{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:31:04Z","timestamp":1748687464789,"version":"3.37.3"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Capes","doi-asserted-by":"crossref","award":["PVE1232013"],"award-info":[{"award-number":["PVE1232013"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["442329\/2014-8"],"award-info":[{"award-number":["442329\/2014-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s00784-020-03478-z","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T14:02:54Z","timestamp":1596808974000},"page":"3347-3362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genotoxicity of root canal sealers: a literature review"],"prefix":"10.1007","volume":"24","author":[{"given":"F\u00e1bio Miguel","family":"dos Santos Costa","sequence":"first","affiliation":[]},{"given":"Maria Helena","family":"Fernandes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-0479","authenticated-orcid":false,"given":"Silvia Regina","family":"Batistuzzo de Medeiros","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"3478_CR1","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.12688\/f1000research.16142.2","volume":"7","author":"L Gadallah","year":"2018","unstructured":"Gadallah L, Hamdy M, El Bardissy A, Abou El Yazeed M (2018) Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review and meta-analysis. F1000Res 7:1560. https:\/\/doi.org\/10.12688\/f1000research.16142.2","journal-title":"F1000Res"},{"key":"3478_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/0972-0707.153054","volume":"18","author":"A Kaur","year":"2015","unstructured":"Kaur A, Shah N, Logani A, Mishra N (2015) Biotoxicity of commonly used root canal sealers: a meta-analysis. J Conserv Dent 18:83\u201388. https:\/\/doi.org\/10.4103\/0972-0707.153054","journal-title":"J Conserv Dent"},{"key":"3478_CR3","unstructured":"International Organization for Standardization (2014) Biological evaluation of medical devices. Part 3. Tests for genotoxicity, carcinogenicity and reproductive toxicity. ISO 10993-3:2014:1-34"},{"key":"3478_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/em.22087","volume":"58","author":"N Chatterjee","year":"2017","unstructured":"Chatterjee N, Walker GC (2017) Mechanisms of DNA damage, repair, and mutagenesis. Environ Mol Mutagen 58:235\u2013263. https:\/\/doi.org\/10.1002\/em.22087","journal-title":"Environ Mol Mutagen"},{"key":"3478_CR5","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1038\/onc.2012.556","volume":"32","author":"O Surova","year":"2013","unstructured":"Surova O, Zhivotovsky B (2013) Various modes of cell death induced by DNA damage. Oncogene 32:3789\u20133797. https:\/\/doi.org\/10.1038\/onc.2012.556","journal-title":"Oncogene"},{"key":"3478_CR6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.cell.2017.01.002","volume":"168","author":"A Tubbs","year":"2017","unstructured":"Tubbs A, Nussenzweig A (2017) Endogenous DNA damage as a source of genomic instability in cancer. Cell 168:644\u2013656. https:\/\/doi.org\/10.1016\/j.cell.2017.01.002","journal-title":"Cell"},{"key":"3478_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/rb\/rbw001","volume":"3","author":"JM Anderson","year":"2016","unstructured":"Anderson JM (2016) Future challenges in the in vitro and in vivo evaluation of biomaterial biocompatibility. Regen Biomater 3:73\u201377. https:\/\/doi.org\/10.1093\/rb\/rbw001","journal-title":"Regen Biomater"},{"key":"3478_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/9753210","volume":"2016","author":"A Al-Haddad","year":"2016","unstructured":"Al-Haddad A, Che Ab Aziz ZA (2016) Bioceramic-based root canal sealers: a review. Int J Biomater 2016:1\u201310. https:\/\/doi.org\/10.1155\/2016\/9753210","journal-title":"Int J Biomater"},{"key":"3478_CR9","doi-asserted-by":"publisher","first-page":"470","DOI":"10.15386\/cjmed-612","volume":"89","author":"S Jitaru","year":"2016","unstructured":"Jitaru S, Hodisan I, Timis L, Lucian A, Bud M (2016) The use of bioceramics in endodontics - literature review. Clujul Med 89:470\u2013473. https:\/\/doi.org\/10.15386\/cjmed-612","journal-title":"Clujul Med"},{"key":"3478_CR10","doi-asserted-by":"publisher","first-page":"e0223575","DOI":"10.1371\/journal.pone.0223575","volume":"14","author":"MS Muniti\u0107","year":"2019","unstructured":"Muniti\u0107 MS, Peri\u010di\u0107 TP, Utrobi\u010di\u0107 A et al (2019) Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: a systematic review. PLoS One 14:e0223575. https:\/\/doi.org\/10.1371\/journal.pone.0223575","journal-title":"PLoS One"},{"key":"3478_CR11","doi-asserted-by":"publisher","first-page":"4113","DOI":"10.3390\/ma12244113","volume":"12","author":"DA Fonseca","year":"2019","unstructured":"Fonseca DA, Paula AB, Marto CM, Coelho A, Paulo S, Martinho JP, Carrilho E, Ferreira MM (2019) Biocompatibility of root canal sealers: a systematic review of in vitro and in vivo studies. Materials (Basel) 12:4113. https:\/\/doi.org\/10.3390\/ma12244113","journal-title":"Materials (Basel)"},{"key":"3478_CR12","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.joen.2008.11.026","volume":"35","author":"S Desai","year":"2009","unstructured":"Desai S, Chandler N (2009) Calcium hydroxide-based root canal sealers: a review. J Endod 35:475\u2013480. https:\/\/doi.org\/10.1016\/j.joen.2008.11.026","journal-title":"J Endod"},{"key":"3478_CR13","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.joen.2009.10.023","volume":"36","author":"YK Kim","year":"2010","unstructured":"Kim YK, Grandini S, Ames JM, Gu LS, Kim SK, Pashley DH, Gutmann JL, Tay FR (2010) Critical review on methacrylate resin-based root canal sealers. J Endod 36:383\u2013399. https:\/\/doi.org\/10.1016\/j.joen.2009.10.023","journal-title":"J Endod"},{"key":"3478_CR14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/978-3-319-68025-5_18","volume-title":"Biomaterials in clinical practice","author":"VJ Cvetkovi\u0107","year":"2018","unstructured":"Cvetkovi\u0107 VJ, Taki\u0107 Miladinov D, Stojanovi\u0107 S (2018) Genotoxicity and mutagenicity testing of biomaterials. In: Biomaterials in clinical practice. Springer International Publishing, Cham, pp 501\u2013527"},{"key":"3478_CR15","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.21873\/anticanres.11786","volume":"37","author":"DA Ribeiro","year":"2017","unstructured":"Ribeiro DA, Yujra VQ, DE Moura CFG et al (2017) Genotoxicity induced by dental materials: a comprehensive review. Anticancer Res 37:4017\u20134024. https:\/\/doi.org\/10.21873\/anticanres.11786","journal-title":"Anticancer Res"},{"key":"3478_CR16","unstructured":"International Organization for Standardization (2018) Biological evaluation of medical devices. Part 1. Evaluation and testing within a risk management process. ISO 10993-1:2018:1-41"},{"key":"3478_CR17","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.biochi.2006.07.004","volume":"88","author":"R Mateuca","year":"2006","unstructured":"Mateuca R, Lombaert N, Aka PV, Decordier I, Kirsch-Volders M (2006) Chromosomal changes: induction, detection methods and applicability in human biomonitoring. Biochimie 88:1515\u20131531. https:\/\/doi.org\/10.1016\/j.biochi.2006.07.004","journal-title":"Biochimie"},{"key":"3478_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.canlet.2012.08.007","volume":"334","author":"JJ Klaene","year":"2013","unstructured":"Klaene JJ, Sharma VK, Glick J, Vouros P (2013) The analysis of DNA adducts: The transition from 32P-postlabeling to mass spectrometry. Cancer Lett 334:10\u201319. https:\/\/doi.org\/10.1016\/j.canlet.2012.08.007","journal-title":"Cancer Lett"},{"key":"3478_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/IJHTS.S70362","volume":"6","author":"R Ranganatha","year":"2016","unstructured":"Ranganatha R, Chakravarthy S, Sukumaran S (2016) High-throughput approaches for genotoxicity testing in drug development: recent advances. Int J High Throughput Screen 6:1. https:\/\/doi.org\/10.2147\/IJHTS.S70362","journal-title":"Int J High Throughput Screen"},{"key":"3478_CR20","first-page":"1","volume":"L142","author":"European Commission","year":"2008","unstructured":"European Commission (2008) Council Regulation (EC) No 440\/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907\/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Off J Eur Union L142:1\u2013739","journal-title":"Off J Eur Union"},{"key":"3478_CR21","doi-asserted-by":"crossref","unstructured":"Maibach H, Wilhelm K-P (2007) OECD guidelines for testing of chemicals. In: Dermatotoxicology, seventh edition. Informa Healthcare, p 303\u2013305","DOI":"10.1201\/9781420009774.ch33"},{"key":"3478_CR22","unstructured":"International Organization for Standardization (2015) Biological evaluation of medical devices. Part 33. Guidance on tests to evaluate genotoxicity ISO\/TR 10993-33:2015:1-47"},{"key":"3478_CR23","unstructured":"OECD (1997) Test No. 471: bacterial reverse mutation test. OECD"},{"key":"3478_CR24","unstructured":"OECD (2016) Test No. 476: in vitro mammalian cell gene mutation tests using the Hprt and xprt genes. OECD"},{"key":"3478_CR25","unstructured":"OECD (2016) Test No. 490: in vitro mammalian cell gene mutation tests using the thymidine kinase gene. OECD"},{"key":"3478_CR26","unstructured":"OECD (2016) Test No. 473: in vitro mammalian chromosomal aberration test. OECD"},{"key":"3478_CR27","unstructured":"OECD (2016) Test No. 487: in vitro mammalian cell micronucleus test. OECD"},{"key":"3478_CR28","unstructured":"OECD (1986) Test No. 482: Genetic toxicology: DNA damage and repair, unscheduled DNA synthesis in mammalian cells in vitro. OECD"},{"key":"3478_CR29","unstructured":"OECD (1986) Test No. 479: genetic toxicology: in vitro sister chromatid exchange assay in mammalian cells. OECD"},{"key":"3478_CR30","unstructured":"OECD (2016) Test No. 475: mammalian bone marrow chromosomal aberration test. OECD"},{"key":"3478_CR31","unstructured":"OECD (2016) Test No. 474: mammalian erythrocyte micronucleus test. OECD"},{"key":"3478_CR32","unstructured":"OECD (2013) Test No. 488: transgenic rodent somatic and germ cell gene mutation assays. OECD"},{"key":"3478_CR33","unstructured":"OECD (2016) Test No. 489: in vivo mammalian alkaline comet assay. OECD"},{"key":"3478_CR34","unstructured":"OECD (1997) Test No. 486: unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo. OECD"},{"key":"3478_CR35","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0099-2399(06)81172-6","volume":"25","author":"H Ersev","year":"1999","unstructured":"Ersev H, Schmalz G, Bayirli G, Schweikl H (1999) Cytotoxic and mutagenic potencies of various root canal filling materials in eukaryotic and prokaryotic cells in vitro. J Endod 25:359\u2013363. https:\/\/doi.org\/10.1016\/S0099-2399(06)81172-6","journal-title":"J Endod"},{"key":"3478_CR36","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/00004770-200112000-00008","volume":"27","author":"T Huang","year":"2001","unstructured":"Huang T, Hueilee D, Kao C (2001) Evaluation of the genotoxicity of zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based root canal sealers by comet assay. J Endod 27:744\u2013748. https:\/\/doi.org\/10.1097\/00004770-200112000-00008","journal-title":"J Endod"},{"key":"3478_CR37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/jbm.1218","volume":"59","author":"K Tai","year":"2002","unstructured":"Tai K, Huang F-M, Huang M, Chang Y (2002) Assessment of the genotoxicity of resin and zinc-oxide eugenol-based root canal sealers using anin vitro mammalian test system. J Biomed Mater Res 59:73\u201377. https:\/\/doi.org\/10.1002\/jbm.1218","journal-title":"J Biomed Mater Res"},{"key":"3478_CR38","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1002\/jbm.10022","volume":"59","author":"F Huang","year":"2002","unstructured":"Huang F, Hsieh Y, Tai K et al (2002) Induction of c-fos and c-jun protooncogenes expression by formaldehyde-releasing and epoxy resin-based root-canal sealers in human osteoblastic cells. J Biomed Mater Res 59:460\u2013465. https:\/\/doi.org\/10.1002\/jbm.10022","journal-title":"J Biomed Mater Res"},{"key":"3478_CR39","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/mutage\/gew026","volume":"31","author":"NCN Santos","year":"2016","unstructured":"Santos NCN, Ramos MESP, Ramos AFB, Cerqueira AB, Cerqueira EMM (2016) Evaluation of the genotoxicity and cytotoxicity of filling pastes used for pulp therapy on deciduous teeth using the micronucleus test on bone marrow from mice (Mus musculus). Mutagenesis 31:589\u2013595. https:\/\/doi.org\/10.1093\/mutage\/gew026","journal-title":"Mutagenesis"},{"key":"3478_CR40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1365-2591.2008.01510.x","volume":"42","author":"V Brzovic","year":"2009","unstructured":"Brzovic V, Miletic I, Zeljezic D, Mladinic M, Kasuba V, Ramic S, Anic I (2009) In vitro genotoxicity of root canal sealers. Int Endod J 42:253\u2013263. https:\/\/doi.org\/10.1111\/j.1365-2591.2008.01510.x","journal-title":"Int Endod J"},{"key":"3478_CR41","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.joen.2013.08.009","volume":"40","author":"CHR Camargo","year":"2014","unstructured":"Camargo CHR, Oliveira TR, Silva GO, Rabelo SB, Valera MC, Cavalcanti BN (2014) Setting time affects in vitro biological properties of root canal sealers. J Endod 40:530\u2013533. https:\/\/doi.org\/10.1016\/j.joen.2013.08.009","journal-title":"J Endod"},{"key":"3478_CR42","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0142-9612(02)00375-7","volume":"24","author":"BP M\u00fcller","year":"2003","unstructured":"M\u00fcller BP, Eisentr\u00e4ger A, Jahnen-Dechent W, Dott W, Hollender J (2003) Effect of sample preparation on the in vitro genotoxicity of a light curable glass ionomer cement. Biomaterials 24:611\u2013617. https:\/\/doi.org\/10.1016\/S0142-9612(02)00375-7","journal-title":"Biomaterials"},{"key":"3478_CR43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1365-2591.2008.01506.x","volume":"42","author":"SEA Camargo","year":"2009","unstructured":"Camargo SEA, Camargo CHR, Hiller K-A, Rode SM, Schweikl H, Schmalz G (2009) Cytotoxicity and genotoxicity of pulp capping materials in two cell lines. Int Endod J 42:227\u2013237. https:\/\/doi.org\/10.1111\/j.1365-2591.2008.01506.x","journal-title":"Int Endod J"},{"key":"3478_CR44","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.joen.2011.12.037","volume":"38","author":"KL Van Landuyt","year":"2012","unstructured":"Van Landuyt KL, Geebelen B, Shehata M et al (2012) No evidence for DNA double-strand breaks caused by endodontic sealers. J Endod 38:636\u2013641. https:\/\/doi.org\/10.1016\/j.joen.2011.12.037","journal-title":"J Endod"},{"key":"3478_CR45","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s00784-015-1567-4","volume":"20","author":"GO Silva","year":"2016","unstructured":"Silva GO, Cavalcanti BN, Oliveira TR, Bin CV, Camargo SEA, Camargo CHR (2016) Cytotoxicity and genotoxicity of natural resin-based experimental endodontic sealers. Clin Oral Investig 20:815\u2013819. https:\/\/doi.org\/10.1007\/s00784-015-1567-4","journal-title":"Clin Oral Investig"},{"key":"3478_CR46","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/iej.12577","volume":"49","author":"AU Eldeniz","year":"2016","unstructured":"Eldeniz AU, Shehata M, H\u00f6gg C, Reichl FX (2016) DNA double-strand breaks caused by new and contemporary endodontic sealers. Int Endod J 49:1141\u20131151. https:\/\/doi.org\/10.1111\/iej.12577","journal-title":"Int Endod J"},{"key":"3478_CR47","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/iej.12785","volume":"51","author":"FC Martinho","year":"2018","unstructured":"Martinho FC, Camargo SEA, Fernandes AMM, Campos MS, Prado RF, Camargo CHR, Valera MC (2018) Comparison of cytotoxicity, genotoxicity and immunological inflammatory biomarker activity of several endodontic sealers against immortalized human pulp cells. Int Endod J 51:41\u201357. https:\/\/doi.org\/10.1111\/iej.12785","journal-title":"Int Endod J"},{"key":"3478_CR48","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.tripleo.2009.07.015","volume":"108","author":"CHR Camargo","year":"2009","unstructured":"Camargo CHR, Camargo SEA, Valera MC, Hiller KA, Schmalz G, Schweikl H (2009) The induction of cytotoxicity, oxidative stress, and genotoxicity by root canal sealers in mammalian cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:952\u2013960. https:\/\/doi.org\/10.1016\/j.tripleo.2009.07.015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3478_CR49","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1365-2591.2011.01869.x","volume":"44","author":"A Baraba","year":"2011","unstructured":"Baraba A, Zelje\u017ei\u0107 D, Kopjar N et al (2011) Evaluation of cytotoxic and genotoxic effects of two resin-based root-canal sealers and their components on human leucocytes in vitro. Int Endod J 44:652\u2013661. https:\/\/doi.org\/10.1111\/j.1365-2591.2011.01869.x","journal-title":"Int Endod J"},{"key":"3478_CR50","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.tdj.2014.06.001","volume":"11","author":"AM Darrag","year":"2014","unstructured":"Darrag AM, Fayyad DM (2014) Genotoxicity of three endodontic sealers by single cell gel-electrophoresis\/comet assay. Tanta Dent J 11:85\u201392. https:\/\/doi.org\/10.1016\/j.tdj.2014.06.001","journal-title":"Tanta Dent J"},{"key":"3478_CR51","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0142-9612(01)00081-3","volume":"23","author":"T Huang","year":"2002","unstructured":"Huang T, Yang J, Li H, Kao C (2002) The biocompatibility evaluation of epoxy resin-based root canal sealers in vitro. Biomaterials 23:77\u201383. https:\/\/doi.org\/10.1016\/S0142-9612(01)00081-3","journal-title":"Biomaterials"},{"key":"3478_CR52","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0099-2399(99)80007-7","volume":"25","author":"G Leyhausen","year":"1999","unstructured":"Leyhausen G, Heil J, Reifferscheid G, Waldmann P, Geurtsen W (1999) Genotoxicity and cytotoxicity of the epoxy resin-based root canal sealer AH plus. J Endod 25:109\u2013113. https:\/\/doi.org\/10.1016\/S0099-2399(99)80007-7","journal-title":"J Endod"},{"key":"3478_CR53","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s007840050057","volume":"2","author":"H Schweikl","year":"1998","unstructured":"Schweikl H, Schmalz G, Federlin M (1998) Mutagenicity of the root canal sealer AHPlus in the Ames test. Clin Oral Investig 2:125\u2013129. https:\/\/doi.org\/10.1007\/s007840050057","journal-title":"Clin Oral Investig"},{"key":"3478_CR54","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/00004770-200006000-00003","volume":"26","author":"S Juki\u0107","year":"2000","unstructured":"Juki\u0107 S, Mileti\u0107 I, Ani\u0107 I et al (2000) The mutagenic potential of AH+ and AH26 by Salmonella\/microsome assay. J Endod 26:321\u2013324. https:\/\/doi.org\/10.1097\/00004770-200006000-00003","journal-title":"J Endod"},{"key":"3478_CR55","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.joen.2011.11.003","volume":"38","author":"CV Bin","year":"2012","unstructured":"Bin CV, Valera MC, Camargo SEA, Rabelo SB, Silva GO, Balducci I, Camargo CHR (2012) Cytotoxicity and genotoxicity of root canal sealers based on mineral trioxide aggregate. J Endod 38:495\u2013500. https:\/\/doi.org\/10.1016\/j.joen.2011.11.003","journal-title":"J Endod"},{"key":"3478_CR56","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/iej.12523","volume":"49","author":"GTM Candeiro","year":"2016","unstructured":"Candeiro GTM, Moura-Netto C, D\u2019Almeida-Couto RS et al (2016) Cytotoxicity, genotoxicity and antibacterial effectiveness of a bioceramic endodontic sealer. Int Endod J 49:858\u2013864. https:\/\/doi.org\/10.1111\/iej.12523","journal-title":"Int Endod J"},{"key":"3478_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/8920356","volume":"2017","author":"A Victoria-Escandell","year":"2017","unstructured":"Victoria-Escandell A, Iba\u00f1ez-Cabellos JS, de Cutanda SB-S, Berenguer-Pascual E, Beltr\u00e1n-Garc\u00eda J, Garc\u00eda-L\u00f3pez E, Pallard\u00f3 FV, Garc\u00eda-Gim\u00e9nez JL, Pallar\u00e9s-Sabater A, Zarzosa-L\u00f3pez I, Monterde M (2017) Cellular responses in human dental pulp stem cells treated with three endodontic materials. Stem Cells Int 2017:1\u201314. https:\/\/doi.org\/10.1155\/2017\/8920356","journal-title":"Stem Cells Int"},{"key":"3478_CR58","doi-asserted-by":"publisher","first-page":"103","DOI":"10.22161\/ijaers.71.13","volume":"7","author":"EF Marques","year":"2020","unstructured":"Marques EF, da Silva Benigno MB, Macedo CP, Bitencourt L (2020) Cytotoxicity and genotoxicity analysis of two endodontic cements in human fibroblast culture in vitro. Int J Adv Eng Res Sci 7:103\u2013108. https:\/\/doi.org\/10.22161\/ijaers.71.13","journal-title":"Int J Adv Eng Res Sci"},{"key":"3478_CR59","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1097\/01.don.0000153842.06657.e2","volume":"31","author":"DA Ribeiro","year":"2005","unstructured":"Ribeiro DA, Duarte MAH, Matsumoto MA et al (2005) Biocompatibility in vitro tests of mineral trioxide aggregate and regular and white Portland cements. J Endod 31:605\u2013607. https:\/\/doi.org\/10.1097\/01.don.0000153842.06657.e2","journal-title":"J Endod"},{"key":"3478_CR60","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.tripleo.2005.02.080","volume":"101","author":"DA Ribeiro","year":"2006","unstructured":"Ribeiro DA, Sugui MM, Matsumoto MA, Duarte MAH, Marques MEA, Salvadori DMF (2006) Genotoxicity and cytotoxicity of mineral trioxide aggregate and regular and white Portland cements on Chinese hamster ovary (CHO) cells in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:258\u2013261. https:\/\/doi.org\/10.1016\/j.tripleo.2005.02.080","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3478_CR61","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1365-2842.2005.01559.x","volume":"33","author":"MG Braz","year":"2006","unstructured":"Braz MG, Camargo EA, Salvadori DMF et al (2006) Evaluation of genetic damage in human peripheral lymphocytes exposed to mineral trioxide aggregate and Portland cements. J Oral Rehabil 33:234\u2013239. https:\/\/doi.org\/10.1111\/j.1365-2842.2005.01559.x","journal-title":"J Oral Rehabil"},{"key":"3478_CR62","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1365-2591.2010.01747.x","volume":"43","author":"EG Zeferino","year":"2010","unstructured":"Zeferino EG, Bueno CES, Oyama LM, Ribeiro DA (2010) Ex vivo assessment of genotoxicity and cytotoxicity in murine fibroblasts exposed to white MTA or white Portland cement with 15% bismuth oxide. Int Endod J 43:843\u2013848. https:\/\/doi.org\/10.1111\/j.1365-2591.2010.01747.x","journal-title":"Int Endod J"},{"key":"3478_CR63","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.joen.2010.03.039","volume":"36","author":"SJ Ding","year":"2010","unstructured":"Ding SJ, Kao CT, Chen CL, Shie MY, Huang TH (2010) Evaluation of human osteosarcoma cell line genotoxicity effects of mineral trixoide aggregate and calcium silicate cements. J Endod 36:1158\u20131162. https:\/\/doi.org\/10.1016\/j.joen.2010.03.039","journal-title":"J Endod"},{"key":"3478_CR64","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4012\/dmj.2013-123","volume":"33","author":"N Naghavi","year":"2014","unstructured":"Naghavi N, Ghoddusi J, Sadeghnia HR et al (2014) Genotoxicity and cytotoxicity of mineral trioxide aggregate and calcium enriched mixture cements on L929 mouse fibroblast cells. Dent Mater 33:64\u201369. https:\/\/doi.org\/10.4012\/dmj.2013-123","journal-title":"Dent Mater"},{"key":"3478_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.mrgentox.2017.01.001","volume":"815","author":"H Ko","year":"2017","unstructured":"Ko H, Jeong Y, Kim M (2017) Cytotoxicities and genotoxicities of cements based on calcium silicate and of dental formocresol. Mutat Res Toxicol Environ Mutagen 815:28\u201334. https:\/\/doi.org\/10.1016\/j.mrgentox.2017.01.001","journal-title":"Mutat Res Toxicol Environ Mutagen"},{"key":"3478_CR66","doi-asserted-by":"publisher","first-page":"419","DOI":"10.22037\/iej.v12i4.15104","volume":"12","author":"A Zakerzadeh","year":"2017","unstructured":"Zakerzadeh A, Esnaashari E, Dadfar S (2017) In vitro comparison of cytotoxicity and genotoxicity of three vital pulp capping materials. Iran Endod J 12:419\u2013425. https:\/\/doi.org\/10.22037\/iej.v12i4.15104","journal-title":"Iran Endod J"},{"key":"3478_CR67","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1590\/S1806-83242005000300005","volume":"19","author":"DA Ribeiro","year":"2005","unstructured":"Ribeiro DA, Matsumoto MA, Duarte MAH, Marques MEA, Salvadori DMF (2005) In vitro biocompatibility tests of two commercial types of mineral trioxide aggregate. Braz Oral Res 19:183\u2013187. https:\/\/doi.org\/10.1590\/S1806-83242005000300005","journal-title":"Braz Oral Res"},{"key":"3478_CR68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1365-2591.2005.01043.x","volume":"39","author":"DA Ribeiro","year":"2006","unstructured":"Ribeiro DA, Matsumoto MA, Duarte MAH, Marques MEA, Salvadori DMF (2006) Ex vivo biocompatibility tests of regular and white forms of mineral trioxide aggregate. Int Endod J 39:26\u201330. https:\/\/doi.org\/10.1111\/j.1365-2591.2005.01043.x","journal-title":"Int Endod J"},{"key":"3478_CR69","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tripleo.2006.02.032","volume":"102","author":"GN da Silva","year":"2006","unstructured":"da Silva GN, Braz MG, de Camargo EA, Salvadori DMF, Ribeiro DA (2006) Genotoxicity in primary human peripheral lymphocytes after exposure to regular and white mineral trioxide aggregate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:50\u201354. https:\/\/doi.org\/10.1016\/j.tripleo.2006.02.032","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3478_CR70","doi-asserted-by":"publisher","first-page":"656","DOI":"10.5005\/jp-journals-10024-2315","volume":"19","author":"AV Nair","year":"2018","unstructured":"Nair AV, Nayak M, Prasada LK et al (2018) Comparative evaluation of cytotoxicity and genotoxicity of two bioceramic sealers on fibroblast cell line: An in vitro study. J Contemp Dent Pract 19:656\u2013661. https:\/\/doi.org\/10.5005\/jp-journals-10024-2315","journal-title":"J Contemp Dent Pract"},{"key":"3478_CR71","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1016\/j.dental.2008.02.020","volume":"24","author":"P Laurent","year":"2008","unstructured":"Laurent P, Camps J, De M\u00e9o M et al (2008) Induction of specific cell responses to a Ca3SiO5-based posterior restorative material. Dent Mater 24:1486\u20131494. https:\/\/doi.org\/10.1016\/j.dental.2008.02.020","journal-title":"Dent Mater"},{"key":"3478_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1807-3107BOR-2016.vol30.0097","volume":"30","author":"GA Nai","year":"2016","unstructured":"Nai GA, de Almeida Logar G, Mori GG et al (2016) Evaluation of the genotoxicity and mutagenicity of Ca3SiO5-based cement. Braz Oral Res 30:1\u20137. https:\/\/doi.org\/10.1590\/1807-3107BOR-2016.vol30.0097","journal-title":"Braz Oral Res"},{"key":"3478_CR73","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/iej.12017","volume":"46","author":"V Opa\u010di\u0107-Gali\u0107","year":"2013","unstructured":"Opa\u010di\u0107-Gali\u0107 V, Petrovi\u0107 V, \u017divkovi\u0107 S, Jokanovi\u0107 V, Nikoli\u0107 B, Kne\u017eevi\u0107-Vuk\u010devi\u0107 J, Miti\u0107-\u0106ulafi\u0107 D (2013) New nanostructural biomaterials based on active silicate systems and hydroxyapatite: Characterization and genotoxicity in human peripheral blood lymphocytes. Int Endod J 46:506\u2013516. https:\/\/doi.org\/10.1111\/iej.12017","journal-title":"Int Endod J"},{"key":"3478_CR74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1046\/j.1365-2591.1999.00173.x","volume":"32","author":"MJ Koch","year":"1999","unstructured":"Koch MJ (1999) Formaldehyde release from root-canal sealers: nfluence of method. Int Endod J 32:10\u201316. https:\/\/doi.org\/10.1046\/j.1365-2591.1999.00173.x","journal-title":"Int Endod J"},{"key":"3478_CR75","first-page":"17055","volume":"8","author":"C Zhu","year":"2015","unstructured":"Zhu C, Ju B, Ni R (2015) Clinical outcome of direct pulp capping with MTA or calcium hydroxide: a systematic review and meta-analysis. Int J Clin Exp Med 8:17055\u201317060","journal-title":"Int J Clin Exp Med"},{"key":"3478_CR76","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/mutage\/gen066","volume":"24","author":"GA Arossi","year":"2008","unstructured":"Arossi GA, Dihl RR, Lehmann M, Cunha KS, Reguly ML, de Andrade HHR (2008) In vivo genotoxicity of dental bonding agents. Mutagenesis 24:169\u2013172. https:\/\/doi.org\/10.1093\/mutage\/gen066","journal-title":"Mutagenesis"},{"key":"3478_CR77","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1600-079X.2011.00877.x","volume":"51","author":"J Blasiak","year":"2011","unstructured":"Blasiak J, Kasznicki J, Drzewoski J, Pawlowska E, Szczepanska J, Reiter RJ (2011) Perspectives on the use of melatonin to reduce cytotoxic and genotoxic effects of methacrylate-based dental materials. J Pineal Res 51:157\u2013162. https:\/\/doi.org\/10.1111\/j.1600-079X.2011.00877.x","journal-title":"J Pineal Res"},{"key":"3478_CR78","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.dental.2013.07.005","volume":"29","author":"S Lottner","year":"2013","unstructured":"Lottner S, Shehata M, Hickel R, Reichl FX, Durner J (2013) Effects of antioxidants on DNA-double strand breaks in human gingival fibroblasts exposed to methacrylate based monomers. Dent Mater 29:991\u2013998. https:\/\/doi.org\/10.1016\/j.dental.2013.07.005","journal-title":"Dent Mater"},{"key":"3478_CR79","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1177\/0748233712462472","volume":"30","author":"M-L Yang","year":"2014","unstructured":"Yang M-L (2014) The effects of cytotoxicity and genotoxicity induced by 2,2-bis{[}4-(acryloxypropoxy)phenyl]propane via caspases in human gingival fibroblasts. Toxicol Ind Health 30:755\u2013764. https:\/\/doi.org\/10.1177\/0748233712462472","journal-title":"Toxicol Ind Health"},{"key":"3478_CR80","doi-asserted-by":"publisher","first-page":"124","DOI":"10.15537\/smj.2018.2.21038","volume":"39","author":"EM Almadi","year":"2018","unstructured":"Almadi EM, Almohaimede AA (2018) Natural products in endodontics. Saudi Med J 39:124\u2013130. https:\/\/doi.org\/10.15537\/smj.2018.2.21038","journal-title":"Saudi Med J"},{"key":"3478_CR81","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2591.2010.01825.x","volume":"44","author":"MR Modareszadeh","year":"2011","unstructured":"Modareszadeh MR, Chogle SA, Mickel AK, Jin G, Kowsar H, Salamat N, Shaikh S, Qutbudin S (2011) Cytotoxicity of set polymer nanocomposite resin root-end filling materials. Int Endod J 44:154\u2013161. https:\/\/doi.org\/10.1111\/j.1365-2591.2010.01825.x","journal-title":"Int Endod J"},{"key":"3478_CR82","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1111\/j.1365-2591.2012.02011.x","volume":"45","author":"F Ndong","year":"2012","unstructured":"Ndong F, Sadhasivam S, Lin FH, Savitha S, Wen-Hsi W, Lin CP (2012) The development of iron-free partially stabilized cement for use as dental root-end filling material. Int Endod J 45:557\u2013564. https:\/\/doi.org\/10.1111\/j.1365-2591.2012.02011.x","journal-title":"Int Endod J"},{"key":"3478_CR83","doi-asserted-by":"publisher","first-page":"194","DOI":"10.5395\/rde.2012.37.4.194","volume":"37","author":"W-K Yang","year":"2012","unstructured":"Yang W-K, Ko H-J, Kim M-R (2012) Evaluation of the rat tissue reaction to experimental new resin cement and mineral trioxide aggregate cement. Restor Dent Endod 37:194\u2013200. https:\/\/doi.org\/10.5395\/rde.2012.37.4.194","journal-title":"Restor Dent Endod"},{"key":"3478_CR84","first-page":"458","volume-title":"Endodontic practice","author":"L Grossman","year":"1981","unstructured":"Grossman L (1981) Endodontic practice, vol 10. Lea Febiger, Philadelphia, p 458"},{"key":"3478_CR85","unstructured":"Ingle JI, Bakland LK, Baumgartner JC. (2008) Ingle's Endodontics 6th edition. Hamilton: BC Decker. p 1555"},{"key":"3478_CR86","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1601-1546.2005.00197.x","volume":"12","author":"DAG Orstavik","year":"2005","unstructured":"Orstavik DAG (2005) Materials used for root canal obturation: technical, biological and clinical testing. Endod Top 12:25\u201338. https:\/\/doi.org\/10.1111\/j.1601-1546.2005.00197.x","journal-title":"Endod Top"},{"key":"3478_CR87","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijheh.2006.09.001","volume":"210","author":"TF Grassi","year":"2007","unstructured":"Grassi TF, Camargo EA, Salvadori DMF, Marques MEA, Ribeiro DA (2007) DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats. Int J Hyg Environ Health 210:163\u2013167. https:\/\/doi.org\/10.1016\/j.ijheh.2006.09.001","journal-title":"Int J Hyg Environ Health"},{"key":"3478_CR88","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4103\/0971-6580.103652","volume":"19","author":"P Saxena","year":"2012","unstructured":"Saxena P, Pant A, Gupta S, Pant V (2012) Release and toxicity of dental resin composite. Toxicol Int 19:225\u2013234. https:\/\/doi.org\/10.4103\/0971-6580.103652","journal-title":"Toxicol Int"},{"key":"3478_CR89","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1177\/154405910608501001","volume":"85","author":"H Schweikl","year":"2006","unstructured":"Schweikl H, Spagnuolo G, Schmalz G (2006) Genetic and cellular toxicology of dental resin monomers. J Dent Res 85:870\u2013877. https:\/\/doi.org\/10.1177\/154405910608501001","journal-title":"J Dent Res"},{"key":"3478_CR90","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/ars.2007.1957","volume":"10","author":"D Trachootham","year":"2008","unstructured":"Trachootham D, Lu W, Ogasawara MA, Valle NRD, Huang P (2008) Redox regulation of cell survival. Antioxid Redox Signal 10:1343\u20131374. https:\/\/doi.org\/10.1089\/ars.2007.1957","journal-title":"Antioxid Redox Signal"},{"key":"3478_CR91","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/eos.12065","volume":"121","author":"G Lodien\u0117","year":"2013","unstructured":"Lodien\u0117 G, Kopperud HM, \u00d8rstavik D, Bruzell EM (2013) Detection of leachables and cytotoxicity after exposure to methacrylate- and epoxy-based root canal sealers in vitro. Eur J Oral Sci 121:488\u2013496. https:\/\/doi.org\/10.1111\/eos.12065","journal-title":"Eur J Oral Sci"},{"key":"3478_CR92","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.joen.2010.05.002","volume":"36","author":"GA Marin-Bauza","year":"2010","unstructured":"Marin-Bauza GA, Rached-Junior FJA, Souza-Gabriel AE, Sousa-Neto MD, Miranda CES, Silva-Sousa YTC (2010) Physicochemical properties of methacrylate resin-based root canal sealers. J Endod 36:1531\u20131536. https:\/\/doi.org\/10.1016\/j.joen.2010.05.002","journal-title":"J Endod"},{"key":"3478_CR93","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.biomaterials.2007.11.049","volume":"29","author":"H Schweikl","year":"2008","unstructured":"Schweikl H, Hiller KA, Eckhardt A, Bolay C, Spagnuolo G, Stempfl T, Schmalz G (2008) Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate. Biomaterials 29:1377\u20131387. https:\/\/doi.org\/10.1016\/j.biomaterials.2007.11.049","journal-title":"Biomaterials"},{"key":"3478_CR94","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/j.biomaterials.2009.11.065","volume":"31","author":"E Urcan","year":"2010","unstructured":"Urcan E, Scherthan H, Styllou M, Haertel U, Hickel R, Reichl FX (2010) Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites. Biomaterials 31:2010\u20132014. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.11.065","journal-title":"Biomaterials"},{"key":"3478_CR95","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1007\/s11033-012-1582-3","volume":"39","author":"J Blasiak","year":"2012","unstructured":"Blasiak J, Synowiec E, Tarnawska J, Czarny P, Poplawski T, Reiter RJ (2012) Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair. Mol Biol Rep 39:7487\u20137496. https:\/\/doi.org\/10.1007\/s11033-012-1582-3","journal-title":"Mol Biol Rep"},{"key":"3478_CR96","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.mrgentox.2009.12.019","volume":"696","author":"E Pawlowska","year":"2010","unstructured":"Pawlowska E, Poplawski T, Ksiazek D, Szczepanska J, Blasiak J (2010) Genotoxicity and cytotoxicity of 2-hydroxyethyl methacrylate. Mutat Res Genet Toxicol Environ Mutagen 696:122\u2013129. https:\/\/doi.org\/10.1016\/j.mrgentox.2009.12.019","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"key":"3478_CR97","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/iej.12232","volume":"47","author":"M Gallorini","year":"2014","unstructured":"Gallorini M, Cataldi A, di Giacomo V (2014) HEMA-induced cytotoxicity: Oxidative stress, genotoxicity and apoptosis. Int Endod J 47:813\u2013818. https:\/\/doi.org\/10.1111\/iej.12232","journal-title":"Int Endod J"},{"key":"3478_CR98","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/2047-783X-15-11-483","volume":"15","author":"S Ghanaati","year":"2010","unstructured":"Ghanaati S, Willershausen I, Barbeck M, Unger RE, Joergens M, Sader RA, Kirkpatrick CJ, Willershausen B (2010) Tissue reaction to sealing materials: different view at biocompatibility. Eur J Med Res 15:483\u2013492. https:\/\/doi.org\/10.1186\/2047-783X-15-11-483","journal-title":"Eur J Med Res"},{"key":"3478_CR99","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.joen.2009.09.010","volume":"36","author":"M Torabinejad","year":"2010","unstructured":"Torabinejad M, Parirokh M (2010) Mineral trioxide aggregate: a comprehensive literature review. Part II. Leakage and biocompatibility investigations. J Endod 36:190\u2013202. https:\/\/doi.org\/10.1016\/j.joen.2009.09.010","journal-title":"J Endod"},{"key":"3478_CR100","doi-asserted-by":"publisher","first-page":"ZG01","DOI":"10.7860\/JCDR\/2017\/25840.10374","volume":"11","author":"M Kaur","year":"2017","unstructured":"Kaur M, Singh H, Dhillon JS et al (2017) MTA versus biodentine: review of literature with a comparative analysis. J Clin Diagn Res 11:ZG01\u2013ZG05. https:\/\/doi.org\/10.7860\/JCDR\/2017\/25840.10374","journal-title":"J Clin Diagn Res"},{"key":"3478_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1807-3107BOR-2016.vol30.0048","volume":"30","author":"AL Gomes-Corn\u00e9lio","year":"2016","unstructured":"Gomes-Corn\u00e9lio AL, Rodrigues EM, Mestieri LB et al (2016) Cytotoxicity and genotoxicity of calcium silicate-based cements on an osteoblast lineage. Braz Oral Res 30:1\u201310. https:\/\/doi.org\/10.1590\/1807-3107BOR-2016.vol30.0048","journal-title":"Braz Oral Res"},{"key":"3478_CR102","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1834-7819.2010.01293.x","volume":"56","author":"SK Sidhu","year":"2011","unstructured":"Sidhu SK (2011) Glass-ionomer cement restorative materials: a sticky subject? Aust Dent J 56:23\u201330. https:\/\/doi.org\/10.1111\/j.1834-7819.2010.01293.x","journal-title":"Aust Dent J"},{"key":"3478_CR103","doi-asserted-by":"publisher","unstructured":"Sidhu SK, Nicholson JW (2016) A review of glass-ionomer cements for clinical dentistry. https:\/\/doi.org\/10.3390\/jfb7030016","DOI":"10.3390\/jfb7030016"},{"key":"3478_CR104","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/em.22045","volume":"58","author":"KL Dearfield","year":"2017","unstructured":"Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, Elespuru RK, Johnson GE, Kirkland DJ, LeBaron MJ, Li AP, Marchetti F, Pottenger LH, Rorije E, Tanir JY, Thybaud V, van Benthem J, Yauk CL, Zeiger E, Luijten M (2017) Next generation testing strategy for assessment of genomic damage: a conceptual framework and considerations. Environ Mol Mutagen 58:264\u2013283. https:\/\/doi.org\/10.1002\/em.22045","journal-title":"Environ Mol Mutagen"},{"key":"3478_CR105","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.fct.2016.08.035","volume":"106","author":"F Nesslany","year":"2017","unstructured":"Nesslany F (2017) The current limitations of in vitro genotoxicity testing and their relevance to the in vivo situation. Food Chem Toxicol 106:609\u2013615. https:\/\/doi.org\/10.1016\/j.fct.2016.08.035","journal-title":"Food Chem Toxicol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03478-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03478-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-020-03478-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T23:42:48Z","timestamp":1628293368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-020-03478-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,7]]},"references-count":105,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["3478"],"URL":"https:\/\/doi.org\/10.1007\/s00784-020-03478-z","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"type":"print","value":"1432-6981"},{"type":"electronic","value":"1436-3771"}],"subject":[],"published":{"date-parts":[[2020,8,7]]},"assertion":[{"value":"13 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}