{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:13:17Z","timestamp":1767651197423,"version":"3.37.3"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/05704\/2020"],"award-info":[{"award-number":["UIDB\/05704\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Polit\u00e9cnico de Leiria"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Home-based exercise training may improve access to surgical prehabilitation in colorectal cancer (CRC) patients, but its efficacy remains unclear. This study systematically investigated the effects of home-based exercise prehabilitation on postoperative exercise capacity, complications, length of hospital stay, and health-related quality of life (HRQoL) in CRC patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Randomized controlled trials (RCTs) comparing home-based exercise prehabilitation with control in CRC patients were eligible. We searched MEDLINE, Scopus, Web of Science, PEDro, and SPORTDiscus from their inception to June 3, 2024. Methodological quality was assessed using the PEDro scale, and certainty of evidence was assessed using GRADE. Data were synthesized using random-effects meta-analyses, with sensitivity analysis on studies with good methodological quality (PEDro score\u2009\u2265\u20096).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Eight RCTs involving 1092 participants were included. The primary analysis showed a significant improvement in postoperative 6-min walk distance following home-based exercise prehabilitation compared to control (mean difference (MD)\u2009=\u200930.62: 95% CI: [2.94; 57.79]; low-certainty evidence). However, sensitivity analysis revealed no significant between-group differences (MD\u2009=\u200922.60: 95% CI: [\u2212\u20096.27; 51.46]). No significant effects of home-based exercise prehabilitation were found on postoperative complications (risk ratio\u2009=\u20091.00: 95% CI: [\u2212\u20090.78; 1.29]; moderate\u2010certainty evidence), length of hospital stay (MD\u2009= \u2212\u20090.20: 95% CI: [\u2212\u20090.65; 0.23]; moderate\u2010certainty evidence), and HRQoL (physical functioning: MD\u2009=\u20092.62: 95% CI: [\u2212\u20096.16; 11.39]; mental functioning: MD\u2009=\u20091.35: 95% CI: [\u2212\u20096.95; 9.65]; low and very-low certainty evidence).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Home-based exercise prehabilitation does not reduce postoperative complications and length of hospital stay after CRC surgery. Its effects on postoperative exercise capacity and HRQoL remain uncertain due to low-quality evidence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00520-024-09069-y","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T01:51:14Z","timestamp":1733968274000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-2778","authenticated-orcid":false,"given":"Pedro","family":"Machado","sequence":"first","affiliation":[]},{"given":"Andr\u00e9","family":"Paix\u00e3o","sequence":"additional","affiliation":[]},{"given":"B\u00e1rbara","family":"Oliveiros","sequence":"additional","affiliation":[]},{"given":"Raul A.","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Cruz","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"9069_CR1","volume-title":"ACSM\u2019s resource manual for guidelines for exercise testing and prescription","author":"American College of Sports Medicine","year":"2014","unstructured":"American College of Sports Medicine (2014) ACSM\u2019s resource manual for guidelines for exercise testing and prescription, 7th edn. Lippincott Williams & Wilkins, Philadelphia","edition":"7"},{"key":"9069_CR2","first-page":"1746","volume":"103","author":"J Andersson","year":"2016","unstructured":"Andersson J, Angenete E, Gellerstedt M, Anger\u00e5s U, Jess P, Rosenberg J, F\u00fcrst A, Bonjer J, Haglind E (2016) Health-related quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial. Br J Surg 103:1746","journal-title":"Br J Surg"},{"key":"9069_CR3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.surg.2014.03.005","volume":"156","author":"I Antonescu","year":"2014","unstructured":"Antonescu I, Scott S, Tran TT, Mayo NE, Feldman LS (2014) Measuring postoperative recovery: what are clinically meaningful differences? Surgery 156:319\u2013327","journal-title":"Surgery"},{"key":"9069_CR4","doi-asserted-by":"crossref","first-page":"e008562","DOI":"10.1136\/bmjopen-2015-008562","volume":"5","author":"S Armijo-Olivo","year":"2015","unstructured":"Armijo-Olivo S, Saltaji H, Da Costa BR et al (2015) What is the influence of randomization sequence generation and allocation concealment on treatment effects of physical therapy trials? A meta-epidemiological study. BMJ Open 5:e008562\u2013e008562","journal-title":"BMJ Open"},{"key":"9069_CR5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10865-023-00437-3","volume":"47","author":"S Atoui","year":"2024","unstructured":"Atoui S, Carli F, Bernard P, Lee L, Stein B, Charlebois P, Liberman AS (2024) Does a multimodal prehabilitation program improve sleep quality and duration in patients undergoing colorectal resection for cancer? Pilot randomized control trial. J Behav Med 47:43\u201361","journal-title":"J Behav Med"},{"key":"9069_CR6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/SLA.0000000000002293","volume":"267","author":"A Barberan-Garcia","year":"2018","unstructured":"Barberan-Garcia A, Ubr\u00e9 M, Roca J, Lacy AM, Burgos F, Risco R, Mombl\u00e1n D, Balust J, Blanco I, Mart\u00ednez-Pall\u00ed G (2018) Personalised prehabilitation in high-risk patients undergoing elective major abdominal surgery: a randomized blinded controlled trial. Ann Surg 267:50\u201356","journal-title":"Ann Surg"},{"key":"9069_CR7","doi-asserted-by":"crossref","first-page":"e299","DOI":"10.1097\/SLA.0000000000004702","volume":"275","author":"AEM Berkel","year":"2022","unstructured":"Berkel AEM, Bongers BC, Kotte H, Weltevreden P, de Jongh FHC, Eijsvogel MMM, Wymenga M, Bigirwamungu-Bargeman M, van der Palen J, van Det MJ, van Meeteren NLU, Klaase JM (2022) Effects of community-based exercise prehabilitation for patients scheduled for colorectal surgery with high risk for postoperative complications: results of a randomized clinical trial. Ann Surg 275:e299\u2013e306","journal-title":"Ann Surg"},{"key":"9069_CR8","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1016\/j.surge.2023.05.006","volume":"21","author":"M Blumenau Pedersen","year":"2023","unstructured":"Blumenau Pedersen M, Saxton J, Birch S, Rasmussen Villumsen B, Bjerggaard Jensen J (2023) The use of digital technologies to support home-based prehabilitation prior to major surgery: a systematic review. Surgeon 21:e305\u2013e315","journal-title":"Surgeon"},{"key":"9069_CR9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10151-015-1407-1","volume":"20","author":"C Boereboom","year":"2016","unstructured":"Boereboom C, Doleman B, Lund JN et al (2016) Systematic review of pre-operative exercise in colorectal cancer patients. Tech Coloproctol 20:81\u201389","journal-title":"Tech Coloproctol"},{"key":"9069_CR10","volume-title":"Comprehensive meta-analysis: a computer program for research synthesis [Computer Software]","author":"M Borenstein","year":"2005","unstructured":"Borenstein M, Hedges L, Higgins J, Rothstein H (2005) Comprehensive meta-analysis: a computer program for research synthesis [Computer Software]. Biostat, Englewood, NJ"},{"key":"9069_CR11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/0284186X.2017.1423180","volume":"57","author":"G Bousquet-Dion","year":"2018","unstructured":"Bousquet-Dion G, Awasthi R, Loiselle S, Minnella EM, Agnihotram RV, Bergdahl A, Carli F, Scheede-Bergdahl C (2018) Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial. Acta Oncol 57:849\u2013859","journal-title":"Acta Oncol"},{"key":"9069_CR12","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","volume":"51","author":"KL Campbell","year":"2019","unstructured":"Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH (2019) Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc 51:2375\u20132390","journal-title":"Med Sci Sports Exerc"},{"key":"9069_CR13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/jamasurg.2019.5474","volume":"155","author":"F Carli","year":"2020","unstructured":"Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M, Stein B, Charlebois P, Ghitulescu G, Morin N, Jagoe T, Scheede-Bergdahl C, Minnella EM, Fiore JF (2020) Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial. JAMA Surg 155:233\u2013242","journal-title":"JAMA Surg"},{"key":"9069_CR14","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/bjs.7102","volume":"97","author":"F Carli","year":"2010","unstructured":"Carli F, Charlebois P, Stein B, Feldman L, Zavorsky G, Kim DJ, Scott S, Mayo NE (2010) Randomized clinical trial of prehabilitation in colorectal surgery. Br J Surg 97:1187\u20131197","journal-title":"Br J Surg"},{"key":"9069_CR15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jphys.2019.08.005","volume":"66","author":"AG Cashin","year":"2020","unstructured":"Cashin AG, McAuley JH (2020) Clinimetrics: physiotherapy evidence database (PEDro) Scale. J Physiother 66:59","journal-title":"J Physiother"},{"key":"9069_CR16","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1016\/j.clcc.2018.01.004","volume":"17","author":"JL Devin","year":"2018","unstructured":"Devin JL, Jenkins DG, Sax AT, Hughes GI, Aitken JF, Chambers SK, Dunn JC, Bolam KA, Skinner TL (2018) Cardiorespiratory fitness and body composition responses to different intensities and frequencies of exercise training in colorectal cancer survivors. Clin Colorectal Cancer 17:e269\u2013e279","journal-title":"Clin Colorectal Cancer"},{"key":"9069_CR17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11764-015-0490-7","volume":"10","author":"JL Devin","year":"2016","unstructured":"Devin JL, Sax AT, Hughes GI, Jenkins DG, Aitken JF, Chambers SK, Dunn JC, Bolam KA, Skinner TL (2016) The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial. J Cancer Surviv 10:467\u2013479","journal-title":"J Cancer Surviv"},{"key":"9069_CR18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1249\/MSS.0000000000002127","volume":"52","author":"CM Fairman","year":"2020","unstructured":"Fairman CM, Nilsen TS, Newton RU, Taaffe DR, Spry N, Joseph D, Chambers SK, Robinson ZP, Hart NH, Zourdos MC, Focht BC, Peddle-McIntyre CJ, Galv\u00e3o DA (2020) Reporting of resistance training dose, adherence, and tolerance in exercise oncology. Med Sci Sports Exerc 52:315\u2013322","journal-title":"Med Sci Sports Exerc"},{"key":"9069_CR19","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s00432-022-04088-w","volume":"148","author":"R Falz","year":"2022","unstructured":"Falz R, Bischoff C, Thieme R, L\u00e4ssing J, Mehdorn M, Stelzner S, Busse M, Gockel I (2022) Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis. J Cancer Res Clin Oncol 148:2187\u20132213","journal-title":"J Cancer Res Clin Oncol"},{"key":"9069_CR20","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1007\/s00520-018-4109-1","volume":"26","author":"V Ferreira","year":"2018","unstructured":"Ferreira V, Agnihotram RV, Bergdahl A, van Rooijen SJ, Awasthi R, Carli F, Scheede-Bergdahl C (2018) Maximizing patient adherence to prehabilitation: what do the patients say? Support Care Cancer 26:2717\u20132723","journal-title":"Support Care Cancer"},{"key":"9069_CR21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/bjsports-2015-094787","volume":"50","author":"JK Gerritsen","year":"2016","unstructured":"Gerritsen JK, Vincent AJ (2016) Exercise improves quality of life in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med 50:796\u2013803","journal-title":"Br J Sports Med"},{"key":"9069_CR22","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/ALN.0000000000000393","volume":"121","author":"C Gillis","year":"2014","unstructured":"Gillis C, Li C, Lee L, Awasthi R, Augustin B, Gamsa A, Liberman AS, Stein B, Charlebois P, Feldman LS, Carli F (2014) Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology 121:937\u2013947","journal-title":"Anesthesiology"},{"key":"9069_CR23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00268-018-4844-y","volume":"43","author":"UO Gustafsson","year":"2019","unstructured":"Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, Rockall TA, Young-Fadok TM, Hill AG, Soop M, de Boer HD, Urman RD, Chang GJ, Fichera A, Kessler H, Grass F, Whang EE, Fawcett WJ, Carli F, Lobo DN, Rollins KE, Balfour A, Baldini G, Riedel B, Ljungqvist O (2019) Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS\u00ae) Society recommendations: 2018. World J Surg 43:659\u2013695","journal-title":"World J Surg"},{"key":"9069_CR24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jclinepi.2011.01.012","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, Jaeschke R, Williams JW Jr, Murad MH, Sinclair D, Falck-Ytter Y, Meerpohl J, Whittington C, Thorlund K, Andrews J, Sch\u00fcnemann HJ (2011) GRADE guidelines 6. Rating the quality of evidence\u2013imprecision. J Clin Epidemiol 64:1283\u20131293","journal-title":"J Clin Epidemiol"},{"key":"9069_CR25","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jclinepi.2011.04.014","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, Akl EA, Post PN, Norris S, Meerpohl J, Shukla VK, Nasser M, Sch\u00fcnemann HJ (2011) GRADE guidelines: 8. Rating the quality of evidence\u2014indirectness. J Clin Epidemiol 64:1303\u20131310","journal-title":"J Clin Epidemiol"},{"key":"9069_CR26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, Norris S, Vist G, Dahm P, Shukla VK, Higgins J, Falck-Ytter Y, Sch\u00fcnemann HJ (2011) GRADE guidelines: 7. Rating the quality of evidence\u2014inconsistency. J Clin Epidemiol 64:1294\u20131302","journal-title":"J Clin Epidemiol"},{"key":"9069_CR27","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jclinepi.2011.01.011","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Montori V, Vist G, Kunz R, Brozek J, Alonso-Coello P, Djulbegovic B, Atkins D, Falck-Ytter Y, Williams JW Jr, Meerpohl J, Norris SL, Akl EA, Sch\u00fcnemann HJ (2011) GRADE guidelines: 5. Rating the quality of evidence\u2013publication bias. J Clin Epidemiol 64:1277\u20131282","journal-title":"J Clin Epidemiol"},{"key":"9069_CR28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","volume":"64","author":"GH Guyatt","year":"2011","unstructured":"Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, Norris SL, Williams JW Jr, Atkins D, Meerpohl J, Sch\u00fcnemann HJ (2011) GRADE guidelines: 4. Rating the quality of evidence\u2013study limitations (risk of bias). J Clin Epidemiol 64:407\u2013415","journal-title":"J Clin Epidemiol"},{"key":"9069_CR29","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924\u2013926","journal-title":"BMJ"},{"key":"9069_CR30","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/DCR.0b013e3181f2f202","volume":"53","author":"S Hendren","year":"2010","unstructured":"Hendren S, Birkmeyer JD, Yin H, Banerjee M, Sonnenday C, Morris AM (2010) Surgical complications are associated with omission of chemotherapy for stage III colorectal cancer. Dis Colon Rectum 53:1587\u20131593","journal-title":"Dis Colon Rectum"},{"key":"9069_CR31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/SLA.0000000000002329","volume":"268","author":"K Hida","year":"2018","unstructured":"Hida K, Okamura R, Sakai Y, Konishi T, Akagi T, Yamaguchi T, Akiyoshi T, Fukuda M, Yamamoto S, Yamamoto M, Nishigori T, Kawada K, Hasegawa S, Morita S, Watanabe M (2018) Open versus laparoscopic surgery for advanced low rectal cancer: a large, multicenter, propensity score matched cohort study in Japan. Ann Surg 268:318\u2013324","journal-title":"Ann Surg"},{"doi-asserted-by":"crossref","unstructured":"Higgins JPT, Green S (2008) Cochrane handbook for systematic reviews of interventions. Version 5.0.2. Wiley-Blackwell,\u00a0Chichester, UK","key":"9069_CR32","DOI":"10.1002\/9780470712184"},{"unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (2023) Cochrane handbook for systematic reviews of interventions, version 6.4. Wiley,\u00a0Chichester, UK","key":"9069_CR33"},{"doi-asserted-by":"crossref","unstructured":"Karlsson E, Farahnak P, Franz\u00e9n E, Nygren-Bonnier M, Dronkers J, Van Meeteren N, Rydwik E (2019) Feasibility of preoperative supervised home-based exercise in older adults undergoing colorectal cancer surgery \u2013 a randomized controlled design. PLoS One 14(7):e0219158","key":"9069_CR34","DOI":"10.1371\/journal.pone.0219158"},{"key":"9069_CR35","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1007\/s00520-021-06343-1","volume":"29","author":"F L\u00f3pez-Rodr\u00edguez-Arias","year":"2021","unstructured":"L\u00f3pez-Rodr\u00edguez-Arias F, S\u00e1nchez-Guill\u00e9n L, Aranaz-Ost\u00e1riz V, Triguero-C\u00e1novas D, Lario-P\u00e9rez S, Barber-Valles X, Lacueva FJ, Ramirez JM, Arroyo A (2021) Effect of home-based prehabilitation in an enhanced recovery after surgery program for patients undergoing colorectal cancer surgery during the COVID-19 pandemic. Support Care Cancer 29:7785\u20137791","journal-title":"Support Care Cancer"},{"key":"9069_CR36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13741-021-00190-8","volume":"10","author":"L Loughney","year":"2021","unstructured":"Loughney L, West MA, Moyses H, Bates A, Kemp GJ, Hawkins L, Varkonyi-Sepp J, Burke S, Barben CP, Calverley PM, Cox T, Palmer DH, Mythen MG, Grocott MPW, Jack S (2021) The effects of neoadjuvant chemoradiotherapy and an in-hospital exercise training programme on physical fitness and quality of life in locally advanced rectal cancer patients: a randomised controlled trial (The EMPOWER Trial). Perioper Med (London, England) 10:23","journal-title":"Perioper Med (London, England)"},{"key":"9069_CR37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jshs.2023.01.002","volume":"12","author":"V Mart\u00ednez-Vizca\u00edno","year":"2023","unstructured":"Mart\u00ednez-Vizca\u00edno V, Cavero-Redondo I, Reina-Guti\u00e9rrez S, Gracia-Marco L, Gil-Cosano JJ, Bizzozero-Peroni B, Rodriguez-Artalejo F, Ubago-Guisado E (2023) Comparative effects of different types of exercise on health-related quality of life during and after active cancer treatment: a systematic review and network meta-analysis. J Sport Health Sci 12:726\u2013738","journal-title":"J Sport Health Sci"},{"key":"9069_CR38","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","volume":"22","author":"ML McHugh","year":"2012","unstructured":"McHugh ML (2012) Interrater reliability: the kappa statistic. Biochemia Medica 22:276\u2013282","journal-title":"Biochemia Medica"},{"issue":"7","key":"9069_CR39","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ejso.2018.04.016","volume":"44","author":"EM Minnella","year":"2018","unstructured":"Minnella EM, Carli F (2018) Prehabilitation and functional recovery for colorectal cancer patients. Eur J Surg Oncol 44(7):919\u2013926","journal-title":"Eur J Surg Oncol"},{"key":"9069_CR40","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/EJA.0000000000001215","volume":"37","author":"EM Minnella","year":"2020","unstructured":"Minnella EM, Ferreira V, Awasthi R, Charlebois P, Stein B, Liberman AS, Scheede-Bergdahl C, Morais JA, Carli F (2020) Effect of two different pre-operative exercise training regimens before colorectal surgery on functional capacity: a randomised controlled trial. Eur J Anaesthesiol 37:969\u2013978","journal-title":"Eur J Anaesthesiol"},{"key":"9069_CR41","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097\u2013e1000097","journal-title":"PLoS Med"},{"key":"9069_CR42","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/jamasurg.2023.0198","volume":"158","author":"CJL Molenaar","year":"2023","unstructured":"Molenaar CJL, Minnella EM, Coca-Martinez M, Ten Cate DWG, Regis M, Awasthi R, Mart\u00ednez-Palli G, L\u00f3pez-Baamonde M, Sebio-Garcia R, Feo CV, van Rooijen SJ, Schreinemakers JMJ, Bojesen RD, G\u00f6genur I, van den Heuvel ER, Carli F, Slooter GD (2023) Effect of multimodal prehabilitation on reducing postoperative complications and enhancing functional capacity following colorectal cancer surgery: the PREHAB randomized clinical trial. JAMA Surg 158:572\u2013581","journal-title":"JAMA Surg"},{"key":"9069_CR43","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1249\/MSS.0000000000001545","volume":"50","author":"TS Nilsen","year":"2018","unstructured":"Nilsen TS, Scott JM, Michalski M, Capaci C, Thomas S, Herndon JE, Sasso J, Eves ND, Jones LW (2018) Novel methods for reporting of exercise dose and adherence: an exploratory analysis. Med Sci Sports Exerc 50:1134\u20131141","journal-title":"Med Sci Sports Exerc"},{"key":"9069_CR44","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1007\/s00520-019-05098-0","volume":"28","author":"MJ Northgraves","year":"2020","unstructured":"Northgraves MJ, Arunachalam L, Madden LA, Marshall P, Hartley JE, MacFie J, Vince RV (2020) Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial. Support Care Cancer 28:3197\u20133206","journal-title":"Support Care Cancer"},{"key":"9069_CR45","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/SLA.0000000000004901","volume":"275","author":"A Onerup","year":"2022","unstructured":"Onerup A, Andersson J, Angenete E, Bock D, B\u00f6rjesson M, Ehrencrona C, Fagevik Ols\u00e9n M, Larsson PA, de la Croix H, Wedin A, Haglind E (2022) Effect of short-term homebased pre- and postoperative exercise on recovery after colorectal cancer surgery (PHYSSURG-C): a randomized clinical trial. Ann Surg 275:448\u2013455","journal-title":"Ann Surg"},{"key":"9069_CR46","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71","journal-title":"BMJ"},{"key":"9069_CR47","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/bjs\/znad252","volume":"110","author":"YS Patel","year":"2023","unstructured":"Patel YS, Sullivan KA, Churchill IF, Beauchamp MK, Wald J, Mbuagbaw L, Fahim C, Hanna WC (2023) Preconditioning program reduces the incidence of prolonged hospital stay after lung cancer surgery: results from the Move For Surgery randomized clinical trial. Br J Surg 110:1467\u20131472","journal-title":"Br J Surg"},{"key":"9069_CR48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1470-2045(20)30675-6","volume":"22","author":"SK Perera","year":"2021","unstructured":"Perera SK, Jacob S, Wilson BE, Ferlay J, Bray F, Sullivan R, Barton M (2021) Global demand for cancer surgery and an estimate of the optimal surgical and anaesthesia workforce between 2018 and 2040: a population-based modelling study. Lancet Oncol 22:182\u2013189","journal-title":"Lancet Oncol"},{"key":"9069_CR49","doi-asserted-by":"crossref","first-page":"e12015","DOI":"10.1002\/cesm.12015","volume":"1","author":"T Pitre","year":"2023","unstructured":"Pitre T, Kirsh S, Jassal T, Anderson M, Padoan A, Xiang A, Mah J, Zeraatkar D (2023) The impact of blinding on trial results: a systematic review and meta-analysis. Cochrane Evid Synth Methods 1:e12015","journal-title":"Cochrane Evid Synth Methods"},{"key":"9069_CR50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.6004\/jnccn.2018.7082","volume":"17","author":"K Schaffer","year":"2019","unstructured":"Schaffer K, Panneerselvam N, Loh KP, Herrmann R, Kleckner IR, Dunne RF, Lin PJ, Heckler CE, Gerbino N, Bruckner LB, Storozynsky E, Ky B, Baran A, Mohile SG, Mustian KM, Fung C (2019) Systematic review of randomized controlled trials of exercise interventions using digital activity trackers in patients with Cancer. J Natl Compr Canc Netw 17:57\u201363","journal-title":"J Natl Compr Canc Netw"},{"key":"9069_CR51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1472-6947-7-16","volume":"7","author":"C Schardt","year":"2007","unstructured":"Schardt C, Adams MB, Owens T et al (2007) Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak 7:16","journal-title":"BMC Med Inform Decis Mak"},{"key":"9069_CR52","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1054\/math.2000.0372","volume":"5","author":"C Sherrington","year":"2000","unstructured":"Sherrington C, Herbert RD, Maher CG, Moseley AM (2000) PEDro. A database of randomized trials and systematic reviews in physiotherapy. Man Ther 5:223\u2013226","journal-title":"Man Ther"},{"key":"9069_CR53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/OAJCT.S34419","volume":"5","author":"F Song","year":"2013","unstructured":"Song F, Hooper L, Loke YK (2013) Publication bias: What is it? How do we measure it? How do we avoid it? Open Access J Clin Trials 5:71\u201381","journal-title":"Open Access J Clin Trials"},{"key":"9069_CR54","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/ans.17602","volume":"92","author":"H Tang","year":"2022","unstructured":"Tang H, Besson A, Deftereos I, Mahon B, Cho J, Faragher I, Gough K, Yeung J (2022) The health-related quality of life changes following surgery in patients with colorectal cancer: a longitudinal study. ANZ J Surg 92:1461\u20131465","journal-title":"ANZ J Surg"},{"key":"9069_CR55","doi-asserted-by":"crossref","first-page":"108270","DOI":"10.1016\/j.ejso.2024.108270","volume":"50","author":"DWG Ten Cate","year":"2024","unstructured":"Ten Cate DWG, Molenaar CJL, Garcia RS, Bojesen RD, Tahasildar BLR, Jansen L, L\u00f3pez-Baamonde M, Feo CV, Mart\u00ednez-Palli G, G\u00f6genur I, Carli F, Slooter GD (2024) Multimodal prehabilitation in elective oncological colorectal surgery enhances postoperative functional recovery: a secondary analysis of the PREHAB randomized clinical trial. Eur J Surg Oncol 50:108270","journal-title":"Eur J Surg Oncol"},{"key":"9069_CR56","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/DCR.0b013e3182a857eb","volume":"56","author":"SE Tevis","year":"2013","unstructured":"Tevis SE, Kohlnhofer BM, Stringfield S, Foley EF, Harms BA, Heise CP, Kennedy GD (2013) Postoperative complications in patients with rectal cancer are associated with delays in chemotherapy that lead to worse disease-free and overall survival. Dis Colon Rectum 56:1339\u20131348","journal-title":"Dis Colon Rectum"},{"key":"9069_CR57","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1016\/j.ejso.2021.07.007","volume":"47","author":"SN Thomsen","year":"2021","unstructured":"Thomsen SN, M\u00f8rup ST, Mau-S\u00f8rensen M, Sillesen M, Lahart I, Christensen JF (2021) Perioperative exercise training for patients with gastrointestinal cancer undergoing surgery: a systematic review and meta-analysis. Eur J Surg Oncol 47:3028\u20133039","journal-title":"Eur J Surg Oncol"},{"issue":"12","key":"9069_CR58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00520-023-08140-4","volume":"31","author":"D Triguero-C\u00e1novas","year":"2023","unstructured":"Triguero-C\u00e1novas D, L\u00f3pez-Rodrg\u00eduez-Arias F, G\u00f3mez-Mart\u00ednez M, S\u00e1nchez-Guill\u00e9n L, Peris-Castell\u00f3 F, Alcaide-Quir\u00f3s MJ, Morillas-Blasco P, Arroyo A, Ram\u00edrez JM (2023) Home-based prehabilitation improves physical conditions measured by ergospirometry and 6MWT in colorectal cancer patients: a randomized controlled pilot study. Support Care Cancer 31(12):673","journal-title":"Support Care Cancer"},{"key":"9069_CR59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/02841860600847053","volume":"46","author":"A Tsunoda","year":"2007","unstructured":"Tsunoda A, Nakao K, Hiratsuka K et al (2007) Prospective analysis of quality of life in the first year after colorectal cancer surgery. Acta Oncol 46:77\u201382","journal-title":"Acta Oncol"},{"key":"9069_CR60","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12885-017-3066-2","volume":"17","author":"M van Zutphen","year":"2017","unstructured":"van Zutphen M, Winkels RM, van Duijnhoven FJB, van Harten-Gerritsen SA, Kok DEG, van Duijvendijk P, van Halteren HK, Hansson BME, Kruyt FM, Bilgen EJS, de Wilt JHW, Dronkers JJ, Kampman E (2017) An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning: a prospective cohort study. BMC Cancer 17:74\u201374","journal-title":"BMC Cancer"},{"key":"9069_CR61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14:135","journal-title":"BMC Med Res Methodol"},{"key":"9069_CR62","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ejso.2021.10.035","volume":"48","author":"AK Warps","year":"2022","unstructured":"Warps AK, Tollenaar R, Tanis PJ, Dekker JWT (2022) Postoperative complications after colorectal cancer surgery and the association with long-term survival. Eur J Surg Oncol 48:873\u2013882","journal-title":"Eur J Surg Oncol"},{"key":"9069_CR63","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00520-020-05547-1","volume":"29","author":"JL Waterland","year":"2021","unstructured":"Waterland JL, Ismail H, Amin B, Granger CL, Denehy L, Riedel B (2021) Patient acceptance of prehabilitation for major surgery: an exploratory survey. Support Care Cancer 29:779\u2013785","journal-title":"Support Care Cancer"},{"key":"9069_CR64","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1365-2702.2009.03099.x","volume":"19","author":"B Wennstr\u00f6m","year":"2010","unstructured":"Wennstr\u00f6m B, Stomberg MW, Modin M, Skullman S (2010) Patient symptoms after colonic surgery in the era of enhanced recovery - a long-term follow-up. J Clin Nurs 19:666\u2013672","journal-title":"J Clin Nurs"},{"issue":"4","key":"9069_CR65","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bpa.2021.01.001","volume":"35","author":"MA West","year":"2021","unstructured":"West MA, Jack S, Grocott MPW (2021) Prehabilitation before surgery: is it for all patients? Best Pract Res Clin Anaesthesiol 35(4):507\u2013516","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"9069_CR66","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/bja\/aeu318","volume":"114","author":"MA West","year":"2015","unstructured":"West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ, Grocott MPW, Jack S (2015) Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth 114:244\u2013251","journal-title":"Br J Anaesth"},{"issue":"4","key":"9069_CR67","doi-asserted-by":"crossref","first-page":"e0231332","DOI":"10.1371\/journal.pone.0231332","volume":"15","author":"S Wheelwright","year":"2020","unstructured":"Wheelwright S, Permyakova NV, Calman L, Din A, Fenlon D, Richardson A, Sodergren S, Smith PWF, Winter J, Foster C (2020) Does quality of life return to pre-treatment levels five years after curative intent surgery for colorectal cancer? Evidence from the ColoREctal Wellbeing (CREW) study. PLoS One 15(4):e0231332","journal-title":"PLoS One"},{"key":"9069_CR68","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/j.ejca.2009.08.014","volume":"45","author":"RN Whistance","year":"2009","unstructured":"Whistance RN, Conroy T, Chie W, Costantini A, Sezer O, Koller M, Johnson CD, Pilkington SA, Arraras J, Ben-Josef E, Pullyblank AM, Fayers P, Blazeby JM (2009) Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. Eur J Cancer 45:3017\u20133026","journal-title":"Eur J Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09069-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-024-09069-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-024-09069-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T09:42:45Z","timestamp":1737366165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-024-09069-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["9069"],"URL":"https:\/\/doi.org\/10.1007\/s00520-024-09069-y","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"29 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"20"}}