{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T19:46:36Z","timestamp":1772480796590,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00467-021-05116-6","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T17:03:17Z","timestamp":1623171797000},"page":"3993-4001","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of the renal angina index for the prediction of acute kidney injury in patients admitted to a European pediatric intensive care unit"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-6019","authenticated-orcid":false,"given":"Francisco","family":"Ribeiro-Mour\u00e3o","sequence":"first","affiliation":[]},{"given":"Ana Carvalho","family":"Vaz","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Marta Jo\u00e3o","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Jardim","sequence":"additional","affiliation":[]},{"given":"Augusto","family":"Ribeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"5116_CR1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000484968","volume":"193","author":"T Fragasso","year":"2018","unstructured":"Fragasso T, Ricci Z, Goldstein SL (2018) Pediatric acute kidney injury. Contrib Nephrol 193:113\u2013126. https:\/\/doi.org\/10.1159\/000484968","journal-title":"Contrib Nephrol"},{"key":"5116_CR2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00467-017-3786-1","volume":"33","author":"JA Kari","year":"2018","unstructured":"Kari JA, Alhasan KA, Shalaby MA, Khathlan N, Safdar OY, Al Rezgan SA, El Desoky S, Albanna AS (2018) Outcome of pediatric acute kidney injury: a multicenter prospective cohort study. Pediatr Nephrol 33:335\u2013340. https:\/\/doi.org\/10.1007\/s00467-017-3786-1","journal-title":"Pediatr Nephrol"},{"key":"5116_CR3","doi-asserted-by":"publisher","first-page":"732","DOI":"10.2215\/CJN.03200906","volume":"2","author":"JM Symons","year":"2007","unstructured":"Symons JM, Chua AN, Somers MJ, Baum MA, Bunchman TE, Benfield MR, Brophy PD, Blowey D, Fortenberry JD, Chand D, Flores FX, Hackbarth R, Alexander SR, Mahan J, McBryde KD, Goldstein SL (2007) Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol 2:732\u2013738. https:\/\/doi.org\/10.2215\/CJN.03200906","journal-title":"Clin J Am Soc Nephrol"},{"key":"5116_CR4","doi-asserted-by":"publisher","first-page":"e0240360","DOI":"10.1371\/journal.pone.0240360","volume":"15","author":"RJ McGalliard","year":"2020","unstructured":"McGalliard RJ, McWilliam SJ, Maguire S, Jones CA, Jennings RJ, Siner S, Newland P, Peak M, Chesters C, Jeffers G, Broughton C, McColl L, Lane S, Paulus S, Cunliffe NA, Baines P, Carrol ED (2020) Identifying critically ill children at high risk of acute kidney injury and renal replacement therapy. PLoS One 15:e0240360. https:\/\/doi.org\/10.1371\/journal.pone.0240360","journal-title":"PLoS One"},{"key":"5116_CR5","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00467-011-2024-5","volume":"27","author":"RK Basu","year":"2012","unstructured":"Basu RK, Chawla LS, Wheeler DS, Goldstein SL (2012) Renal angina: an emerging paradigm to identify children at risk for acute kidney injury. Pediatr Nephrol 27:1067\u20131078. https:\/\/doi.org\/10.1007\/s00467-011-2024-5","journal-title":"Pediatr Nephrol"},{"key":"5116_CR6","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00467-016-3433-2","volume":"32","author":"N Lameire","year":"2017","unstructured":"Lameire N, Van Biesen W, Vanholder R (2017) Epidemiology of acute kidney injury in children worldwide, including developing countries. Pediatr Nephrol 32:1301\u20131314. https:\/\/doi.org\/10.1007\/s00467-016-3433-2","journal-title":"Pediatr Nephrol"},{"key":"5116_CR7","doi-asserted-by":"publisher","first-page":"948","DOI":"10.2215\/CJN.05431207","volume":"3","author":"M Zappitelli","year":"2008","unstructured":"Zappitelli M, Parikh CR, Akcan-Arikan A, Washburn KK, Moffett BS, Goldstein SL (2008) Ascertainment and epidemiology of acute kidney injury varies with definition interpretation. Clin J Am Soc Nephrol 3:948\u2013954. https:\/\/doi.org\/10.2215\/CJN.05431207","journal-title":"Clin J Am Soc Nephrol"},{"key":"5116_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1053\/j.ackd.2016.03.001","volume":"23","author":"BA McMahon","year":"2016","unstructured":"McMahon BA, Koyner JL (2016) Risk stratification for acute kidney injury: are biomarkers enough? Adv Chronic Kidney Dis 23:167\u2013178. https:\/\/doi.org\/10.1053\/j.ackd.2016.03.001","journal-title":"Adv Chronic Kidney Dis"},{"key":"5116_CR9","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2215\/CJN.07201009","volume":"5","author":"SL Goldstein","year":"2010","unstructured":"Goldstein SL, Chawla LS (2010) Renal angina. Clin J Am Soc Nephrol 5:943\u2013949. https:\/\/doi.org\/10.2215\/CJN.07201009","journal-title":"Clin J Am Soc Nephrol"},{"key":"5116_CR10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12882-015-0016-6","volume":"16","author":"RK Basu","year":"2015","unstructured":"Basu RK, Kaddourah A, Terrell T, Mottes T, Arnold P, Jacobs J, Andringa J, Goldstein SL, Prospective Pediatric AKI Research Group (ppAKI) (2015) Assessment of Worldwide Acute Kidney Injury, Renal Angina and Epidemiology in critically ill children (AWARE): study protocol for a prospective observational study. BMC Nephrol 16:24. https:\/\/doi.org\/10.1186\/s12882-015-0016-6","journal-title":"BMC Nephrol"},{"key":"5116_CR11","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ekir.2018.03.004","volume":"3","author":"SL Goldstein","year":"2018","unstructured":"Goldstein SL (2018) The renal angina index to predict acute kidney injury: are adults just large children? Kidney Int Rep 3:516\u2013518. https:\/\/doi.org\/10.1016\/j.ekir.2018.03.004","journal-title":"Kidney Int Rep"},{"key":"5116_CR12","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1681\/ASN.2008070669","volume":"20","author":"SS Waikar","year":"2009","unstructured":"Waikar SS, Bonventre JV (2009) Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 20:672\u2013679. https:\/\/doi.org\/10.1681\/ASN.2008070669","journal-title":"J Am Soc Nephrol"},{"key":"5116_CR13","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1681\/ASN.2008060617","volume":"20","author":"K Doi","year":"2009","unstructured":"Doi K, Yuen PS, Eisner C, Hu X, Leelahavanichkul A, Schnermann J, Star RA (2009) Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol 20:1217\u20131221. https:\/\/doi.org\/10.1681\/ASN.2008060617","journal-title":"J Am Soc Nephrol"},{"key":"5116_CR14","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/ki.2013.349","volume":"85","author":"RK Basu","year":"2014","unstructured":"Basu RK, Zappitelli M, Brunner L, Wang Y, Wong HR, Chawla LS, Wheeler DS, Goldstein SL (2014) Derivation and validation of the renal angina index to improve the prediction of acute kidney injury in critically ill children. Kidney Int 85:659\u2013667. https:\/\/doi.org\/10.1038\/ki.2013.349","journal-title":"Kidney Int"},{"key":"5116_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S2352-4642(17)30183-9","volume":"2","author":"Z Ricci","year":"2018","unstructured":"Ricci Z (2018) A renal angina index to overcome the silence of the kidneys. Lancet Child Adolesc Health 2:83\u201384. https:\/\/doi.org\/10.1016\/S2352-4642(17)30183-9","journal-title":"Lancet Child Adolesc Health"},{"key":"5116_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S2352-4642(17)30181-5","volume":"2","author":"RK Basu","year":"2018","unstructured":"Basu RK, Kaddourah A, Goldstein SL, AWARE Study Investigators (2018) Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study. Lancet Child Adolesc Health 2:112\u2013120. https:\/\/doi.org\/10.1016\/S2352-4642(17)30181-5","journal-title":"Lancet Child Adolesc Health"},{"key":"5116_CR17","doi-asserted-by":"publisher","first-page":"654","DOI":"10.2215\/CJN.09720913","volume":"9","author":"RK Basu","year":"2014","unstructured":"Basu RK, Wang Y, Wong HR, Chawla LS, Wheeler DS, Goldstein SL (2014) Incorporation of biomarkers with the renal angina index for prediction of severe AKI in critically ill children. Clin J Am Soc Nephrol 9:654\u2013662. https:\/\/doi.org\/10.2215\/CJN.09720913","journal-title":"Clin J Am Soc Nephrol"},{"key":"5116_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/ndt\/gfv457","volume":"31","author":"S Menon","year":"2016","unstructured":"Menon S, Goldstein SL, Mottes T, Fei L, Kaddourah A, Terrell T, Arnold P, Bennett MR, Basu RK (2016) Urinary biomarker incorporation into the renal angina index early in intensive care unit admission optimizes acute kidney injury prediction in critically ill children: a prospective cohort study. Nephrol Dial Transplant 31:586\u2013594. https:\/\/doi.org\/10.1093\/ndt\/gfv457","journal-title":"Nephrol Dial Transplant"},{"key":"5116_CR19","first-page":"e39","volume":"8","author":"A Abbasi","year":"2020","unstructured":"Abbasi A, Mehdipour Rabori P, Farajollahi R, Mohammed Ali K, Ataei N, Yousefifard M, Hosseini M (2020) Discriminatory precision of renal angina index in predicting acute kidney injury in children; a systematic review and meta-analysis. Arch Acad Emerg Med 8:e39","journal-title":"Arch Acad Emerg Med"},{"key":"5116_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/kisup.2012.7","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl 2:1\u2013138. https:\/\/doi.org\/10.1038\/kisup.2012.7","journal-title":"Kidney Int Suppl"},{"key":"5116_CR21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/s12882-020-02023-0","volume":"21","author":"L Huang","year":"2020","unstructured":"Huang L, Shi T, Quan W, Li W, Zhang L, Liu X, Huang S, Li Y, Li X (2020) Assessment of early renal angina index for prediction of subsequent severe acute kidney injury during septic shock in children. BMC Nephrol 21:358. https:\/\/doi.org\/10.1186\/s12882-020-02023-0","journal-title":"BMC Nephrol"},{"key":"5116_CR22","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s13312-019-1587-2","volume":"56","author":"J Gawadia","year":"2019","unstructured":"Gawadia J, Mishra K, Kumar M, Saikia D (2019) Prediction of severe acute kidney injury using renal angina index in a pediatric intensive care unit. Indian Pediatr 56:647\u2013652. https:\/\/doi.org\/10.1007\/s13312-019-1587-2","journal-title":"Indian Pediatr"},{"key":"5116_CR23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fped.2018.00118","volume":"6","author":"SK Sethi","year":"2018","unstructured":"Sethi SK, Raghunathan V, Shah S, Dhaliwal M, Jha P, Kumar M, Paluri S, Bansal S, Mhanna MJ, Raina R (2018) Fluid overload and renal angina index at admission are associated with worse outcomes in critically ill children. Front Pediatr 6:118. https:\/\/doi.org\/10.3389\/fped.2018.00118","journal-title":"Front Pediatr"},{"key":"5116_CR24","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1093\/ndt\/gfs533","volume":"28","author":"HE Wang","year":"2013","unstructured":"Wang HE, Jain G, Glassock RJ, Warnock DG (2013) Comparison of absolute serum creatinine changes versus Kidney Disease: Improving Global Outcomes consensus definitions for characterizing stages of acute kidney injury. Nephrol Dial Transplant 28:1447\u20131454. https:\/\/doi.org\/10.1093\/ndt\/gfs533","journal-title":"Nephrol Dial Transplant"},{"key":"5116_CR25","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0140-6736(17)30543-3","volume":"389","author":"J Barasch","year":"2017","unstructured":"Barasch J, Zager R, Bonventre JV (2017) Acute kidney injury: a problem of definition. Lancet 389:779\u2013781. https:\/\/doi.org\/10.1016\/S0140-6736(17)30543-3","journal-title":"Lancet"},{"key":"5116_CR26","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1007\/s00467-019-04294-8","volume":"34","author":"JP Roy","year":"2019","unstructured":"Roy JP, Johnson C, Towne B, Menke F, Kiger S, Young W, Basu R, Chima R, Fei L, Krallman K, Goldstein SL (2019) Use of height-independent baseline creatinine imputation method with renal angina index. Pediatr Nephrol 34:1777\u20131784. https:\/\/doi.org\/10.1007\/s00467-019-04294-8","journal-title":"Pediatr Nephrol"},{"key":"5116_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1611391","volume":"376","author":"A Kaddourah","year":"2017","unstructured":"Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL, AWARE Investigators\u00a0(2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376:11\u201320. https:\/\/doi.org\/10.1056\/NEJMoa1611391","journal-title":"N Engl J Med"},{"key":"5116_CR28","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s00467-018-4001-8","volume":"33","author":"R Kaur","year":"2018","unstructured":"Kaur R, Dhooria GS, Pooni PA, Bhat D, Bhargava S, Kakkar S, Arora K, Bansal N (2018) Utilization of the renal angina index in PICU of a developing country for prediction of subsequent severe acute kidney injury. Pediatr Nephrol 33:2185\u20132191. https:\/\/doi.org\/10.1007\/s00467-018-4001-8","journal-title":"Pediatr Nephrol"},{"key":"5116_CR29","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1097\/PCC.0000000000002411","volume":"21","author":"S Raman","year":"2020","unstructured":"Raman S, Tai CW, Le Marsney R, Schibler A, Gibbons K, Schlapbach LJ (2020) Prediction of acute kidney injury on admission to pediatric intensive care. Pediatr Crit Care Med 21:811\u2013819. https:\/\/doi.org\/10.1097\/PCC.0000000000002411","journal-title":"Pediatr Crit Care Med"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-021-05116-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-021-05116-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-021-05116-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T16:16:20Z","timestamp":1646669780000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-021-05116-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["5116"],"URL":"https:\/\/doi.org\/10.1007\/s00467-021-05116-6","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]},"assertion":[{"value":"3 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval was obtained from the ethics committee of Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Waived by ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Waived by ethics committee","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}