{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:25:33Z","timestamp":1760077533326,"version":"3.40.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s00520-020-05618-3","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:02:30Z","timestamp":1594771350000},"page":"1403-1411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Baseline anaemia increases locally advanced rectal cancer mortality in older patients undergoing preoperative chemoradiation"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-3952","authenticated-orcid":false,"given":"Darlene","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"Joana","family":"Sim\u00f5es","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-3683","authenticated-orcid":false,"given":"Laetitia","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Aires","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"C\u00e1rmen","family":"Rey","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Sarmento","sequence":"additional","affiliation":[]},{"given":"Margarida","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"5618_CR1","unstructured":"GLOBOCAN (2018) Estimated number of new cases in 2018, Europe. https:\/\/gco.iarc.fr\/today\/online-analysis-table. Accessed 10.11.2019"},{"issue":"4","key":"5618_CR2","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.ijrobp.2017.12.261","volume":"100","author":"SJ Wang","year":"2018","unstructured":"Wang SJ, Hathout L, Malhotra U, Maloney-Patel N, Kilic S, Poplin E, Jabbour SK (2018) Decision-making strategy for rectal Cancer management using radiation therapy for elderly or comorbid patients. Int J Radiat Oncol Biol Phys 100(4):926\u2013944. https:\/\/doi.org\/10.1016\/j.ijrobp.2017.12.261","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"5618_CR3","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1177\/030089161009600511","volume":"96","author":"V Fiscon","year":"2010","unstructured":"Fiscon V, Portale G, Migliorini G, Frigo F (2010) Laparoscopic resection of colorectal cancer in elderly patients. Tumori 96(5):704\u2013708","journal-title":"Tumori"},{"issue":"5","key":"5618_CR4","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1700\/1190.13204","volume":"98","author":"G Ausili Cefaro","year":"2012","unstructured":"Ausili Cefaro G, Genovesi D, Vinciguerra A, Augurio A, Di Tommaso M, Marchese R, Borzillo V, Tasciotti L, Taraborrelli M, Innocenti P, Colecchia G, Di Nicola M (2012) Effects of preoperative radiochemotherapy with capecitabine for resectable locally advanced rectal cancer in elderly patients. Tumori 98(5):622\u2013629. https:\/\/doi.org\/10.1700\/1190.13204","journal-title":"Tumori"},{"key":"5618_CR5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1471-2407-9-68","volume":"9","author":"B Jung","year":"2009","unstructured":"Jung B, Pahlman L, Johansson R, Nilsson E (2009) Rectal cancer treatment and outcome in the elderly: an audit based on the Swedish Rectal Cancer Registry 1995-2004. BMC Cancer 9:68. https:\/\/doi.org\/10.1186\/1471-2407-9-68","journal-title":"BMC Cancer"},{"issue":"2","key":"5618_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.21037\/jgo.2017.10.10","volume":"9","author":"L Hathout","year":"2018","unstructured":"Hathout L, Maloney-Patel N, Malhotra U, Wang SJ, Chokhavatia S, Dalal I, Poplin E, Jabbour SK (2018) Management of locally advanced rectal cancer in the elderly: a critical review and algorithm. J Gastrointest Oncol 9(2):363\u2013376. https:\/\/doi.org\/10.21037\/jgo.2017.10.10","journal-title":"J Gastrointest Oncol"},{"issue":"11","key":"5618_CR7","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/j.ejso.2018.08.003","volume":"44","author":"I Montroni","year":"2018","unstructured":"Montroni I, Ugolini G, Saur NM, Spinelli A, Rostoft S, Millan M, Wolthuis A, Daniels IR, Hompes R, Penna M, Furst A, Papamichael D, Desai AM, Cascinu S, Gerard JP, Myint AS, Lemmens V, Berho M, Lawler M, De Liguori CN, Potenti F, Nanni O, Altini M, Beets G, Rutten H, Winchester D, Wexner SD, Audisio RA (2018) Personalized management of elderly patients with rectal cancer: expert recommendations of the European Society of Surgical Oncology, European Society of Coloproctology, International Society of Geriatric Oncology, and American College of Surgeons Commission on Cancer. Eur J Surg Oncol 44(11):1685\u20131702. https:\/\/doi.org\/10.1016\/j.ejso.2018.08.003","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"5618_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/17474086.2017.1285695","volume":"10","author":"R Halawi","year":"2017","unstructured":"Halawi R, Moukhadder H, Taher A (2017) Anemia in the elderly: a consequence of aging? Expert Rev Hematol 10(4):327\u2013335. https:\/\/doi.org\/10.1080\/17474086.2017.1285695","journal-title":"Expert Rev Hematol"},{"issue":"1","key":"5618_CR9","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/s41598-018-19572-y","volume":"8","author":"JP V\u00e4yrynen","year":"2018","unstructured":"V\u00e4yrynen JP, Tuomisto A, V\u00e4yrynen SA, Klintrup K, Karhu T, M\u00e4kel\u00e4 J, Herzig KH, Karttunen TJ, M\u00e4kinen MJ (2018) Preoperative anemia in colorectal cancer: relationships with tumor characteristics, systemic inflammation, and survival. Sci Rep 8(1):1126. https:\/\/doi.org\/10.1038\/s41598-018-19572-y","journal-title":"Sci Rep"},{"issue":"1","key":"5618_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/030089160008600104","volume":"86","author":"D Smaniotto","year":"2000","unstructured":"Smaniotto D, Luzi S, Morganti AG, Cellini N (2000) Prognostic significance of anemia and role of erythropoietin in radiation therapy. Tumori 86(1):17\u201323","journal-title":"Tumori"},{"key":"5618_CR11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1201\/b13224-18","volume-title":"Basic clinical radiobiology","author":"MR Horsman","year":"2009","unstructured":"Horsman MR, Van der Kogel AJ (2009) Therapeutic approaches to tumour hypoxia. In: Joiner MKA (ed) Basic clinical radiobiology, 4th edn. Edward Arnold, London, pp 233\u2013245","edition":"4"},{"issue":"11","key":"5618_CR12","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","volume":"47","author":"M Charlson","year":"1994","unstructured":"Charlson M, Szatrowski TP, Peterson J, Gold J (1994) Validation of a combined comorbidity index. J Clin Epidemiol 47(11):1245\u20131251. https:\/\/doi.org\/10.1016\/0895-4356(94)90129-5","journal-title":"J Clin Epidemiol"},{"key":"5618_CR13","unstructured":"WHO (2011) Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. WHO. https:\/\/www.who.int\/vmnis\/indicators\/haemoglobin.pdf. Accessed 09\/11\/2019"},{"key":"5618_CR14","unstructured":"U.S.Department-of-Health-and-Human-Services (2017) Common terminology criteria for adverse events (CTCAE) version 5.0 https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_5x7.pdf. Accessed 09\/11\/2019"},{"issue":"5B","key":"5618_CR15","first-page":"3913","volume":"26","author":"LM Pasetto","year":"2006","unstructured":"Pasetto LM, Friso ML, Pucciarelli S, Basso U, Falci C, Bortolami A, Toppan P, Agostini M, Rugge M, Serpentini S, Nitti D, Monfardini S (2006) Rectal cancer neoadjuvant treatment in elderly patients. Anticancer Res 26(5B):3913\u20133923","journal-title":"Anticancer Res"},{"issue":"6","key":"5618_CR16","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s40266-016-0367-0","volume":"33","author":"V Guimas","year":"2016","unstructured":"Guimas V, Boustani J, Schipman B, Lescut N, Puyraveau M, Bosset JF, Servagi-Vernat S (2016) Preoperative chemoradiotherapy for rectal Cancer in patients aged 75 years and older: acute toxicity, compliance with treatment, and early results. Drugs Aging 33(6):419\u2013425. https:\/\/doi.org\/10.1007\/s40266-016-0367-0","journal-title":"Drugs Aging"},{"issue":"2","key":"5618_CR17","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3892\/mco.2019.1873","volume":"11","author":"T Nishikawa","year":"2019","unstructured":"Nishikawa T, Kawai K, Hata K, Emoto S, Murono K, Sasaki K, Tanaka T, Nozawa H, Ishihara S (2019) Clinical outcomes of preoperative chemoradiotherapy in octogenarian with locally advanced rectal cancer. Mol Clin Oncol 11(2):181\u2013188. https:\/\/doi.org\/10.3892\/mco.2019.1873","journal-title":"Mol Clin Oncol"},{"key":"5618_CR18","unstructured":"Correia CMFFV (2016) An\u00e1lise de sobreviv\u00eancia ao cancro colo-retal nos per\u00edodos 2000\u20132001 e 2007\u20132008 na regi\u00e3o norte de Portugal. Master\u2019s Degree, Universidade Aberta, Portugal"},{"issue":"6","key":"5618_CR19","doi-asserted-by":"publisher","first-page":"e499","DOI":"10.3747\/co.25.4102","volume":"25","author":"SL Liu","year":"2018","unstructured":"Liu SL, O'Brien P, Zhao Y, Hopman WM, Lamond N, Ramjeesingh R (2018) Adjuvant treatment in older patients with rectal cancer: a population-based review. Curr Oncol 25(6):e499\u2013e506. https:\/\/doi.org\/10.3747\/co.25.4102","journal-title":"Curr Oncol"},{"issue":"4","key":"5618_CR20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.clcc.2017.03.016","volume":"16","author":"JM McGrane","year":"2017","unstructured":"McGrane JM, Humes DJ, Acheson AG, Minear F, Wheeler JMD, Walter CJ (2017) Significance of anemia in outcomes after neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Clin Colorectal Cancer 16(4):381\u2013385. https:\/\/doi.org\/10.1016\/j.clcc.2017.03.016","journal-title":"Clin Colorectal Cancer"},{"issue":"3","key":"5618_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3857\/roj.2012.30.3.117","volume":"30","author":"H Lee","year":"2012","unstructured":"Lee H, Park HC, Park W, Choi DH, Kim YI, Park YS, Park JO, Chun HK, Lee WY, Kim HC, Yun SH, Cho YB, Park YA (2012) Negative impact of pretreatment anemia on local control after neoadjuvant chemoradiotherapy and surgery for rectal cancer. Radiat Oncol J 30(3):117\u2013123. https:\/\/doi.org\/10.3857\/roj.2012.30.3.117","journal-title":"Radiat Oncol J"},{"issue":"3","key":"5618_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00384-018-3211-7","volume":"34","author":"ST McSorley","year":"2019","unstructured":"McSorley ST, Johnstone M, Steele CW, Roxburgh CSD, Horgan PG, McMillan DC, Mansouri D (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. Int J Color Dis 34(3):401\u2013408. https:\/\/doi.org\/10.1007\/s00384-018-3211-7","journal-title":"Int J Color Dis"},{"issue":"45","key":"5618_CR23","doi-asserted-by":"publisher","first-page":"79453","DOI":"10.18632\/oncotarget.18401","volume":"8","author":"Y Tian","year":"2017","unstructured":"Tian Y, Jian Z, Xu B, Liu H (2017) Age-adjusted Charlson comorbidity index score as predictor of survival of patients with digestive system cancer who have undergone surgical resection. Oncotarget 8(45):79453\u201379461. https:\/\/doi.org\/10.18632\/oncotarget.18401","journal-title":"Oncotarget"},{"issue":"5","key":"5618_CR24","first-page":"236","volume":"22","author":"O Kostek","year":"2019","unstructured":"Kostek O, Bozkaya Y, Hacioglu MB, Yildirim Ozdemir N, Yilmaz E, Demircan NC, Erdogan B, Uzunoglu S, Cicin I, Zengin N (2019) Is the Charlson comorbidity index a prognostic Indicator for toxicity and mortality in elderly patients with locally advanced rectal cancer? Arch Iran Med 22(5):236\u2013241","journal-title":"Arch Iran Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-020-05618-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-020-05618-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-020-05618-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:04:47Z","timestamp":1626307487000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-020-05618-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["5618"],"URL":"https:\/\/doi.org\/10.1007\/s00520-020-05618-3","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2020,7,15]]},"assertion":[{"value":"25 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the Ethics Committee of the Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, E.P.E. (reference number: 204\/19).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Formal consent was not required as the article was based on the Radiotherapy Department\u2019s electronic health records.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent for publication"}}]}}