{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T22:48:35Z","timestamp":1765493315559,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00586-019-06099-7","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T06:02:46Z","timestamp":1565676166000},"page":"238-247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical effectiveness of Enneking appropriate versus Enneking inappropriate procedure in patients with primary osteosarcoma of the spine: a systematic review with meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-2368","authenticated-orcid":false,"given":"Bruno","family":"Pombo","sequence":"first","affiliation":[]},{"given":"Ana","family":"Cristina Ferreira","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Oliveira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"issue":"1","key":"6099_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.nec.2007.10.004","volume":"19","author":"JH Chi","year":"2008","unstructured":"Chi JH, Bydon A, Hsieh P, Witham T, Wolinsky JP, Gokaslan ZL (2008) Epidemiology and demographics for primary vertebral tumors. Neurosurg Clin N Am 19(1):111\u2013117","journal-title":"Neurosurg Clin N Am"},{"issue":"1","key":"6099_CR2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.spinee.2014.07.005","volume":"15","author":"ML Groves","year":"2015","unstructured":"Groves ML, Zadnik PL, Kaloostian P, Sui J, Goodwin CR, Wolinsky J-P, Witham TF, Bydon A, Gokaslan ZL, Sciubba DM (2015) Epidemiologic, functional, and oncologic outcome analysis of spinal sarcomas treated surgically at a single institution over 10 years. Spine J 15(1):110\u2013114","journal-title":"Spine J"},{"issue":"8","key":"6099_CR3","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.spinee.2010.05.017","volume":"10","author":"AJ Schoenfeld","year":"2010","unstructured":"Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Garcia RT, DeLaney TF, Springfield D, Mankin HJ, Schwab JH (2010) Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J 10(8):708\u2013714","journal-title":"Spine J"},{"issue":"5","key":"6099_CR4","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.jbspin.2013.04.003","volume":"80","author":"G Lefebvre","year":"2013","unstructured":"Lefebvre G, Renaud A, Rocourt N, Cortet B, Ceugnart L, Cotten A (2013) Primary vertebral osteosarcoma: five cases. Joint Bone Spine. 80(5):534\u2013537","journal-title":"Joint Bone Spine."},{"issue":"8","key":"6099_CR5","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/annonc\/mdt154","volume":"24","author":"K Zils","year":"2013","unstructured":"Zils K, Bielack S, Wilhelm M, Werner M, Schwarz R, Windhager R, Hofmann-Wackersreuther G, Andus T, Kager L, Kuehne T, Reichardt P, von Kalle T (2013) Osteosarcoma of the mobile spine. Ann Oncol 24(8):2190\u20132195","journal-title":"Ann Oncol"},{"issue":"4","key":"6099_CR6","doi-asserted-by":"publisher","first-page":"495","DOI":"10.3109\/02688697.2013.869550","volume":"28","author":"R Bhatia","year":"2014","unstructured":"Bhatia R, Beckles V, Fox Z, Tirabosco R, Rezajooi K, Casey AT (2014) Osteosarcoma of the spine: dismal past, any hope for the future? Br J Neurosurg 28(4):495\u2013502","journal-title":"Br J Neurosurg"},{"issue":"2","key":"6099_CR7","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.ijrobp.2004.05.051","volume":"61","author":"TF DeLaney","year":"2005","unstructured":"DeLaney TF, Park L, Goldberg SI, Hug EB, Liebsch NJ, Munzenrider JE, Suit HD (2005) Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys 61(2):492\u2013498","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"6099_CR8","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1002\/cncr.10258","volume":"94","author":"T Ozaki","year":"2002","unstructured":"Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M, Jurgens H, Kotz R, Winkelmann W, Bielack SS (2002) Osteosarcoma of the spine\u2014experience of the cooperative osteosarcoma study group. Cancer 94(4):1069\u20131077","journal-title":"Cancer"},{"issue":"22 Suppl","key":"6099_CR9","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.1097\/BRS.0b013e3181ba6436","volume":"34","author":"DM Sciubba","year":"2009","unstructured":"Sciubba DM, Okuno SH, Dekutoski MB, Gokaslan ZL (2009) Ewing and osteogenic sarcoma: evidence for multidisciplinary management. Spine 34(22 Suppl):S58\u2013S68","journal-title":"Spine"},{"issue":"6","key":"6099_CR10","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1227\/00006123-198812000-00005","volume":"23","author":"N Sundaresan","year":"1988","unstructured":"Sundaresan N, Rosen G, Huvos AG, Krol G (1988) Combined treatment of osteosarcoma of the spine. Neurosurgery 23(6):714\u2013719","journal-title":"Neurosurgery"},{"issue":"3","key":"6099_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s00761-017-0329-0","volume":"24","author":"C Netzer","year":"2018","unstructured":"Netzer C (2018) Treatment options for sarcomas of the spine. A heterogenic disease picture which requires an individual and interdisciplinary treatment concept. Onkologe 24(3):224\u2013230","journal-title":"Onkologe"},{"issue":"3","key":"6099_CR12","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s11864-014-0290-8","volume":"15","author":"A Ozturk","year":"2014","unstructured":"Ozturk A, Gokaslan Z, Wolinsky J-P (2014) Surgical treatment of sarcomas of the spine. Curr Treat Options Oncol 15(3):482\u2013492","journal-title":"Curr Treat Options Oncol"},{"issue":"7","key":"6099_CR13","first-page":"199","volume":"18","author":"P Katonis","year":"2012","unstructured":"Katonis P, Datsis G, Karantanas A, Kampouroglou A, Lianoudakis S, Licoudis S, Papoutsopoulou E, Alpantaki K (2012) Spinal osteosarcoma. Clin Med Insights Oncol 18(7):199\u2013208","journal-title":"Clin Med Insights Oncol"},{"issue":"5","key":"6099_CR14","doi-asserted-by":"publisher","first-page":"660","DOI":"10.2106\/00004623-198668050-00004","volume":"68","author":"TC Shives","year":"1986","unstructured":"Shives TC, Dahlin DC, Sim FH, Pritchard DJ, Earle JD (1986) Osteosarcoma of the spine. J Bone Joint Surg Am 68(5):660\u2013668","journal-title":"J Bone Joint Surg Am"},{"key":"6099_CR15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00003086-200204000-00018","volume":"397","author":"R Talac","year":"2002","unstructured":"Talac R, Yaszemski MJ, Currier BL, Fuchs B, Dekutoski MB, Kim CW, Sim FH (2002) Relationship between surgical margins and local recurrence in sarcomas of the spine. Clin Orthop Relat Res 397:127\u2013132","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"6099_CR16","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3171\/SPI\/2008\/9\/8\/120","volume":"9","author":"G Rao","year":"2008","unstructured":"Rao G, Suki D, Chakrabarti I, Feiz-Erfan I, Mody MG, McCutcheon IE, Gokaslan Z, Patel S, Rhines LD (2008) Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine 9(2):120\u2013128","journal-title":"J Neurosurg Spine"},{"issue":"6","key":"6099_CR17","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1097\/00006123-200112000-00001","volume":"49","author":"MH Bilsky","year":"2001","unstructured":"Bilsky MH, Boland PJ, Panageas KS, Woodruff JM, Brennan MF, Healey JH (2001) Intralesional resection of primary and metastatic sarcoma involving the spine: outcome analysis of 59 patients. Neurosurgery 49(6):1277\u20131286","journal-title":"Neurosurgery"},{"issue":"3","key":"6099_CR18","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/1097-0142(19800801)46:3<595::AID-CNCR2820460328>3.0.CO;2-8","volume":"46","author":"KW Barwick","year":"1980","unstructured":"Barwick KW, Huvos AG, Smith J (1980) Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients. Cancer 46(3):595\u2013604","journal-title":"Cancer"},{"key":"6099_CR19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00003086-198011000-00013","volume":"153","author":"WF Enneking","year":"1980","unstructured":"Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res. 153:106\u2013120","journal-title":"Clin Orthop Relat Res."},{"issue":"16","key":"6099_CR20","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1097\/01.brs.0000174114.90657.74","volume":"30","author":"CG Fisher","year":"2005","unstructured":"Fisher CG, Keynan O, Boyd MC, Dvorak MF (2005) The surgical management of primary tumors of the spine\u2014initial results of an ongoing prospective cohort study. Spine (Phila Pa 1976) 30(16):1899\u20131908","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"6099_CR21","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s00132-008-1231-7","volume":"37","author":"H Halm","year":"2008","unstructured":"Halm H, Richter A, Lerner T, Liljenqvist U (2008) En-bloc spondylectomy and reconstruction for primary tumors and solitary metastasis of the spine. Orthopade 37(4):356\u2013366","journal-title":"Orthopade"},{"issue":"22","key":"6099_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/BRS.0b013e3181b8b796","volume":"34","author":"T Yamazaki","year":"2009","unstructured":"Yamazaki T, McLoughlin GS, Patel S, Rhines LD, Fourney DR (2009) Feasibility and safety of en bloc resection for primary spine tumors a systematic review by the spine oncology study group. Spine (Phila Pa 1976) 34(22):31\u201338","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"6099_CR23","doi-asserted-by":"publisher","first-page":"E381","DOI":"10.1097\/BRS.0b013e31822fb1a7","volume":"37","author":"J Schwab","year":"2012","unstructured":"Schwab J, Gasbarrini A, Bandiera S, Boriani L, Amendola L, Picci P, Ferrari S, Boriani S (2012) Osteosarcoma of the mobile spine. Spine (Phila Pa 1976) 37(6):E381\u2013E386","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"6099_CR24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1477-7819-11-89","volume":"11","author":"D Feng","year":"2013","unstructured":"Feng D, Yang X, Liu T, Xiao J, Wu Z, Huang Q, Ma J, Huang W, Zheng W, Cui Z, Xu H, Teng Y (2013) Osteosarcoma of the spine: surgical treatment and outcomes. World J Surg Oncol 11(1):89","journal-title":"World J Surg Oncol"},{"issue":"4","key":"6099_CR25","first-page":"457","volume":"79","author":"JBT Lim","year":"2013","unstructured":"Lim JBT, Sharma H, MacDuff E, Reece AT (2013) Primary osteosarcoma of the spine a review of 10 cases. Acta Orthop Belg 79(4):457\u2013462","journal-title":"Acta Orthop Belg"},{"issue":"1","key":"6099_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3171\/2015.11.SPINE15870","volume":"25","author":"MB Dekutoski","year":"2016","unstructured":"Dekutoski MB, Clarke MJ, Rose P, Luzzati A, Rhines LD, Varga PP, Fisher CG, Chou D, Fehlings MG, Reynolds JJ, Williams R, Quraishi NA, Germscheid NM, Sciubba DM, Gokaslan ZL, Boriani S (2016) Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study. J Neurosurg Spine 25(1):59\u201368","journal-title":"J Neurosurg Spine"},{"key":"6099_CR27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.wneu.2016.10.086","volume":"98","author":"S Boriani","year":"2017","unstructured":"Boriani S, Gasbarrini A, Bandiera S, Ghermandi R, Lador R (2017) En bloc resections in the spine: the experience of 220 patients during 25 years. World Neurosurg 98:217\u2013229","journal-title":"World Neurosurg"},{"issue":"1","key":"6099_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3171\/2016.12.SPINE16995","volume":"27","author":"GM Shankar","year":"2017","unstructured":"Shankar GM, Clarke MJ, Ailon T, Rhines LD, Patel SR, Sahgal A, Laufer I, Chou D, Bilsky MH, Sciubba DM, Fehlings MG, Fisher CG, Gokaslan ZL, Shin JH (2017) The role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis. J Neurosurg Spine 27(1):97\u2013104","journal-title":"J Neurosurg Spine"},{"key":"6099_CR29","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700","journal-title":"BMJ"},{"issue":"8","key":"6099_CR30","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1007\/s00270-018-1959-3","volume":"41","author":"MR Meijerink","year":"2018","unstructured":"Meijerink MR, Puijk RS, van Tilborg AAJM, Henningsen KH, Fernandez LG, Neyt M, Heymans J, Frankema JS, de Jong KP, Richel DJ, Prevoo W, Vlayen J (2018) Radiofrequency and microwave ablation compared to systemic chemotherapy and to partial hepatectomy in the treatment of colorectal liver metastases: a systematic review and meta-analysis. Cardiovasc Intervent Radiol 41(8):1189\u20131204","journal-title":"Cardiovasc Intervent Radiol"},{"key":"6099_CR31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jclinepi.2017.05.006","volume":"87","author":"M Hultcrantz","year":"2017","unstructured":"Hultcrantz M, Rind D, Akl EA, Treweek S, Mustafa RA, Iorio A, Alper BS, Meerpohl JJ, Murad MH, Ansari MT, Katikireddi SV, \u00d6stlund P, Tran\u00e6us S, Christensen R, Gartlehner G, Brozek J, Izcovich A, Sch\u00fcnemann H, Guyatt G (2017) The GRADE working group clarifies the construct of certainty of evidence. J Clin Epidemiol 87:4\u201313","journal-title":"J Clin Epidemiol"},{"issue":"17","key":"6099_CR32","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1182\/blood-2010-05-280883","volume":"116","author":"M Crowther","year":"2010","unstructured":"Crowther M, Lim W, Crowther MA (2010) Systematic review and meta-analysis methodology. Blood 116(17):3140\u20133146","journal-title":"Blood"},{"issue":"2","key":"6099_CR33","first-page":"112","volume":"4","author":"K Phan","year":"2015","unstructured":"Phan K, Tian DH, Cao C, Black D, Yan TD (2015) Systematic review and meta-analysis: techniques and a guide for the academic surgeon. Ann Cardiothorac Surg 4(2):112\u2013122","journal-title":"Ann Cardiothorac Surg"},{"issue":"4","key":"6099_CR34","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088\u20131101","journal-title":"Biometrics"},{"issue":"7109","key":"6099_CR35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"issue":"4","key":"6099_CR36","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1007\/s00586-017-4967-0","volume":"27","author":"R Lador","year":"2018","unstructured":"Lador R, Gasbarrini A, Gambarotti M, Bandiera S, Ghermandi R, Boriani S (2018) Surgeon's perception of margins in spinal en bloc resection surgeries: how reliable is it? Eur Spine J 27(4):868\u2013873","journal-title":"Eur Spine J"},{"issue":"3","key":"6099_CR37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/sj.sc.3100968","volume":"38","author":"E Abe","year":"2000","unstructured":"Abe E, Sato K, Tazawa H, Murai H, Okada K, Shimada Y, Morita H (2000) Total spondylectomy for primary tumor of the thoracolumbar spine. Spinal Cord 38(3):146\u2013152","journal-title":"Spinal Cord"},{"issue":"4","key":"6099_CR38","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s00586-008-0599-8","volume":"17","author":"U Liljenqvist","year":"2008","unstructured":"Liljenqvist U, Lerner T, Halm H, Buerger H, Gosheger G, Winkelmann W (2008) En bloc spondylectomy in malignant tumors of the spine. Eur Spine J 17(4):600\u2013609","journal-title":"Eur Spine J"},{"issue":"3","key":"6099_CR39","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/00007632-199702010-00018","volume":"22","author":"K Tomita","year":"1997","unstructured":"Tomita K, Kawahara N, Baba H, Tsuchiya H, Fujita T, Toribatake Y (1997) Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors. Spine (Phila Pa 1976) 22(3):324\u2013333","journal-title":"Spine (Phila Pa 1976)"},{"issue":"10","key":"6099_CR40","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1200\/JCO.1989.7.10.1485","volume":"7","author":"N Sundaresan","year":"1989","unstructured":"Sundaresan N, DiGiacinto GV, Krol G, Hughes JE (1989) Spondylectomy for malignant tumors of the spine. J Clin Oncol 7(10):1485\u20131491","journal-title":"J Clin Oncol"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-019-06099-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00586-019-06099-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-019-06099-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T14:23:28Z","timestamp":1664115808000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00586-019-06099-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["6099"],"URL":"https:\/\/doi.org\/10.1007\/s00586-019-06099-7","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"type":"print","value":"0940-6719"},{"type":"electronic","value":"1432-0932"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"7 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}