{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:11:20Z","timestamp":1774397480309,"version":"3.50.1"},"reference-count":186,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Tissue Res"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00441-021-03461-4","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T07:10:12Z","timestamp":1622272212000},"page":"497-518","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach"],"prefix":"10.1007","volume":"385","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3258-1773","authenticated-orcid":false,"given":"Andreia","family":"Gomes","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Costa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"3461_CR1","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/j.1742-481X.2008.00457.x","volume":"5","author":"JB Acosta","year":"2008","unstructured":"Acosta JB, del Barco DG, Vera DC, Savigne W, Lopez-Saura P, Guillen Nieto G, Schultz GS (2008) The pro-inflammatory environment in recalcitrant diabetic foot wounds. Int Wound J 5:530\u2013539","journal-title":"Int Wound J"},{"key":"3461_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1161\/CIRCRESAHA.117.311769","volume":"122","author":"M Adamiak","year":"2018","unstructured":"Adamiak M, Cheng G, Bobis-Wozowicz S, Zhao L, Kedracka-Krok S, Samanta A, Karnas E, Xuan YT, Skupien-Rabian B, Chen X, Jankowska U, Girgis M, Sekula M, Davani A, Lasota S, Vincent RJ, Sarna M, Newell KL, Wang OL, Dudley N, Madeja Z, Dawn B, Zuba-Surma EK (2018) Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs. Circ Res 122:296\u2013309","journal-title":"Circ Res"},{"key":"3461_CR3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.dsx.2015.04.002","volume":"10","author":"J Ahmad","year":"2016","unstructured":"Ahmad J (2016) The diabetic foot Diabetes Metab Syndr 10:48\u201360","journal-title":"The diabetic foot Diabetes Metab Syndr"},{"key":"3461_CR4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jcrc.2007.08.002","volume":"23","author":"S Ambiru","year":"2008","unstructured":"Ambiru S, Furuyama N, Aono M, Otsuka H, Suzuki T, Miyazaki M (2008) Analysis of risk factors associated with complications of hyperbaric oxygen therapy. J Crit Care 23:295\u2013300","journal-title":"J Crit Care"},{"key":"3461_CR5","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1056\/NEJMra1615439","volume":"376","author":"DG Armstrong","year":"2017","unstructured":"Armstrong DG, Boulton AJM, Bus SA (2017) Diabetic foot ulcers and their recurrence. N Engl J Med 376:2367\u20132375","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"3461_CR6","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.2337\/dc09-S062","volume":"32","author":"AD Association","year":"2009","unstructured":"Association AD (2009) Diagnosis and classification of diabetes mellitus. Diabetes Care 32(Suppl 1):S62-67","journal-title":"Diabetes Care"},{"key":"3461_CR7","doi-asserted-by":"publisher","first-page":"S90","DOI":"10.2337\/dc19-S009","volume":"42","author":"AD Association","year":"2019","unstructured":"Association AD (2019) 9. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes. Diabetes Care 42:S90\u2013S102","journal-title":"Diabetes Care"},{"key":"3461_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13287-017-0609-z","volume":"8","author":"L Avercenc-Leger","year":"2017","unstructured":"Avercenc-Leger L, Guerci P, Virion JM, Cauchois G, Hupont S, Rahouadj R, Magdalou J, Stoltz JF, Bensoussan D, Huselstein C, Reppel L (2017) Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation. Stem Cell Res Ther 8:161","journal-title":"Stem Cell Res Ther"},{"key":"3461_CR9","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.bbrc.2008.11.052","volume":"378","author":"Y Bai","year":"2009","unstructured":"Bai Y, Cui M, Meng Z, Shen L, He Q, Zhang X, Chen F, Xiao J (2009) Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway. Biochem Biophys Res Commun 378:296\u2013301","journal-title":"Biochem Biophys Res Commun"},{"key":"3461_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2217\/rme.09.74","volume":"5","author":"PR Baraniak","year":"2010","unstructured":"Baraniak PR, McDevitt TC (2010) Stem cell paracrine actions and tissue regeneration. Regen Med 5:121\u2013143","journal-title":"Regen Med"},{"key":"3461_CR11","doi-asserted-by":"publisher","first-page":"3660","DOI":"10.1172\/JCI36157","volume":"118","author":"B Bedogni","year":"2008","unstructured":"Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ, Powell MB (2008) Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest 118:3660\u20133670","journal-title":"J Clin Invest"},{"key":"3461_CR12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1089\/scd.2016.0275","volume":"26","author":"S Bhansali","year":"2017","unstructured":"Bhansali S, Dutta P, Kumar V, Yadav MK, Jain A, Mudaliar S, Bhansali S, Sharma RR, Jha V, Marwaha N, Khandelwal N, Srinivasan A, Sachdeva N, Hawkins M, Bhansali A (2017) Efficacy of autologous bone marrow-derived mesenchymal stem cell and mononuclear cell transplantation in type 2 diabetes mellitus: a randomized, placebo-controlled comparative study. Stem Cells Dev 26:471\u2013481","journal-title":"Stem Cells Dev"},{"key":"3461_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1177\/1534734609337151","volume":"8","author":"R Blakytny","year":"2009","unstructured":"Blakytny R, Jude EB (2009) Altered molecular mechanisms of diabetic foot ulcers. Int J Low Extrem Wounds 8:95\u2013104","journal-title":"Int J Low Extrem Wounds"},{"key":"3461_CR14","doi-asserted-by":"publisher","first-page":"616","DOI":"10.2337\/dc08-zb03","volume":"31","author":"ZT Bloomgarden","year":"2008","unstructured":"Bloomgarden ZT (2008) Diabetic neuropathy. Diabetes Care 31:616\u2013621","journal-title":"Diabetic neuropathy. Diabetes Care"},{"key":"3461_CR15","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.tibs.2006.10.002","volume":"31","author":"JL Bos","year":"2006","unstructured":"Bos JL (2006) Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci 31:680\u2013686","journal-title":"Trends Biochem Sci"},{"key":"3461_CR16","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1172\/JCI32169","volume":"117","author":"H Brem","year":"2007","unstructured":"Brem H, Tomic-Canic M (2007) Cellular and molecular basis of wound healing in diabetes. J Clin Invest 117:1219\u20131222","journal-title":"J Clin Invest"},{"key":"3461_CR17","doi-asserted-by":"publisher","first-page":"E1150","DOI":"10.21037\/jtd.2016.10.93","volume":"8","author":"D Buccheri","year":"2016","unstructured":"Buccheri D, Piraino D, Andolina G, Cortese B (2016) Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment. J Thorac Dis 8:E1150\u2013E1162","journal-title":"J Thorac Dis"},{"key":"3461_CR18","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1002\/hep.20920","volume":"42","author":"E Bugianesi","year":"2005","unstructured":"Bugianesi E, McCullough AJ, Marchesini G (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology (Baltimore, MD) 42:987\u20131000","journal-title":"Hepatology (Baltimore, MD)"},{"key":"3461_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102\u2013110","journal-title":"Diabetes"},{"key":"3461_CR20","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1210\/en.2014-1595","volume":"155","author":"Q Cao","year":"2014","unstructured":"Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B (2014) Inhibiting DNA methylation by 5-aza-2\u2019-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology 155:4925\u20134938","journal-title":"Endocrinology"},{"key":"3461_CR21","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1161\/hs1001.096194","volume":"32","author":"SE Capes","year":"2001","unstructured":"Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC (2001) Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32:2426\u20132432","journal-title":"Stroke"},{"key":"3461_CR22","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1182\/blood-2007-04-086231","volume":"111","author":"G Carmona","year":"2008","unstructured":"Carmona G, Chavakis E, Koehl U, Zeiher AM, Dimmeler S (2008) Activation of Epac stimulates integrin-dependent homing of progenitor cells. Blood 111:2640\u20132646","journal-title":"Blood"},{"key":"3461_CR23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fendo.2013.00037","volume":"4","author":"ME Cerf","year":"2013","unstructured":"Cerf ME (2013) Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne) 4:37","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2019","key":"3461_CR24","first-page":"4961865","volume":"27","author":"Y Chang","year":"2019","unstructured":"Chang Y, Dong M, Wang Y, Yu H, Sun C, Jiang X, Chen W, Wang X, Xu N, Liu W, Jin N (2019) GLP-1 gene-modified human umbilical cord mesenchymal stem cell line improves blood glucose level in type 2 diabetic mice. Stem Cells Int 27:4961865","journal-title":"Stem Cells Int"},{"key":"3461_CR25","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/B978-0-7020-4087-0.00051-6","volume":"120","author":"G Charnogursky","year":"2014","unstructured":"Charnogursky G, Lee H, Lopez N (2014) Diabetic neuropathy. Handb Clin Neurol 120:773\u2013785","journal-title":"Handb Clin Neurol"},{"key":"3461_CR26","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s13287-020-01865-7","volume":"11","author":"G Chen","year":"2020","unstructured":"Chen G, Fan XY, Zheng XP, Jin YL, Liu Y, Liu SC (2020) Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K\/Akt and Erk\/MAPKs signaling pathways in the skeletal muscles of db\/db mice. Stem Cell Res Ther 11:401","journal-title":"Stem Cell Res Ther"},{"key":"3461_CR27","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/stem.2193","volume":"34","author":"J Chen","year":"2016","unstructured":"Chen J, Ning R, Zacharek A, Cui C, Cui X, Yan T, Venkat P, Zhang Y, Chopp M (2016a) MiR-126 contributes to human umbilical cord blood cell-induced neurorestorative effects after stroke in type-2 diabetic mice. Stem Cells 34:102\u2013113","journal-title":"Stem Cells"},{"key":"3461_CR28","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","author":"J Chen","year":"2001","unstructured":"Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, Sanchez-Ramos J, Chopp M (2001) Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32:2682\u20132688","journal-title":"Stroke"},{"key":"3461_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11596-021-2323-4","volume":"41","author":"MT Chen","year":"2021","unstructured":"Chen MT, Zhao YT, Zhou LY, Li M, Zhang Q, Han Q, Xiao XH (2021) Exosomes derived from human umbilical cord mesenchymal stem cells enhance insulin sensitivity in insulin resistant human adipocytes. Curr Medl Sci 41:87\u201393","journal-title":"Curr Medl Sci"},{"key":"3461_CR30","first-page":"41","volume":"9","author":"S Chen","year":"2016","unstructured":"Chen S, Zhang W, Wang JM, Duan HT, Kong JH, Wang YX, Dong M, Bi X, Song J (2016b) Differentiation of isolated human umbilical cord mesenchymal stem cells into neural stem cells. Int J Ophthalmol 9:41\u201347","journal-title":"Int J Ophthalmol"},{"key":"3461_CR31","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","volume":"376","author":"N Cheung","year":"2010","unstructured":"Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet (London, England) 376:124\u2013136","journal-title":"Lancet (London, England)"},{"key":"3461_CR32","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jconrel.2017.07.023","volume":"262","author":"B Crivelli","year":"2017","unstructured":"Crivelli B, Chlapanidas T, Perteghella S, Lucarelli E, Pascucci L, Brini AT, Ferrero I, Marazzi M, Pessina A, Torre ML, CellG, IMS (2017) Mesenchymal stem\/stromal cell extracellular vesicles: from active principle to next generation drug delivery system. J Control Release 262:104\u2013117","journal-title":"J Control Release"},{"key":"3461_CR33","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/eye.2009.108","volume":"23","author":"TM Curtis","year":"2009","unstructured":"Curtis TM, Gardiner TA, Stitt AW (2009) Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? Eye (Lond) 23:1496\u20131508","journal-title":"Eye (Lond)"},{"key":"3461_CR34","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1359\/jbmr.1999.14.7.1115","volume":"14","author":"G D'Ippolito","year":"1999","unstructured":"D\u2019Ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA (1999) Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res Off J Am Soc Bone Miner Res 14:1115\u20131122","journal-title":"J Bone Miner Res Off J Am Soc Bone Miner Res"},{"key":"3461_CR35","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/sctm.16-0492","volume":"6","author":"JE Davies","year":"2017","unstructured":"Davies JE, Walker JT, Keating A (2017) Concise review: Wharton\u2019s jelly: the rich, but enigmatic, source of mesenchymal stromal cells. Stem Cells Transl Med 6:1620\u20131630","journal-title":"Stem Cells Transl Med"},{"key":"3461_CR36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11892-018-0970-z","volume":"18","author":"FM Davis","year":"2018","unstructured":"Davis FM, Kimball A, Boniakowski A, Gallagher K (2018) Dysfunctional wound healing in diabetic foot ulcers: new crossroads. Curr Diab Rep 18:2","journal-title":"Curr Diab Rep"},{"key":"3461_CR37","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/ar.24067","volume":"303","author":"SC de Groot","year":"2020","unstructured":"de Groot SC, Sliedregt K, van Benthem PPG, Rivolta MN, Huisman MA (2020) Building an artificial stem cell niche: prerequisites for future 3D-formation of inner ear structures-toward 3D inner ear biotechnology. Anat Rec (Hoboken) 303:408\u2013426","journal-title":"Anat Rec (Hoboken)"},{"key":"3461_CR38","doi-asserted-by":"publisher","first-page":"15019","DOI":"10.1038\/nrdp.2015.19","volume":"1","author":"RA DeFronzo","year":"2015","unstructured":"DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R (2015) Type 2 diabetes mellitus. Nat Rev Dis Primers 1:15019","journal-title":"Nat Rev Dis Primers"},{"key":"3461_CR39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/BF02169795","volume":"227","author":"R Diepold","year":"1989","unstructured":"Diepold R, Kreuter J, Himber J, Gurny R, Lee VH, Robinson JR, Saettone MF, Schnaudigel OE (1989) Comparison of different models for the testing of pilocarpine eyedrops using conventional eyedrops and a novel depot formulation (nanoparticles). Graefes Arch Clin Exp Ophthalmol 227:188\u2013193","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3461_CR40","first-page":"67","volume":"18","author":"CC Doan","year":"2014","unstructured":"Doan CC, Le TL, Hoang NS, Doan NT, Le VD, Do MS (2014) Differentiation of umbilical cord lining membrane-derived mesenchymal stem cells into endothelial-like cells. Iran Biomed J 18:67\u201375","journal-title":"Iran Biomed J"},{"key":"3461_CR41","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nri2925","volume":"11","author":"MY Donath","year":"2011","unstructured":"Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98\u2013107","journal-title":"Nat Rev Immunol"},{"key":"3461_CR42","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.2337\/db06-1650","volume":"56","author":"JA Ehses","year":"2007","unstructured":"Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, Gueripel X, Ellingsgaard H, Schneider MK, Biollaz G, Fontana A, Reinecke M, Homo-Delarche F, Donath MY (2007) Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56:2356\u20132370","journal-title":"Diabetes"},{"key":"3461_CR43","first-page":"113","volume":"31","author":"N Ende","year":"2000","unstructured":"Ende N (2000) The Berashis cell: a review\u2013is it similar to the embryonic stem cell? J Med 31:113\u2013130","journal-title":"J Med"},{"key":"3461_CR44","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.bbrc.2004.06.121","volume":"321","author":"N Ende","year":"2004","unstructured":"Ende N, Chen R, Reddi AS (2004) Transplantation of human umbilical cord blood cells improves glycemia and glomerular hypertrophy in type 2 diabetic mice. Biochem Biophys Res Commun 321:168\u2013171","journal-title":"Biochem Biophys Res Commun"},{"key":"3461_CR45","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1161\/CIRCHEARTFAILURE.112.000162","volume":"6","author":"DT Eurich","year":"2013","unstructured":"Eurich DT, Weir DL, Majumdar SR, Tsuyuki RT, Johnson JA, Tjosvold L, Vanderloo SE, McAlister FA (2013) Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients. Circ Heart Fail 6:395\u2013402","journal-title":"Circ Heart Fail"},{"key":"3461_CR46","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/nyas.13569","volume":"1411","author":"E Everett","year":"2018","unstructured":"Everett E, Mathioudakis N (2018) Update on management of diabetic foot ulcers. Ann N Y Acad Sci 1411:153\u2013165","journal-title":"Ann N Y Acad Sci"},{"key":"3461_CR47","doi-asserted-by":"publisher","first-page":"e86","DOI":"10.1111\/aos.12113","volume":"92","author":"F Ezquer","year":"2014","unstructured":"Ezquer F, Ezquer M, Arango-Rodriguez M, Conget P (2014) Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy? Acta Ophthalmol 92:e86-95","journal-title":"Acta Ophthalmol"},{"key":"3461_CR48","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.bbmt.2009.07.022","volume":"15","author":"F Ezquer","year":"2009","unstructured":"Ezquer F, Ezquer M, Simon V, Pardo F, Ya\u00f1ez A, Carpio D, Conget P (2009) Endovenous administration of bone-marrow-derived multipotent mesenchymal stromal cells prevents renal failure in diabetic mice. Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 15:1354\u20131365","journal-title":"Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation"},{"key":"3461_CR49","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","volume":"366","author":"V Falanga","year":"2005","unstructured":"Falanga V (2005) Wound healing and its impairment in the diabetic foot. Lancet (London, England) 366:1736\u20131743","journal-title":"Lancet (London, England)"},{"key":"3461_CR50","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.3389\/fimmu.2018.02837","volume":"9","author":"JR Ferreira","year":"2018","unstructured":"Ferreira JR, Teixeira GQ, Santos SG, Barbosa MA, Almeida-Porada G, Goncalves RM (2018) Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning. Front Immunol 9:2837","journal-title":"Front Immunol"},{"key":"3461_CR51","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.imbio.2018.01.001","volume":"223","author":"A Fiori","year":"2018","unstructured":"Fiori A, Terlizzi V, Kremer H, Gebauer J, Hammes HP, Harmsen MC, Bieback K (2018) Mesenchymal stromal\/stem cells as potential therapy in diabetic retinopathy. Immunobiol 223:729\u2013743","journal-title":"Immunobiol"},{"key":"3461_CR52","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/jcb.24661","volume":"115","author":"CY Fong","year":"2014","unstructured":"Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, Armugam A, Jeyaseelan K, Choolani M, Biswas A, Bongso A (2014) Human Wharton\u2019s jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds. J Cell Biochem 115:290\u2013302","journal-title":"J Cell Biochem"},{"key":"3461_CR53","doi-asserted-by":"publisher","first-page":"e79416","DOI":"10.1371\/journal.pone.0079416","volume":"8","author":"RW Freilich","year":"2013","unstructured":"Freilich RW, Woodbury ME, Ikezu T (2013) Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. PLoS One 8:e79416","journal-title":"PLoS One"},{"key":"3461_CR54","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0002-9394(01)01269-7","volume":"133","author":"H Funatsu","year":"2002","unstructured":"Funatsu H, Yamashita H, Noma H, Mimura T, Yamashita T, Hori S (2002) Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol 133:70\u201377","journal-title":"Am J Ophthalmol"},{"key":"3461_CR55","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s13287-019-1338-2","volume":"10","author":"J Gao","year":"2019","unstructured":"Gao J, Cheng Y, Hao H, Yin Y, Xue J, Zhang Q, Li L, Liu J, Xie Z, Yu S, Li B, Han W, Mu Y (2019) Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice. Stem Cell Res Ther 10:259","journal-title":"Stem Cell Res Ther"},{"key":"3461_CR56","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrn1927","volume":"7","author":"JM Gidday","year":"2006","unstructured":"Gidday JM (2006) Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci 7:437\u2013448","journal-title":"Nat Rev Neurosci"},{"key":"3461_CR57","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1053\/bbmt.2001.v7.pm11760145","volume":"7","author":"HS Goodwin","year":"2001","unstructured":"Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA (2001) Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 7:581\u2013588","journal-title":"Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation"},{"key":"3461_CR58","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nrendo.2013.138","volume":"9","author":"RW Gruessner","year":"2013","unstructured":"Gruessner RW, Gruessner AC (2013) The current state of pancreas transplantation. Nat Rev Endocrinol 9:555\u2013562","journal-title":"Nat Rev Endocrinol"},{"key":"3461_CR59","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.3892\/etm.2015.2339","volume":"9","author":"LX Guan","year":"2015","unstructured":"Guan LX, Guan H, Li HB, Ren CA, Liu L, Chu JJ, Dai LJ (2015) Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes. Exp Ther Med 9:1623\u20131630","journal-title":"Exp Ther Med"},{"key":"3461_CR60","doi-asserted-by":"publisher","first-page":"7219297","DOI":"10.1155\/2019\/7219297","volume":"2019","author":"BS Guerrouahen","year":"2019","unstructured":"Guerrouahen BS, Sidahmed H, Al Sulaiti A, Al Khulaifi M, Cugno C (2019) Enhancing mesenchymal stromal cell immunomodulation for treating conditions influenced by the immune system. Stem Cells Int 2019:7219297","journal-title":"Stem Cells Int"},{"key":"3461_CR61","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/0022034509359125","volume":"89","author":"S Guo","year":"2010","unstructured":"Guo S, Dipietro LA (2010) Factors affecting wound healing. J Dent Res 89:219\u2013229","journal-title":"J Dent Res"},{"key":"3461_CR62","doi-asserted-by":"publisher","first-page":"9322","DOI":"10.1038\/srep09322","volume":"5","author":"E Hajizadeh-Saffar","year":"2015","unstructured":"Hajizadeh-Saffar E, Tahamtani Y, Aghdami N, Azadmanesh K, Habibi-Anbouhi M, Heremans Y, De Leu N, Heimberg H, Ravassard P, Shokrgozar MA, Baharvand H (2015) Inducible VEGF expression by human embryonic stem cell-derived mesenchymal stromal cells reduces the minimal islet mass required to reverse diabetes. Sci Rep 5:9322","journal-title":"Sci Rep"},{"key":"3461_CR63","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40001-019-0366-9","volume":"24","author":"Y Han","year":"2019","unstructured":"Han Y, Sun T, Han Y, Lin L, Liu C, Liu J, Yan G, Tao R (2019) Human umbilical cord mesenchymal stem cells implantation accelerates cutaneous wound healing in diabetic rats via the Wnt signaling pathway. Eur J Med Res 24:10","journal-title":"Eur J Med Res"},{"key":"3461_CR64","first-page":"2666","volume":"19","author":"YF Han","year":"2015","unstructured":"Han YF, Sun TJ, Han YQ, Xu G, Liu J, Tao R (2015) Clinical perspectives on mesenchymal stem cells promoting wound healing in diabetes mellitus patients by inducing autophagy. Eur Rev Med Pharmacol Sci 19:2666\u20132670","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3461_CR65","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1111\/jocd.12931","volume":"18","author":"SS Hashemi","year":"2019","unstructured":"Hashemi SS, Mohammadi AA, Kabiri H, Hashempoor MR, Mahmoodi M, Amini M, Mehrabani D (2019) The healing effect of Wharton\u2019s jelly stem cells seeded on biological scaffold in chronic skin ulcers: a randomized clinical trial. J Cosmet Dermatol 18:1961\u20131967","journal-title":"J Cosmet Dermatol"},{"key":"3461_CR66","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1177\/0091270006289850","volume":"46","author":"GA Herman","year":"2006","unstructured":"Herman GA, Bergman A, Liu F, Stevens C, Wang AQ, Zeng W, Chen L, Snyder K, Hilliard D, Tanen M, Tanaka W, Meehan AG, Lasseter K, Dilzer S, Blum R, Wagner JA (2006) Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. J Clin Pharmacol 46:876\u2013886","journal-title":"J Clin Pharmacol"},{"key":"3461_CR67","first-page":"327","volume":"136","author":"G Herrmann","year":"1988","unstructured":"Herrmann G, Haverich A, Ziemer G, Luhmer I, Kallfelz HC, Borst HG (1988) Orthotopic heart transplantation in childhood and adolescence. Asian Cardiovasc Thorac Ann 136:327\u2013330","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"3461_CR68","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2337\/diaclin.33.4.175","volume":"33","author":"DA Hinnen","year":"2015","unstructured":"Hinnen DA (2015) Therapeutic options for the management of postprandial glucose in patients with type 2 diabetes on basal insulin. Clin Diabetes 33:175","journal-title":"Clin Diabetes"},{"key":"3461_CR69","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2337\/diabetes.53.1.5","volume":"53","author":"GG Holz","year":"2004","unstructured":"Holz GG (2004) Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 53:5\u201313","journal-title":"Diabetes"},{"key":"3461_CR70","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s12020-013-9984-0","volume":"45","author":"J Hu","year":"2014","unstructured":"Hu J, Wang F, Sun R, Wang Z, Yu X, Wang L, Gao H, Zhao W, Yan S, Wang Y (2014) Effect of combined therapy of human Wharton\u2019s jelly-derived mesenchymal stem cells from umbilical cord with sitagliptin in type 2 diabetic rats. Endocrine 45:279\u2013287","journal-title":"Endocrine"},{"key":"3461_CR71","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.3892\/etm.2016.3544","volume":"12","author":"J Hu","year":"2016","unstructured":"Hu J, Wang Y, Gong H, Yu C, Guo C, Wang F, Yan S, Xu H (2016) Long term effect and safety of Wharton\u2019s jelly-derived mesenchymal stem cells on type 2 diabetes. Exp Ther Med 12:1857\u20131866","journal-title":"Exp Ther Med"},{"key":"3461_CR72","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1507\/endocrj.EJ12-0343","volume":"60","author":"J Hu","year":"2013","unstructured":"Hu J, Yu X, Wang Z, Wang F, Wang L, Gao H, Chen Y, Zhao W, Jia Z, Yan S, Wang Y (2013) Long term effects of the implantation of Wharton\u2019s jelly-derived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocr J 60:347\u2013357","journal-title":"Endocr J"},{"key":"3461_CR73","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s10038-006-0070-9","volume":"51","author":"N Ishii","year":"2006","unstructured":"Ishii N, Ozaki K, Sato H, Mizuno H, Susumu S, Takahashi A, Miyamoto Y, Ikegawa S, Kamatani N, Hori M, Satoshi S, Nakamura Y, Tanaka T (2006) Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. J Hum Genet 51:1087\u20131099","journal-title":"J Hum Genet"},{"issue":"Suppl 1","key":"3461_CR74","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1038\/ncponc0355","volume":"2","author":"JP Issa","year":"2005","unstructured":"Issa JP (2005) Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection. Nat Clin Pract Oncol 2(Suppl 1):S24-29","journal-title":"Nat Clin Pract Oncol"},{"key":"3461_CR75","doi-asserted-by":"publisher","first-page":"49688","DOI":"10.18632\/oncotarget.10434","volume":"7","author":"Q Jiang","year":"2016","unstructured":"Jiang Q, Shan K, Qun-Wang X, Zhou RM, Yang H, Liu C, Li YJ, Yao J, Li XM, Shen Y, Cheng H, Yuan J, Zhang YY, Yan B (2016) Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain. Oncotarget 7:49688\u201349698","journal-title":"Oncotarget"},{"key":"3461_CR76","doi-asserted-by":"publisher","first-page":"e12712","DOI":"10.1111\/cpr.12712","volume":"53","author":"W Jiang","year":"2020","unstructured":"Jiang W, Xu J (2020) Immune modulation by mesenchymal stem cells. Cell Prolif 53:e12712","journal-title":"Cell Prolif"},{"key":"3461_CR77","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2337\/diab.27.1.S201","volume":"27","author":"DG Johnston","year":"1978","unstructured":"Johnston DG, Alberti KGMM, Wright R, Smith-Laing G, Stewart AM, Sherlock S, Faber O, Binder C (1978) C-peptide and insulin in liver disease. Diabetes 27:201\u2013206","journal-title":"Diabetes"},{"key":"3461_CR78","doi-asserted-by":"publisher","first-page":"933","DOI":"10.2217\/rme.10.72","volume":"5","author":"N Joyce","year":"2010","unstructured":"Joyce N, Annett G, Wirthlin L, Olson S, Bauer G, Nolta JA (2010) Mesenchymal stem cells for the treatment of neurodegenerative disease. Regen Med 5:933\u2013946","journal-title":"Regen Med"},{"key":"3461_CR79","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/iwj.12849","volume":"15","author":"JA Jung","year":"2018","unstructured":"Jung JA, Yoon YD, Lee HW, Kang SR, Han SK (2018) Comparison of human umbilical cord blood-derived mesenchymal stem cells with healthy fibroblasts on wound-healing activity of diabetic fibroblasts. Int Wound J 15:133\u2013139","journal-title":"Int Wound J"},{"key":"3461_CR80","first-page":"137","volume":"39","author":"KH Jung","year":"2011","unstructured":"Jung KH, Uhm YK, Lim YJ, Yim SV (2011) Human umbilical cord blood-derived mesenchymal stem cells improve glucose homeostasis in rats with liver cirrhosis. Int J Oncol 39:137\u2013143","journal-title":"Int J Oncol"},{"key":"3461_CR81","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13287-016-0374-4","volume":"7","author":"DH Kassem","year":"2016","unstructured":"Kassem DH, Kamal MM, El-Kholy AE-LG, El-Mesallamy HO (2016) Exendin-4 enhances the differentiation of Wharton\u2019s jelly mesenchymal stem cells into insulin-producing cells through activation of various \u03b2-cell markers. Stem Cell Res Ther 7:108","journal-title":"Stem Cell Res Ther"},{"key":"3461_CR82","doi-asserted-by":"crossref","unstructured":"Kim KS, Choi YK, Kim MJ, Hwang JW, Min K, Jung SY, Kim SK, Choi YS, Cho YW (2020) Umbilical cord-mesenchymal stem cell-conditioned medium improves insulin resistance in C2C12 cell. Diabetes Metab J 32662257","DOI":"10.4093\/dmj.2019.0191"},{"key":"3461_CR83","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.7754\/Clin.Lab.2014.140305","volume":"60","author":"D Kong","year":"2014","unstructured":"Kong D, Zhuang X, Wang D, Qu H, Jiang Y, Li X, Wu W, Xiao J, Liu X, Liu J, Li A, Wang J, Dou A, Wang Y, Sun J, Lv H, Zhang G, Zhang X, Chen S, Ni Y, Zheng C (2014) Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. Clin Lab 60:1969\u20131976","journal-title":"Clin Lab"},{"key":"3461_CR84","doi-asserted-by":"crossref","unstructured":"L PK, Kandoi S, Misra R, Vijayalakshmi S, Rajagopal K, Verma RS (2019) The mesenchymal stem cell secretome:a new paradigm towards cell-free therapeutic mode in regenerative medicine. Cytokine Growth Factor Rev 46:1\u20139","DOI":"10.1016\/j.cytogfr.2019.04.002"},{"key":"3461_CR85","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fneur.2019.00332","volume":"10","author":"F Laso-Garcia","year":"2019","unstructured":"Laso-Garcia F, Diekhorst L, Gomez-de Frutos MC, Otero-Ortega L, Fuentes B, Ruiz-Ares G, Diez-Tejedor E, Gutierrez-Fernandez M (2019) Cell-based therapies for stroke: promising solution or dead end? Mesenchymal stem cells and comorbidities in preclinical stroke research. Front Neurol 10:332","journal-title":"Front Neurol"},{"key":"3461_CR86","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.2337\/dc15-2171","volume":"39","author":"JL Leasher","year":"2016","unstructured":"Leasher JL, Bourne RR, Flaxman SR, Jonas JB, Keeffe J, Naidoo K, Pesudovs K, Price H, White RA, Wong TY, Resnikoff S, Taylor HR (2016) Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010. Diabetes Care 39:1643\u20131649","journal-title":"Diabetes Care"},{"key":"3461_CR87","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1182\/blood-2003-05-1670","volume":"103","author":"OK Lee","year":"2004","unstructured":"Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH (2004) Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103:1669\u20131675","journal-title":"Blood"},{"key":"3461_CR88","doi-asserted-by":"publisher","first-page":"C207","DOI":"10.1152\/ajpcell.00579.2008","volume":"297","author":"SH Lee","year":"2009","unstructured":"Lee SH, Kim MH, Han HJ (2009) Arachidonic acid potentiates hypoxia-induced VEGF expression in mouse embryonic stem cells: involvement of Notch, Wnt, and HIF-1alpha. Am J Physiol Cell Physiol 297:C207-216","journal-title":"Am J Physiol Cell Physiol"},{"key":"3461_CR89","doi-asserted-by":"publisher","first-page":"e111059","DOI":"10.1371\/journal.pone.0111059","volume":"9","author":"C Leite","year":"2014","unstructured":"Leite C, Silva NT, Mendes S, Ribeiro A, de Faria JP, Lourenco T, dos Santos F, Andrade PZ, Cardoso CM, Vieira M, Paiva A, da Silva CL, Cabral JM, Relvas JB, Graos M (2014) Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage. PLoS One 9:e111059","journal-title":"PLoS One"},{"key":"3461_CR90","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S0006-8993(98)00651-9","volume":"804","author":"PA Li","year":"1998","unstructured":"Li PA, Gisselsson L, Keuker J, Vogel J, Smith ML, Kuschinsky W, Siesjo BK (1998) Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction. Brain Res 804:36\u201344","journal-title":"Brain Res"},{"key":"3461_CR91","doi-asserted-by":"publisher","first-page":"4893","DOI":"10.2174\/13816128113199990326","volume":"19","author":"XY Li","year":"2013","unstructured":"Li XY, Zheng ZH, Li XY, Guo J, Zhang Y, Li H, Wang YW, Ren J, Wu ZB (2013) Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies. Curr Pharm Des 19:4893\u20134899","journal-title":"Curr Pharm Des"},{"key":"3461_CR92","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nrendo.2009.101","volume":"5","author":"F Liang","year":"2009","unstructured":"Liang F, Kume S, Koya D (2009) SIRT1 and insulin resistance. Nat Rev Endocrinol 5:367\u2013373","journal-title":"Nat Rev Endocrinol"},{"key":"3461_CR93","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.retram.2019.09.001","volume":"68","author":"LL Liau","year":"2020","unstructured":"Liau LL, Ruszymah BHI, Ng MH, Law JX (2020) Characteristics and clinical applications of Wharton\u2019s jelly-derived mesenchymal stromal cells. Curr Res Transl Med 68:5\u201316","journal-title":"Curr Res Transl Med"},{"key":"3461_CR94","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.nbd.2013.05.006","volume":"58","author":"CH Lin","year":"2013","unstructured":"Lin CH, Lee HT, Lee SD, Lee W, Cho CW, Lin SZ, Wang HJ, Okano H, Su CY, Yu YL, Hsu CY, Shyu WC (2013) Role of HIF-1alpha-activated Epac1 on HSC-mediated neuroplasticity in stroke model. Neurobiol Dis 58:76\u201391","journal-title":"Neurobiol Dis"},{"key":"3461_CR95","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1742-481X.2012.01105.x","volume":"10","author":"G Lu","year":"2013","unstructured":"Lu G, Huang S (2013) Bioengineered skin substitutes: key elements and novel design for biomedical applications. Int Wound J 10:365\u2013371","journal-title":"Int Wound J"},{"key":"3461_CR96","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jdi.12255","volume":"6","author":"Y Maezawa","year":"2015","unstructured":"Maezawa Y, Takemoto M, Yokote K (2015) Cell biology of diabetic nephropathy: roles of endothelial cells, tubulointerstitial cells and podocytes. J Diabetes Investig 6:3\u201315","journal-title":"J Diabetes Investig"},{"key":"3461_CR97","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1478-811X-7-6","volume":"7","author":"I Majore","year":"2009","unstructured":"Majore I, Moretti P, Hass R, Kasper C (2009) Identification of subpopulations in mesenchymal stem cell-like cultures from human umbilical cord. Cell Commun Signal 7:6","journal-title":"Cell Commun Signal"},{"key":"3461_CR98","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s12015-010-9165-y","volume":"7","author":"I Majore","year":"2011","unstructured":"Majore I, Moretti P, Stahl F, Hass R, Kasper C (2011) Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord. Stem Cell Rev Rep 7:17\u201331","journal-title":"Stem Cell Rev Rep"},{"key":"3461_CR99","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/art.37908","volume":"65","author":"C Manferdini","year":"2013","unstructured":"Manferdini C, Maumus M, Gabusi E, Piacentini A, Filardo G, Peyrafitte JA, Jorgensen C, Bourin P, Fleury-Cappellesso S, Facchini A, No\u00ebl D, Lisignoli G (2013) Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. Arthritis Rheum 65:1271\u20131281","journal-title":"Arthritis Rheum"},{"key":"3461_CR100","first-page":"699","volume":"12","author":"R Marti-Centelles","year":"2017","unstructured":"Marti-Centelles R, Murga J, Falomira E, Carda M, Marco JA (2017) Synthesis and biological evaluation of imines structurally related to resveratrol as dual inhibitors of VEGF protein secretion and hTERT gene expression. Nat Prod Commun 12:699\u2013703","journal-title":"Nat Prod Commun"},{"key":"3461_CR101","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.immuni.2014.05.010","volume":"41","author":"JC McNelis","year":"2014","unstructured":"McNelis JC, Olefsky JM (2014) Macrophages, immunity, and metabolic disease. Immunity 41:36\u201348","journal-title":"Immunity"},{"key":"3461_CR102","doi-asserted-by":"publisher","first-page":"e6839","DOI":"10.5867\/medwave.2017.01.6839","volume":"17","author":"CE Meza Letelier","year":"2017","unstructured":"Meza Letelier CE, San Mart\u00edn Ojeda CA, Ruiz Provoste JJ, Frugone Zaror CJ (2017) Pathophysiology of diabetic nephropathy: a literature review. Medwave 17:e6839","journal-title":"Medwave"},{"key":"3461_CR103","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1007\/s00018-016-2229-7","volume":"73","author":"M Mo","year":"2016","unstructured":"Mo M, Wang S, Zhou Y, Li H, Wu Y (2016) Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential. Cell Mol Life Sci 73:3311\u20133321","journal-title":"Cell Mol Life Sci"},{"key":"3461_CR104","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.jcyt.2017.03.074","volume":"19","author":"KC Moon","year":"2017","unstructured":"Moon KC, Lee JS, Han SK, Lee HW, Dhong ES (2017) Effects of human umbilical cord blood-derived mesenchymal stromal cells and dermal fibroblasts on diabetic wound healing. Cytotherapy 19:821\u2013828","journal-title":"Cytotherapy"},{"key":"3461_CR105","first-page":"160","volume":"15","author":"S Moradian","year":"2020","unstructured":"Moradian S, Ebrahimi M, Kanaani A, Faramarzi A, Safi S (2020) Topical umbilical cord serum for corneal epithelial efects after diabetic vitrectomy. J Ophthalmic Vis Res 15:160\u2013165","journal-title":"J Ophthalmic Vis Res"},{"key":"3461_CR106","doi-asserted-by":"publisher","first-page":"R109","DOI":"10.1530\/JME-17-0117","volume":"59","author":"A Moreira","year":"2017","unstructured":"Moreira A, Kahlenberg S, Hornsby P (2017) Therapeutic potential of mesenchymal stem cells for diabetes. J Mol Endocrinol 59:R109\u2013R120","journal-title":"J Mol Endocrinol"},{"key":"3461_CR107","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1634\/stemcells.2004-0123","volume":"23","author":"C Moriscot","year":"2005","unstructured":"Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, Favrot M, Benhamou PY (2005) Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and\/or microenvironmental manipulation in vitro. Stem Cells 23:594\u2013603","journal-title":"Stem Cells"},{"key":"3461_CR108","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.2337\/db08-0022","volume":"57","author":"KA Muller","year":"2008","unstructured":"Muller KA, Ryals JM, Feldman EL, Wright DE (2008) Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. Diabetes 57:1693\u20131701","journal-title":"Diabetes"},{"key":"3461_CR109","doi-asserted-by":"publisher","first-page":"8484","DOI":"10.1038\/s41598-017-08921-y","volume":"7","author":"K Nagaishi","year":"2017","unstructured":"Nagaishi K, Mizue Y, Chikenji T, Otani M, Nakano M, Saijo Y, Tsuchida H, Ishioka S, Nishikawa A, Saito T, Fujimiya M (2017) Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy. Sci Rep 7:8484","journal-title":"Sci Rep"},{"key":"3461_CR110","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000324942","volume":"170","author":"B Najafian","year":"2011","unstructured":"Najafian B, Alpers CE, Fogo AB (2011) Pathology of human diabetic nephropathy. Contrib Nephrol 170:36\u201347","journal-title":"Contrib Nephrol"},{"key":"3461_CR111","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.cellsig.2009.01.038","volume":"21","author":"S Namkoong","year":"2009","unstructured":"Namkoong S, Kim CK, Cho YL, Kim JH, Lee H, Ha KS, Choe J, Kim PH, Won MH, Kwon YG, Shim EB, Kim YM (2009) Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K\/Akt\/eNOS signaling. Cell Signal 21:906\u2013915","journal-title":"Cell Signal"},{"key":"3461_CR112","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3727\/000000006783982043","volume":"15","author":"JD Newcomb","year":"2006","unstructured":"Newcomb JD, Ajmo CT Jr, Sanberg CD, Sanberg PR, Pennypacker KR, Willing AE (2006) Timing of cord blood treatment after experimental stroke determines therapeutic efficacy. Cell Transplant 15:213\u2013223","journal-title":"Cell Transplant"},{"key":"3461_CR113","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/ndt\/gfr267","volume":"27","author":"H Noh","year":"2012","unstructured":"Noh H, Yu MR, Kim HJ, Jeon JS, Kwon SH, Jin SY, Lee J, Jang J, Park JO, Ziyadeh F, Han DC, Lee HB (2012) Uremia induces functional incompetence of bone marrow-derived stromal cells. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association 27:218\u2013225","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association"},{"key":"3461_CR114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.metabol.2010.09.010","volume":"60","author":"EA Nyenwe","year":"2011","unstructured":"Nyenwe EA, Jerkins TW, Umpierrez GE, Kitabchi AE (2011) Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metab Clin Exp 60:1\u201323","journal-title":"Metab Clin Exp"},{"key":"3461_CR115","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","volume":"128","author":"K Ogurtsova","year":"2017","unstructured":"Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Makaroff LE (2017) IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 128:40\u201350","journal-title":"Diabetes Res Clin Pract"},{"key":"3461_CR116","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","volume":"72","author":"JM Olefsky","year":"2010","unstructured":"Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219\u2013246","journal-title":"Annu Rev Physiol"},{"key":"3461_CR117","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1089\/wound.2012.0406","volume":"2","author":"M Pakyari","year":"2013","unstructured":"Pakyari M, Farrokhi A, Maharlooei MK, Ghahary A (2013) Critical role of transforming growth factor beta in different phases of wound healing. Adv Wound Care (New Rochelle) 2:215\u2013224","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"3461_CR118","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mcp.2017.04.002","volume":"34","author":"X-H Pan","year":"2017","unstructured":"Pan X-H, Huang X, Ruan G-P, Pang R-Q, Chen Q, Wang J-X, He J, Zhao J, Cai X-M, Zhao N, Chen Y, Zhu X-Q (2017) Umbilical cord mesenchymal stem cells are able to undergo differentiation into functional islet-like cells in type 2 diabetic tree shrews. Mol Cell Probes 34:1\u201312","journal-title":"Mol Cell Probes"},{"key":"3461_CR119","doi-asserted-by":"publisher","first-page":"218","DOI":"10.23736\/S0026-4806.17.05496-9","volume":"109","author":"N Papadopoulou-Marketou","year":"2018","unstructured":"Papadopoulou-Marketou N, Paschou SA, Marketos N, Adamidi S, Adamidis S, Kanaka-Gantenbein C (2018) Diabetic nephropathy in type 1 diabetes. Minerva Med 109:218\u2013228","journal-title":"Minerva Med"},{"key":"3461_CR120","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2174\/157339912800563963","volume":"8","author":"N Papanas","year":"2012","unstructured":"Papanas N, Eleftheriadou I, Tentolouris N, Maltezos E (2012) Advances in the topical treatment of diabetic foot ulcers. Curr Diabetes Rev 8:209\u2013218","journal-title":"Curr Diabetes Rev"},{"key":"3461_CR121","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev-bioeng-070909-105309","volume":"12","author":"B Parekkadan","year":"2010","unstructured":"Parekkadan B, Milwid JM (2010) Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng 12:87\u2013117","journal-title":"Annu Rev Biomed Eng"},{"key":"3461_CR122","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.diabres.2012.09.034","volume":"98","author":"JH Park","year":"2012","unstructured":"Park JH, Hwang I, Hwang SH, Han H, Ha H (2012a) Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine action. Diabetes Res Clin Pract 98:465\u2013473","journal-title":"Diabetes Res Clin Pract"},{"key":"3461_CR123","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.transproceed.2012.03.044","volume":"44","author":"JH Park","year":"2012","unstructured":"Park JH, Park J, Hwang SH, Han H, Ha H (2012b) Delayed treatment with human umbilical cord blood-derived stem cells attenuates diabetic renal injury. Transplant Proc 44:1123\u20131126","journal-title":"Transplant Proc"},{"key":"3461_CR124","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neulet.2003.08.082","volume":"353","author":"S Park","year":"2003","unstructured":"Park S, Kim EY, Ghil GS, Joo WS, Wang KC, Kim YS, Lee YJ, Lim J (2003) Genetically modified human embryonic stem cells relieve symptomatic motor behavior in a rat model of Parkinson\u2019s disease. Neurosci Lett 353:91\u201394","journal-title":"Neurosci Lett"},{"key":"3461_CR125","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/pr.2017.249","volume":"83","author":"WS Park","year":"2018","unstructured":"Park WS, Ahn SY, Sung SI, Ahn JY, Chang YS (2018) Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders. Pediatr Res 83:214\u2013222","journal-title":"Pediatr Res"},{"key":"3461_CR126","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3389\/fphys.2018.00995","volume":"9","author":"I Pena-Villalobos","year":"2018","unstructured":"Pena-Villalobos I, Casanova-Maldonado I, Lois P, Prieto C, Pizarro C, Lattus J, Osorio G, Palma V (2018) Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol 9:995","journal-title":"Front Physiol"},{"key":"3461_CR127","doi-asserted-by":"publisher","first-page":"327","DOI":"10.4093\/dmj.2017.41.5.327","volume":"41","author":"M Periasamy","year":"2017","unstructured":"Periasamy M, Herrera JL, Reis FCG (2017) Skeletal muscle thermogenesis and Its role in whole body energy metabolism. Diabetes Metab J 41:327\u2013336","journal-title":"Diabetes Metab J"},{"key":"3461_CR128","doi-asserted-by":"crossref","unstructured":"Perry HD, Foulks GN, Thoft RA, Tolentino FI (1978) Corneal complications after closed vitrectomy through the pars plana. Arch Ophthalmol\u00a0(Chicago, Ill : 1960) 96:1401\u20131403","DOI":"10.1001\/archopht.1978.03910060155011"},{"key":"3461_CR129","doi-asserted-by":"publisher","first-page":"8637138","DOI":"10.1155\/2017\/8637138","volume":"2017","author":"C Qi","year":"2017","unstructured":"Qi C, Mao X, Zhang Z, Wu H (2017) Classification and differential diagnosis of diabetic nephropathy. J Diabetes Res 2017:8637138","journal-title":"J Diabetes Res"},{"key":"3461_CR130","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1055\/s-0042-103684","volume":"124","author":"HL Qin","year":"2016","unstructured":"Qin HL, Zhu XH, Zhang B, Zhou L, Wang WY (2016) Clinical evaluation of human umbilical cord mesenchymal stem cell transplantation after angioplasty for diabetic foot. Exp Clin Endocrinol Diabetes 124:497\u2013503","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"3461_CR131","doi-asserted-by":"crossref","unstructured":"Raj V, Claudine S, Subramanian A, Tam K, Biswas A, Bongso A, Fong CY (2019) Histological, immunohistochemical, and genomic evaluation of excisional and diabetic wounds treated with human Wharton\u2019s jelly stem cells with and without a nanocarrier. J Cell Biochem","DOI":"10.1002\/jcb.28398"},{"key":"3461_CR132","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejim.2019.11.011","volume":"71","author":"J Rigor","year":"2020","unstructured":"Rigor J, Martins-Mendes D, Monteiro-Soares M (2020) Risk factors for mortality in patients with a diabetic foot ulcer: a cohort study. Eur J Intern Med 71:107\u2013110","journal-title":"Eur J Intern Med"},{"key":"3461_CR133","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1634\/stemcells.21-1-105","volume":"21","author":"YA Romanov","year":"2003","unstructured":"Romanov YA, Svintsitskaya VA, Smirnov VN (2003) Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 21:105\u2013110","journal-title":"Stem Cells"},{"key":"3461_CR134","doi-asserted-by":"publisher","first-page":"710","DOI":"10.2337\/diabetes.50.4.710","volume":"50","author":"EA Ryan","year":"2001","unstructured":"Ryan EA, Lakey JRT, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kneteman NM, Warnock GL, Larsen I, Shapiro AMJ (2001) Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 50:710","journal-title":"Diabetes"},{"key":"3461_CR135","doi-asserted-by":"publisher","first-page":"34","DOI":"10.21037\/sci.2019.08.11","volume":"6","author":"P Saeedi","year":"2019","unstructured":"Saeedi P, Halabian R, Imani Fooladi AA (2019) A revealing review of mesenchymal stem cells therapy, clinical perspectives and Modification strategies. Stem Cell Investig 6:34","journal-title":"Stem Cell Investig"},{"key":"3461_CR136","doi-asserted-by":"publisher","first-page":"789526","DOI":"10.1155\/2009\/789526","volume":"2009","author":"RC Schugar","year":"2009","unstructured":"Schugar RC, Chirieleison SM, Wescoe KE, Schmidt BT, Askew Y, Nance JJ, Evron JM, Peault B, Deasy BM (2009) High harvest yield, high expansion, and phenotype stability of CD146 mesenchymal stromal cells from whole primitive human umbilical cord tissue. J Biomed Biotechnol 2009:789526","journal-title":"J Biomed Biotechnol"},{"key":"3461_CR137","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s12015-009-9098-5","volume":"5","author":"M Secco","year":"2009","unstructured":"Secco M, Moreira YB, Zucconi E, Vieira NM, Jazedje T, Muotri AR, Okamoto OK, Verjovski-Almeida S, Zatz M (2009) Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood. Stem Cell Rev Rep 5:387\u2013401","journal-title":"Stem Cell Rev Rep"},{"key":"3461_CR138","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1159\/000073890","volume":"3","author":"R Shah","year":"2003","unstructured":"Shah R, Jindal RM (2003) Reversal of diabetes in the rat by injection of hematopoietic stem cells infected with recombinant adeno-associated virus containing the preproinsulin II gene. Pancreatology: official journal of the International Association of Pancreatology (IAP) 3:422\u2013428","journal-title":"Pancreatology: official journal of the International Association of Pancreatology (IAP)"},{"key":"3461_CR139","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.7150\/thno.18082","volume":"7","author":"H Shi","year":"2017","unstructured":"Shi H, Xu X, Zhang B, Xu J, Pan Z, Gong A, Zhang X, Li R, Sun Y, Yan Y, Mao F, Qian H, Xu W (2017) 3,3\u2019-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing. Theranostics 7:1674\u20131688","journal-title":"Theranostics"},{"key":"3461_CR140","doi-asserted-by":"publisher","first-page":"592454","DOI":"10.1155\/2013\/592454","volume":"2013","author":"C Shrestha","year":"2013","unstructured":"Shrestha C, Zhao L, Chen K, He H, Mo Z (2013) Enhanced healing of diabetic wounds by subcutaneous administration of human umbilical cord derived stem cells and their conditioned media. Int J Endocrinol 2013:592454","journal-title":"Int J Endocrinol"},{"key":"3461_CR141","doi-asserted-by":"publisher","first-page":"8872","DOI":"10.1002\/jcb.27140","volume":"119","author":"Y Shu","year":"2018","unstructured":"Shu Y, Yang C, Ji X, Zhang L, Bi Y, Yang K, Gong M, Liu X, Guo Q, Su Y, Qu X, Nan G, Zhao C, Zeng Z, Yu X, Zhang R, Yan S, Lei J, Wu K, Wu Y, An L, Huang S, Gong C, Yuan C, Liu W, Huang B, Feng Y, Zhang B, Dai Z, Shen Y, Luo W, Wang X, Haydon RC, Luu HH, Reid RR, Wolf JM, Lee MJ, He TC, Li Y (2018) Reversibly immortalized human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are responsive to BMP9-induced osteogenic and adipogenic differentiation. J Cell Biochem 119:8872\u20138886","journal-title":"J Cell Biochem"},{"key":"3461_CR142","first-page":"302","volume":"378","author":"AJ Singer","year":"2018","unstructured":"Singer AJ, Tassiopoulos A, Kirsner RS (2018) Evaluation and management of lower-extremity ulcers. N Engl J Med 378:302\u2013303","journal-title":"N Engl J Med"},{"key":"3461_CR143","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/01.ASW.0000305485.98734.1f","volume":"22","author":"BJ Snyder","year":"2009","unstructured":"Snyder BJ, Waldman BJ (2009) Venous thromboembolism prophylaxis and wound healing in patients undergoing major orthopedic surgery. Adv Skin Wound Care 22:311\u2013315","journal-title":"Adv Skin Wound Care"},{"key":"3461_CR144","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.placenta.2004.10.008","volume":"26","author":"K Sobolewski","year":"2005","unstructured":"Sobolewski K, Malkowski A, Bankowski E, Jaworski S (2005) Wharton\u2019s jelly as a reservoir of peptide growth factors. Placenta 26:747\u2013752","journal-title":"Placenta"},{"key":"3461_CR145","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2337\/dc16-2641","volume":"40","author":"SD Solomon","year":"2017","unstructured":"Solomon SD, Chew E, Duh EJ, Sobrin L, Sun JK, VanderBeek BL, Wykoff CC, Gardner TW (2017) Diabetic retinopathy: a position statement by the American Diabetes Association. Diabetes Care 40:412\u2013418","journal-title":"Diabetes Care"},{"key":"3461_CR146","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","volume":"49","author":"B Soria","year":"2000","unstructured":"Soria B, Roche E, Bern\u00e1 G, Le\u00f3n-Quinto T, Reig JA, Mart\u00edn F (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49:157\u2013162","journal-title":"Diabetes"},{"key":"3461_CR147","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/j.2205-0140.2012.tb00013.x","volume":"15","author":"J Spurway","year":"2012","unstructured":"Spurway J, Logan P, Pak S (2012) The development, structure and blood flow within the umbilical cord with particular reference to the venous system. Australas J Ultrasound Med 15:97\u2013102","journal-title":"Australas J Ultrasound Med"},{"key":"3461_CR148","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1161\/01.RES.0000074906.98021.55","volume":"92","author":"V Stepanovic","year":"2003","unstructured":"Stepanovic V, Awad O, Jiao C, Dunnwald M, Schatteman Gina C (2003) Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing. Circ Res 92:1247\u20131253","journal-title":"Circ Res"},{"key":"3461_CR149","doi-asserted-by":"publisher","first-page":"e0127992","DOI":"10.1371\/journal.pone.0127992","volume":"10","author":"A Subramanian","year":"2015","unstructured":"Subramanian A, Fong CY, Biswas A, Bongso A (2015) Comparative characterization of cells from the various compartments of the human umbilical cord shows that the Wharton\u2019s jelly compartment provides the best source of clinically utilizable mesenchymal stem cells. PLoS One 10:e0127992","journal-title":"PLoS One"},{"key":"3461_CR150","first-page":"2460","volume":"18","author":"TJ Sun","year":"2014","unstructured":"Sun TJ, Tao R, Han YQ, Xu G, Liu J, Han YF (2014) Therapeutic potential of umbilical cord mesenchymal stem cells with Wnt\/beta-catenin signaling pathway pre-activated for the treatment of diabetic wounds. Eur Rev Med Pharmacol Sci 18:2460\u20132464","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3461_CR151","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s13287-017-0668-1","volume":"8","author":"X Sun","year":"2017","unstructured":"Sun X, Hao H, Han Q, Song X, Liu J, Dong L, Han W, Mu Y (2017) Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats. Stem Cell Res Ther 8:241","journal-title":"Stem Cell Res Ther"},{"key":"3461_CR152","doi-asserted-by":"publisher","first-page":"7613","DOI":"10.1021\/acsnano.7b07643","volume":"12","author":"Y Sun","year":"2018","unstructured":"Sun Y, Shi H, Yin S, Ji C, Zhang X, Zhang B, Wu P, Shi Y, Mao F, Yan Y, Xu W, Qian H (2018) Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving \u03b2-cell destruction. ACS Nano 12:7613\u20137628","journal-title":"ACS Nano"},{"key":"3461_CR153","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrendo.2016.86","volume":"12","author":"AA Tahrani","year":"2016","unstructured":"Tahrani AA, Barnett AH, Bailey CJ (2016) Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol 12:566\u2013592","journal-title":"Nat Rev Endocrinol"},{"key":"3461_CR154","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/jcb.24723","volume":"115","author":"K Tam","year":"2014","unstructured":"Tam K, Cheyyatraviendran S, Venugopal J, Biswas A, Choolani M, Ramakrishna S, Bongso A, Fong CY (2014) A nanoscaffold impregnated with human Wharton\u2019s jelly stem cells or its secretions improves healing of wounds. J Cell Biochem 115:794\u2013803","journal-title":"J Cell Biochem"},{"key":"3461_CR155","doi-asserted-by":"publisher","first-page":"5825971","DOI":"10.1155\/2017\/5825971","volume":"2017","author":"M Tavakoli","year":"2017","unstructured":"Tavakoli M, Gogas Yavuz D, Tahrani AA, Selvarajah D, Bowling FL, Fadavi H (2017) Diabetic neuropathy: current status and future prospects. J Diabetes Res 2017:5825971","journal-title":"J Diabetes Res"},{"key":"3461_CR156","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2012.01.032","volume":"148","author":"RI Tennen","year":"2012","unstructured":"Tennen RI, Michishita-Kioi E, Chua KF (2012) Finding a target for resveratrol. Cell 148:387\u2013389","journal-title":"Cell"},{"key":"3461_CR157","first-page":"3094","volume":"128","author":"J Thangavel","year":"2015","unstructured":"Thangavel J, Samanta S, Rajasingh S, Barani B, Xuan YT, Dawn B, Rajasingh J (2015) Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. J Cell Sci 128:3094\u20133105","journal-title":"J Cell Sci"},{"key":"3461_CR158","doi-asserted-by":"publisher","first-page":"E1501","DOI":"10.1210\/jc.2013-1451","volume":"98","author":"Q Tong","year":"2013","unstructured":"Tong Q, Duan L, Xu Z, Wang H, Wang X, Li Z, Zhang W, Zheng H (2013) Improved insulin secretion following intrapancreatic UCB transplantation in patients with T2DM. J Clin Endocrinol Metab 98:E1501-1504","journal-title":"J Clin Endocrinol Metab"},{"key":"3461_CR159","doi-asserted-by":"crossref","unstructured":"Tsiapalis D, O'Driscoll L (2020) Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications. Cells 16;9(4):991","DOI":"10.3390\/cells9040991"},{"key":"3461_CR160","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.neuropharm.2017.08.036","volume":"134","author":"P Venkat","year":"2018","unstructured":"Venkat P, Shen Y, Chopp M, Chen J (2018) Cell-based and pharmacological neurorestorative therapies for ischemic stroke. Neuropharmacol 134:310\u2013322","journal-title":"Neuropharmacol"},{"key":"3461_CR161","doi-asserted-by":"publisher","first-page":"224","DOI":"10.2337\/db06-0427","volume":"56","author":"JA Vincent","year":"2007","unstructured":"Vincent JA, Mohr S (2007) Inhibition of caspase-1\/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56:224\u2013230","journal-title":"Diabetes"},{"key":"3461_CR162","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.2337\/diacare.26.5.1553","volume":"26","author":"AI Vinik","year":"2003","unstructured":"Vinik AI, Maser RE, Mitchell BD, Freeman R (2003) Diabetic autonomic neuropathy. Diabetes Care 26:1553\u20131579","journal-title":"Diabetes Care"},{"key":"3461_CR163","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1158\/2326-6066.CIR-15-0073","volume":"3","author":"L Wang","year":"2015","unstructured":"Wang L, Amoozgar Z, Huang J, Saleh MH, Xing D, Orsulic S, Goldberg MS (2015) Decitabine enhances lymphocyte migration and function and synergizes with CTLA-4 blockade in a murine ovarian cancer model. Cancer Immunol Res 3:1030\u20131041","journal-title":"Cancer Immunol Res"},{"key":"3461_CR164","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.nbd.2004.12.016","volume":"19","author":"L Wei","year":"2005","unstructured":"Wei L, Cui L, Snider BJ, Rivkin M, Yu SS, Lee CS, Adams LD, Gottlieb DI, Johnson EM Jr, Yu SP, Choi DW (2005) Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis 19:183\u2013193","journal-title":"Neurobiol Dis"},{"key":"3461_CR165","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1007\/s11064-017-2401-y","volume":"42","author":"W WenBo","year":"2017","unstructured":"WenBo W, Fei Z, YiHeng D, Wei W, TingMang Y, WenHao Z, QianRu L, HaiTao L (2017) Human umbilical cord mesenchymal stem cells overexpressing nerve growth factor ameliorate diabetic cystopathy in rats. Neurochem Res 42:3537\u20133547","journal-title":"Neurochem Res"},{"key":"3461_CR166","doi-asserted-by":"publisher","first-page":"107755","DOI":"10.1016\/j.diabres.2019.05.034","volume":"156","author":"Y Xian","year":"2019","unstructured":"Xian Y, Lin Y, Cao C, Li L, Wang J, Niu J, Guo Y, Sun Y, Wang Y, Wang W (2019) Protective effect of umbilical cord mesenchymal stem cells combined with resveratrol against renal podocyte damage in NOD mice. Diabetes Res Clin Pract 156:107755","journal-title":"Diabetes Res Clin Pract"},{"key":"3461_CR167","doi-asserted-by":"publisher","first-page":"E1211","DOI":"10.1073\/pnas.1321347111","volume":"111","author":"X Xiao","year":"2014","unstructured":"Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK (2014) M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. PNAS USA 111:E1211-1220","journal-title":"PNAS USA"},{"key":"3461_CR168","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.diff.2009.01.001","volume":"77","author":"QP Xie","year":"2009","unstructured":"Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL (2009) Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation 77:483\u2013491","journal-title":"Differentiation"},{"key":"3461_CR169","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1002\/stem.2238","volume":"34","author":"Z Xie","year":"2016","unstructured":"Xie Z, Hao H, Tong C, Cheng Y, Liu J, Pang Y, Si Y, Guo Y, Zang L, Mu Y, Han W (2016) Human umbilical cord-derived mesenchymal stem cells elicit macrophages into an anti-inflammatory phenotype to alleviate insulin resistance in type 2 diabetic rats. Stem Cells 34:627\u2013639","journal-title":"Stem Cells"},{"key":"3461_CR170","doi-asserted-by":"publisher","first-page":"4689798","DOI":"10.1155\/2020\/4689798","volume":"2020","author":"J Xue","year":"2020","unstructured":"Xue J, Cheng Y, Hao H, Gao J, Yin Y, Yu S, Zou J, Liu J, Zhang Q, Mu Y (2020) Low-dose decitabine assists human umbilical cord-derived mesenchymal stem cells in protecting \u03b2 cells via the modulation of the macrophage phenotype in type 2 diabetic mice. Stem Cells Int 2020:4689798","journal-title":"Stem Cells Int"},{"key":"3461_CR171","doi-asserted-by":"publisher","first-page":"e002238","DOI":"10.1161\/JAHA.112.002238","volume":"1","author":"J Yan","year":"2012","unstructured":"Yan J, Tie G, Wang S, Messina KE, DiDato S, Guo S, Messina LM (2012) Type 2 diabetes restricts multipotency of mesenchymal stem cells and impairs their capacity to augment postischemic neovascularization in db\/db mice. J Am Heart Assoc 1:e002238","journal-title":"J Am Heart Assoc"},{"key":"3461_CR172","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1161\/STROKEAHA.115.009870","volume":"46","author":"T Yan","year":"2015","unstructured":"Yan T, Venkat P, Chopp M, Zacharek A, Ning R, Cui Y, Roberts C, Kuzmin-Nichols N, Sanberg CD, Chen J (2015) Neurorestorative therapy of stroke in type 2 diabetes mellitus rats treated with human umbilical cord blood cells. Stroke 46:2599\u20132606","journal-title":"Stroke"},{"key":"3461_CR173","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.intimp.2018.04.051","volume":"60","author":"Y Yin","year":"2018","unstructured":"Yin Y, Hao H, Cheng Y, Gao J, Liu J, Xie Z, Zhang Q, Zang L, Han W, Mu Y (2018a) The homing of human umbilical cord-derived mesenchymal stem cells and the subsequent modulation of macrophage polarization in type 2 diabetic mice. Int Immunopharmacol 60:235\u2013245","journal-title":"Int Immunopharmacol"},{"key":"3461_CR174","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41419-018-0801-9","volume":"9","author":"Y Yin","year":"2018","unstructured":"Yin Y, Hao H, Cheng Y, Zang L, Liu J, Gao J, Xue J, Xie Z, Zhang Q, Han W, Mu Y (2018b) Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice. Cell Death Dis 9:760","journal-title":"Cell Death Dis"},{"key":"3461_CR175","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.jcyt.2015.06.011","volume":"17","author":"HJ You","year":"2015","unstructured":"You HJ, Namgoong S, Han SK, Jeong SH, Dhong ES, Kim WK (2015) Wound-healing potential of human umbilical cord blood-derived mesenchymal stromal cells in vitro-a pilot study. Cytotherapy 17:1506\u20131513","journal-title":"Cytotherapy"},{"key":"3461_CR176","doi-asserted-by":"publisher","first-page":"591","DOI":"10.7150\/ijms.38078","volume":"17","author":"C Yu","year":"2020","unstructured":"Yu C, Yang K, Meng X, Cao B, Wang F (2020) Downregulation of long noncoding RNA MIAT in the retina of diabetic rats with tail-vein Injection of human umbilical-cord mesenchymal stem cells. Int J Med Sci 17:591\u2013598","journal-title":"Int J Med Sci"},{"key":"3461_CR177","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s12975-012-0251-0","volume":"4","author":"SP Yu","year":"2013","unstructured":"Yu SP, Wei Z, Wei L (2013) Preconditioning strategy in stem cell transplantation therapy. Transl Stroke Res 4:76\u201388","journal-title":"Transl Stroke Res"},{"key":"3461_CR178","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/1753-0407.12272","volume":"7","author":"Z Yuan","year":"2015","unstructured":"Yuan Z, Tang Z, He C, Tang W (2015) Diabetic cystopathy: a review. J. Diabetes 7:442\u2013447","journal-title":"Diabetes"},{"key":"3461_CR179","first-page":"110","volume":"13","author":"YC Yun","year":"2019","unstructured":"Yun YC, Jeong SG, Kim SH, Cho GW (2019) Reduced sirtuin 1\/adenosine monophosphate-activated protein kinase in amyotrophic lateral sclerosis patient-derived mesenchymal stem cells can be restored by resveratrol. J Tissue Eng Regen Med 13:110\u2013115","journal-title":"J Tissue Eng Regen Med"},{"key":"3461_CR180","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/stem.1771","volume":"33","author":"B Zhang","year":"2015","unstructured":"Zhang B, Wang M, Gong A, Zhang X, Wu X, Zhu Y, Shi H, Wu L, Zhu W, Qian H, Xu W (2015) HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing. Stem Cells 33:2158\u20132168","journal-title":"Stem Cells"},{"key":"3461_CR181","doi-asserted-by":"crossref","unstructured":"Zhang J, Chen M, Chen J, Lin S, Cai D, Chen C, Chen Z (2017a) Long non-coding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing miR-29b and regulating cell apoptosis. Biosci Rep 37:BSR20170036","DOI":"10.1042\/BSR20170036"},{"key":"3461_CR182","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/s41419-018-0959-1","volume":"9","author":"R Zhang","year":"2018","unstructured":"Zhang R, Yin L, Zhang B, Shi H, Sun Y, Ji C, Chen J, Wu P, Zhang L, Xu W, Qian H (2018) Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury. Cell Death Dis 9:965","journal-title":"Cell Death Dis"},{"key":"3461_CR183","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/s41598-017-00298-2","volume":"7","author":"W Zhang","year":"2017","unstructured":"Zhang W, Wang Y, Kong J, Dong M, Duan H, Chen S (2017b) Therapeutic efficacy of neural stem cells originating from umbilical cord-derived mesenchymal stem cells in diabetic retinopathy. Sci Rep 7:408","journal-title":"Sci Rep"},{"key":"3461_CR184","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/jmcb\/mjw040","volume":"8","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Mei H, Chang X, Chen F, Zhu Y, Han X (2016) Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155. J Mol Cell Biol 8:505\u2013517","journal-title":"J Mol Cell Biol"},{"key":"3461_CR185","first-page":"1625","volume":"8","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Hu Q, Chen F, Zhang J, Guo J, Wang H, Gu J, Ma L, Ho G (2015) Human umbilical cord matrix-derived stem cells exert trophic effects on \u03b2-cell survival in diabetic rats and isolated islets. Dis Model Mech 8:1625\u20131633","journal-title":"Dis Model Mech"},{"key":"3461_CR186","doi-asserted-by":"publisher","first-page":"F621","DOI":"10.1152\/ajprenal.00344.2015","volume":"310","author":"Q Zhu","year":"2016","unstructured":"Zhu Q, Li X-X, Wang W, Hu J, Li P-L, Conley S, Li N (2016) Mesenchymal stem cell transplantation inhibited high salt-induced activation of the NLRP3 inflammasome in the renal medulla in Dahl S rats. Am J Physiol Renal Physiol 310:F621\u2013F627","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Cell and Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-021-03461-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00441-021-03461-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00441-021-03461-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T21:04:27Z","timestamp":1675371867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00441-021-03461-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":186,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["3461"],"URL":"https:\/\/doi.org\/10.1007\/s00441-021-03461-4","relation":{},"ISSN":["0302-766X","1432-0878"],"issn-type":[{"value":"0302-766X","type":"print"},{"value":"1432-0878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]},"assertion":[{"value":"26 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All the authors have read and approved the final manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Author AG is an employee of \u201cBeb\u00e9 Vida - Ci\u00eancias Para A Vida, S.A,\u201d a Portuguese cord blood banking company.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}