{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:16:13Z","timestamp":1775981773523,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T00:00:00Z","timestamp":1407628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Extremophiles"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s00792-014-0661-x","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T05:45:25Z","timestamp":1407563125000},"page":"835-852","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mannosylglycerate: structural analysis of biosynthesis and evolutionary history"],"prefix":"10.1007","volume":"18","author":[{"given":"Nuno","family":"Borges","sequence":"first","affiliation":[]},{"given":"Carla D.","family":"Jorge","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds G.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Pedro M.","family":"Matias","sequence":"additional","affiliation":[]},{"given":"Helena","family":"Santos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,8,10]]},"reference":[{"key":"661_CR1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.enzmictec.2012.10.008","volume":"52","author":"S Alarico","year":"2013","unstructured":"Alarico S, Empadinhas N, da Costa MS (2013) A new bacterial hydrolase specific for the compatible solutes \u03b1-d-mannopyranosyl-(1\u21922)-d-glycerate and \u03b1-d-glucopyranosyl-(1\u21922)-d-glycerate. Enzyme Microb Technol 52:77\u201383","journal-title":"Enzyme Microb Technol"},{"key":"661_CR2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.carres.2006.01.002","volume":"341","author":"SD Asc\u00eancio","year":"2006","unstructured":"Asc\u00eancio SD, Orsato A, Fran\u00e7a RA, Duarte MER, Noseda MD (2006) Complete 1H and 13C NMR assignment of digeneaside, a low-molecular-mass carbohydrate produced by red seaweeds. Carbohydr Res 341:677\u2013682","journal-title":"Carbohydr Res"},{"key":"661_CR3","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1021\/pr300371b","volume":"11","author":"V Behrends","year":"2012","unstructured":"Behrends V, Williams KJ, Jenkins VA, Robertson BD, Bundy JG (2012) Free glucosylglycerate is a novel marker of nitrogen stress in Mycobacterium smegmatis. J Proteome Res 11:3888\u20133896","journal-title":"J Proteome Res"},{"key":"661_CR4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.phytochem.2008.12.021","volume":"70","author":"S Bondu","year":"2009","unstructured":"Bondu S, Cerantola S, Kervarec N, Deslandes E (2009) Impact of the salt stress on the photosynthetic carbon flux and 13C-label distribution within floridoside and digeneaside in Solieria chordalis. Phytochemistry 70:173\u2013184","journal-title":"Phytochemistry"},{"key":"661_CR5","unstructured":"Borges N (2005) The Role of Mannosylglycerate in Thermo- and Osmo-Adaptation of Rhodothermus marinus: Biosynthesis, Regulation and Applications. Ph.D. Thesis dissertation, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa"},{"key":"661_CR6","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.1074\/jbc.M312186200","volume":"279","author":"N Borges","year":"2004","unstructured":"Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H (2004) Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus. J Biol Chem 279:9892\u20139898","journal-title":"J Biol Chem"},{"key":"661_CR7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3891\/acta.chem.scand.09-0807","volume":"9","author":"H Bouveng","year":"1955","unstructured":"Bouveng H, Lindberg B, Wickberg B (1955) Low-molecular carbohydrates in algae. Structure of the glyceric acid mannoside from red algae. Acta Chem Scand 9:807\u2013809","journal-title":"Acta Chem Scand"},{"key":"661_CR8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s004250050404","volume":"206","author":"A Broberg","year":"1998","unstructured":"Broberg A, Kenne L, Peders\u00e9n M (1998) In-situ identification of major metabolites in the red alga Gracilariopsis lemaneiformis using high-resolution magic angle spinning nuclear, magnetic resonance spectroscopy. Planta 206:300\u2013307","journal-title":"Planta"},{"key":"661_CR9","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jmb.2006.06.049","volume":"361","author":"AM Burroughs","year":"2006","unstructured":"Burroughs AM, Allen KN, Dunaway-Mariano D, Aravind L (2006) Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol 361:1003\u20131034","journal-title":"J Mol Biol"},{"key":"661_CR10","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.carres.2009.01.007","volume":"344","author":"A Claude","year":"2009","unstructured":"Claude A, Bondu S, Michaud F, Bourgougnon N, Deslandes E (2009) X-ray structure of a sodium salt of digeneaside isolated from red alga Ceramium botryocarpum. Carbohydr Res 344:707\u2013710","journal-title":"Carbohydr Res"},{"key":"661_CR11","first-page":"1450","volume":"208","author":"H Colin","year":"1939","unstructured":"Colin H, Augier J (1939) Un glucide original chez les florid\u00e9es du genre Polysiphonia le d-mannoside de l-glyc\u00e9rate de sodium. C R Acad Sci 208:1450\u20131453","journal-title":"C R Acad Sci"},{"key":"661_CR12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1128\/JB.188.3.1022-1030.2006","volume":"188","author":"J Costa","year":"2006","unstructured":"Costa J, Empadinhas N, Gon\u00e7alves L, Lamosa P, Santos H, da Costa MS (2006) Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii. J Bacteriol 188:1022\u20131030","journal-title":"J Bacteriol"},{"key":"661_CR13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0022-2836(03)00307-3","volume":"328","author":"PM Coutinho","year":"2003","unstructured":"Coutinho PM, Deleury E, Davies GJ, Henrissat B (2003) An evolving hierarchical family classification for glycosyltransferases. J Mol Biol 328:307\u2013317","journal-title":"J Mol Biol"},{"key":"661_CR14","first-page":"117","volume":"61","author":"MS Costa da","year":"1998","unstructured":"da Costa MS, Santos H, Galinski EA (1998) An overview of the role and diversity of compatible solutes in Bacteria and Archaea. Adv Biochem Eng Biotechnol 61:117\u2013153","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"661_CR15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jembe.2006.11.015","volume":"343","author":"A Eggert","year":"2007","unstructured":"Eggert A, Nitschke U, West JA, Michalik D, Karsten U (2007) Acclimation of the intertidal red alga Bangiopsis subsimplex (Stylonematophyceae) to salinity changes. J Exp Mar Biol Ecol 343:176\u2013186","journal-title":"J Exp Mar Biol Ecol"},{"key":"661_CR16","unstructured":"Empadinhas N (2005) Pathways for the synthesis of mannosylglycerate in prokaryotes: genes, enzymes and evolutionary implications. Ph.D. Thesis Dissertation, University of Coimbra, Portugal"},{"key":"661_CR17","first-page":"199","volume":"9","author":"N Empadinhas","year":"2006","unstructured":"Empadinhas N, da Costa MS (2006) Diversity and biosynthesis of compatible solutes in hyper\/thermophiles. Int Microbiol 9:199\u2013206","journal-title":"Int Microbiol"},{"key":"661_CR18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.syapm.2008.05.002","volume":"31","author":"N Empadinhas","year":"2008","unstructured":"Empadinhas N, da Costa MS (2008a) To be or not to be a compatible solute: bioversatility of mannosylglycerate and glucosylglycerate. Syst Appl Microbiol 31:159\u2013168","journal-title":"Syst Appl Microbiol"},{"key":"661_CR19","first-page":"151","volume":"11","author":"N Empadinhas","year":"2008","unstructured":"Empadinhas N, da Costa MS (2008b) Osmoadaptation mechanisms in prokaryotes: distribution of compatible solutes. Int Microbiol 11:151\u2013161","journal-title":"Int Microbiol"},{"key":"661_CR20","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/j.1462-2920.2010.02390.x","volume":"13","author":"N Empadinhas","year":"2011","unstructured":"Empadinhas N, da Costa MS (2011) Diversity, biological roles and biosynthetic pathways for sugar-glycerate containing compatible solutes in bacteria and archaea. Environ Microbiol 13:2056\u20132077","journal-title":"Environ Microbiol"},{"key":"661_CR21","doi-asserted-by":"crossref","first-page":"43580","DOI":"10.1074\/jbc.M108054200","volume":"276","author":"N Empadinhas","year":"2001","unstructured":"Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS (2001) Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes. J Biol Chem 276:43580\u201343588","journal-title":"J Biol Chem"},{"key":"661_CR22","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1128\/AEM.69.6.3272-3279.2003","volume":"69","author":"N Empadinhas","year":"2003","unstructured":"Empadinhas N, Albuquerque L, Henne A, Santos H, da Costa MS (2003) The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for the synthesis of mannosylglycerate. Appl Environ Microbiol 69:3272\u20133279","journal-title":"Appl Environ Microbiol"},{"key":"661_CR23","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1128\/JB.186.13.4075-4084.2004","volume":"186","author":"N Empadinhas","year":"2004","unstructured":"Empadinhas N, Albuquerque L, Costa J, Zinder SH, Santos MA, Santos H, da Costa MS (2004) A gene from the mesophilic bacterium Dehalococcoides ethenogenes encodes a novel mannosylglycerate synthase. J Bacteriol 186:4075\u20134084","journal-title":"J Bacteriol"},{"key":"661_CR24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00792-007-0084-z","volume":"11","author":"N Empadinhas","year":"2007","unstructured":"Empadinhas N, Mendes V, Sim\u00f5es C, Santos MS, Mingote A, Lamosa P, Santos H, da Costa MS (2007) Organic solutes in Rubrobacter xylanophilus: the first example of di-myo-inositol-phosphate in a thermophile. Extremophiles 11:667\u2013673","journal-title":"Extremophiles"},{"key":"661_CR25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1574-6968.2007.01064.x","volume":"280","author":"N Empadinhas","year":"2008","unstructured":"Empadinhas N, Albuquerque L, Mendes V, Macedo-Ribeiro S, da Costa MS (2008) Identification of the mycobacterial glucosyl-3-phosphoglycerate synthase. FEMS Microbiol Lett 280:195\u2013202","journal-title":"FEMS Microbiol Lett"},{"key":"661_CR26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2958.2010.07432.x","volume":"79","author":"N Empadinhas","year":"2011","unstructured":"Empadinhas N, Pereira PJ, Albuquerque L, Costa J, S\u00e1-Moura B, Marques AT, Macedo-Ribeiro S, da Costa MS (2011) Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity. Mol Microbiol 79:76\u201393","journal-title":"Mol Microbiol"},{"key":"661_CR27","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1016\/j.bbagen.2013.04.015","volume":"1830","author":"C Faria","year":"2013","unstructured":"Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H (2013) Inhibition of formation of \u03b1-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson\u2019s disease. Biochim Biophys Acta 1830:4065\u20134072","journal-title":"Biochim Biophys Acta"},{"key":"661_CR28","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1128\/JB.00075-07","volume":"189","author":"C Fernandes","year":"2007","unstructured":"Fernandes C, Empadinhas N, da Costa MS (2007) Single-step pathway for synthesis of glucosylglycerate in Persephonella marina. J Bacteriol 189:4014\u20134019","journal-title":"J Bacteriol"},{"key":"661_CR29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nsmb950","volume":"12","author":"J Flint","year":"2005","unstructured":"Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ (2005) Structural dissection and high-throughput screening of mannosylglycerate synthase. Nat Struct Mol Biol 12:608\u2013614","journal-title":"Nat Struct Mol Biol"},{"key":"661_CR30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1574-6968.2003.tb11523.x","volume":"218","author":"LG Gon\u00e7alves","year":"2003","unstructured":"Gon\u00e7alves LG, Huber R, da Costa MS, Santos H (2003) A variant of the hyperthermophile Archaeoglobus fulgidus adapted to grow at high salinity. FEMS Microbiol Lett 218:239\u2013244","journal-title":"FEMS Microbiol Lett"},{"key":"661_CR31","doi-asserted-by":"crossref","first-page":"17857","DOI":"10.1074\/jbc.M109.095976","volume":"285","author":"S Gon\u00e7alves","year":"2010","unstructured":"Gon\u00e7alves S, Borges N, Esteves AM, Victor BL, Soares CM, Santos H, Matias PM (2010) Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases. J Biol Chem 285:17857\u201317868","journal-title":"J Biol Chem"},{"key":"661_CR32","doi-asserted-by":"crossref","first-page":"9551","DOI":"10.1021\/bi201171h","volume":"50","author":"S Gon\u00e7alves","year":"2011","unstructured":"Gon\u00e7alves S, Esteves AM, Santos H, Borges N, Matias PM (2011a) Three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the haloalcanoic acid dehalogenase superfamily. Biochemistry 50:9551\u20139567","journal-title":"Biochemistry"},{"key":"661_CR33","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1107\/S1744309111002843","volume":"67","author":"S Gon\u00e7alves","year":"2011","unstructured":"Gon\u00e7alves S, Esteves AM, Borges N, Santos H, Matias PM (2011b) Crystallization and preliminary X-ray analysis of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27. Acta Crystallogr Sect F Struct Biol Cryst Commun 67:390\u2013396","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"661_CR34","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","volume":"52","author":"S Guindon","year":"2003","unstructured":"Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696\u2013704","journal-title":"Syst Biol"},{"key":"661_CR35","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.1100025","volume":"305","author":"SJ Hallam","year":"2004","unstructured":"Hallam SJ, Putnam N, Preston CM, Detter JC, Rokhsar D, Richardson PM, DeLong EF (2004) Reverse methanogenesis: testing the hypothesis with environmental genomics. Science 305:1457\u20131462","journal-title":"Science"},{"key":"661_CR36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/bioinformatics\/btq003","volume":"26","author":"Y Huang","year":"2010","unstructured":"Huang Y, Niu B, Gao Y, Fu L, Li W (2010) CD-HIT Suite: a web server for clustering and comparing biological sequences. Bioinformatics 26:680\u2013682","journal-title":"Bioinformatics"},{"key":"661_CR37","first-page":"669","volume":"32","author":"U Karsten","year":"1994","unstructured":"Karsten U, Barrow KD, Mostaert AS, King RJ, West JA (1994) 13C- and 1H-NMR studies on digeneaside in the red alga Caloglossa leprieurii\u2014a re-evaluation of its osmotic significance. Plant Physiol Biochem 32:669\u2013676","journal-title":"Plant Physiol Biochem"},{"key":"661_CR38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF01007701","volume":"201","author":"U Karsten","year":"1997","unstructured":"Karsten U, Barrow KD, Nixdorf O, West JA, King RJ (1997) Characterization of mannitol metabolism in the mangrove red alga Caloglossa leprieurii (Montagne) J Agardh. Planta 201:173\u2013178","journal-title":"Planta"},{"key":"661_CR39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00425-005-1527-3","volume":"222","author":"U Karsten","year":"2005","unstructured":"Karsten U, Michalik D, Michalik M, West JA (2005) A new unusual low molecular weight carbohydrate in the red algal genus Hypoglossum (Delesseriaceae, Ceramiales) and its possible function as osmolyte. Planta 222:319\u2013326","journal-title":"Planta"},{"key":"661_CR40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2216\/06-29.1","volume":"46","author":"U Karsten","year":"2007","unstructured":"Karsten U, G\u00f6rs S, Eggert A, West JA (2007) Trehalose, digeneaside, and floridoside in the Florideophyceae (Rhodophyta)\u2014a reevaluation of its chemotaxonomic value. Phycologia 46:143\u2013150","journal-title":"Phycologia"},{"key":"661_CR41","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1107\/S0907444908033817","volume":"64","author":"T Kawamura","year":"2008","unstructured":"Kawamura T, Watanabe N, Tanaka I (2008) Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii. Acta Crystallogr D Biol Crystallogr 64:1267\u20131276","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"661_CR42","first-page":"539","volume":"6","author":"GO Kirst","year":"1979","unstructured":"Kirst GO, Bisson MA (1979) Regulation of turgor pressure in marine algae: ions and low-molecular-weight organic compounds. Aust J Plant Physiol 6:539\u2013556","journal-title":"Aust J Plant Physiol"},{"key":"661_CR43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1462-2920.2009.02045.x","volume":"12","author":"S Kl\u00e4hn","year":"2010","unstructured":"Kl\u00e4hn S, Steglich C, Hess WR, Hagemann M (2010) Glucosylglycerate: a secondary compatible solute common to marine cyanobacteria from nitrogen-poor environments. Environ Microbiol 12:83\u201394","journal-title":"Environ Microbiol"},{"key":"661_CR44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/prot.10034","volume":"46","author":"A Koumanov","year":"2002","unstructured":"Koumanov A, Ruterjans H, Karshikoff A (2002) Continuum electrostatic analysis of irregular ionization and proton allocation in proteins. Proteins 46:85\u201396","journal-title":"Proteins"},{"key":"661_CR45","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00071618000650401","volume":"15","author":"BP Kremer","year":"1980","unstructured":"Kremer BP (1980) Taxonomic implications of algal photoassimilate patterns. Br Phycol J 15:399\u2013409","journal-title":"Br Phycol J"},{"key":"661_CR46","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.biochem.76.061005.092322","volume":"77","author":"LL Lairson","year":"2008","unstructured":"Lairson LL, Henrissat B, Davies GJ, Withers SG (2008) Glycosyltransferases: structures, functions, and mechanisms. Annu Rev Biochem 77:521\u2013555","journal-title":"Annu Rev Biochem"},{"key":"661_CR47","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1128\/AEM.64.10.3591-3598.1998","volume":"64","author":"P Lamosa","year":"1998","unstructured":"Lamosa P, Martins LO, da Costa MS, Santos H (1998) Effects of temperature, salinity, and medium composition on compatible solute accumulation by Thermococcus spp. Appl Environ Microbiol 64:3591\u20133598","journal-title":"Appl Environ Microbiol"},{"key":"661_CR48","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00792-012-0500-x","volume":"17","author":"P Lamosa","year":"2013","unstructured":"Lamosa P, Rodrigues MV, Gon\u00e7alves LG, Carr J, Ventura R, Maycock C, Raven ND, Santos H (2013) Organic solutes in the deepest phylogenetic branches of the Bacteria: identification of \u03b1(1-6)glucosyl-\u03b1(1-2)glucosylglycerate in Persephonella marina. Extremophiles 17:137\u2013146","journal-title":"Extremophiles"},{"key":"661_CR49","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1039\/c0np00067a","volume":"28","author":"C Luley-Goedl","year":"2011","unstructured":"Luley-Goedl C, Nidetzky B (2011) Glycosides as compatible solutes: biosynthesis and applications. Nat Prod Rep 28:875\u2013896","journal-title":"Nat Prod Rep"},{"key":"661_CR50","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1128\/AEM.61.9.3299-3303.1995","volume":"61","author":"LO Martins","year":"1995","unstructured":"Martins LO, Santos H (1995) Accumulation of mannosylglycerate and di-myo-inositol-phosphate by Pyrococcus furiosus in response to salinity and temperature. Appl Environ Microbiol 61:3299\u20133303","journal-title":"Appl Environ Microbiol"},{"key":"661_CR51","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1128\/AEM.63.3.896-902.1997","volume":"63","author":"LO Martins","year":"1997","unstructured":"Martins LO, Huber R, Huber H, Stetter KO, da Costa MS, Santos H (1997) Organic solutes in hyperthermophilic Archaea. Appl Environ Microbiol 63:896\u2013902","journal-title":"Appl Environ Microbiol"},{"key":"661_CR52","doi-asserted-by":"crossref","first-page":"35407","DOI":"10.1074\/jbc.274.50.35407","volume":"274","author":"LO Martins","year":"1999","unstructured":"Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H (1999) Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase. J Biol Chem 274:35407\u201335414","journal-title":"J Biol Chem"},{"key":"661_CR53","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.mib.2005.10.011","volume":"8","author":"V M\u00fcller","year":"2005","unstructured":"M\u00fcller V, Spanheimer R, Santos H (2005) Stress response by solute accumulation in archaea. Curr Opin Microbiol 8:729\u2013736","journal-title":"Curr Opin Microbiol"},{"key":"661_CR54","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1128\/AEM.71.12.8091-8098.2005","volume":"71","author":"C Neves","year":"2005","unstructured":"Neves C, da Costa MS, Santos H (2005) Compatible solutes of the hyperthermophile Palaeococcus ferrophilus: osmoadaptation and thermoadaptation in the order Thermococcales. Appl Environ Microbiol 71:8091\u20138098","journal-title":"Appl Environ Microbiol"},{"key":"661_CR55","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1074\/jbc.M110.199844","volume":"286","author":"MM Nielsen","year":"2011","unstructured":"Nielsen MM, Suits MD, Yang M, Barry CS, Martinez-Fleites C, Tailford LE, Flint JE, Dumon C, Davis BG, Gilbert HJ, Davies GJ (2011) Substrate and metal ion promiscuity in mannosylglycerate synthase. J Biol Chem 286:15155\u201315164","journal-title":"J Biol Chem"},{"key":"661_CR56","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00425-012-1808-6","volume":"237","author":"A Nobre","year":"2013","unstructured":"Nobre A, Empadinhas N, Nobre MF, Louren\u00e7o EC, Maycock C, Ventura MR, Mingote A, da Costa MS (2013) The plant Selaginella moellendorffii possesses enzymes for synthesis and hydrolysis of the compatible solutes mannosylglycerate and glucosylglycerate. Planta 237:891\u2013901","journal-title":"Planta"},{"key":"661_CR57","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/AEM.61.6.2351-2357.1995","volume":"61","author":"OC Nunes","year":"1995","unstructured":"Nunes OC, Manaia CM, da Costa MS, Santos H (1995) Compatible solutes in the thermophilic bacteria Rhodothermus marinus and \u201cThermus thermophilus\u201d. Appl Environ Microbiol 61:2351\u20132357","journal-title":"Appl Environ Microbiol"},{"key":"661_CR58","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","volume":"35","author":"E Pruesse","year":"2007","unstructured":"Pruesse E, Quast C, Knittel K, Fuchs B, Ludwig W, Peplies J, Gl\u00f6ckner FO (2007) SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB. Nucleic Acids Res 35:7188\u20137196","journal-title":"Nucleic Acids Res"},{"key":"661_CR59","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1462-2920.2002.00345.x","volume":"4","author":"A Quaiser","year":"2002","unstructured":"Quaiser A, Ochsenreiter T, Klenk HP, Kletzin A, Treusch AH, Meurer G, Eck J, Sensen CW, Schleper C (2002) First insight into the genome of an uncultivated crenarchaeote from soil. Environ Microbiol 4:603\u2013611","journal-title":"Environ Microbiol"},{"key":"661_CR60","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.2741\/1366","volume":"9","author":"MF Roberts","year":"2004","unstructured":"Roberts MF (2004) Osmoadaptation and osmoregulation in archaea: update 2004. Front Biosci 9:1999\u20132019","journal-title":"Front Biosci"},{"key":"661_CR61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1746-1448-1-5","volume":"1","author":"MF Roberts","year":"2005","unstructured":"Roberts MF (2005) Organic compatible solutes of halotolerant and halophilic microorganisms. Saline Syst 1:5","journal-title":"Saline Syst"},{"key":"661_CR62","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(01)34478-6","volume":"334","author":"H Santos","year":"2001","unstructured":"Santos H, da Costa MS (2001) Organic solutes from thermophiles and hyperthermophiles. Methods Enzymol 334:302\u2013315","journal-title":"Methods Enzymol"},{"key":"661_CR63","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1462-2920.2002.00335.x","volume":"4","author":"H Santos","year":"2002","unstructured":"Santos H, da Costa MS (2002) Compatible solutes of organisms that live in hot saline environments. Environ Microbiol 4:501\u2013509","journal-title":"Environ Microbiol"},{"key":"661_CR64","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1128\/9781555815813.ch7","volume-title":"Physiology and biochemistry of extremophiles","author":"H Santos","year":"2007","unstructured":"Santos H, Lamosa P, Faria TQ, Borges N, Neves C (2007) The physiological role, biosynthesis and mode of action of compatible solutes from (hyper)thermophiles. In: Gerday C, Glansdorff N (eds) Physiology and biochemistry of extremophiles. ASM publishers, Washington, DC, pp 86\u2013104"},{"key":"661_CR65","volume-title":"Thermophiles","author":"H Santos","year":"2008","unstructured":"Santos H, Lamosa P, Faria TQ, Pais TM, de la Paz ML, Serrano L (2008) Compatible solutes of (hyper)thermophiles and their role in protein stabilization. In: Antranikian G, Driesen A, Robb F (eds) Thermophiles. CRC Taylor and Francis, USA"},{"key":"661_CR66","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/978-4-431-53898-1_23","volume-title":"Extremophiles handbook","author":"H Santos","year":"2011","unstructured":"Santos H, Lamosa P, Borges N, Gon\u00e7alves LG, Pais TM, Rodrigues MV (2011) Organic compatible solutes of prokaryotes that thrive in hot environments: the importance of ionic compounds for thermostabilization. In: Horikoshi K, Antranikian G, Bull AT, Robb FT, Stetter KO (eds) Extremophiles handbook. Springer, Tokyo, pp 497\u2013520"},{"key":"661_CR67","unstructured":"Scheller HV, Harholt J, Ulvskov P (2010) Stress-tolerant plants expressing mannosylglycerate-producing enzymes. European Patent Office. (International publication number WO 2010\/129574 A1)"},{"key":"661_CR68","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s007920050112","volume":"3","author":"Z Silva","year":"1999","unstructured":"Silva Z, Borges N, Martins LO, Wait R, da Costa MS, Santos H (1999) Combined effect of the growth temperature and salinity of the medium on the accumulation of compatible solutes by Rhodothermus marinus and Rhodothermus obamensis. Extremophiles 3:163\u2013172","journal-title":"Extremophiles"},{"key":"661_CR69","first-page":"512","volume":"10","author":"K Tamura","year":"1993","unstructured":"Tamura K, Nei M (1993) Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol 10:512\u2013526","journal-title":"Mol Biol Evol"},{"key":"661_CR70","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","volume":"30","author":"K Tamura","year":"2013","unstructured":"Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Mol Biol Evol 30:2725\u20132729","journal-title":"Mol Biol Evol"},{"key":"661_CR71","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1462-2920.2004.00663.x","volume":"6","author":"AH Treusch","year":"2004","unstructured":"Treusch AH, Kletzin A, Raddat G, Ochsenreiter T, Quaiser A, Meurer G, Schuster SC, Schleper C (2004) Characterization of large-insert DNA libraries from soil for environmental genomic studies of Archaea. Environ Microbiol 6:970\u2013980","journal-title":"Environ Microbiol"},{"key":"661_CR72","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4490\/algae.2011.26.2.167","volume":"26","author":"EC Yang","year":"2011","unstructured":"Yang EC, Scott J, West JA, Yoon HS, Yokoyama A, Karsten U, de Go\u00ebr SL, Orlova E (2011) Erythrolobus australicus sp. nov. (Porphyridiophyceae, Rhodophyta): a description based on several approaches. Algae 26:167\u2013180","journal-title":"Algae"}],"container-title":["Extremophiles"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00792-014-0661-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00792-014-0661-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00792-014-0661-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T02:15:01Z","timestamp":1598148901000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00792-014-0661-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,10]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["661"],"URL":"https:\/\/doi.org\/10.1007\/s00792-014-0661-x","relation":{},"ISSN":["1431-0651","1433-4909"],"issn-type":[{"value":"1431-0651","type":"print"},{"value":"1433-4909","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,10]]}}}