{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:30:14Z","timestamp":1770150614612,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Unidade Local de Sa\u00fade de Santo Ant\u00f3nio"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to objectively assess physical activity levels in cancer patients treated with immune-checkpoint inhibitors (ICIs) and explore their association with patient-reported fatigue and quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study was conducted among adult patients with solid cancer\n                      <jats:italic>receiving<\/jats:italic>\n                      ICI treatment in the day hospital of our institution from March 26 to April 24, 2024. Physical activity levels were assessed using accelerometer monitors and the IPAQ questionnaire, while patient-reported fatigue and QoL were assessed with the FACIT-Fatigue and EQ-5D questionnaires, respectively. Descriptive statistics and between-group comparisons were performed, specifically between active and non-active patients, based on the WHO recommendation for healthy PA of\u2009\u2265\u2009150\u00a0min\/week of moderate-to-vigorous PA (MVPA), as well as between patients with or without problems in QoL domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 23 patients were enrolled, with a mean age of 61\u2009\u00b1\u200912\u00a0years, 65.5% male. Eleven patients (47.8%) were active, with a mean MVPA of 22.5\u2009\u00b1\u200916.5\u00a0min\/day based on objective measurements. Active and non-active subgroups were balanced for characteristics other than BMI. Based on 18 objective measurements, the mean MVPA time was 22.5\u2009\u00b1\u200916.5\u00a0min\/day. Reported fatigue was higher than population norms, and 85.7% reported issues in QoL domains. Patients without problems in self-care or in usual activities reached higher PA levels, and patients without problems in mobility, self-care, or pain\/discomfort reported less fatigue and a higher index of global health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Less than half of ICI-treated patients follow the recommendation for healthy PA. Patients engaging in more MVPA may have less problems in self-care and in usual activities. It reinforces the need to promote PA during immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-025-09824-9","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:18:33Z","timestamp":1755512313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Objective measurement of physical activity levels and patient-reported outcomes in cancer patients receiving immune-checkpoint inhibitors: a cross-sectional study"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4650-5595","authenticated-orcid":false,"given":"Rita Carrilho","family":"Pichel","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-4731","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Soares Miranda","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-5554","authenticated-orcid":false,"given":"Hugo Miguel","family":"Miranda","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-9361","authenticated-orcid":false,"given":"Susana","family":"Vale","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4195-9352","authenticated-orcid":false,"given":"Jo\u00e3o Queir\u00f3s","family":"Coelho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7195-1476","authenticated-orcid":false,"given":"Laura Pratas","family":"Guerra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-7340","authenticated-orcid":false,"given":"Miguel Martins","family":"Braga","sequence":"additional","affiliation":[]},{"given":"Gustavo","family":"Pinhol","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-7059","authenticated-orcid":false,"given":"Paula","family":"Fidalgo","sequence":"additional","affiliation":[]},{"given":"Alexandra","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-3584","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Ara\u00fajo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"issue":"9384","key":"9824_CR1","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/S0140-6736(03)14186-4","volume":"362","author":"K Ahlberg","year":"2003","unstructured":"Ahlberg K, Ekman T, Gaston-Johansson F, Mock V (2003) Assessment and management of cancer-related fatigue in adults. 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