{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:24:59Z","timestamp":1772119499466,"version":"3.50.1"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Ministerio de Ciencia y Tecnolog\u00eda, Spain","award":["BMC2001-0719"],"award-info":[{"award-number":["BMC2001-0719"]}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Ministerio de Ciencia y Tecnolog\u00eda, Spain","award":["BMC2001-0719"],"award-info":[{"award-number":["BMC2001-0719"]}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Ministerio de Ciencia y Tecnolog\u00eda, Spain","award":["BMC2001-0719"],"award-info":[{"award-number":["BMC2001-0719"]}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Ministerio de Ciencia y Tecnolog\u00eda, Spain","award":["BMC2001-0719"],"award-info":[{"award-number":["BMC2001-0719"]}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Ministerio de Ciencia y Tecnolog\u00eda, Spain","award":["BMC2001-0719"],"award-info":[{"award-number":["BMC2001-0719"]}]},{"name":"Direcci\u00f3n General de Investigaci\u00f3n, Ministerio de Ciencia y Tecnolog\u00eda, Spain","award":["BMC2001-0719"],"award-info":[{"award-number":["BMC2001-0719"]}]},{"DOI":"10.13039\/501100015720","name":"Universidad de Extremadura","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015720","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Amino Acids"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nucleotide-pyrophosphatases\/phosphodiesterases (NPP\/PDE) are membrane or secreted Zn\n                    <jats:sup>2+<\/jats:sup>\n                    -metallohydrolases of nucleoside-5\u00b4-monophosphate derivatives. They hydrolyze, for instance, ATP and 4-nitrophenyl-dTMP, and belong to the ecto-nucleotide pyrophosphatase\/phosphodiesterase (ENPP) family that contains seven members (ENPP1-ENPP7). Earlier we had shown that an NPP\/PDE activity solubilized and partially purified from rat liver membranes is inactivated by EDTA in a time-dependent fashion, an effect enhanced by glycine and blocked by the 4-nitrophenyl-dTMP. Here, we extended this observation to other free amino acids. Activity assays started after different incubation lengths with EDTA provided first-order, apparent inactivation constants (k\n                    <jats:sub>i(ap)<\/jats:sub>\n                    ). With the exception of cysteine (a strong inhibitor) and histidine (itself evoking a time-dependent inactivation), free amino acids themselves did not affect activity but increased k\n                    <jats:sub>i(ap)<\/jats:sub>\n                    . The results are compatible with a conformational change of NPP\/PDE evoked by interaction with free amino acids. The enzyme preparation was analyzed to identify what ENPP family members were present. First, the hydrolytic activity on 2\u00b4,3\u00b4-cGAMP was assayed because until very recently ENPP1 was the only mammalian enzyme known to display it. 2\u00b4,3\u00b4-cGAMP hydrolase activity was clearly detected, but mass spectrometry data obtained by LC-MS\/MS gave evidence that only rat Enpp3, Enpp4 and Enpp5 were present with low abundance. This finding coincided in time with a recent publication claiming that mouse Enpp3 hydrolyzes 2\u00b4,3\u00b4-cGAMP, and that Enpp1 and Enpp3 account for all the 2\u00b4,3\u00b4-cGAMP hydrolase activity in mice. So, our results are confirmatory of Enpp3 activity towards 2\u00b4,3\u00b4-cGAMP. Finally, the effect of amino acids could be relevant to NPP\/PDE actions dependent on protein-protein interactions, like the known insulin-related effects of ENPP1 and possibly ENPP3.\n                  <\/jats:p>","DOI":"10.1007\/s00726-024-03431-4","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T10:31:12Z","timestamp":1733481072000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase\/phosphodiesterase Enpp3 elicited by EDTA"],"prefix":"10.1007","volume":"57","author":[{"given":"Ana","family":"Romero","sequence":"first","affiliation":[]},{"given":"Guadalupe","family":"Cumplido-Laso","sequence":"additional","affiliation":[]},{"given":"Ascensi\u00f3n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[]},{"given":"Javier","family":"Moreno","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Canales","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2478-7963","authenticated-orcid":false,"given":"Rui","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Juan","family":"L\u00f3pez-G\u00f3mez","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-1402","authenticated-orcid":false,"given":"Jo\u00e3o Meireles","family":"Ribeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8815-1839","authenticated-orcid":false,"given":"Mar\u00eda Jes\u00fas","family":"Costas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-081X","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Cameselle","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"3431_CR1","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1182\/blood-2012-04-425215","volume":"120","author":"RA Albright","year":"2012","unstructured":"Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT (2012) NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood 120:4432\u20134440. https:\/\/doi.org\/10.1182\/blood-2012-04-425215","journal-title":"Blood"},{"key":"3431_CR2","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1074\/jbc.M113.505867","volume":"289","author":"RA Albright","year":"2014","unstructured":"Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT (2014) Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase\/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem 289:3294\u20133306. https:\/\/doi.org\/10.1074\/jbc.M113.505867","journal-title":"J Biol Chem"},{"key":"3431_CR3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3390\/life11060552","volume":"11","author":"R Arianti","year":"2021","unstructured":"Arianti R, Ariani NL, Muhammad AA, Sadewa AH, Farmawati A, Sunarti Hastuti P, Krist\u00f3f E (2021) Influence of Single Nucleotide Polymorphism of ENPP1 and ADIPOQ on Insulin Resistance and Obesity: A Case-Control Study in a Javanese Population. Life 11:552. https:\/\/doi.org\/10.3390\/life11060552","journal-title":"Life"},{"key":"3431_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1432-1033.1975.tb03935.x","volume":"51","author":"E Bischoff","year":"1975","unstructured":"Bischoff E, Tran-Thi TA, Decker KF (1975) Nucleotide pyrophosphatase of rat liver. A comparative study on the enzymes solubilized and purified from plasma membrane and endoplasmic reticulum. Eur J Biochem 51:353\u2013361. https:\/\/doi.org\/10.1111\/j.1432-1033.1975.tb03935.x","journal-title":"Eur J Biochem"},{"key":"3431_CR5","doi-asserted-by":"publisher","first-page":"33811","DOI":"10.1038\/srep33811","volume":"6","author":"NR Boggavarapu","year":"2016","unstructured":"Boggavarapu NR, Lalitkumar S, Joshua V, Kasvandik S, Salumets A, Lalitkumar PG, Gemzell-Danielsson K (2016) Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form. Sci Rep 6:33811. https:\/\/doi.org\/10.1038\/srep33811","journal-title":"Sci Rep"},{"key":"3431_CR6","doi-asserted-by":"publisher","first-page":"101526","DOI":"10.1016\/j.jbc.2021.101526","volume":"298","author":"R Borza","year":"2021","unstructured":"Borza R, Salgado-Polo F, Moolenaar WH, Perrakis A (2021) Structure and function of the Ecto-Nucleotide Pyrophosphatase-Phosphodiesterase (ENPP) family: tidying up diversity. J Biol Chem 298:101526. https:\/\/doi.org\/10.1016\/j.jbc.2021.101526","journal-title":"J Biol Chem"},{"key":"3431_CR7","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1182\/blood.v97.10.3303","volume":"97","author":"HJ B\u00fchring","year":"2001","unstructured":"B\u00fchring HJ, Seiffert M, Giesert C, Marxer A, Kanz L, Valent P, Sano K (2001) The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase\/phosphodiesterase 3. Blood 97:3303\u20133305. https:\/\/doi.org\/10.1182\/blood.v97.10.3303","journal-title":"Blood"},{"key":"3431_CR8","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1016\/S0021-9258(17)43230-3","volume":"259","author":"JC Cameselle","year":"1984","unstructured":"Cameselle JC, Costas MJ, G\u00fcnther Sillero MA, Sillero A (1984) Two low Km hydrolytic activities on dinucleoside 5\u2019,5\"\u2019-P1, P4-tetraphosphates in rat liver. Characterization as the specific dinucleoside tetraphosphatase and a phosphodiesterase I-like enzyme. J Biol Chem 259:2879\u20132885. https:\/\/doi.org\/10.1016\/S0021-9258(17)43230-3","journal-title":"J Biol Chem"},{"key":"3431_CR9","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.chembiol.2020.07.007","volume":"27","author":"JA Carozza","year":"2020","unstructured":"Carozza JA, Brown JA, B\u00f6hnert V, Fernandez D, AlSaif Y, Mardjuki RE, Smith M, Li L (2020) Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP. Cell Chem Biol 27:1347-1358.e1345. https:\/\/doi.org\/10.1016\/j.chembiol.2020.07.007","journal-title":"Cell Chem Biol"},{"key":"3431_CR10","doi-asserted-by":"publisher","first-page":"e2119189119","DOI":"10.1073\/pnas.2119189119","volume":"119","author":"JA Carozza","year":"2022","unstructured":"Carozza JA, Cordova AF, Brown JA, AlSaif Y, B\u00f6hnert V, Cao X, Mardjuki RE, Skariah G, Fernandez D, Li L (2022) ENPP1\u2019s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling. Proc Natl Acad Sci U S A 119:e2119189119. https:\/\/doi.org\/10.1073\/pnas.2119189119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3431_CR11","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/S0076-6879(55)02300-8","volume":"2","author":"B Chance","year":"1955","unstructured":"Chance B, Maehly AC (1955) Assay of catalases and peroxidases. Methods Enzymol 2:764\u2013775. https:\/\/doi.org\/10.1016\/S0076-6879(55)02300-8","journal-title":"Methods Enzymol"},{"key":"3431_CR12","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1071\/rd17257","volume":"30","author":"Q Chen","year":"2018","unstructured":"Chen Q, Xin A, Qu R, Zhang W, Li L, Chen J, Lu X, Gu Y, Li J, Sun X (2018) Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation. Reprod Fertil Dev 30:1277\u20131285. https:\/\/doi.org\/10.1071\/rd17257","journal-title":"Reprod Fertil Dev"},{"key":"3431_CR13","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.clnu.2022.06.039","volume":"41","author":"S Chen","year":"2022","unstructured":"Chen S, Miki T, Fukunaga A, Eguchi M, Kochi T, Nanri A, Kabe I, Mizoue T (2022) Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan. Clin Nutr 41:1827\u20131833. https:\/\/doi.org\/10.1016\/j.clnu.2022.06.039","journal-title":"Clin Nutr"},{"key":"3431_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ejphar.2009.01.016","volume":"606","author":"CN Chin","year":"2009","unstructured":"Chin CN, Dallas-Yang Q, Liu F, Ho T, Ellsworth K, Fischer P, Natasha T, Ireland C, Lu P, Li C, Wang IM, Strohl W, Berger JP, An Z, Zhang BB, Jiang G (2009) Evidence that inhibition of insulin receptor signaling activity by PC-1\/ENPP1 is dependent on its enzyme activity. Eur J Pharmacol 606:17\u201324. https:\/\/doi.org\/10.1016\/j.ejphar.2009.01.016","journal-title":"Eur J Pharmacol"},{"key":"3431_CR15","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.chembiol.2020.11.001","volume":"27","author":"D Cogan","year":"2020","unstructured":"Cogan D, Bakhoum SF (2020) Re-awakening Innate Immune Signaling in Cancer: The Development of Highly Potent ENPP1 Inhibitors. Cell Chem Biol 27:1327\u20131328. https:\/\/doi.org\/10.1016\/j.chembiol.2020.11.001","journal-title":"Cell Chem Biol"},{"key":"3431_CR16","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/0005-2744(69)90351-9","volume":"191","author":"CN Corder","year":"1969","unstructured":"Corder CN, Lowry OH (1969) The zinc requirement of dinucleotide pyrophosphatase in mammalian organs. Biochim Biophys Acta 191:579\u2013587. https:\/\/doi.org\/10.1016\/0005-2744(69)90351-9","journal-title":"Biochim Biophys Acta"},{"key":"3431_CR17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","volume":"21","author":"A Decout","year":"2021","unstructured":"Decout A, Katz JD, Venkatraman S, Ablasser A (2021) The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol 21:548\u2013569. https:\/\/doi.org\/10.1038\/s41577-021-00524-z","journal-title":"Nat Rev Immunol"},{"key":"3431_CR18","doi-asserted-by":"publisher","first-page":"9849","DOI":"10.1074\/jbc.270.17.9849","volume":"270","author":"H Deissler","year":"1995","unstructured":"Deissler H, Lottspeich F, Rajewsky MF (1995) Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. J Biol Chem 270:9849\u20139855. https:\/\/doi.org\/10.1074\/jbc.270.17.9849","journal-title":"J Biol Chem"},{"key":"3431_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1096\/fasebj.13.6.657","volume":"13","author":"H Deissler","year":"1999","unstructured":"Deissler H, Blass-Kampmann S, Bruyneel E, Mareel M, Rajewsky MF (1999) Neural cell surface differentiation antigen gp130(RB13-6) induces fibroblasts and glioma cells to express astroglial proteins and invasive properties. FASEB J 13:657\u2013666. https:\/\/doi.org\/10.1096\/fasebj.13.6.657","journal-title":"FASEB J"},{"key":"3431_CR20","doi-asserted-by":"publisher","first-page":"e19462","DOI":"10.1371\/journal.pone.0019462","volume":"6","author":"R Di Paola","year":"2011","unstructured":"Di Paola R, Caporarello N, Marucci A, Dimatteo C, Iadicicco C, Del Guerra S, Prudente S, Sudano D, Miele C, Parrino C, Piro S, Beguinot F, Marchetti P, Trischitta V, Frittitta L (2011) ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies. PLoS One 6:e19462. https:\/\/doi.org\/10.1371\/journal.pone.0019462","journal-title":"PLoS One"},{"key":"3431_CR21","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.bbamcr.2012.10.017","volume":"1833","author":"C Dimatteo","year":"2013","unstructured":"Dimatteo C, Marucci A, Palazzo A, Cisternino C, Marsano RM, Trischitta V, Di Paola R (2013) Role of somatomedin-B-like domains on ENPP1 inhibition of insulin signaling. Biochim Biophys Acta 1833:552\u2013558. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.10.017","journal-title":"Biochim Biophys Acta"},{"key":"3431_CR22","doi-asserted-by":"publisher","first-page":"10874","DOI":"10.1038\/s41598-018-28814-y","volume":"8","author":"C Dohler","year":"2018","unstructured":"Dohler C, Zebisch M, Strater N (2018) Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase\/pyrophosphatase-3 (NPP3). Sci Rep 8:10874. https:\/\/doi.org\/10.1038\/s41598-018-28814-y","journal-title":"Sci Rep"},{"key":"3431_CR23","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1146\/annurev-pathmechdis-051222-121126","volume":"19","author":"CR Ferreira","year":"2023","unstructured":"Ferreira CR, Carpenter TO, Braddock DT (2023) ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency. Annu Rev Pathol 19:507\u2013540. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-051222-121126","journal-title":"Annu Rev Pathol"},{"key":"3431_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172509","volume":"12","author":"Y Furuta","year":"2017","unstructured":"Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K (2017) E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLoS One 12:e0172509. https:\/\/doi.org\/10.1371\/journal.pone.0172509","journal-title":"PLoS One"},{"key":"3431_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/10408363.2017.1414143","volume":"55","author":"C Gar","year":"2018","unstructured":"Gar C, Rottenkolber M, Prehn C, Adamski J, Seissler J, Lechner A (2018) Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes. Crit Rev Clin Lab Sci 55:21\u201332. https:\/\/doi.org\/10.1080\/10408363.2017.1414143","journal-title":"Crit Rev Clin Lab Sci"},{"key":"3431_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1677\/jme-07-0002","volume":"39","author":"H Ghanaat-Pour","year":"2007","unstructured":"Ghanaat-Pour H, Huang Z, Lehtihet M, Sj\u00f6holm A (2007) Global expression profiling of glucose-regulated genes in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. J Mol Endocrinol 39:135\u2013150. https:\/\/doi.org\/10.1677\/jme-07-0002","journal-title":"J Mol Endocrinol"},{"key":"3431_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1023\/A:1006878001180","volume":"182","author":"ID Goldfine","year":"1998","unstructured":"Goldfine ID, Maddux BA, Youngren JF, Frittitta L, Trischitta V, Dohm GL (1998) Membrane glycoprotein PC-1 and insulin resistance. Mol Cell Biochem 182:177\u2013184. https:\/\/doi.org\/10.1023\/A:1006878001180","journal-title":"Mol Cell Biochem"},{"key":"3431_CR28","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1749-6632.1999.tb07797.x","volume":"892","author":"ID Goldfine","year":"1999","unstructured":"Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L (1999) Role of PC-1 in the etiology of insulin resistance. Ann N Y Acad Sci 892:204\u2013222. https:\/\/doi.org\/10.1111\/j.1749-6632.1999.tb07797.x","journal-title":"Ann N Y Acad Sci"},{"key":"3431_CR29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1210\/er.2007-0004","volume":"29","author":"ID Goldfine","year":"2008","unstructured":"Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L (2008) The role of membrane glycoprotein plasma cell antigen 1\/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities. Endocr Rev 29:62\u201375. https:\/\/doi.org\/10.1210\/er.2007-0004","journal-title":"Endocr Rev"},{"key":"3431_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061870","volume":"8","author":"M Goldsworthy","year":"2013","unstructured":"Goldsworthy M, Absalom NL, Schr\u00f6ter D, Matthews HC, Bogani D, Moir L, Long A, Church C, Hugill A, Anstee QM, Goldin R, Thursz M, Hollfelder F, Cox RD (2013) Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS One 8:e61870. https:\/\/doi.org\/10.1371\/journal.pone.0061870","journal-title":"PLoS One"},{"key":"3431_CR31","doi-asserted-by":"publisher","first-page":"6376","DOI":"10.1074\/jbc.M115.711085","volume":"291","author":"A Gorelik","year":"2016","unstructured":"Gorelik A, Illes K, Superti-Furga G, Nagar B (2016) Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J Biol Chem 291:6376\u20136385. https:\/\/doi.org\/10.1074\/jbc.M115.711085","journal-title":"J Biol Chem"},{"key":"3431_CR32","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1111\/febs.14266","volume":"284","author":"A Gorelik","year":"2017","unstructured":"Gorelik A, Randriamihaja A, Illes K, Nagar B (2017) A Key Tyrosine Substitution Restricts Nucleotide Hydrolysis by the Ectoenzyme NPP5. FEBS J 284:3718\u20133726. https:\/\/doi.org\/10.1111\/febs.14266","journal-title":"FEBS J"},{"key":"3431_CR33","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1111\/febs.14489","volume":"285","author":"A Gorelik","year":"2018","unstructured":"Gorelik A, Randriamihaja A, Illes K, Nagar B (2018) Structural Basis for Nucleotide Recognition by the Ectoenzyme CD203c. FEBS J 285:2481\u20132494. https:\/\/doi.org\/10.1111\/febs.14489","journal-title":"FEBS J"},{"key":"3431_CR34","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1007\/s00125-006-0353-x","volume":"49","author":"N Grarup","year":"2006","unstructured":"Grarup N, Urhammer SA, Ek J, Albrechtsen A, Gl\u00fcmer C, Borch-Johnsen K, J\u00f8rgensen T, Hansen T, Pedersen O (2006) Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects. Diabetologia 49:2097\u20132104. https:\/\/doi.org\/10.1007\/s00125-006-0353-x","journal-title":"Diabetologia"},{"key":"3431_CR35","doi-asserted-by":"publisher","first-page":"22085","DOI":"10.1074\/jbc.270.38.22085","volume":"270","author":"A Grupe","year":"1995","unstructured":"Grupe A, Alleman J, Goldfine ID, Sadick M, Stewart TA (1995) Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine. J Biol Chem 270:22085\u201322088. https:\/\/doi.org\/10.1074\/jbc.270.38.22085","journal-title":"J Biol Chem"},{"key":"3431_CR36","volume-title":"CRC Handbook of Chemistry and Physics","author":"WM Haynes","year":"2017","unstructured":"Haynes WM, Lide DR, Bruno TJ (2017) CRC Handbook of Chemistry and Physics, 97th edn. CRC Press, Boca Raton, FL","edition":"97"},{"key":"3431_CR37","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1016\/j.immuni.2023.10.001","volume":"56","author":"Y Hou","year":"2023","unstructured":"Hou Y, Wang Z, Liu P, Wei X, Zhang Z, Fan S, Zhang L, Han F, Song Y, Chu L, Zhang C (2023) SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity 56:2492-2507.e2410. https:\/\/doi.org\/10.1016\/j.immuni.2023.10.001","journal-title":"Immunity"},{"key":"3431_CR38","doi-asserted-by":"publisher","first-page":"4424","DOI":"10.1038\/s41467-018-06922-7","volume":"9","author":"K Kato","year":"2018","unstructured":"Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O (2018) Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun 9:4424. https:\/\/doi.org\/10.1038\/s41467-018-06922-7","journal-title":"Nat Commun"},{"key":"3431_CR39","doi-asserted-by":"publisher","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","volume":"51","author":"S Kim","year":"2023","unstructured":"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE (2023) PubChem 2023 update. Nucleic Acids Res 51:D1373-d1380. https:\/\/doi.org\/10.1093\/nar\/gkac956","journal-title":"Nucleic Acids Res"},{"key":"3431_CR40","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1007\/s00726-023-03352-8","volume":"55","author":"J Kolic","year":"2023","unstructured":"Kolic J, Sun WG, Johnson JD, Guess N (2023) Amino acid-stimulated insulin secretion: a path forward in type 2 diabetes. Amino Acids 55:1857\u20131866. https:\/\/doi.org\/10.1007\/s00726-023-03352-8","journal-title":"Amino Acids"},{"key":"3431_CR41","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nmeth.4256","volume":"14","author":"AT Kong","year":"2017","unstructured":"Kong AT, Leprevost FV, Avtonomov DM, Mellacheruvu D, Nesvizhskii AI (2017) MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics. Nat Methods 14:513\u2013520. https:\/\/doi.org\/10.1038\/nmeth.4256","journal-title":"Nat Methods"},{"key":"3431_CR42","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2337\/diabetes.51.3.599","volume":"51","author":"M Krebs","year":"2002","unstructured":"Krebs M, Krssak M, Bernroider E, Anderwald C, Brehm A, Meyerspeer M, Nowotny P, Roth E, Waldh\u00e4usl W, Roden M (2002) Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes 51:599\u2013605. https:\/\/doi.org\/10.2337\/diabetes.51.3.599","journal-title":"Diabetes"},{"key":"3431_CR43","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/jcp.31051","volume":"238","author":"T Kulesza","year":"2023","unstructured":"Kulesza T, Typiak M, Rachubik P, Rogacka D, Audzeyenka I, Saleem MA, Piwkowska A (2023) Pit 1 transporter (SLC20A1) as a key factor in the NPP1-mediated inhibition of insulin signaling in human podocytes. J Cell Physiol 238:1921\u20131936. https:\/\/doi.org\/10.1002\/jcp.31051","journal-title":"J Cell Physiol"},{"key":"3431_CR44","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.diabres.2018.03.028","volume":"140","author":"SG Lee","year":"2018","unstructured":"Lee SG, Yim YS, Lee YH, Lee BW, Kim HS, Kim KS, Lee YW, Kim JH (2018) Fasting serum amino acids concentration is associated with insulin resistance and pro-inflammatory cytokines. Diabetes Res Clin Pract 140:107\u2013117. https:\/\/doi.org\/10.1016\/j.diabres.2018.03.028","journal-title":"Diabetes Res Clin Pract"},{"key":"3431_CR45","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/nchembio.1661","volume":"10","author":"L Li","year":"2014","unstructured":"Li L, Yin Q, Kuss P, Maliga Z, Millan JL, Wu H, Mitchison TJ (2014) Hydrolysis of 2\u20193\u2019-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol 10:1043\u20131048. https:\/\/doi.org\/10.1038\/nchembio.1661","journal-title":"Nat Chem Biol"},{"key":"3431_CR46","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1177\/1933719116676394","volume":"24","author":"FX Li","year":"2017","unstructured":"Li FX, Yu JJ, Liu Y, Miao XP, Curry TE Jr (2017) Induction of Ectonucleotide Pyrophosphatase\/Phosphodiesterase 3 During the Periovulatory Period in the Rat Ovary. Reprod Sci 24:1033\u20131040. https:\/\/doi.org\/10.1177\/1933719116676394","journal-title":"Reprod Sci"},{"key":"3431_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152510","volume":"215","author":"GM Liu","year":"2019","unstructured":"Liu GM, Zeng HD, Zhang CY, Xu JW (2019) Key genes associated with diabetes mellitus and hepatocellular carcinoma. Pathol Res Pract 215:152510. https:\/\/doi.org\/10.1016\/j.prp.2019.152510","journal-title":"Pathol Res Pract"},{"key":"3431_CR48","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0014-5793(97)01536-6","volume":"421","author":"J L\u00f3pez-G\u00f3mez","year":"1998","unstructured":"L\u00f3pez-G\u00f3mez J, Costas MJ, Meireles Ribeiro J, Fern\u00e1ndez A, Romero A, \u00c1valos M, Cameselle JC (1998) Glycine-enhanced inhibition of rat liver nucleotide pyrophosphatase\/phosphodiesterase-I by EDTA: a full account of the reported inhibition by commercial preparations of acidic fibroblast growth factor (FGF-1). FEBS Lett 421:77\u201379. https:\/\/doi.org\/10.1016\/s0014-5793(97)01536-6","journal-title":"FEBS Lett"},{"key":"3431_CR49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2337\/diabetes.49.1.13","volume":"49","author":"BA Maddux","year":"2000","unstructured":"Maddux BA, Goldfine ID (2000) Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 49:13\u201319. https:\/\/doi.org\/10.2337\/diabetes.49.1.13","journal-title":"Diabetes"},{"key":"3431_CR50","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/373448a0","volume":"373","author":"BA Maddux","year":"1995","unstructured":"Maddux BA, Sbraccia P, Kumakura S, Sasson S, Youngren J, Fisher A, Spencer S, Grupe A, Henzel W, Stewart TA et al (1995) Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 373:448\u2013451. https:\/\/doi.org\/10.1038\/373448a0","journal-title":"Nature"},{"key":"3431_CR51","doi-asserted-by":"publisher","first-page":"E746","DOI":"10.1152\/ajpendo.00298.2005","volume":"290","author":"BA Maddux","year":"2006","unstructured":"Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren JF, Goldfine ID (2006) Overexpression of the Insulin Receptor Inhibitor, PC-1\/NPP1, Induces Insulin Resistance and Hyperglycemia. Am J Physiol Endocrinol Metab 290:E746-749. https:\/\/doi.org\/10.1152\/ajpendo.00298.2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3431_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114209","volume":"43","author":"R Mardjuki","year":"2024","unstructured":"Mardjuki R, Wang S, Carozza J, Zirak B, Subramanyam V, Abhiraman G, Lyu X, Goodarzi H, Li L (2024) Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint. Cell Rep 43:114209. https:\/\/doi.org\/10.1016\/j.celrep.2024.114209","journal-title":"Cell Rep"},{"key":"3431_CR53","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1016\/S0021-9258(18)64180-8","volume":"236","author":"RG Martin","year":"1961","unstructured":"Martin RG, Ames BN (1961) A method for determining the sedimentation behavior of enzymes: application to protein mixtures. J Biol Chem 236:1372\u20131379. https:\/\/doi.org\/10.1016\/S0021-9258(18)64180-8","journal-title":"J Biol Chem"},{"key":"3431_CR54","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/s0006-291x(03)01454-2","volume":"308","author":"Y Ohe","year":"2003","unstructured":"Ohe Y, Ohnishi H, Okazawa H, Tomizawa K, Kobayashi H, Okawa K, Matozaki T (2003) Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Biochem Biophys Res Commun 308:719\u2013725. https:\/\/doi.org\/10.1016\/s0006-291x(03)01454-2","journal-title":"Biochem Biophys Res Commun"},{"key":"3431_CR55","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.3390\/molecules24224192","volume":"24","author":"KI Onyedibe","year":"2019","unstructured":"Onyedibe KI, Wang M, Sintim HO (2019) ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors-A STING in the Tale of ENPP1. Molecules 24:4192. https:\/\/doi.org\/10.3390\/molecules24224192","journal-title":"Molecules"},{"key":"3431_CR56","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.coph.2016.03.003","volume":"28","author":"IR Orriss","year":"2016","unstructured":"Orriss IR, Arnett TR, Russell RG (2016) Pyrophosphate: a key inhibitor of mineralisation. Curr Opin Pharmacol 28:57\u201368. https:\/\/doi.org\/10.1016\/j.coph.2016.03.003","journal-title":"Curr Opin Pharmacol"},{"key":"3431_CR57","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1172\/JCI1326","volume":"101","author":"ME Patti","year":"1998","unstructured":"Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR (1998) Bidirectional modulation of insulin action by amino acids. J Clin Invest 101:1519\u20131529. https:\/\/doi.org\/10.1172\/JCI1326","journal-title":"J Clin Invest"},{"key":"3431_CR58","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1002\/prot.24582","volume":"82","author":"C Peters","year":"2014","unstructured":"Peters C, Elofsson A (2014) Why is the biological hydrophobicity scale more accurate than earlier experimental hydrophobicity scales? Proteins 82:2190\u20132198. https:\/\/doi.org\/10.1002\/prot.24582","journal-title":"Proteins"},{"key":"3431_CR59","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.3390\/chemistry5040142","volume":"5","author":"A Rauf","year":"2023","unstructured":"Rauf A, Akram Z, Naveed M, AlMasoud N, Alomar TS, Saleem M, Waheed A, Ribaudo G (2023) Studies on the Inhibition of Ectonucleotide Pyrophosphatase\/Phosphodiesterase 1 (ENPP1) by 2-(3,4-Dihydroxyphenyl)-7,8-dihydroxy-3-methoxychromen-4-one, a Flavonoid from Pistacia chinensis. Chemistry 5:2094\u20132103. https:\/\/doi.org\/10.3390\/chemistry5040142","journal-title":"Chemistry"},{"key":"3431_CR60","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1042\/bj3460025","volume":"346","author":"JM Ribeiro","year":"2000","unstructured":"Ribeiro JM, L\u00f3pez-G\u00f3mez J, Vergeles JM, Costas MJ, Garc\u00eda-D\u00edaz M, Fern\u00e1ndez A, Flores A, Cameselle JC (2000) Rat liver nucleotide pyrophosphatase\/phosphodiesterase is an efficient adenylyl transferase. Biochem J 346:25\u201331. https:\/\/doi.org\/10.1042\/bj3460025","journal-title":"Biochem J"},{"key":"3431_CR61","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.3390\/ijms24044150","volume":"24","author":"JM Ribeiro","year":"2023","unstructured":"Ribeiro JM, Canales J, Costas MJ, Cabezas A, Pinto RM, Garc\u00eda-D\u00edaz M, Mart\u00edn-Cordero P, Cameselle JC (2023) Genomic Distribution of Pro-Virulent cpdB-like Genes in Eubacteria and Comparison of the Enzyme Specificity of CpdB-like Proteins from Salmonella enterica, Escherichia coli and Streptococcus suis. Int J Mol Sci 24:4150. https:\/\/doi.org\/10.3390\/ijms24044150","journal-title":"Int J Mol Sci"},{"key":"3431_CR62","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1146\/annurev-biochem-040320-101629","volume":"91","author":"C Ritchie","year":"2022","unstructured":"Ritchie C, Carozza JA, Li L (2022) Biochemistry, Cell Biology, and Pathophysiology of the Innate Immune cGAS-cGAMP-STING Pathway. Annu Rev Biochem 91:599\u2013628. https:\/\/doi.org\/10.1146\/annurev-biochem-040320-101629","journal-title":"Annu Rev Biochem"},{"key":"3431_CR63","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1016\/j.tibs.2019.01.010","volume":"15","author":"F Roberts","year":"2019","unstructured":"Roberts F, Zhu D, Farquharson C, Macrae VE (2019) ENPP1 in the Regulation of Mineralization and Beyond. Trends Biochem Sci 15:3010\u20133037. https:\/\/doi.org\/10.1016\/j.tibs.2019.01.010","journal-title":"Trends Biochem Sci"},{"key":"3431_CR64","unstructured":"Romero A (2003) Efecto de los amino\u00e1cidos comunes sobre la inactivaci\u00f3n de la nucle\u00f3tido pirofosfatasa por el quelante de metales EDTA: Evidencia de un cambio conformacional debido a los amino\u00e1cidos libres. PhD Thesis, Universidad de Extremadura, Spain,"},{"key":"3431_CR65","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1158\/1078-0432.Ccr-22-1681","volume":"29","author":"B Ruiz-Fern\u00e1ndez de C\u00f3rdoba","year":"2023","unstructured":"Ruiz-Fern\u00e1ndez de C\u00f3rdoba B, Mart\u00ednez-Monge R, Lecanda F (2023) ENPP1 Immunobiology as a Therapeutic Target. Clin Cancer Res 29:2184\u20132193. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-22-1681","journal-title":"Clin Cancer Res"},{"key":"3431_CR66","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1007\/s12010-019-02956-9","volume":"188","author":"T Saleem","year":"2019","unstructured":"Saleem T, Dahpy M, Ezzat G, Abdelrahman G, Abdel-Aziz E, Farghaly R (2019) The Profile of Plasma Free Amino Acids in Type 2 Diabetes Mellitus with Insulin Resistance: Association with Microalbuminuria and Macroalbuminuria. Appl Biochem Biotechnol 188:854\u2013867. https:\/\/doi.org\/10.1007\/s12010-019-02956-9","journal-title":"Appl Biochem Biotechnol"},{"key":"3431_CR67","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1002\/hep.510250434","volume":"25","author":"LJ Scott","year":"1997","unstructured":"Scott LJ, Delautier D, Meerson NR, Trugnan G, Goding JW, Maurice M (1997) Biochemical and molecular identification of distinct forms of alkaline phosphodiesterase I expressed on the apical and basolateral plasma membrane surfaces of rat hepatocytes. Hepatology 25:995\u20131002. https:\/\/doi.org\/10.1002\/hep.510250434","journal-title":"Hepatology"},{"key":"3431_CR68","doi-asserted-by":"publisher","first-page":"e12392","DOI":"10.14814\/phy2.12392","volume":"3","author":"R Seibert","year":"2015","unstructured":"Seibert R, Abbasi F, Hantash FM, Caulfield MP, Reaven G, Kim SH (2015) Relationship between insulin resistance and amino acids in women and men. Physiol Rep 3:e12392. https:\/\/doi.org\/10.14814\/phy2.12392","journal-title":"Physiol Rep"},{"key":"3431_CR69","volume-title":"NIST Critically Selected Stability Constants by Metal Complexes, NIST Standard Reference Database 46 version 80","author":"RM Smith","year":"2004","unstructured":"Smith RM, Martell AE, Motekaitis RJ (2004) NIST Critically Selected Stability Constants by Metal Complexes, NIST Standard Reference Database 46 version 80. National Institute of Standards and Technology, Gaitherburg, MD"},{"key":"3431_CR70","doi-asserted-by":"publisher","first-page":"980","DOI":"10.2337\/diab.45.7.980","volume":"45","author":"C Stefan","year":"1996","unstructured":"Stefan C, Wera S, Stalmans W, Bollen M (1996) The inhibition of the insulin receptor by the receptor protein PC-1 is not specific and results from the hydrolysis of ATP. Diabetes 45:980\u2013983. https:\/\/doi.org\/10.2337\/diab.45.7.980","journal-title":"Diabetes"},{"key":"3431_CR71","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1042\/bj3250811w","volume":"325","author":"C Stefan","year":"1997","unstructured":"Stefan C, Stalmans W, Bollen M (1997) Inhibition of the membrane protein PC-1 by commercial acidic fibroblast growth factor is due to a non-protein contaminant. Biochem J 325:814. https:\/\/doi.org\/10.1042\/bj3250811w","journal-title":"Biochem J"},{"key":"3431_CR72","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.tibs.2005.08.005","volume":"30","author":"C Stefan","year":"2005","unstructured":"Stefan C, Jansen S, Bollen M (2005) NPP-type ectophosphodiesterases: unity in diversity. Trends Biochem Sci 30:542\u2013550. https:\/\/doi.org\/10.1016\/j.tibs.2005.08.005","journal-title":"Trends Biochem Sci"},{"key":"3431_CR73","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s11302-005-5303-4","volume":"2","author":"C Stefan","year":"2006","unstructured":"Stefan C, Jansen S, Bollen M (2006) Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal 2:361\u2013370. https:\/\/doi.org\/10.1007\/s11302-005-5303-4","journal-title":"Purinergic Signal"},{"key":"3431_CR74","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fendo.2018.00098","volume":"9","author":"EJ Tassone","year":"2018","unstructured":"Tassone EJ, Cimellaro A, Perticone M, Hribal ML, Sciacqua A, Andreozzi F, Sesti G, Perticone F (2018) Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells. Front Endocrinol 9:98. https:\/\/doi.org\/10.3389\/fendo.2018.00098","journal-title":"Front Endocrinol"},{"key":"3431_CR75","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s0168-8227(99)00056-x","volume":"45","author":"S Teno","year":"1999","unstructured":"Teno S, Kanno H, Oga S, Kumakura S, Kanamuro R, Iwamoto Y (1999) Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance. Diabetes Res Clin Pract 45:25\u201330. https:\/\/doi.org\/10.1016\/s0168-8227(99)00056-x","journal-title":"Diabetes Res Clin Pract"},{"key":"3431_CR76","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.2001.281.1.C1","volume":"281","author":"RA Terkeltaub","year":"2001","unstructured":"Terkeltaub RA (2001) Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 281:C1\u2013C11. https:\/\/doi.org\/10.1152\/ajpcell.2001.281.1.C1","journal-title":"Am J Physiol Cell Physiol"},{"key":"3431_CR77","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11302-005-5304-3","volume":"2","author":"R Terkeltaub","year":"2006","unstructured":"Terkeltaub R (2006) Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase\/phosphodiesterase family focusing on NPP1 in calcification. Purinergic Signal 2:371\u2013377. https:\/\/doi.org\/10.1007\/s11302-005-5304-3","journal-title":"Purinergic Signal"},{"key":"3431_CR78","doi-asserted-by":"publisher","first-page":"32895","DOI":"10.1074\/jbc.M114.612341","volume":"289","author":"M Traini","year":"2014","unstructured":"Traini M, Quinn CM, Sandoval C, Johansson E, Schroder K, Kockx M, Meikle PJ, Jessup W, Kritharides L (2014) Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. J Biol Chem 289:32895\u201332913. https:\/\/doi.org\/10.1074\/jbc.M114.612341","journal-title":"J Biol Chem"},{"key":"3431_CR79","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev.nutr.25.050304.092545","volume":"27","author":"F Tremblay","year":"2007","unstructured":"Tremblay F, Lavigne C, Jacques H, Marette A (2007) Role of dietary proteins and amino acids in the pathogenesis of insulin resistance. Annu Rev Nutr 27:293\u2013310. https:\/\/doi.org\/10.1146\/annurev.nutr.25.050304.092545","journal-title":"Annu Rev Nutr"},{"key":"3431_CR80","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.immuni.2015.01.015","volume":"42","author":"SH Tsai","year":"2015","unstructured":"Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K (2015) The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells. Immunity 42:279\u2013293. https:\/\/doi.org\/10.1016\/j.immuni.2015.01.015","journal-title":"Immunity"},{"key":"3431_CR81","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3892\/ijmm.12.5.763","volume":"12","author":"Y Yano","year":"2003","unstructured":"Yano Y, Hayashi Y, Sano K, Shinmaru H, Kuroda Y, Yokozaki H, Yoon S, Kasuga M (2003) Expression and localization of ecto-nucleotide pyrophosphatase\/phosphodiesterase I-3 (E-NPP3\/CD203c\/PD-I beta\/B10\/gp130RB13-6) in human colon carcinoma. Int J Mol Med 12:763\u2013766. https:\/\/doi.org\/10.3892\/ijmm.12.5.763","journal-title":"Int J Mol Med"},{"key":"3431_CR82","doi-asserted-by":"publisher","first-page":"1309917","DOI":"10.3389\/fendo.2024.1309917","volume":"15","author":"C Ye","year":"2024","unstructured":"Ye C, Fu Y, Zhou X, Zhou F, Zhu X, Chen Y (2024) Identification and validation of NAD+ metabolism-related biomarkers in patients with diabetic peripheral neuropathy. Front Endocrinol 15:1309917. https:\/\/doi.org\/10.3389\/fendo.2024.1309917","journal-title":"Front Endocrinol"},{"key":"3431_CR83","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ejphar.2009.06.057","volume":"616","author":"HH Zhou","year":"2009","unstructured":"Zhou HH, Chin CN, Wu M, Ni W, Quan S, Liu F, Dallas-Yang Q, Ellsworth K, Ho T, Zhang A, Natasha T, Li J, Chapman K, Strohl W, Li C, Wang IM, Berger J, An Z, Zhang BB, Jiang G (2009) Suppression of PC-1\/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Eur J Pharmacol 616:346\u2013352. https:\/\/doi.org\/10.1016\/j.ejphar.2009.06.057","journal-title":"Eur J Pharmacol"}],"container-title":["Amino Acids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-024-03431-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00726-024-03431-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00726-024-03431-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:17:09Z","timestamp":1766423829000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00726-024-03431-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,6]]},"references-count":83,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3431"],"URL":"https:\/\/doi.org\/10.1007\/s00726-024-03431-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.06.27.601032","asserted-by":"object"}]},"ISSN":["1438-2199"],"issn-type":[{"value":"1438-2199","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,6]]},"assertion":[{"value":"3 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1"}}