{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:30:29Z","timestamp":1778103029698,"version":"3.51.4"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Diabetol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00592-019-01416-4","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T04:01:15Z","timestamp":1569038475000},"page":"1341-1350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Real-world outcomes of non-responding diabetic macular edema treated with continued anti-VEGF therapy versus early switch to dexamethasone implant: 2-year results"],"prefix":"10.1007","volume":"56","author":[{"name":"for the International Retina Group","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-4663","authenticated-orcid":false,"given":"Catharina","family":"Busch","sequence":"first","affiliation":[]},{"given":"Samantha","family":"Fraser-Bell","sequence":"additional","affiliation":[]},{"given":"Matias","family":"Iglicki","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Lupidi","sequence":"additional","affiliation":[]},{"given":"Aude","family":"Couturier","sequence":"additional","affiliation":[]},{"given":"Voraporn","family":"Chaikitmongkol","sequence":"additional","affiliation":[]},{"given":"Ermete","family":"Giancipoli","sequence":"additional","affiliation":[]},{"given":"Patricio J.","family":"Rodr\u00edguez-Vald\u00e9s","sequence":"additional","affiliation":[]},{"given":"Pierre-Henry","family":"Gabrielle","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"La\u00edns","sequence":"additional","affiliation":[]},{"given":"Ana Rita","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Zafer","family":"Cebeci","sequence":"additional","affiliation":[]},{"given":"Atchara","family":"Amphornphruet","sequence":"additional","affiliation":[]},{"given":"Valentin","family":"Degenhardt","sequence":"additional","affiliation":[]},{"given":"Jan-Darius","family":"Unterlauft","sequence":"additional","affiliation":[]},{"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[]},{"given":"Val\u00e9rie","family":"Man\u00e9-Tauty","sequence":"additional","affiliation":[]},{"given":"Giuseppe","family":"D\u2019Amico Ricci","sequence":"additional","affiliation":[]},{"given":"Isaac","family":"Hindi","sequence":"additional","affiliation":[]},{"given":"Kushal","family":"Agrawal","sequence":"additional","affiliation":[]},{"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[]},{"given":"Anat","family":"Loewenstein","sequence":"additional","affiliation":[]},{"given":"Dinah","family":"Zur","sequence":"additional","affiliation":[]},{"given":"Matus","family":"Rehak","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,9,21]]},"reference":[{"key":"1416_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","volume":"138","author":"NH Cho","year":"2018","unstructured":"Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW et al (2018) IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 138:271\u2013281","journal-title":"Diabetes Res Clin Pract"},{"issue":"3","key":"1416_CR2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2337\/dc11-1909","volume":"35","author":"JW Yau","year":"2012","unstructured":"Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T et al (2012) Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35(3):556\u2013564","journal-title":"Diabetes Care"},{"issue":"4","key":"1416_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000458539","volume":"237","author":"U Schmidt-Erfurth","year":"2017","unstructured":"Schmidt-Erfurth U, Garcia-Arumi J, Bandello F, Berg K, Chakravarthy U, Gerendas BS et al. (2017) Guidelines for the management of diabetic macular edema by the European Society of Retina Specialists (EURETINA). Ophthalmologica 237(4):185\u2013222. \n                    https:\/\/doi.org\/10.1159\/000458539","journal-title":"Ophthalmologica"},{"key":"1416_CR4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ajo.2016.09.012","volume":"172","author":"VH Gonzalez","year":"2016","unstructured":"Gonzalez VH, Campbell J, Holekamp NM, Kiss S, Loewenstein A, Augustin AJ et al (2016) Early and long-term responses to anti-vascular endothelial growth factor therapy in diabetic macular edema: analysis of protocol I Data. Am J Ophthalmol 172:72\u201379","journal-title":"Am J Ophthalmol"},{"key":"1416_CR5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ajo.2018.07.030","volume":"195","author":"NM Bressler","year":"2018","unstructured":"Bressler NM, Beaulieu WT, Maguire MG, Glassman AR, Blinder KJ, Bressler SB et al (2018) Early response to anti-vascular endothelial growth factor and two-year outcomes among eyes with diabetic macular edema in protocol T. Am J Ophthalmol 195:93\u2013100","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"1416_CR6","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1097\/IAE.0000000000001687","volume":"38","author":"AR Santos","year":"2018","unstructured":"Santos AR, Costa MA, Schwartz C, Alves D, Figueira J, Silva R et al (2018) Optical coherence tomography baseline predictors for initial best-corrected visual acuity response to intravitreal anti-vascular endothelial growth factor treatment in eyes with diabetic macular edema: the chartres study. Retina. 38(6):1110\u20131119","journal-title":"Retina."},{"key":"1416_CR7","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ajo.2018.08.004","volume":"195","author":"E Maggio","year":"2018","unstructured":"Maggio E, Sartore M, Attanasio M, Maraone G, Guerriero M, Polito A et al (2018) Anti-vascular endothelial growth factor treatment for diabetic macular edema in a real-world clinical setting. Am J Ophthalmol 195:209\u2013222 PubMed PMID: 30098350","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"1416_CR8","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1016\/j.ophtha.2014.04.024","volume":"121","author":"DS Boyer","year":"2014","unstructured":"Boyer DS, Yoon YH, Belfort R Jr, Bandello F, Maturi RK, Augustin AJ et al (2014) Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology 121(10):1904\u20131914","journal-title":"Ophthalmology"},{"issue":"1","key":"1416_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/IAE.0000000000002196","volume":"39","author":"M Iglicki","year":"2018","unstructured":"Iglicki M, Busch C, Zur D, Okada M, Mariussi M, Chhablani JK, et al. (2018) Dexamethasone implant for diabetic macular edema in naive compared with refractory eyes: The International Retina Group real-life 24-month multicenter study. The IRGREL-DEX study. Retina 39(1), pp. 44\u201351. \n                    https:\/\/doi.org\/10.1097\/IAE.0000000000002196","journal-title":"Retina"},{"issue":"4","key":"1416_CR10","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/IAE.0000000000001234","volume":"37","author":"A Malcles","year":"2017","unstructured":"Malcles A, Dot C, Voirin N, Agard E, Vie AL, Bellocq D et al (2017) Real-life study in diabetic macular edema treated with dexamethasone implant: the reldex study. Retina. 37(4):753\u2013760","journal-title":"Retina."},{"issue":"8","key":"1416_CR11","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00592-018-1151-x","volume":"55","author":"C Busch","year":"2018","unstructured":"Busch C, Zur D, Fraser-Bell S, Lains I, Santos AR, Lupidi M et al (2018) Shall we stay, or shall we switch? Continued anti-VEGF therapy versus early switch to dexamethasone implant in refractory diabetic macular edema. Acta Diabetol 55(8):789\u2013796","journal-title":"Acta Diabetol"},{"issue":"9","key":"1416_CR12","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1001\/archophthalmol.2012.1107","volume":"130","author":"SB Bressler","year":"2012","unstructured":"Bressler SB, Qin H, Beck RW, Chalam KV, Kim JE, Melia M et al (2012) Factors associated with changes in visual acuity and central subfield thickness at 1\u00a0year after treatment for diabetic macular edema with ranibizumab. Archives of ophthalmology. 130(9):1153\u20131161","journal-title":"Archives of ophthalmology."},{"issue":"2","key":"1416_CR13","first-page":"627","volume":"4","author":"K Hajian-Tilaki","year":"2013","unstructured":"Hajian-Tilaki K (2013) Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Casp J Intern Med. 4(2):627\u2013635","journal-title":"Casp J Intern Med."},{"issue":"6","key":"1416_CR14","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.ophtha.2016.02.022","volume":"123","author":"JA Wells","year":"2016","unstructured":"Wells JA, Glassman AR, Ayala AR, Jampol LM, Bressler NM, Bressler SB et al (2016) Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema: two-year results from a comparative effectiveness randomized clinical trial. Ophthalmology. 123(6):1351\u20131359","journal-title":"Ophthalmology."},{"issue":"4","key":"1416_CR15","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.ophtha.2010.12.033","volume":"118","author":"MJ Elman","year":"2011","unstructured":"Elman MJ, Bressler NM, Qin H, Beck RW, Ferris FL, Friedman SM et al (2011) Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 118(4):609\u2013614","journal-title":"Ophthalmology."},{"issue":"3","key":"1416_CR16","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.oret.2018.11.002","volume":"3","author":"X Gao","year":"2019","unstructured":"Gao X, Obeid A, Aderman CM, Talcott KE, Ali FS, Adam MK et al (2019) Loss to follow-up after intravitreal anti-vascular endothelial growth factor injections in patients with diabetic macular edema. Ophthalmol Retina. 3(3):230\u2013236","journal-title":"Ophthalmol Retina."},{"issue":"6","key":"1416_CR17","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1007\/s13300-018-0513-2","volume":"9","author":"F Ziemssen","year":"2018","unstructured":"Ziemssen F, Wachtlin J, Kuehlewein L, Gamulescu MA, Bertelmann T, Feucht N et al (2018) Intravitreal ranibizumab therapy for diabetic macular edema in routine practice: two-year real-life data from a non-interventional, multicenter study in Germany. Diabetes Ther. 9(6):2271\u20132289","journal-title":"Diabetes Ther."}],"container-title":["Acta Diabetologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-019-01416-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00592-019-01416-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00592-019-01416-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T23:15:57Z","timestamp":1600557357000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00592-019-01416-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,21]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1416"],"URL":"https:\/\/doi.org\/10.1007\/s00592-019-01416-4","relation":{},"ISSN":["0940-5429","1432-5233"],"issn-type":[{"value":"0940-5429","type":"print"},{"value":"1432-5233","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,21]]},"assertion":[{"value":"20 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the individual institutional review board of the participating centers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}