{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:20:06Z","timestamp":1777706406479,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Continuous kidney replacement therapy (CKRT) has recently become the preferred kidney replacement modality for children with acute kidney injury (AKI). We hypothesise that CKRT technical parameters and treatment settings in addition to the clinical characteristics of patients may influence the circuit lifetime in children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study involved children included in the EurAKId registry (NCT 02960867), who underwent CKRT treatment. We analysed patient characteristics and CKRT parameters. The primary end point was mean circuit lifetime (MCL). Secondary end points were number of elective circuit changes and occurrence of dialysis-related complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The analysis was composed of 247 children who underwent 37,562\u00a0h of CKRT (median 78, IQR 37\u2013165\u00a0h per patient). A total of 1357 circuits were utilised (3, IQR 2\u20136 per patient). MCL was longer in regional citrate anticoagulation (RCA), compared to heparin (HA) and no anticoagulation (NA) (42, IQR 32-58\u00a0h; 24, IQR 14-34\u00a0h; 18, IQR 12-24\u00a0h, respectively, p\u2009&lt;\u20090.001). RCA was associated with longer MCL regardless of the patient\u2019s age or dialyser surface. In multivariate analysis, MCL correlated with dialyser surface area (beta\u2009=\u20090.14, p\u2009=\u20090.016), left internal jugular vein vascular access site (beta\u2009=\u2009-0.37, p\u2009=\u20090.027), and the use of HA (beta\u2009=\u2009-0.14, p\u2009=\u20090.038) or NA (beta\u2009=\u2009-0.37, p\u2009&lt;\u20090.001) vs. RCA. RCA was associated with the highest ratio of elective circuit changes and the lowest incidence of complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Anticoagulation modality, dialyser surface, and vascular access site influence MCL. RCA should be considered when choosing first-line anticoagulation for CKRT in children. Further efforts should focus on developing guidelines and clinical practice recommendations for paediatric CKRT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00467-024-06459-6","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T07:01:48Z","timestamp":1721286108000},"page":"3353-3362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Factors influencing circuit lifetime in paediatric continuous kidney replacement therapies \u2013 results from the EurAKId registry"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-4140","authenticated-orcid":false,"given":"Anna","family":"Deja","sequence":"first","affiliation":[]},{"given":"Isabella","family":"Guzzo","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Cappoli","sequence":"additional","affiliation":[]},{"given":"Raffaella","family":"Labbadia","sequence":"additional","affiliation":[]},{"given":"Aysun Karabay","family":"Bayazit","sequence":"additional","affiliation":[]},{"given":"Dincer","family":"Yildizdas","sequence":"additional","affiliation":[]},{"given":"Claus Peter","family":"Schmitt","sequence":"additional","affiliation":[]},{"given":"Marcin","family":"Tkaczyk","sequence":"additional","affiliation":[]},{"given":"Mirjana","family":"Cvetkovic","sequence":"additional","affiliation":[]},{"given":"Mirjana","family":"Kostic","sequence":"additional","affiliation":[]},{"given":"Wesley","family":"Hayes","sequence":"additional","affiliation":[]},{"given":"Rukshana","family":"Shroff","sequence":"additional","affiliation":[]},{"given":"Augustina","family":"Jankauskiene","sequence":"additional","affiliation":[]},{"given":"Ernestas","family":"Virsilas","sequence":"additional","affiliation":[]},{"given":"Germana","family":"Longo","sequence":"additional","affiliation":[]},{"given":"Enrico","family":"Vidal","sequence":"additional","affiliation":[]},{"given":"Sevgi","family":"Mir","sequence":"additional","affiliation":[]},{"given":"Ipek Kaplan","family":"Bulut","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Pasini","sequence":"additional","affiliation":[]},{"given":"Fabio","family":"Paglialonga","sequence":"additional","affiliation":[]},{"given":"Giovanni","family":"Montini","sequence":"additional","affiliation":[]},{"given":"Ebru","family":"Yilmaz","sequence":"additional","affiliation":[]},{"given":"Liane","family":"Correia Costa","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Franz","family":"Schaefer","sequence":"additional","affiliation":[]},{"name":"for the ESCAPE Network","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"6459_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41390-021-01452-3","volume":"91","author":"R Raina","year":"2022","unstructured":"Raina R, Chakraborty R, Tibrewal A, Sethi SK, Bunchman T (2022) Advances in pediatric acute kidney injury. 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The results in this article have not been published previously in whole or part, including not being published in abstract form.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}