{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:13:43Z","timestamp":1761894823619},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T00:00:00Z","timestamp":1231372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s10096-008-0684-2","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T12:47:31Z","timestamp":1231332451000},"page":"623-629","source":"Crossref","is-referenced-by-count":20,"title":["The role of polysaccharide intercellular adhesin (PIA) in Staphylococcus epidermidis adhesion to host tissues and subsequent antibiotic tolerance"],"prefix":"10.1007","volume":"28","author":[{"given":"A. R.","family":"Costa","sequence":"first","affiliation":[]},{"given":"M.","family":"Henriques","sequence":"additional","affiliation":[]},{"given":"R.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"J.","family":"Azeredo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,1,8]]},"reference":[{"key":"684_CR1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1473-3099(02)00438-3","volume":"2","author":"C Eiff von","year":"2002","unstructured":"von Eiff C, Peters G, Heilmann C (2002) Pathogenesis of infections due to coagulase-negative staphylococci. Lancet Infect Dis 2:677\u2013685 doi: 10.1016\/S1473-3099(02)00438-3","journal-title":"Lancet Infect Dis"},{"key":"684_CR2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0142-9612(99)00033-2","volume":"20","author":"KM Holgers","year":"1999","unstructured":"Holgers KM, Ljungh A (1999) Cell surface characteristics of microbiological isolates from human percutaneous titanium implants in the head and neck. Biomaterials 20:1319\u20131326 doi: 10.1016\/S0142-9612(99)00033-2","journal-title":"Biomaterials"},{"key":"684_CR3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0167-7012(01)00342-6","volume":"48","author":"A Belkum Van","year":"2002","unstructured":"Van Belkum A, Kools-Sijmons M, Verbrugh H (2002) Attachment of Staphylococcus aureus to eukaryotic cells and experimental pitfalls in staphylococcal adherence assays: a critical appraisal. J Microbiol Methods 48:19\u201342 doi: 10.1016\/S0167-7012(01)00342-6","journal-title":"J Microbiol Methods"},{"key":"684_CR4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s100960050417","volume":"18","author":"C Eiff von","year":"1999","unstructured":"von Eiff C, Heilmann C, Peters G (1999) New aspects in the molecular basis of polymer-associated infections due to staphylococci. Eur J Clin Microbiol Infect Dis 18:843\u2013846 doi: 10.1007\/s100960050417","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"684_CR5","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1128\/IAI.67.5.2656-2659.1999","volume":"67","author":"ME Rupp","year":"1999","unstructured":"Rupp ME, Ulphani JS, Fey PD et al (1999) Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin\/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat model. Infect Immun 67:2656\u20132659","journal-title":"Infect Immun"},{"key":"684_CR6","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1128\/IAI.66.10.4711-4720.1998","volume":"66","author":"D McKenney","year":"1998","unstructured":"McKenney D, H\u00fcbner J, Muller E et al (1998) The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide\/adhesin. Infect Immun 66:4711\u20134720","journal-title":"Infect Immun"},{"key":"684_CR7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0195-6701(99)90074-9","volume":"43","author":"D Mack","year":"1999","unstructured":"Mack D (1999) Molecular mechanisms of Staphylococcus epidermidis biofilm formation. J Hosp Infect 43:113\u2013125 doi: 10.1016\/S0195-6701(99)90074-9","journal-title":"J Hosp Infect"},{"key":"684_CR8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s002840010273","volume":"43","author":"EN Ahanotu","year":"2001","unstructured":"Ahanotu EN, Stone JH, Mcallister SK et al (2001) Vancomycin resistance among strains of Staphylococcus epidermidis: effects on adherence to silicone. Curr Microbiol 43:124\u2013128 doi: 10.1007\/s002840010273","journal-title":"Curr Microbiol"},{"key":"684_CR9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","volume":"9","author":"TFC Mah","year":"2001","unstructured":"Mah TFC, O\u2019Toole GA (2001) Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 9:34\u201339 doi: 10.1016\/S0966-842X(00)01913-2","journal-title":"Trends Microbiol"},{"key":"684_CR10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.resmic.2005.01.007","volume":"156","author":"N Cerca","year":"2005","unstructured":"Cerca N, Pier GB, Vilanova M et al (2005) Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis. Res Microbiol 156:506\u2013514 doi: 10.1016\/j.resmic.2005.01.007","journal-title":"Res Microbiol"},{"key":"684_CR11","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1365-2958.2002.02827.x","volume":"43","author":"F G\u00f6tz","year":"2002","unstructured":"G\u00f6tz F (2002) Staphylococcus and biofilms. Mol Microbiol 43:1367\u20131378 doi: 10.1046\/j.1365-2958.2002.02827.x","journal-title":"Mol Microbiol"},{"key":"684_CR12","volume-title":"Infections associated with indwelling medical devices","author":"F G\u00f6tz","year":"2000","unstructured":"G\u00f6tz F, Peters G (2000) Colonization of medical devices by coagulase-negative staphylococci. In: Waldvogel FA, Bisno AL (eds) Infections associated with indwelling medical devices, 3rd edn. ASM Press, Washington, DC","edition":"3"},{"key":"684_CR13","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1128\/IAI.68.7.3799-3807.2000","volume":"68","author":"D Mack","year":"2000","unstructured":"Mack D, Rohde H, Dobinsky S et al (2000) Identification of three essential regulatory gene loci governing expression of Staphylococcus epidermidis polysaccharide intercellular adhesin and biofilm formation. Infect Immun 68:3799\u20133807 doi: 10.1128\/IAI.68.7.3799-3807.2000","journal-title":"Infect Immun"},{"key":"684_CR14","doi-asserted-by":"crossref","unstructured":"Foster TJ (2002) Surface protein adhesins of staphylococci. In: Wilson M (ed) Bacterial adhesion to host tissues: mechanisms and consequences. Advances in Molecular and Cellular Microbiology. Cambridge University Press","DOI":"10.1017\/CBO9780511541575.002"},{"key":"684_CR15","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2958.1996.tb02548.x","volume":"20","author":"C Heilmann","year":"1996","unstructured":"Heilmann C, Schweitzer O, Gerke C et al (1996) Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis. Mol Microbiol 20:1083\u20131091 doi: 10.1111\/j.1365-2958.1996.tb02548.x","journal-title":"Mol Microbiol"},{"key":"684_CR16","doi-asserted-by":"crossref","first-page":"18586","DOI":"10.1074\/jbc.273.29.18586","volume":"273","author":"C Gerke","year":"1998","unstructured":"Gerke C, Kraft A, S\u00fcssmuth R et al (1998) Characterization of the N-acetylglucosaminyltransferase activity involved in the biosynthesis of the Staphylococcus epidermidis polysaccharide intercellular adhesin. J Biol Chem 273:18586\u201318593 doi: 10.1074\/jbc.273.29.18586","journal-title":"J Biol Chem"},{"key":"684_CR17","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1086\/319279","volume":"183","author":"ME Rupp","year":"2001","unstructured":"Rupp ME, Fey PD, Heilmann C et al (2001) Characterization of the importance of Staphylococcus epidermidis autolysin and polysaccharide intercellular adhesin in the pathogenesis of intravascular catheter-associated infection in a rat model. J Infect Dis 183:1038\u20131042 doi: 10.1086\/319279","journal-title":"J Infect Dis"},{"key":"684_CR18","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1128\/IAI.62.8.3244-3253.1994","volume":"62","author":"D Mack","year":"1994","unstructured":"Mack D, Nedelmann M, Krokotsch A et al (1994) Characterization of transposon mutants of biofilm-producing Staphylococcus epidermidis impaired in the accumulative phase of biofilm production: genetic identification of a hexosamine-containing polysaccharide intercellular adhesin. Infect Immun 62:3244\u20133253","journal-title":"Infect Immun"},{"key":"684_CR19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1128\/jb.178.1.175-183.1996","volume":"178","author":"D Mack","year":"1996","unstructured":"Mack D, Fischer W, Krokotsch A et al (1996) The intercellular adhesin involved in biofilm accumulation of Staphylococcus epidermidis is a linear \u03b2-1,6-linked glucosaminoglycan: purification and structural analysis. J Bacteriol 178:175\u2013183","journal-title":"J Bacteriol"},{"key":"684_CR20","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1128\/IAI.70.8.4433-4440.2002","volume":"70","author":"T Maira-Litr\u00e1n","year":"2002","unstructured":"Maira-Litr\u00e1n T, Kropec A, Abeygunawardana C et al (2002) Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide. Infect Immun 70:4433\u20134440 doi: 10.1128\/IAI.70.8.4433-4440.2002","journal-title":"Infect Immun"},{"key":"684_CR21","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1128\/IAI.73.5.3007-3017.2005","volume":"73","author":"I Sadovskaya","year":"2005","unstructured":"Sadovskaya I, Vinogradov E, Flahaut S et al (2005) Extracellular carbohydrate-containing polymers of a model biofilm-producing strain, Staphylococcus epidermidis RP62A. Infect Immun 73:3007\u20133017 doi: 10.1128\/IAI.73.5.3007-3017.2005","journal-title":"Infect Immun"},{"key":"684_CR22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/AAC.46.1.178-183.2002","volume":"46","author":"D Mack","year":"2002","unstructured":"Mack D, Sabottke A, Dobinsky S et al (2002) Differential expression of methicillin resistance by different biofilm-negative Staphylococcus epidermidis transposon mutant classes. Antimicrob Agents Chemother 46:178\u2013183 doi: 10.1128\/AAC.46.1.178-183.2002","journal-title":"Antimicrob Agents Chemother"},{"key":"684_CR23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00365540410021018","volume":"37","author":"PW Feiter de","year":"2005","unstructured":"de Feiter PW, Jacobs JA, Jacobs MJ et al (2005) Successful treatment of Staphylococcus epidermidis prosthetic valve endocarditis with linezolid after failure of treatment with oxacillin, gentamicin, rifampicin, vancomycin, and fusidic acid regimens. Scand J Infect Dis 37:173\u2013176 doi: 10.1080\/00365540410021018","journal-title":"Scand J Infect Dis"},{"key":"684_CR24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1099\/0022-1317-50-7-582","volume":"50","author":"JP O\u2019Gara","year":"2001","unstructured":"O\u2019Gara JP, Humphreys H (2001) Staphylococcus epidermidis biofilms: importance and implications. J Med Microbiol 50:582\u2013587","journal-title":"J Med Microbiol"},{"key":"684_CR25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/S1517-83822005000100004","volume":"36","author":"L Michelim","year":"2005","unstructured":"Michelim L, Lahude M, Ara\u00fajo PR et al (2005) Pathogenic factors and antimicrobial resistance of Staphylococcus epidermidis associated with nosocomial infections occurring in intensive care units. Braz J Microbiol 36:17\u201323 doi: 10.1590\/S1517-83822005000100004","journal-title":"Braz J Microbiol"},{"key":"684_CR26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0140-6736(01)05321-1","volume":"358","author":"PS Stewart","year":"2001","unstructured":"Stewart PS, Costerton JW (2001) Antibiotic resistance of bacteria in biofilms. Lancet 358:135\u2013138 doi: 10.1016\/S0140-6736(01)05321-1","journal-title":"Lancet"},{"key":"684_CR27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/jac\/dki217","volume":"56","author":"N Cerca","year":"2005","unstructured":"Cerca N, Martins S, Cerca F et al (2005) Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry. J Antimicrob Chemother 56:331\u2013336 doi: 10.1093\/jac\/dki217","journal-title":"J Antimicrob Chemother"},{"key":"684_CR28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.resmic.2005.02.004","volume":"156","author":"N Cerca","year":"2005","unstructured":"Cerca N, Martins S, Pier GB et al (2005) The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm. Res Microbiol 156:650\u2013655 doi: 10.1016\/j.resmic.2005.02.004","journal-title":"Res Microbiol"},{"key":"684_CR29","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1099\/00221287-143-7-2407","volume":"143","author":"I Williams","year":"1997","unstructured":"Williams I, Venables WA, Lloyd D et al (1997) The effects of adherence to silicone surfaces on antibiotic susceptibility in Staphylococcus aureus. Microbiology 143:2407\u20132413","journal-title":"Microbiology"},{"key":"684_CR30","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1128\/IAI.60.5.2048-2057.1992","volume":"60","author":"D Mack","year":"1992","unstructured":"Mack D, Siemssen N, Laufs R (1992) Parallel induction by glucose of adherence and a polysaccharide antigen specific for plastic-adherent Staphylococcus epidermidis: evidence for functional relation to intercellular adhesion. Infect Immun 60:2048\u20132057","journal-title":"Infect Immun"},{"key":"684_CR31","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1128\/IAI.62.8.3244-3253.1994","volume":"62","author":"D Mack","year":"1994","unstructured":"Mack D, Nedelmann M, Krokotsch A et al (1994) Characterization of transposon mutants of biofilm-producing Staphylococcus epidermidis impaired in the accumulative phase of biofilm production: genetic identification of a hexosamine-containing polysaccharide intercellular adhesin. Infect Immun 62:3244\u20133253","journal-title":"Infect Immun"},{"key":"684_CR32","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1128\/AEM.69.10.5812-5818.2003","volume":"69","author":"JK Knobloch","year":"2003","unstructured":"Knobloch JK, Nedelmann M, Kiel K et al (2003) Establishment of an arbitrary PCR for rapid identification of Tn917 insertion sites in Staphylococcus epidermidis: characterization of biofilm-negative and nonmucoid mutants. Appl Environ Microbiol 69:5812\u20135818 doi: 10.1128\/AEM.69.10.5812-5818.2003","journal-title":"Appl Environ Microbiol"},{"key":"684_CR33","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/IAI.67.2.1004-1008.1999","volume":"67","author":"D Mack","year":"1999","unstructured":"Mack D, Riedewald J, Rohde H et al (1999) Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination. Infect Immun 67:1004\u20131008","journal-title":"Infect Immun"},{"key":"684_CR34","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1128\/IAI.67.5.2627-2632.1999","volume":"67","author":"ME Rupp","year":"1999","unstructured":"Rupp ME, Ulphani JS, Fey PD et al (1999) Characterization of the importance of polysaccharide intercellular adhesin\/hemagglutinin of Staphylococcus epidermidis in the pathogenesis of biomaterial-based infection in a mouse foreign body infection model. Infect Immun 67:2627\u20132632","journal-title":"Infect Immun"},{"key":"684_CR35","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","volume":"8","author":"RM Donlan","year":"2002","unstructured":"Donlan RM (2002) Biofilms: microbial life on surfaces. Emerg Infect Dis 8:881\u2013890","journal-title":"Emerg Infect Dis"},{"key":"684_CR36","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/IAI.67.2.589-594.1999","volume":"67","author":"N Mohamed","year":"1999","unstructured":"Mohamed N, Teeters MA, Patti JM et al (1999) Inhibition of Staphylococcus aureus adherence to collagen under dynamic conditions. Infect Immun 67:589\u2013594","journal-title":"Infect Immun"},{"key":"684_CR37","first-page":"322","volume":"16","author":"PA M\u00e5rdh","year":"1979","unstructured":"M\u00e5rdh PA, Colleen S, Hovelius B (1979) Attachment of bacteria to exfoliated cells from the urogenital tract. Invest Urol 16:322\u2013326","journal-title":"Invest Urol"},{"key":"684_CR38","first-page":"466","volume":"7","author":"MJ Carbonero","year":"1989","unstructured":"Carbonero MJ, Pascual A, Mart\u00ednez-Mart\u00ednez L et al (1989) Adhesion capacity and surface properties of Staphylococcus epidermidis and Staphylococcus saprophyticus. Enferm Infecc Microbiol Clin 7:466\u2013470","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"684_CR39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s004300100090","volume":"189","author":"GJ Merkel","year":"2001","unstructured":"Merkel GJ, Scofield BA (2001) Interaction of Staphylococcus epidermidis with endothelial cells in vitro. Med Microbiol Immunol 189:217\u2013223 doi: 10.1007\/s004300100090","journal-title":"Med Microbiol Immunol"},{"key":"684_CR40","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1128\/IAI.66.6.2666-2673.1998","volume":"66","author":"M Nilsson","year":"1998","unstructured":"Nilsson M, Frykberg L, Flock JI et al (1998) A fibrinogen-binding protein of Staphylococcus epidermidis. Infect Immun 66:2666\u20132673","journal-title":"Infect Immun"},{"key":"684_CR41","volume-title":"Methods for determining bactericidal activity of antimicrobial agents. Approved guideline M26-A","author":"National Committee for Clinical Laboratory Standards (NCCLS)","year":"1999","unstructured":"National Committee for Clinical Laboratory Standards (NCCLS) (1999) Methods for determining bactericidal activity of antimicrobial agents. Approved guideline M26-A. NCCLS, Wayne, PA"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-008-0684-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-008-0684-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-008-0684-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T12:27:25Z","timestamp":1589459245000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-008-0684-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,8]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["684"],"URL":"https:\/\/doi.org\/10.1007\/s10096-008-0684-2","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,8]]}}}