.003","DOI":"10.1016\/j.ehj.2004.06.003"},{"key":"2278_CR51","first-page":"4514","volume":"9","author":"SK Lutgendorf","year":"2003","unstructured":"Lutgendorf SK et al (2003) Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Cancer Res 9:4514\u20134521","journal-title":"Cancer Res"},{"key":"2278_CR52","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1200\/jco.2009.26.9357","volume":"28","author":"SK Lutgendorf","year":"2010","unstructured":"Lutgendorf SK, Sood AK, Antoni MH (2010) Host factors and cancer progression: biobehavioral signaling pathways and interventions. J Clin Oncol 28:4094\u20134099. doi: 10.1200\/jco.2009.26.9357","journal-title":"J Clin Oncol"},{"key":"2278_CR53","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.2174\/092986709788186048","volume":"16","author":"IA Luthy","year":"2009","unstructured":"Luthy IA, Bruzzone A, Pinero CP, Castillo LF, Chiesa IJ, Vazquez SM, Sarappa MG (2009) Adrenoceptors: non conventional target for breast cancer? Curr Med Chem 16:1850\u20131862. doi: 10.2174\/092986709788186048","journal-title":"Curr Med Chem"},{"key":"2278_CR54","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1124\/mol.115.099630","volume":"88","author":"LM Luttrell","year":"2015","unstructured":"Luttrell LM, Maudsley S, Bohn LM (2015) Fulfilling the promise of \u201cbiased\u201d G protein-coupled receptor agonism. Mol Pharmacol 88:579\u2013588. doi: 10.1124\/mol.115.099630","journal-title":"Mol Pharmacol"},{"key":"2278_CR55","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s10549-011-1348-y","volume":"130","author":"KS Madden","year":"2011","unstructured":"Madden KS, Szpunar MJ, Brown EB (2011) \u03b2-Adrenergic receptors (\u03b2-AR) regulate VEGF and IL-6 production by divergent pathways in high \u03b2-AR-expressing breast cancer cell lines. Breast Cancer Res Treat 130:747\u2013758. doi: 10.1007\/s10549-011-1348-y","journal-title":"Breast Cancer Res Treat"},{"key":"2278_CR56","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00726-011-1186-6","volume":"45","author":"F Marino","year":"2013","unstructured":"Marino F, Cosentino M (2013) Adrenergic modulation of immune cells: an update. Amino Acids 45:55\u201371. doi: 10.1007\/s00726-011-1186-6","journal-title":"Amino Acids"},{"key":"2278_CR57","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.mehy.2014.05.009","volume":"83","author":"MF McCarty","year":"2014","unstructured":"McCarty MF (2014) A role for cAMP-driven transactivation of EGFR in cancer aggressiveness\u2014therapeutic implications. Med Hypotheses 83:142\u2013147. doi: 10.1016\/j.mehy.2014.05.009","journal-title":"Med Hypotheses"},{"key":"2278_CR58","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1185\/03007995.2013.772505","volume":"29","author":"M Monami","year":"2013","unstructured":"Monami M et al (2013) Further data on \u03b2-blockers and cancer risk: observational study and meta-analysis of randomized clinical trials. Curr Med Res Opin 29:369\u2013378. doi: 10.1185\/03007995.2013.772505","journal-title":"Curr Med Res Opin"},{"key":"2278_CR59","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.2217\/fon.10.142","volume":"6","author":"M Moreno-Smith","year":"2010","unstructured":"Moreno-Smith M (2010) Impact of stress on cancer metastasis. Future Oncol 6:1863\u20131881. doi: 10.2217\/fon.10.142","journal-title":"Future Oncol"},{"key":"2278_CR60","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/labinvest.2012.175","volume":"93","author":"S Moretti","year":"2013","unstructured":"Moretti S et al (2013) \u03b2-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines. Lab Invest 93:279\u2013290. doi: 10.1038\/labinvest.2012.175","journal-title":"Lab Invest"},{"key":"2278_CR61","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1517\/13543784.2013.825250","volume":"22","author":"AS Nagaraja","year":"2013","unstructured":"Nagaraja AS, Sadaoui NC, Lutgendorf SK, Ramondetta LM, Sood AK (2013) \u03b2-blockers: a new role in cancer chemotherapy? Expert Opin Investig Drugs 22:1359\u20131363. doi: 10.1517\/13543784.2013.825250","journal-title":"Expert Opin Investig Drugs"},{"key":"2278_CR62","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature10653","volume":"480","author":"KD Nguyen","year":"2011","unstructured":"Nguyen KD (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480:104\u2013108. doi: 10.1038\/nature10653","journal-title":"Nature"},{"key":"2278_CR63","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/bf02772201","volume":"14","author":"RB Penn","year":"1996","unstructured":"Penn RB, Frielle T, McCullough JR, Aberg G, Benovic JL (1996) Comparison of R-, S-, and RS-albuterol interaction with human \u03b2 1- and \u03b2 2-adrenergic receptors. Clin Rev Allergy Immunol 14:37\u201345. doi: 10.1007\/bf02772201","journal-title":"Clin Rev Allergy Immunol"},{"key":"2278_CR64","unstructured":"Perez D, H\u00e9bert T, Cotecchia S, Doze VA, Graham RM, Bylund DB, Altosaar K, Devost D, Gora S, Goupil E, Kan S, Machkalyan G, Michel MC, Sleno R, Summers R, Zylbergold P, Balaji P, Bond RA, Eikenburg DC, Hieble JP, Minneman KP, Sergio P, Hills R (2016) Adrenoceptors, introduction. Last modified on 10\/08\/2015. IUPHAR\/BPS Guide Pharmacol. http:\/\/www.guidetopharmacology.org\/GRAC\/FamilyDisplayForward?familyId=4. Accessed 30 May 2016"},{"key":"2278_CR65","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/j.1476-5381.2011.01791.x","volume":"166","author":"C P\u00e9rez Pi\u00f1ero","year":"2012","unstructured":"P\u00e9rez Pi\u00f1ero C, Bruzzone A, Sarappa MG, Castillo LF, L\u00fcthy IA (2012) Involvement of \u03b12- and \u03b22-adrenoceptors on breast cancer cell proliferation and tumour growth regulation. Br J Pharmacol 166:721\u2013736. doi: 10.1111\/j.1476-5381.2011.01791.x","journal-title":"Br J Pharmacol"},{"key":"2278_CR66","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3727\/096504010X12828372551867","volume":"19","author":"M Perez-Sayans","year":"2010","unstructured":"Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Diz PG, Gandara Rey JM, Garcia-Garcia A (2010) \u03b2-adrenergic receptors in cancer: therapeutic implications. Oncol Res 19:45\u201354. doi: 10.3727\/096504010X12828372551867","journal-title":"Oncol Res"},{"key":"2278_CR67","unstructured":"Pimentel MA, Chai MG, Le CP, Cole SW, Sloan EK (2012) Sympathetic nervous system regulation of metastasis. In: Rahul Jandial and Kent Hunter (eds) Metastatic cancer: integrated organ system and biological approach, pp 1\u201311"},{"key":"2278_CR68","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1016\/j.cjca.2013.12.001","volume":"30","author":"L Poirier","year":"2014","unstructured":"Poirier L, Tobe SW (2014) Contemporary use of \u03b2-blockers: clinical relevance of subclassification. Can J Cardiol 30:S9\u2013S15. doi: 10.1016\/j.cjca.2013.12.001","journal-title":"Can J Cardiol"},{"key":"2278_CR69","doi-asserted-by":"publisher","first-page":"628","DOI":"10.18632\/oncotarget.101009","volume":"1","author":"DG Powe","year":"2010","unstructured":"Powe DG, Voss MJ, Zanker KS, Habashy HO, Green AR, Ellis IO, Entschladen F (2010) \u03b2-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival. Oncotarget 1:628\u2013638. doi: 10.18632\/oncotarget.101009","journal-title":"Oncotarget"},{"key":"2278_CR70","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrd3024","volume":"9","author":"S Rajagopal","year":"2010","unstructured":"Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 9:373\u2013386. doi: 10.1038\/nrd3024","journal-title":"Nat Rev Drug Discov"},{"key":"2278_CR71","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/pros.20778","volume":"68","author":"H Ramberg","year":"2008","unstructured":"Ramberg H et al (2008) Hormonal regulation of \u03b22-adrenergic receptor level in prostate cancer. Prostate 68:1133\u20131142. doi: 10.1002\/pros.20778","journal-title":"Prostate"},{"key":"2278_CR72","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1083\/jcb.200209105","volume":"160","author":"S Rangarajan","year":"2003","unstructured":"Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL (2003) Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the \u03b2 2-adrenergic receptor. J Cell Biol 160:487\u2013493. doi: 10.1083\/jcb.200209105","journal-title":"J Cell Biol"},{"key":"2278_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00171","author":"A Scanzano","year":"2015","unstructured":"Scanzano A, Cosentino M (2015) Adrenergic regulation of innate immunity: a review. Front Pharmacol. doi: 10.3389\/fphar.2015.00171","journal-title":"Front Pharmacol"},{"key":"2278_CR74","doi-asserted-by":"publisher","first-page":"466","DOI":"10.18632\/oncotarget.101102","volume":"1","author":"HM Schuller","year":"2010","unstructured":"Schuller HM (2010) \u03b2-adrenergic signaling, a novel target for cancer therapy? Oncotarget 1:466\u2013469. doi: 10.18632\/oncotarget.101102","journal-title":"Oncotarget"},{"key":"2278_CR75","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3233\/cbm-130323","volume":"13","author":"HM Schuller","year":"2013","unstructured":"Schuller HM (2013) Effects of tobacco constituents and psychological stress on the \u03b2-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: implications for intervention. Cancer Biomark 13:133\u2013144. doi: 10.3233\/cbm-130323","journal-title":"Cancer Biomark"},{"key":"2278_CR76","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1093\/carcin\/10.9.1753","volume":"10","author":"HM Schuller","year":"1989","unstructured":"Schuller HM, Cole B (1989) Regulation of cell proliferation by \u03b2-adrenergic receptors in a human lung adenocarcinoma cell line. Carcinogenesis 10:1753\u20131755. doi: 10.1093\/carcin\/10.9.1753","journal-title":"Carcinogenesis"},{"key":"2278_CR77","first-page":"1960","volume":"50","author":"HM Schuller","year":"1990","unstructured":"Schuller HM, Witschi HP, Nylen E, Joshi PA, Correa E, Becker KL (1990) Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the modulating effect of hyperoxia. Cancer Res 50:1960\u20131965","journal-title":"Cancer Res"},{"key":"2278_CR78","first-page":"4510","volume":"59","author":"HM Schuller","year":"1999","unstructured":"Schuller HM, Tithof PK, Williams M, Plummer H 3rd (1999) The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a \u03b2-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via \u03b2-adrenergic receptor-mediated release of arachidonic acid. Cancer Res 59:4510\u20134515","journal-title":"Cancer Res"},{"key":"2278_CR79","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/cas.12438","volume":"105","author":"T Shan","year":"2014","unstructured":"Shan T, Cui X, Li W, Lin W, Li Y, Chen X, Wu T (2014) Novel regulatory program for norepinephrine-induced epithelial-mesenchymal transition in gastric adenocarcinoma cell lines. Cancer Sci 105:847\u2013856. doi: 10.1111\/cas.12438","journal-title":"Cancer Sci"},{"key":"2278_CR80","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/j.1600-0714.2008.00691.x","volume":"38","author":"ZJ Shang","year":"2009","unstructured":"Shang ZJ, Liu K, de Liang F (2009) Expression of \u03b22-adrenergic receptor in oral squamous cell carcinoma. J Oral Pathol Med 38:371\u2013376. doi: 10.1111\/j.1600-0714.2008.00691.x","journal-title":"J Oral Pathol Med"},{"key":"2278_CR81","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.3748\/wjg.14.2358","volume":"14","author":"SG Shen","year":"2008","unstructured":"Shen SG, Zhang D, Hu HT, Li JH, Wang Z, Ma QY (2008) Effects of alpha-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro. World J Gastroenterol 14:2358\u20132363. doi: 10.3748\/wjg.14.2358","journal-title":"World J Gastroenterol"},{"key":"2278_CR82","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s10549-010-0822-2","volume":"125","author":"M Shi","year":"2011","unstructured":"Shi M et al (2011) The \u03b22-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells. Breast Cancer Res Treat 125:351\u2013362. doi: 10.1007\/s10549-010-0822-2","journal-title":"Breast Cancer Res Treat"},{"key":"2278_CR83","doi-asserted-by":"publisher","first-page":"5600","DOI":"10.4049\/jimmunol.1202364","volume":"190","author":"M Shi","year":"2013","unstructured":"Shi M et al (2013) Catecholamine-induced \u03b22-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. J Immunol (Baltimore, MD: 1950) 190:5600\u20135608. doi: 10.4049\/jimmunol.1202364","journal-title":"J Immunol (Baltimore, MD: 1950)"},{"key":"2278_CR84","doi-asserted-by":"publisher","first-page":"7042","DOI":"10.1158\/0008-5472.can-10-0522","volume":"70","author":"EK Sloan","year":"2010","unstructured":"Sloan EK et al (2010) The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res 70:7042\u20137052. doi: 10.1158\/0008-5472.can-10-0522","journal-title":"Cancer Res"},{"key":"2278_CR85","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/1097-0142(19940815)74:4+<1453::AID-CNCR2820741609>3.0.CO;2-1","volume":"74","author":"D Spiegel","year":"1994","unstructured":"Spiegel D (1994) Health caring. Psychosocial support for patients with cancer. Cancer 74:1453\u20131457","journal-title":"Cancer"},{"key":"2278_CR86","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-3223(03)00566-3","volume":"54","author":"D Spiegel","year":"2003","unstructured":"Spiegel D, Giese-Davis J (2003) Depression and cancer: mechanisms and disease progression. Biol Psychiatry 54:269\u2013282","journal-title":"Biol Psychiatry"},{"key":"2278_CR87","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.semcancer.2013.08.009","volume":"23","author":"J Tang","year":"2013","unstructured":"Tang J, Li Z, Lu L, Cho CH (2013) \u03b2-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy. Semin Cancer Biol 23:533\u2013542. doi: 10.1016\/j.semcancer.2013.08.009","journal-title":"Semin Cancer Biol"},{"key":"2278_CR88","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/nm1447","volume":"12","author":"PH Thaker","year":"2006","unstructured":"Thaker PH et al (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12:939\u2013944. doi: 10.1038\/nm1447","journal-title":"Nat Med"},{"key":"2278_CR89","doi-asserted-by":"publisher","first-page":"430","DOI":"10.4161\/cc.6.4.3829","volume":"6","author":"PH Thaker","year":"2007","unstructured":"Thaker PH, Lutgendorf SK, Sood AK (2007) The neuroendocrine impact of chronic stress on cancer. Cell Cycle (Georgetown, TX) 6:430\u2013433. doi: 10.4161\/cc.6.4.3829","journal-title":"Cell Cycle (Georgetown, TX)"},{"key":"2278_CR90","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1111\/liv.12782","volume":"35","author":"M Thiele","year":"2015","unstructured":"Thiele M, Albillos A, Abazi R, Wiest R, Gluud LL, Krag A (2015) Non-selective \u03b2-blockers may reduce risk of hepatocellular carcinoma: a meta-analysis of randomized. Liver Int 35:2009\u20132016. doi: 10.1111\/liv.12782","journal-title":"Liver Int"},{"key":"2278_CR91","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87\u2013108. doi: 10.3322\/caac.21262","journal-title":"CA Cancer J Clin"},{"key":"2278_CR92","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.pharmthera.2011.01.009","volume":"130","author":"C Vaklavas","year":"2011","unstructured":"Vaklavas C, Chatzizisis YS, Tsimberidou AM (2011) Common cardiovascular medications in cancer therapeutics. Pharmacol Ther 130:177\u2013190. doi: 10.1016\/j.pharmthera.2011.01.009","journal-title":"Pharmacol Ther"},{"key":"2278_CR93","doi-asserted-by":"publisher","first-page":"e45491","DOI":"10.1371\/journal.pone.0045491","volume":"7","author":"L Wang","year":"2012","unstructured":"Wang L, Liu H, Chen X, Zhang M, Xie K, Ma Q (2012) Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells. PLoS One 7:e45491. doi: 10.1371\/journal.pone.0045491","journal-title":"PLoS One"},{"key":"2278_CR94","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1093\/annonc\/mds616","volume":"24","author":"HM Wang","year":"2013","unstructured":"Wang HM et al (2013) Improved survival outcomes with the incidental use of \u03b2-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy. Ann Oncol 24:1312\u20131319. doi: 10.1093\/annonc\/mds616","journal-title":"Ann Oncol"},{"key":"2278_CR95","doi-asserted-by":"publisher","first-page":"3444","DOI":"10.1002\/cncr.29392","volume":"121","author":"JL Watkins","year":"2015","unstructured":"Watkins JL et al (2015) Clinical impact of selective and nonselective \u03b2-blockers on survival in patients with ovarian cancer. Cancer 121:3444\u20133451. doi: 10.1002\/cncr.29392","journal-title":"Cancer"},{"key":"2278_CR96","unstructured":"Westfall TCWaDP (2011) Adrenergic agonists and antagonists. In: Brunton LL (ed) Goodman & Gilman\u2019s the pharmacological basis of therapeutics, 12th edn. The McGraw-Hill"},{"key":"2278_CR97","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1080\/15384047.2015.1070988","volume":"16","author":"JM Wilson","year":"2015","unstructured":"Wilson JM, Lorimer E, Tyburski MD, Williams CL (2015) \u03b2-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells. Cancer Biol Ther 16:1364\u20131374. doi: 10.1080\/15384047.2015.1070988","journal-title":"Cancer Biol Ther"},{"key":"2278_CR98","doi-asserted-by":"publisher","first-page":"161","DOI":"10.18632\/oncotarget.1083","volume":"5","author":"JK Wolter","year":"2014","unstructured":"Wolter JK et al (2014) Anti-tumor activity of the \u03b2-adrenergic receptor antagonist propranolol in neuroblastoma. Oncotarget 5:161\u2013172. doi: 10.18632\/oncotarget.1083","journal-title":"Oncotarget"},{"key":"2278_CR99","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.lfs.2011.04.007","volume":"88","author":"HP Wong","year":"2011","unstructured":"Wong HP et al (2011) Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci 88:1108\u20131112. doi: 10.1016\/j.lfs.2011.04.007","journal-title":"Life Sci"},{"key":"2278_CR100","doi-asserted-by":"publisher","first-page":"5272","DOI":"10.1158\/0008-5472.can-05-0205","volume":"65","author":"WK Wu","year":"2005","unstructured":"Wu WK et al (2005) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via \u03b2-adrenoceptors. Cancer Res 65:5272\u20135277. doi: 10.1158\/0008-5472.can-05-0205","journal-title":"Cancer Res"},{"key":"2278_CR101","doi-asserted-by":"publisher","first-page":"10357","DOI":"10.1158\/0008-5472.can-06-2496","volume":"66","author":"EV Yang","year":"2006","unstructured":"Yang EV et al (2006) Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66:10357\u201310364. doi: 10.1158\/0008-5472.can-06-2496","journal-title":"Cancer Res"},{"key":"2278_CR102","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.bbi.2008.10.005","volume":"23","author":"EV Yang","year":"2009","unstructured":"Yang EV et al (2009) Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun 23:267\u2013275. doi: 10.1016\/j.bbi.2008.10.005","journal-title":"Brain Behav Immun"},{"key":"2278_CR103","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4161\/cbt.10.1.11944","volume":"10","author":"D Zhang","year":"2010","unstructured":"Zhang D, Ma QY, Hu HT, Zhang M (2010) \u03b22-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFkappaB and AP-1. Cancer Biol Ther 10:19\u201329. doi: 10.4161\/cbt.10.1.11944","journal-title":"Cancer Biol Ther"},{"key":"2278_CR104","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.3892\/or.2011.1417","volume":"26","author":"P Zhang","year":"2011","unstructured":"Zhang P, He X, Tan J, Zhou X, Zou L (2011) \u03b2-Arrestin2 mediates \u03b2-2 adrenergic receptor signaling inducing prostate cancer cell progression. Oncol Rep 26:1471\u20131477. doi: 10.3892\/or.2011.1417","journal-title":"Oncol Rep"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-016-2278-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-016-2278-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-016-2278-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T00:25:43Z","timestamp":1498350343000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-016-2278-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":104,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["2278"],"URL":"https:\/\/doi.org\/10.1007\/s00432-016-2278-1","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]}}}