{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:12:32Z","timestamp":1740107552076,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006752","name":"Universidade do Porto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Spine J"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Over the last years, the number of vertebral arthrodesis has been steadily increasing. The use of iliac crest bone autograft remains the \u201cgold standard\u201d for bone graft substitute in these procedures. However, this solution has some side effects, such as the problem of donor site morbidity indicating that there is a real need for adequate alternatives. This pilot study aimed to evaluate the usefulness of chitosan (Ch) porous 3D scaffolds incorporated with resolvin D1 (RvD1) as an alternative implant to iliac bone autograft.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We have performed bilateral posterolateral lumbar vertebral arthrodesis in a rat animal model. Three experimental groups were used: (i) non-operated animals; (ii) animals implanted with Ch scaffolds incorporated with RvD1 and (iii) animals implanted with iliac bone autograft.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The collagenous fibrous capsule formed around the Ch scaffolds with RvD1 is less dense when compared with the iliac bone autograft, suggesting an important anti-inflammatory effect of RvD1. Additionally, new bone formation was observed in the Ch scaffolds with RvD1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These results demonstrate the potential of these scaffolds for bone tissue repair applications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00586-023-07725-1","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T18:12:19Z","timestamp":1682619139000},"page":"1985-1991","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chitosan 3D scaffolds with resolvin D1 for vertebral arthrodesis: a pilot study"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-2336","authenticated-orcid":false,"given":"Daniela P.","family":"Vasconcelos","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1101-3515","authenticated-orcid":false,"given":"Madalena","family":"Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-2912","authenticated-orcid":false,"given":"Joaquim L.","family":"Reis","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-8166","authenticated-orcid":false,"given":"Vasco S.","family":"Pinto","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-0499","authenticated-orcid":false,"given":"Ana B.","family":"Sousa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-9517","authenticated-orcid":false,"given":"Artur P.","family":"\u00c1guas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-7482","authenticated-orcid":false,"given":"M\u00e1rio A.","family":"Barbosa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-2790","authenticated-orcid":false,"given":"Judite N.","family":"Barbosa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"issue":"12","key":"7725_CR1","doi-asserted-by":"publisher","first-page":"e20309","DOI":"10.7759\/cureus.20309","volume":"13","author":"T Noh","year":"2021","unstructured":"Noh T, Zakaria H, Massie L, Ogasawara CT, Lee GA, Chedid M (2021) Bone marrow aspirate in spine surgery: case series and review of the literature. Cureus 13(12):e20309. https:\/\/doi.org\/10.7759\/cureus.20309","journal-title":"Cureus"},{"issue":"6","key":"7725_CR2","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.spinee.2017.10.011","volume":"18","author":"ED Sheha","year":"2018","unstructured":"Sheha ED, Meredith DS, Shifflett GD, Bjerke BT, Iyer S, Shue J, Nguyen J, Huang RC (2018) Postoperative pain following posterior iliac crest bone graft harvesting in spine surgery: a prospective, randomized trial. Spine J 18(6):986\u2013992. https:\/\/doi.org\/10.1016\/j.spinee.2017.10.011","journal-title":"Spine J"},{"issue":"1","key":"7725_CR3","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13018-021-02364-y","volume":"16","author":"H Kim","year":"2021","unstructured":"Kim H, Kar AK, Kaja A, Lim EJ, Choi W, Son WS, Oh JK, Sakong S, Cho JW (2021) More weighted cancellous bone can be harvested from the proximal tibia with less donor site pain than anterior iliac crest corticocancellous bone harvesting: retrospective review. J Orthop Surg Res 16(1):220. https:\/\/doi.org\/10.1186\/s13018-021-02364-y","journal-title":"J Orthop Surg Res"},{"issue":"6","key":"7725_CR4","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/2021.3.FOCUS201044","volume":"50","author":"B Fiani","year":"2021","unstructured":"Fiani B, Jarrah R, Shields J, Sekhon M (2021) Enhanced biomaterials: systematic review of alternatives to supplement spine fusion including silicon nitride, bioactive glass, amino peptide bone graft, and tantalum. Neurosurg Focus 50(6):E10. https:\/\/doi.org\/10.3171\/2021.3.FOCUS201044","journal-title":"Neurosurg Focus"},{"key":"7725_CR5","doi-asserted-by":"publisher","first-page":"112466","DOI":"10.1016\/j.msec.2021.112466","volume":"130","author":"CE Gillman","year":"2021","unstructured":"Gillman CE, Jayasuriya AC (2021) FDA-approved bone grafts and bone graft substitute devices in bone regeneration. Mater Sci Eng C Mater Biol Appl 130:112466. https:\/\/doi.org\/10.1016\/j.msec.2021.112466","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"Suppl 1","key":"7725_CR6","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1093\/ons\/opaa383","volume":"21","author":"JL Golubovsky","year":"2021","unstructured":"Golubovsky JL, Ejikeme T, Winkelman R, Steinmetz MP (2021) Osteobiologics. Oper Neurosurg (Hagerstown) 21(Suppl 1):S2\u2013S9. https:\/\/doi.org\/10.1093\/ons\/opaa383","journal-title":"Oper Neurosurg (Hagerstown)"},{"key":"7725_CR7","doi-asserted-by":"publisher","first-page":"665813","DOI":"10.3389\/fcell.2021.665813","volume":"9","author":"G Tang","year":"2021","unstructured":"Tang G, Liu Z, Liu Y, Yu J, Wang X, Tan Z, Ye X (2021) Recent trends in the development of bone regenerative biomaterials. Front Cell Dev Biol 9:665813. https:\/\/doi.org\/10.3389\/fcell.2021.665813","journal-title":"Front Cell Dev Biol"},{"key":"7725_CR8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.biomaterials.2015.02.120","volume":"53","author":"DP Vasconcelos","year":"2015","unstructured":"Vasconcelos DP, Costa M, Amaral IF, Barbosa MA, Aguas AP, Barbosa JN (2015) Development of an immunomodulatory biomaterial: using resolvin D1 to modulate inflammation. Biomaterials 53:566\u2013573. https:\/\/doi.org\/10.1016\/j.biomaterials.2015.02.120","journal-title":"Biomaterials"},{"key":"7725_CR9","doi-asserted-by":"publisher","first-page":"899760","DOI":"10.3389\/fbioe.2022.899760","volume":"10","author":"Y Tian","year":"2022","unstructured":"Tian Y, Wu D, Wu D, Cui Y, Ren G, Wang Y, Wang J, Peng C (2022) Chitosan-based biomaterial scaffolds for the repair of infected bone defects. Front Bioeng Biotechnol 10:899760. https:\/\/doi.org\/10.3389\/fbioe.2022.899760","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"7725_CR10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/prd.12034","volume":"63","author":"MO Freire","year":"2013","unstructured":"Freire MO, Van Dyke TE (2013) Natural resolution of inflammation. Periodontol 2000 63(1):149\u2013164. https:\/\/doi.org\/10.1111\/prd.12034","journal-title":"Periodontol 2000"},{"issue":"6","key":"7725_CR11","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1002\/jbm.a.36370","volume":"106","author":"DP Vasconcelos","year":"2018","unstructured":"Vasconcelos DP, Costa M, Neves N, Teixeira JH, Vasconcelos DM, Santos SG, Aguas AP, Barbosa MA, Barbosa JN (2018) Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing. J Biomed Mater Res, Part A 106(6):1626\u20131633. https:\/\/doi.org\/10.1002\/jbm.a.36370","journal-title":"J Biomed Mater Res, Part A"},{"issue":"38","key":"7725_CR12","doi-asserted-by":"publisher","first-page":"9952","DOI":"10.1016\/j.biomaterials.2013.09.012","volume":"34","author":"DP Vasconcelos","year":"2013","unstructured":"Vasconcelos DP, Fonseca AC, Costa M, Amaral IF, Barbosa MA, Aguas AP, Barbosa JN (2013) Macrophage polarization following chitosan implantation. Biomaterials 34(38):9952\u20139959. https:\/\/doi.org\/10.1016\/j.biomaterials.2013.09.012","journal-title":"Biomaterials"},{"issue":"6","key":"7725_CR13","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.spinee.2017.01.012","volume":"17","author":"AT Brecevich","year":"2017","unstructured":"Brecevich AT, Kiely PD, Yoon BV, Nguyen JT, Cammisa FP, Abjornson C (2017) Efficacy comparison of Accell Evo3 and Grafton demineralized bone matrix putties against autologous bone in a rat posterolateral spine fusion model. Spine J 17(6):855\u2013862. https:\/\/doi.org\/10.1016\/j.spinee.2017.01.012","journal-title":"Spine J"},{"issue":"Suppl 3","key":"7725_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/s0074-02761991000700002","volume":"86","author":"GS Montes","year":"1991","unstructured":"Montes GS, Junqueira LC (1991) The use of the Picrosirius-polarization method for the study of the biopathology of collagen. Mem Inst Oswaldo Cruz 86(Suppl 3):1\u201311. https:\/\/doi.org\/10.1590\/s0074-02761991000700002","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"5","key":"7725_CR15","doi-asserted-by":"publisher","first-page":"e0128021","DOI":"10.1371\/journal.pone.0128021","volume":"10","author":"AE Vieira","year":"2015","unstructured":"Vieira AE, Repeke CE, Ferreira Junior Colavite SdeBPM, Biguetti CC, Oliveira RC, Assis GF, Taga R, Trombone AP, Garlet GP (2015) Intramembranous bone healing process subsequent to tooth extraction in mice: micro-computed tomography, histomorphometric and molecular characterization. PLoS ONE 10(5):e0128021. https:\/\/doi.org\/10.1371\/journal.pone.0128021","journal-title":"PLoS ONE"},{"issue":"2","key":"7725_CR16","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/jbm.a.36237","volume":"106","author":"BF Masalskas","year":"2018","unstructured":"Masalskas BF, Martins W, Leoni GB, Faloni APD, Marcaccini AM, Sousa YTCS, de Castro-Raucci LMS (2018) Local delivery of strontium ranelate promotes regeneration of critical size bone defects filled with collagen sponge. J Biomed Mater Res Part A 106(2):333\u2013341. https:\/\/doi.org\/10.1002\/jbm.a.36237","journal-title":"J Biomed Mater Res Part A"},{"issue":"s1","key":"7725_CR17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.14444\/8058","volume":"15","author":"MA Plantz","year":"2021","unstructured":"Plantz MA, Gerlach EB, Hsu WK (2021) Synthetic bone graft materials in spine fusion: current evidence and future trends. Int J Spine Surg 15(s1):104\u2013112","journal-title":"Int J Spine Surg"},{"issue":"6 Suppl","key":"7725_CR18","doi-asserted-by":"publisher","first-page":"209S","DOI":"10.1097\/BRS.0000000000004142","volume":"5","author":"IH Drespe","year":"2005","unstructured":"Drespe IH, Polzhofer GK, Turner AS, Grauer JN (2005) Animal models for spinal fusion. Spine J 5(6 Suppl):209S-216S. https:\/\/doi.org\/10.1097\/BRS.0000000000004142","journal-title":"Spine J"},{"key":"7725_CR19","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ijbiomac.2022.06.079","volume":"215","author":"M Rahimi","year":"2022","unstructured":"Rahimi M, Mir SM, Baghban R, Charmi G, Plummer CM, Shafiei-Irannejad V, Soleymani J, Pietrasik J (2022) Chitosan-based biomaterials for the treatment of bone disorders. Int J Biol Macromol 215:346\u2013367. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.06.079","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"7725_CR20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.31616\/asj.2019.0091","volume":"14","author":"M Rodriguez-Vazquez","year":"2020","unstructured":"Rodriguez-Vazquez M, Ramos-Zuniga R (2020) Chitosan-hydroxyapatite scaffold for tissue engineering in experimental lumbar laminectomy and Posterolateral spinal fusion in Wistar rats. Asian Spine J 14(2):139\u2013147. https:\/\/doi.org\/10.31616\/asj.2019.0091","journal-title":"Asian Spine J"},{"issue":"1","key":"7725_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1179\/1743132814Y.0000000414","volume":"37","author":"M Carvalho","year":"2015","unstructured":"Carvalho M, Costa LM, Pereira JE, Shirosaki Y, Hayakawa S, Santos JD, Geuna S, Fregnan F, Cabrita AM, Mauricio AC, Varejao AS (2015) The role of hybrid chitosan membranes on scarring process following lumbar surgery: post-laminectomy experimental model. Neurol Res 37(1):23\u201329. https:\/\/doi.org\/10.1179\/1743132814Y.0000000414","journal-title":"Neurol Res"},{"key":"7725_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3389\/fendo.2020.00386","volume":"11","author":"M Maruyama","year":"2020","unstructured":"Maruyama M, Rhee C, Utsunomiya T, Zhang N, Ueno M, Yao Z, Goodman SB (2020) Modulation of the inflammatory response and bone healing. Front Endocrinol (Lausanne) 11:386. https:\/\/doi.org\/10.3389\/fendo.2020.00386","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"7725_CR23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbalip.2014.08.006","volume":"1851","author":"CN Serhan","year":"2015","unstructured":"Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N (2015) Protectins and maresins: new pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochem Biophys Acta 1851(4):397\u2013413. https:\/\/doi.org\/10.1016\/j.bbalip.2014.08.006","journal-title":"Biochem Biophys Acta"},{"issue":"13","key":"7725_CR24","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.3390\/polym13132129","volume":"13","author":"HY Chen","year":"2021","unstructured":"Chen HY, Lin TC, Chiang CY, Wey SL, Lin FH, Yang KC, Chang CH, Hu MH (2021) Antifibrotic effect of Bletilla striata polysaccharide-resveratrol-impregnated dual-layer carboxymethyl cellulose-based sponge for the prevention of epidural fibrosis after laminectomy. Polymers (Basel) 13(13):2129. https:\/\/doi.org\/10.3390\/polym13132129","journal-title":"Polymers (Basel)"},{"issue":"7","key":"7725_CR25","doi-asserted-by":"publisher","first-page":"8202","DOI":"10.1021\/acsnano.0c01658","volume":"14","author":"Y Wang","year":"2020","unstructured":"Wang Y, Li L, Ma Y, Tang Y, Zhao Y, Li Z, Pu W, Huang B, Wen X, Cao X, Chen J, Chen W, Zhou Y, Zhang J (2020) Multifunctional supramolecular hydrogel for prevention of epidural adhesion after laminectomy. ACS Nano 14(7):8202\u20138219. https:\/\/doi.org\/10.1021\/acsnano.0c01658","journal-title":"ACS Nano"}],"container-title":["European Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-023-07725-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00586-023-07725-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00586-023-07725-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:08:20Z","timestamp":1685614100000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00586-023-07725-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["7725"],"URL":"https:\/\/doi.org\/10.1007\/s00586-023-07725-1","relation":{},"ISSN":["0940-6719","1432-0932"],"issn-type":[{"type":"print","value":"0940-6719"},{"type":"electronic","value":"1432-0932"}],"subject":[],"published":{"date-parts":[[2023,4,27]]},"assertion":[{"value":"24 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflict of interest to this article was reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocols were planned and performed in accordance with guidelines approved by the Ethics Committee and the Portuguese Official Authority on Animal Welfare and Experimentation (DGAV). The procedures were also reviewed and authorized by the in-house Animal Welfare Body, \u201c\u00d3rg\u00e3o Respons\u00e1vel pelo Bem-Estar Animal: ORBEA\u201d, to positively affect the quality of the studies and animal welfare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}