{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:52:05Z","timestamp":1760953925693},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s10067-016-3219-8","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T07:48:09Z","timestamp":1456472889000},"page":"1743-1751","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impaired angiogenesis as a feature of digital ulcers in systemic sclerosis"],"prefix":"10.1007","volume":"35","author":[{"given":"Ivone","family":"Silva","sequence":"first","affiliation":[]},{"given":"Cristiana","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Vasconcelos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"issue":"2","key":"3219_CR1","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1186\/ar4217","volume":"15","author":"J Avouac","year":"2013","unstructured":"Avouac J, Vallucci M, Smith V, Senet P, Ruiz B, Sulli A et al (2013) Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis. Arthritis Res Ther 15(2):R55","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"3219_CR2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.autrev.2014.10.009","volume":"14","author":"I Silva","year":"2015","unstructured":"Silva I, Almeida J, Vasconcelos C (2015) A PRISMA-driven systematic review for predictive risk factors of digital ulcers in systemic sclerosis patients. Autoimmun Rev 14(2):140\u201352","journal-title":"Autoimmun Rev"},{"issue":"1","key":"3219_CR3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11926-012-0303-1","volume":"15","author":"AL Herrick","year":"2013","unstructured":"Herrick AL (2013) Management of Raynaud\u2019s phenomenon and digital ischemia. Curr Rheumatol Rep 15(1):303","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"3219_CR4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00005792-200203000-00004","volume":"81","author":"C Ferri","year":"2002","unstructured":"Ferri C, Valentini G, Cozzi F, Sebastiani M, Michelassi C, La Montagna G et al (2002) Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients. Medicine 81(2):139\u201353","journal-title":"Medicine"},{"issue":"7","key":"3219_CR5","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/rheumatology\/keq097","volume":"49","author":"L Amanzi","year":"2010","unstructured":"Amanzi L, Braschi F, Fiori G, Galluccio F, Miniati I, Guiducci S et al (2010) Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation of 1614 digital lesions. Rheumatol (Oxford, England) 49(7):1374\u201382","journal-title":"Rheumatol (Oxford, England)"},{"issue":"1","key":"3219_CR6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11926-011-0219-1","volume":"14","author":"BJ Rabquer","year":"2012","unstructured":"Rabquer BJ, Koch AE (2012) Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts. Curr Rheumatol Rep 14(1):56\u201363","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"3219_CR7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.mvr.2010.07.005","volume":"80","author":"SN Lambova","year":"2010","unstructured":"Lambova SN, Muller-Ladner U (2010) Capillaroscopic pattern in systemic sclerosis\u2014an association with dynamics of processes of angio- and vasculogenesis. Microvasc Res 80(3):534\u20139","journal-title":"Microvasc Res"},{"issue":"6","key":"3219_CR8","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar596","volume":"4","author":"O Distler","year":"2002","unstructured":"Distler O, Del Rosso A, Giacomelli R, Cipriani P, Conforti ML, Guiducci S et al (2002) Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 4(6):R11","journal-title":"Arthritis Res"},{"issue":"Suppl 5","key":"3219_CR9","doi-asserted-by":"crossref","first-page":"v18","DOI":"10.1093\/rheumatology\/ken267","volume":"47","author":"S Guiducci","year":"2008","unstructured":"Guiducci S, Distler O, Distler JH, Matucci-Cerinic M (2008) Mechanisms of vascular damage in SSc\u2014implications for vascular treatment strategies. Rheumatol (Oxford, England) 47(Suppl 5):v18\u201320","journal-title":"Rheumatol (Oxford, England)"},{"issue":"1","key":"3219_CR10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/art.37705","volume":"65","author":"S Serrati","year":"2013","unstructured":"Serrati S, Chilla A, Laurenzana A, Margheri F, Giannoni E, Magnelli L et al (2013) Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)\/transforming growth factor beta-dependent mesenchymal-to-mesenchymal transition. Arthritis Rheum 65(1):258\u201369","journal-title":"Arthritis Rheum"},{"issue":"7","key":"3219_CR11","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1136\/ard.2010.140657","volume":"70","author":"JH Distler","year":"2011","unstructured":"Distler JH, Strapatsas T, Huscher D, Dees C, Akhmetshina A, Kiener HP et al (2011) Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease. Ann Rheum Dis 70(7):1197\u2013202","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"3219_CR12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/1756-185X.12130","volume":"16","author":"HM Farouk","year":"2013","unstructured":"Farouk HM, Hamza SH, El Bakry SA, Youssef SS, Aly IM, Moustafa AA et al (2013) Dysregulation of angiogenic homeostasis in systemic sclerosis. Int J Rheum Dis 16(4):448\u201354","journal-title":"Int J Rheum Dis"},{"issue":"7","key":"3219_CR13","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/rheumatology\/ken100","volume":"47","author":"J Wipff","year":"2008","unstructured":"Wipff J, Avouac J, Borderie D, Zerkak D, Lemarechal H, Kahan A et al (2008) Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin. Rheumatol (Oxford, England) 47(7):972\u20135","journal-title":"Rheumatol (Oxford, England)"},{"issue":"2","key":"3219_CR14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0092-8674(00)81848-6","volume":"88","author":"MS O'Reilly","year":"1997","unstructured":"O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS et al (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88(2):277\u201385","journal-title":"Cell"},{"issue":"4","key":"3219_CR15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/1529-0131(200004)43:4<889::AID-ANR21>3.0.CO;2-5","volume":"43","author":"M Hebbar","year":"2000","unstructured":"Hebbar M, Peyrat JP, Hornez L, Hatron PY, Hachulla E, Devulder B (2000) Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis. Arthritis Rheum 43(4):889\u201393","journal-title":"Arthritis Rheum"},{"key":"3219_CR16","doi-asserted-by":"crossref","unstructured":"Committee SfSCotARADaTC. Preliminary criteria for the classification of systemic sclerosis (scleroderma). 1980;23:581\u201390.","DOI":"10.1002\/art.1780230510"},{"issue":"2","key":"3219_CR17","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr et al (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. The Journal of rheumatology 15(2):202\u20135","journal-title":"The Journal of rheumatology"},{"issue":"6","key":"3219_CR18","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.berh.2008.09.001","volume":"22","author":"M Cutolo","year":"2008","unstructured":"Cutolo M, Pizzorni C, Secchi ME, Sulli A (2008) Capillaroscopy. Best Prac Res Clin Rheumatol 22(6):1093\u2013108","journal-title":"Best Prac Res Clin Rheumatol"},{"issue":"10","key":"3219_CR19","first-page":"2159","volume":"26","author":"TA Medsger Jr","year":"1999","unstructured":"Medsger TA Jr, Silman AJ, Steen VD, Black CM, Akesson A, Bacon PA et al (1999) A disease severity scale for systemic sclerosis: development and testing. J Rheumatol 26(10):2159\u201367","journal-title":"J Rheumatol"},{"issue":"1","key":"3219_CR20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.RES.0000134644.89917.96","volume":"95","author":"O Distler","year":"2004","unstructured":"Distler O, Distler JH, Scheid A, Acker T, Hirth A, Rethage J et al (2004) Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis. Circ Res 95(1):109\u201316","journal-title":"Circ Res"},{"key":"3219_CR21","doi-asserted-by":"crossref","unstructured":"Coral-Alvarado PX, Garces MF, Caminos JE, Iglesias-Gamarra A, Restrepo JF, Quintana G (2010) Serum endoglin levels in patients suffering from systemic sclerosis and elevated systolic pulmonary arterial pressure. Int J Rheumatol 2010","DOI":"10.1155\/2010\/969383"},{"issue":"12","key":"3219_CR22","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1002\/jcp.22690","volume":"226","author":"E Morris","year":"2011","unstructured":"Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P et al (2011) Endoglin promotes TGF-beta\/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol 226(12):3340\u20138","journal-title":"J Cell Physiol"},{"issue":"4","key":"3219_CR23","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/rheumatology\/keq392","volume":"50","author":"M Michalska-Jakubus","year":"2011","unstructured":"Michalska-Jakubus M, Kowal-Bielecka O, Chodorowska G, Bielecki M, Krasowska D (2011) Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: high angiopoietin-2 levels are associated with greater severity and higher activity of the disease. Rheumatol (Oxford, England) 50(4):746\u201355","journal-title":"Rheumatol (Oxford, England)"},{"key":"3219_CR24","doi-asserted-by":"crossref","unstructured":"Ichimura Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T et al (2013) Serum angiopoietin-like protein 3 levels: possible correlation with progressive skin sclerosis, digital ulcers and pulmonary vascular involvement in patients with systemic sclerosis. Acta Derm Venereol","DOI":"10.2340\/00015555-1680"},{"issue":"7","key":"3219_CR25","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tcm.2012.05.011","volume":"21","author":"M Manetti","year":"2011","unstructured":"Manetti M, Guiducci S, Ibba-Manneschi L, Matucci-Cerinic M (2011) Impaired angiogenesis in systemic sclerosis: the emerging role of the antiangiogenic VEGF(165)b splice variant. Trends Cardiovasc Med 21(7):204\u201310","journal-title":"Trends Cardiovasc Med"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-016-3219-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-016-3219-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-016-3219-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T01:01:05Z","timestamp":1567645265000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-016-3219-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,26]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["3219"],"URL":"https:\/\/doi.org\/10.1007\/s10067-016-3219-8","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,26]]}}}