{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:10:52Z","timestamp":1758633052457,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s10072-024-07371-5","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:46:33Z","timestamp":1706676393000},"page":"3201-3208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between neuroimaging, neurological phenotype, and functional outcomes in Wilson\u2019s disease"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-906X","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Moura","sequence":"first","affiliation":[]},{"given":"Catarina","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Freixo","sequence":"additional","affiliation":[]},{"given":"Helder","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Ramos","sequence":"additional","affiliation":[]},{"given":"Ermelinda","family":"Santos Silva","sequence":"additional","affiliation":[]},{"given":"Filipe","family":"Nery","sequence":"additional","affiliation":[]},{"given":"Judit","family":"Gandara","sequence":"additional","affiliation":[]},{"given":"Vitor","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Presa","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Manuel","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Helena Pessegueiro","family":"Miranda","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"7371_CR1","doi-asserted-by":"publisher","unstructured":"Cz\u0142onkowska A, Litwin T, Dusek P et al (2018) Wilson disease. Nat Rev Dis Prim 4(1). https:\/\/doi.org\/10.1038\/s41572-018-0018-3","DOI":"10.1038\/s41572-018-0018-3"},{"issue":"1","key":"7371_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1474-4422(14)70190-5","volume":"14","author":"O Bandmann","year":"2015","unstructured":"Bandmann O, Weiss KH, Kaler SG (2015) Wilson\u2019s disease and other neurological copper disorders. Lancet Neurol 14(1):103\u2013113. https:\/\/doi.org\/10.1016\/S1474-4422(14)70190-5","journal-title":"Lancet Neurol"},{"issue":"3","key":"7371_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2165\/00023210-200519030-00001","volume":"19","author":"GJ Brewer","year":"2005","unstructured":"Brewer GJ (2005) Neurologically presenting Wilson\u2019s disease: Epidemiology, pathophysiology and treatment. CNS Drugs 19(3):185\u2013192. https:\/\/doi.org\/10.2165\/00023210-200519030-00001","journal-title":"CNS Drugs"},{"issue":"5","key":"7371_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/BF00319740","volume":"238","author":"W Oder","year":"1991","unstructured":"Oder W, Grimm G, Kollegger H, Ferenci P, Schneider B, Deecke L (1991) Neurological and neuropsychiatric spectrum of Wilson\u2019s disease: A prospective study of 45 cases. J Neurol 238(5):281\u2013287. https:\/\/doi.org\/10.1007\/BF00319740","journal-title":"J Neurol"},{"issue":"7","key":"7371_CR5","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.parkreldis.2011.05.002","volume":"17","author":"JF Burke","year":"2011","unstructured":"Burke JF, Dayalu P, Nan B, Askari F, Brewer GJ, Lorincz MT (2011) Prognostic significance of neurologic examination findings in Wilson disease. Park Relat Disord 17(7):551\u2013556. https:\/\/doi.org\/10.1016\/j.parkreldis.2011.05.002","journal-title":"Park Relat Disord"},{"issue":"3","key":"7371_CR6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/J.JHEP.2011.11.007","volume":"56","author":"P Ferenci","year":"2012","unstructured":"Ferenci P, Czlonkowska A, Stremmel W et al (2012) EASL clinical practice guidelines: Wilson\u2019s disease. J Hepatol 56(3):671\u2013685. https:\/\/doi.org\/10.1016\/J.JHEP.2011.11.007","journal-title":"J Hepatol"},{"issue":"1","key":"7371_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/nyas.12343","volume":"1315","author":"W Hermann","year":"2014","unstructured":"Hermann W (2014) Morphological and functional imaging in neurological and non-neurological Wilson\u2019s patients. Ann N Y Acad Sci 1315(1):24\u201329. https:\/\/doi.org\/10.1111\/nyas.12343","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"7371_CR8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1001\/archneur.1987.00520160007005","volume":"44","author":"S Starosta-Rubinstein","year":"1987","unstructured":"Starosta-Rubinstein S, Young AB, Kluin K et al (1987) Clinical assessment of 31 patients with Wilson\u2019s disease: Correlations with structural changes on magnetic resonance imaging. Arch Neurol 44(4):365\u2013370. https:\/\/doi.org\/10.1001\/archneur.1987.00520160007005","journal-title":"Arch Neurol"},{"issue":"6","key":"7371_CR9","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/mds.28018","volume":"35","author":"P Dusek","year":"2020","unstructured":"Dusek P, Smolinski L, Redzia-Ogrodnik B et al (2020) Semiquantitative scale for assessing brain MRI abnormalities in Wilson disease: A validation study. Mov Disord 35(6):994\u20131001. https:\/\/doi.org\/10.1002\/mds.28018","journal-title":"Mov Disord"},{"issue":"7","key":"7371_CR10","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/qjmed\/hct217","volume":"107","author":"A Gupta","year":"2014","unstructured":"Gupta A, Chakravarthi S, Goyal MK (2014) \u201cFace of giant panda\u201d: A rare imaging sign in Wilson\u2019s disease. QJM 107(7):579. https:\/\/doi.org\/10.1093\/qjmed\/hct217","journal-title":"QJM"},{"key":"7371_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/B978-0-444-63625-6.00014-8","volume":"142","author":"P Ferenci","year":"2017","unstructured":"Ferenci P (2017) Diagnosis of Wilson disease. Handb Clin Neurol 142:171\u2013180. https:\/\/doi.org\/10.1016\/B978-0-444-63625-6.00014-8","journal-title":"Handb Clin Neurol"},{"key":"7371_CR12","doi-asserted-by":"publisher","unstructured":"Federici S, Bracalenti M, Meloni F, Luciano JV (2017) World Health Organization disability assessment schedule 2.0: An international systematic review. Disabil Rehabil 39(23):2347\u20132380. https:\/\/doi.org\/10.1080\/09638288.2016.1223177","DOI":"10.1080\/09638288.2016.1223177"},{"issue":"4","key":"7371_CR13","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1002\/mds.22231","volume":"24","author":"A Aggarwal","year":"2009","unstructured":"Aggarwal A, Aggarwal N, Nagral A, Jankharia G, Bhatt M (2009) A novel global assessment scale for Wilson\u2019s disease (GAS for WD). Mov Disord 24(4):509\u2013518. https:\/\/doi.org\/10.1002\/mds.22231","journal-title":"Mov Disord"},{"issue":"5","key":"7371_CR14","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1007\/s00415-019-09506-7","volume":"268","author":"L Zhuang","year":"2021","unstructured":"Zhuang L, Yang Y, Gao J (2021) Cognitive assessment tools for mild cognitive impairment screening. J Neurol 268(5):1615\u20131622. https:\/\/doi.org\/10.1007\/s00415-019-09506-7","journal-title":"J Neurol"},{"key":"7371_CR15","doi-asserted-by":"publisher","unstructured":"Levis B, Benedetti A, Thombs BD (2019) Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: Individual participant data meta-analysis. BMJ 365. https:\/\/doi.org\/10.1136\/bmj.l1476","DOI":"10.1136\/bmj.l1476"},{"issue":"3","key":"7371_CR16","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s13760-022-02091-z","volume":"123","author":"T Ziemssen","year":"2023","unstructured":"Ziemssen T, Smolinski L, Cz\u0142onkowska A et al (2023) Serum neurofilament light chain and initial severity of neurological disease predict the early neurological deterioration in Wilson\u2019s disease. Acta Neurol Belg 123(3):917\u2013925. https:\/\/doi.org\/10.1007\/s13760-022-02091-z","journal-title":"Acta Neurol Belg"},{"issue":"7","key":"7371_CR17","doi-asserted-by":"publisher","first-page":"3492","DOI":"10.1007\/s00415-023-11681-7","volume":"270","author":"I Stankovi\u0107","year":"2023","unstructured":"Stankovi\u0107 I, Jovanovi\u0107 \u010c, Vitkovi\u0107 J et al (2023) Long-term outcome of patients with neurological form of Wilson\u2019s disease compliant to the de-coppering treatment. J Neurol 270(7):3492\u20133498. https:\/\/doi.org\/10.1007\/s00415-023-11681-7","journal-title":"J Neurol"},{"issue":"9","key":"7371_CR18","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1007\/s10072-020-05013-0","volume":"42","author":"B Samanci","year":"2021","unstructured":"Samanci B, Sahin E, Bilgic B et al (2021) Neurological features and outcomes of Wilson\u2019s disease: A single-center experience. Neurol Sci 42(9):3829\u20133834. https:\/\/doi.org\/10.1007\/s10072-020-05013-0","journal-title":"Neurol Sci"},{"issue":"Suppl 2","key":"7371_CR19","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.21037\/ATM.2019.02.43","volume":"7","author":"P Dusek","year":"2019","unstructured":"Dusek P, Litwin T, Cz\u0142onkowska A (2019) Neurologic impairment in Wilson disease. Ann Transl Med 7(Suppl 2):S64\u2013S64. https:\/\/doi.org\/10.21037\/ATM.2019.02.43","journal-title":"Ann Transl Med"},{"issue":"6","key":"7371_CR20","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/mds.22689","volume":"25","author":"LK Prashanth","year":"2010","unstructured":"Prashanth LK, Sinha S, Taly AB, Vasudev MK (2010) Do MRI features distinguish Wilson\u2019s disease from other early onset extrapyramidal disorders? An analysis of 100 cases. Mov Disord 25(6):672\u2013678. https:\/\/doi.org\/10.1002\/mds.22689","journal-title":"Mov Disord"},{"issue":"3","key":"7371_CR21","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF00589114","volume":"32","author":"L Prayer","year":"1990","unstructured":"Prayer L, Wimberger D, Kramer J, Grimm G, Oder W, Imhof H (1990) Cranial MRI in Wilson\u2019s disease. Neuroradiology 32(3):211\u2013214. https:\/\/doi.org\/10.1007\/BF00589114","journal-title":"Neuroradiology"},{"key":"7371_CR22","doi-asserted-by":"publisher","unstructured":"R\u0119dzia-Ogrodnik B, Cz\u0142onkowska A, Antos A et al (2023) Pathognomonic neuroradiological signs in Wilson\u2019s disease \u2013 Truth or myth? Park Relat Disord 107. https:\/\/doi.org\/10.1016\/j.parkreldis.2022.105247","DOI":"10.1016\/j.parkreldis.2022.105247"},{"key":"7371_CR23","doi-asserted-by":"publisher","unstructured":"Zhou ZH, Wu YF, Cao J et al (2019) Characteristics of neurological Wilson\u2019s disease with corpus callosum abnormalities. BMC Neurol 19(1). https:\/\/doi.org\/10.1186\/s12883-019-1313-7","DOI":"10.1186\/s12883-019-1313-7"},{"issue":"7","key":"7371_CR24","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/mdc3.13547","volume":"9","author":"C Pinto","year":"2022","unstructured":"Pinto C, Malaquias MJ, Miranda HP et al (2022) Brain MRI in the decision for liver transplantation in pediatric neurological Wilson\u2019s disease. Mov Disord Clin Pract 9(7):941\u2013948. https:\/\/doi.org\/10.1002\/mdc3.13547","journal-title":"Mov Disord Clin Pract"},{"issue":"7","key":"7371_CR25","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.transproceed.2014.07.059","volume":"46","author":"F Mocchegiani","year":"2014","unstructured":"Mocchegiani F, Gemini S, Vincenzi P et al (2014) Liver transplantation in neurological Wilson\u2019s disease: Is there indication? a case report. Transplant Proc 46(7):2360\u20132364. https:\/\/doi.org\/10.1016\/j.transproceed.2014.07.059","journal-title":"Transplant Proc"},{"issue":"12","key":"7371_CR26","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1002\/mds.29229","volume":"37","author":"L Smolinski","year":"2022","unstructured":"Smolinski L, Ziemssen T, Akgun K, Antos A, Skowro\u0144ska M, Kurkowska-Jastrz\u0119bska I, Cz\u0142onkowska A, Litwin T (2022) Brain atrophy is substantially accelerated in neurological Wilson\u2019s disease: A longitudinal study. Mov Disord 37(12):2446\u20132451. https:\/\/doi.org\/10.1002\/mds.29229","journal-title":"Mov Disord"},{"issue":"7","key":"7371_CR27","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1007\/s10072-022-06001-2","volume":"43","author":"B R\u0119dzia-Ogrodnik","year":"2022","unstructured":"R\u0119dzia-Ogrodnik B, Cz\u0142onkowska A, Bembenek J et al (2022) Brain magnetic resonance imaging and severity of neurological disease in Wilson\u2019s disease \u2014 the neuroradiological correlations. Neurol Sci 43(7):4405\u20134412. https:\/\/doi.org\/10.1007\/s10072-022-06001-2","journal-title":"Neurol Sci"},{"issue":"4","key":"7371_CR28","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1007\/s11682-020-00373-9","volume":"15","author":"Y Song","year":"2021","unstructured":"Song Y, Zou L, Zhao J et al (2021) Whole brain volume and cortical thickness abnormalities in Wilson\u2019s disease: A clinical correlation study. Brain Imaging Behav 15(4):1778\u20131787. https:\/\/doi.org\/10.1007\/s11682-020-00373-9","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"7371_CR29","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/mds.27641","volume":"34","author":"L Zou","year":"2019","unstructured":"Zou L, Song Y, Zhou X, Chu J, Tang X (2019) Regional morphometric abnormalities and clinical relevance in Wilson\u2019s disease. Mov Disord 34(4):545\u2013554. https:\/\/doi.org\/10.1002\/mds.27641","journal-title":"Mov Disord"},{"issue":"1","key":"7371_CR30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/brain\/awab274","volume":"145","author":"S Shribman","year":"2022","unstructured":"Shribman S, Bocchetta M, Sudre CH et al (2022) Neuroimaging correlates of brain injury in Wilson\u2019s disease: A multimodal, whole-brain MRI study. Brain 145(1):263\u2013275. https:\/\/doi.org\/10.1093\/brain\/awab274","journal-title":"Brain"},{"issue":"3","key":"7371_CR31","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1148\/radiol.2021202846","volume":"299","author":"P Dusek","year":"2021","unstructured":"Dusek P, Lescinskij A, Ruzicka F et al (2021) Associations of brain atrophy and cerebral iron accumulation at MRI with clinical severity in Wilson disease. Radiology 299(3):662\u2013672. https:\/\/doi.org\/10.1148\/radiol.2021202846","journal-title":"Radiology"},{"issue":"3","key":"7371_CR32","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1148\/radiol.2021210106","volume":"299","author":"J Du","year":"2021","unstructured":"Du J, Bydder GM (2021) Brain atrophy is a better biomarker than susceptibility for evaluating clinical severity in Wilson disease. Radiology 299(3):673\u2013674. https:\/\/doi.org\/10.1148\/radiol.2021210106","journal-title":"Radiology"},{"key":"7371_CR33","doi-asserted-by":"publisher","unstructured":"Volpert HM, Pfeiffenberger J, Gr\u00f6ner JB et al (2017) Comparative assessment of clinical rating scales in Wilson\u2019s disease. BMC Neurol 17(1). https:\/\/doi.org\/10.1186\/s12883-017-0921-3","DOI":"10.1186\/s12883-017-0921-3"},{"issue":"3","key":"7371_CR34","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4103\/0976-3147.176195","volume":"7","author":"S Mukherjee","year":"2016","unstructured":"Mukherjee S, Solanki B, Guha G, Saha SP (2016) White matter changes in Wilson\u2019s disease: A radiological enigma. J Neurosci Rural Pract 7(3):447\u2013449. https:\/\/doi.org\/10.4103\/0976-3147.176195","journal-title":"J Neurosci Rural Pract"},{"issue":"2","key":"7371_CR35","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1148\/radiology.198.2.8596862","volume":"198","author":"HN Van Wassenaer-van Hall","year":"1996","unstructured":"Van Wassenaer-van Hall HN, Van Den Heuvel AG, Algra A, Hoogenraad TU, Mali WPTM (1996) Wilson disease: Findings at MR imaging and CT of the brain with clinical correlation. Radiology 198(2):531\u2013536. https:\/\/doi.org\/10.1148\/radiology.198.2.8596862","journal-title":"Radiology"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-024-07371-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-024-07371-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-024-07371-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T01:02:23Z","timestamp":1718326943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-024-07371-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["7371"],"URL":"https:\/\/doi.org\/10.1007\/s10072-024-07371-5","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"type":"print","value":"1590-1874"},{"type":"electronic","value":"1590-3478"}],"subject":[],"published":{"date-parts":[[2024,1,31]]},"assertion":[{"value":"22 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for patient data collection was obtained from the hospital\u2019s Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"This retrospective study involving human participants was in accordance with the ethical standards of the\u00a0institutional Research Committee and with the 1964 Helsinki Declaration and its later amendments. The Hospital\u2019s\u00a0Ethics Committee approved this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was waived.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure of potential conflicts of interest"}}]}}