{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:33:27Z","timestamp":1761824007873,"version":"3.37.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1114218","APP1092957"],"award-info":[{"award-number":["GNT1114218","APP1092957"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00467-018-3932-4","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T12:33:58Z","timestamp":1520944438000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A guide to missing data for the pediatric nephrologist"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-4884","authenticated-orcid":false,"given":"Nicholas G.","family":"Larkins","sequence":"first","affiliation":[]},{"given":"Jonathan C.","family":"Craig","sequence":"additional","affiliation":[]},{"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"3932_CR1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1191\/1740774504cn032oa","volume":"1","author":"AM Wood","year":"2004","unstructured":"Wood AM, White IR, Thompson SG (2004) Are missing outcome data adequately handled? A review of published randomized controlled trials in major medical journals. Clin Trials 1:368\u2013376","journal-title":"Clin Trials"},{"key":"3932_CR2","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","volume":"367","author":"RJ Little","year":"2012","unstructured":"Little RJ, D'Agostino R, Cohen ML, Dickersin K, Emerson SS, Farrar JT, Frangakis C, Hogan JW, Molenberghs G, Sa M, Neaton JD, Rotnitzky A, Scharfstein D, Shih WJ, Siegel JP, Stern H (2012) The prevention and treatment of missing data in clinical trials. N Engl J Med 367:1355\u20131360","journal-title":"N Engl J Med"},{"key":"3932_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","volume":"61","author":"E Elm von","year":"2008","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344\u2013349","journal-title":"J Clin Epidemiol"},{"key":"3932_CR4","doi-asserted-by":"publisher","first-page":"663","DOI":"10.7326\/0003-4819-134-8-200104170-00012","volume":"134","author":"DG Altman","year":"2001","unstructured":"Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Lang T (2001) The revised CONSORT statement for reporting randomized trials. Ann Intern Med 134:663\u2013694","journal-title":"Ann Intern Med"},{"key":"3932_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.7326\/0003-4819-154-2-201101180-00010","volume":"154","author":"TR Fleming","year":"2011","unstructured":"Fleming TR (2011) Research and reporting methods addressing missing data in clinical trials. Ann Intern Med 154:113\u2013113","journal-title":"Ann Intern Med"},{"key":"3932_CR6","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1056\/NEJMoa1401811","volume":"370","author":"A Hoberman","year":"2014","unstructured":"Hoberman A, Greenfield SP, Mattoo TK, Keren R, Mathews R, Pohl HG, Kropp BP, Skoog SJ, Nelson CP, Moxey-Mims M, Chesney RW, Carpenter MA (2014) Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 370:2367\u20132376","journal-title":"N Engl J Med"},{"key":"3932_CR7","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1056\/NEJMc1408559","volume":"371","author":"JC Craig","year":"2014","unstructured":"Craig JC, Williams GJ, Hodson EM (2014) Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 371:1070\u20131070","journal-title":"N Engl J Med"},{"key":"3932_CR8","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1056\/NEJMra1510059","volume":"375","author":"I Ford","year":"2016","unstructured":"Ford I, Norrie J (2016) Pragmatic trials. N Engl J Med 375:454\u2013463","journal-title":"N Engl J Med"},{"key":"3932_CR9","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/jpc.13008","volume":"51","author":"C Jeffries-Stokes","year":"2015","unstructured":"Jeffries-Stokes C, Stokes A, McDonald L (2015) Pulkurlkpa: the joy of research in aboriginal communities. J Paediatr Child Health 51:1054\u20131059","journal-title":"J Paediatr Child Health"},{"key":"3932_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.eheart.2003.12.001","volume":"6","author":"JGF Cleland","year":"2004","unstructured":"Cleland JGF, Torp-pedersen C, Coletta AP, Lammiman MJ (2004) A method to reduce loss to follow-up in clinical trials: informed, withdrawal of consent. Eur J Heart Fail 6:1\u20132","journal-title":"Eur J Heart Fail"},{"key":"3932_CR11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/1753-6405.12586","volume":"40","author":"C Young","year":"2016","unstructured":"Young C, Gunasekera H, Kong K, Purcell A, Muthayya S, Vincent F, Wright D, Gordon R, Bell J, Gillor G, Booker J, Fernando P, Kalucy D, Sherriff S, Tong A, Parter C, Bailey S, Redman S, Banks E, Craig JC (2016) A case study of enhanced clinical care enabled by aboriginal health research: the Hearing, EAr health and Language Services (HEALS) project. Aust N Z J Public Health 40:523\u2013528","journal-title":"Aust N Z J Public Health"},{"key":"3932_CR12","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/biomet\/63.3.581","volume":"63","author":"DB Rubin","year":"1976","unstructured":"Rubin DB (1976) Inference and missing data. Biometrika 63:581\u2013592","journal-title":"Biometrika"},{"key":"3932_CR13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1037\/1082-989X.7.2.147","volume":"7","author":"JL Schafer","year":"2002","unstructured":"Schafer JL, Graham JW (2002) Missing data: our view of the state of the art. Psychol Methods 7:147\u2013177","journal-title":"Psychol Methods"},{"key":"3932_CR14","volume-title":"Statistical analysis with missing data","author":"RJA Little","year":"2014","unstructured":"Little RJA, Rubin DB (2014) Statistical analysis with missing data. Wiley, Hoboken"},{"key":"3932_CR15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1093\/aje\/kwr302","volume":"175","author":"RH Groenwold","year":"2012","unstructured":"Groenwold RH, Donders AR, Roes KC, Harrell FE Jr, Moons KG (2012) Dealing with missing outcome data in randomized trials and observational studies. Am J Epidemiol 175:210\u2013217","journal-title":"Am J Epidemiol"},{"key":"3932_CR16","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1093\/aje\/kwv114","volume":"182","author":"JW Bartlett","year":"2015","unstructured":"Bartlett JW, Harel O, Carpenter JR (2015) Asymptotically unbiased estimation of exposure odds ratios in complete records logistic regression. Am J Epidemiol 182:730\u2013736","journal-title":"Am J Epidemiol"},{"key":"3932_CR17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/aje\/kws215","volume":"176","author":"V Liublinska","year":"2012","unstructured":"Liublinska V, Rubin DB (2012) Re: \u201cDealing with missing outcome data in randomized trials and observational studies\u201d. Am J Epidemiol 176:357\u2013358","journal-title":"Am J Epidemiol"},{"key":"3932_CR18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1093\/aje\/kww066","volume":"184","author":"J Cologne","year":"2016","unstructured":"Cologne J, Furukawa K (2016) Re: \u201cAsymptotically unbiased estimation of exposure odds ratios in complete records logistic regression\u201d. Am J Epidemiol 184:160","journal-title":"Am J Epidemiol"},{"key":"3932_CR19","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1002\/sim.3944","volume":"29","author":"IR White","year":"2010","unstructured":"White IR, Carlin JB (2010) Bias and efficiency of multiple imputation compared with complete-case analysis for missing covariate values. Stat Med 29:2920\u20132931","journal-title":"Stat Med"},{"key":"3932_CR20","first-page":"949","volume":"14","author":"R Little","year":"2004","unstructured":"Little R, An H (2004) Robust likelihood-based analysis of multivariate data with missing values. Stat Sin 14:949\u2013968","journal-title":"Stat Sin"},{"key":"3932_CR21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1198\/016214504000001844","volume":"100","author":"JG Ibrahim","year":"2005","unstructured":"Ibrahim JG, Chen M-H, Lipsitz SR, Herring AH (2005) Missing-data methods for generalized linear models. J Am Stat Assoc 100:332\u2013346","journal-title":"J Am Stat Assoc"},{"key":"3932_CR22","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/sim.4038","volume":"29","author":"J Cheng","year":"2010","unstructured":"Cheng J, Edwards LJ, Maldonado-Molina MM, Komro KA, Muller KE (2010) Real longitudinal data analysis for real people: building a good enough mixed model. Stat Med 29:504\u2013520","journal-title":"Stat Med"},{"key":"3932_CR23","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1177\/0962280212445834","volume":"23","author":"G Verbeke","year":"2014","unstructured":"Verbeke G, Fieuws S, Molenberghs G, Davidian M (2014) The analysis of multivariate longitudinal data: a review. Stat Methods Med Res 23:42\u201359","journal-title":"Stat Methods Med Res"},{"key":"3932_CR24","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1161\/CIRCOUTCOMES.111.961581","volume":"4","author":"A Teixeira-Pinto","year":"2011","unstructured":"Teixeira-Pinto A, Mauri L (2011) Statistical analysis of noncommensurate multiple outcomes. Circ Cardiovasc Qual Outcomes 4:650\u2013656","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"3932_CR25","doi-asserted-by":"publisher","first-page":"d40","DOI":"10.1136\/bmj.d40","volume":"342","author":"IR White","year":"2011","unstructured":"White IR, Horton NJ, Carpenter J, Pocock SJ (2011) Strategy for intention to treat analysis in randomised trials with missing outcome data. BMJ 342:d40","journal-title":"BMJ"},{"key":"3932_CR26","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1200\/JCO.2009.25.0654","volume":"28","author":"JG Ibrahim","year":"2010","unstructured":"Ibrahim JG, Chu H, Chen LM (2010) Basic concepts and methods for joint models of longitudinal and survival data. J Clin Oncol 28:2796\u20132801","journal-title":"J Clin Oncol"},{"key":"3932_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.0006-341X.2002.00037.x","volume":"58","author":"CL Faucett","year":"2002","unstructured":"Faucett CL, Schenker N, Jeremy MGT (2002) Survival analysis using auxiliary variables via multiple imputation, with application to AIDS clinical trial data. Biometrics 58:37\u201347","journal-title":"Biometrics"},{"key":"3932_CR28","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/(SICI)1097-0258(19970215)16:3<239::AID-SIM483>3.0.CO;2-X","volume":"16","author":"JW Hogan","year":"1997","unstructured":"Hogan JW, Laird NM (1997) Mixture models for the joint distribution of repeated measures and event times. Stat Med 16:239\u2013257","journal-title":"Stat Med"},{"key":"3932_CR29","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/0962280210395740","volume":"22","author":"SR Seaman","year":"2013","unstructured":"Seaman SR, White IR (2013) Review of inverse probability weighting for dealing with missing data. Stat Methods Med Res 22:278\u2013295","journal-title":"Stat Methods Med Res"},{"key":"3932_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1536867X0700700101","volume":"7","author":"F Kreuter","year":"2007","unstructured":"Kreuter F, Valliant R (2007) A survey on survey statistics: what is done and can be done in Stata. Stata J 7:1\u201321","journal-title":"Stata J"},{"key":"3932_CR31","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1093\/ndt\/gft221","volume":"28","author":"MCM Goeij De","year":"2013","unstructured":"De Goeij MCM, Van Diepen M, Jager KJ, Tripepi G, Zoccali C, Dekker FW (2013) Multiple imputation: dealing with missing data. Nephrol Dial Transplant 28:2415\u20132420","journal-title":"Nephrol Dial Transplant"},{"key":"3932_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","volume":"45","author":"S Buuren van","year":"2011","unstructured":"van Buuren S, Groothuis-Oudshoorn K (2011) Mice : multivariate imputation by chained equations in R. J Stat Softw 45:1\u201367. \n                    https:\/\/doi.org\/10.18637\/jss.v045.i03","journal-title":"J Stat Softw"},{"key":"3932_CR33","volume-title":"Stata 14 base reference manual","author":"StataCorp","year":"2015","unstructured":"StataCorp (2015) Stata 14 base reference manual. Stata Press, College Station"},{"key":"3932_CR34","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.jclinepi.2006.01.009","volume":"59","author":"KGM Moons","year":"2006","unstructured":"Moons KGM, Donders RART, Stijnen T, Harrell FE Jr (2006) Using the outcome for imputation of missing predictor values was preferred. J Clin Epidemiol 59:1092\u20131101","journal-title":"J Clin Epidemiol"},{"key":"3932_CR35","doi-asserted-by":"publisher","first-page":"b2393","DOI":"10.1136\/bmj.b2393","volume":"338","author":"JAC Sterne","year":"2009","unstructured":"Sterne JAC, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR (2009) Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ 338:b2393","journal-title":"BMJ"},{"key":"3932_CR36","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1136\/bmj.39261.471806.55","volume":"335","author":"J Hippisley-Cox","year":"2007","unstructured":"Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, May M, Brindle P (2007) Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study. BMJ 335:136\u2013136","journal-title":"BMJ"},{"key":"3932_CR37","unstructured":"Peto R (2007) Doubts about QRISK score: total\/HDL cholesterol should be important [electronic response to Hippisley-Cox J, et al]. BMJ [rapid response]. \n                    http:\/\/www.bmj.com\/rapid-response\/2011\/11\/01\/doubts-about-qrisk-score-total-hdl-cholesterol-should-be-important"},{"key":"3932_CR38","unstructured":"Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, May M, Brindle P (2007) QRISK: authors\u2019 response. BMJ [rapid response]. \n                    http:\/\/www.bmj.com\/rapid-response\/2011\/11\/01\/qrisk-authors-response"},{"key":"3932_CR39","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s11121-007-0070-9","volume":"8","author":"JW Graham","year":"2007","unstructured":"Graham JW, Olchowski AE, Gilreath TD (2007) How many imputations are really needed? Some practical clarifications of multiple imputation theory. Prev Sci 8:206\u2013213","journal-title":"Prev Sci"},{"key":"3932_CR40","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1207\/s15327906mbr3304_5","volume":"33","author":"JL Schafer","year":"1998","unstructured":"Schafer JL, Olsen MK (1998) Multiple imputation for multivariate missing-data problems: a data analyst\u2019s perspective. Multivariate Behav Res 33:545\u2013571","journal-title":"Multivariate Behav Res"},{"key":"3932_CR41","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1046\/j.1467-9876.2003.05168.x","volume":"53","author":"AH Herring","year":"2004","unstructured":"Herring AH, Ibrahim JG, Lipsitz SR (2004) Non-ignorable missing covariate data in survival analysis: a case-study of an International Breast Cancer Study Group trial. J R Stat Soc Ser C Appl Stat 53:293\u2013310","journal-title":"J R Stat Soc Ser C Appl Stat"},{"key":"3932_CR42","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/aje\/kwn071","volume":"168","author":"MA Klebanoff","year":"2008","unstructured":"Klebanoff MA, Cole SR (2008) Use of multiple imputation in the epidemiologic literature. Am J Epidemiol 168:355\u2013357","journal-title":"Am J Epidemiol"},{"key":"3932_CR43","doi-asserted-by":"publisher","first-page":"450","DOI":"10.7326\/0003-4819-146-6-200703200-00154","volume":"146","author":"C Laine","year":"2007","unstructured":"Laine C, Goodman SN, Griswold ME, Sox HC (2007) Reproducible research: moving toward research the public can really trust. Ann Intern Med 146:450\u2013453","journal-title":"Ann Intern Med"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-018-3932-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-3932-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-3932-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T20:26:20Z","timestamp":1552422380000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-018-3932-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,13]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["3932"],"URL":"https:\/\/doi.org\/10.1007\/s00467-018-3932-4","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2018,3,13]]},"assertion":[{"value":"11 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}