{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:37:08Z","timestamp":1764333428650,"version":"3.37.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-024-04059-2","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T05:01:51Z","timestamp":1714021311000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advantages of the co2 laser use in the rare condition of nasal mucosa squamous cell carcinoma surgery in dogs\u2014a clinical prospective study"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-2806","authenticated-orcid":false,"given":"L. Miguel","family":"Carreira","sequence":"first","affiliation":[]},{"given":"P.","family":"Azevedo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"issue":"7","key":"4059_CR1","first-page":"851","volume":"37","author":"BR Madewell","year":"1976","unstructured":"Madewell BR, Priester WA, Gillete EL et al (1976) Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by 13 veterinary colleges. Am J Vet Res 37(7):851\u2013856","journal-title":"Am J Vet Res"},{"key":"4059_CR2","first-page":"309","volume":"14","author":"RS Brodey","year":"1970","unstructured":"Brodey RS (1970) Canine and feline neoplasia. Adv Vet Sci Comp Med 14:309\u2013354","journal-title":"Adv Vet Sci Comp Med"},{"key":"4059_CR3","first-page":"103","volume":"25","author":"AK Patnaik","year":"1989","unstructured":"Patnaik AK (1989) Canine sinonasal neoplasms: clinicopathological study of 285 Cases. J Am Anim Hosp Assoc 25:103\u2013114","journal-title":"J Am Anim Hosp Assoc"},{"issue":"3","key":"4059_CR4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1740-8261.1999.tb00367.x","volume":"40","author":"TA LaDue","year":"1999","unstructured":"LaDue TA, Dodge R, Page RL et al (1999) Factors influencing survival after radiotherapy of nasal tumors in 130 dogs. Vet Radiol Ultrasound 40(3):312\u2013317","journal-title":"Vet Radiol Ultrasound"},{"issue":"1","key":"4059_CR5","first-page":"45","volume":"170","author":"EG MacEwen","year":"1977","unstructured":"MacEwen EG, Withrow SJ, Patnaik AK (1977) Nasal tumors in the dog: retrospective evaluation of diagnosis, prognosis, and treatment. J Am Vet Med Assoc 170(1):45\u201348","journal-title":"J Am Vet Med Assoc"},{"issue":"3","key":"4059_CR6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1740-8261.2009.01545.x","volume":"50","author":"WM Adams","year":"2009","unstructured":"Adams WM, Kleiter MM, Thrall DE et al (2009) Prognostic significance of tumor histology and computed tomographic staging for radiation treatment response of canine nasal tumors. Vet Radiol Ultrasound 50(3):330\u2013335","journal-title":"Vet Radiol Ultrasound"},{"issue":"1","key":"4059_CR7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.rvsc.2007.03.004","volume":"84","author":"JH Yoon","year":"2008","unstructured":"Yoon JH, Feeney DA, Jessen CR et al (2008) External-beam Co-60 radiotherapy for canine nasal tumors: a comparison of survival by treatment protocol. Res Vet Sci 84(1):140\u2013149","journal-title":"Res Vet Sci"},{"issue":"6","key":"4059_CR8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1939-1676.1998.tb02147.x","volume":"12","author":"CJ Henry","year":"1998","unstructured":"Henry CJ, Brewer WG Jr, Tyler JW et al (1998) Survival in dogs with nasal adenocarcinoma: 64 cases (1981\u20131995). J Vet Intern Med 12(6):436\u2013439","journal-title":"J Vet Intern Med"},{"issue":"3","key":"4059_CR9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1740-8261.2004.04046.x","volume":"45","author":"M Kleiter","year":"2004","unstructured":"Kleiter M, Malarkey DE, Ruslander DE et al (2004) Expression of cyclooxygenase-2 in canine epithelial nasal tumors. Vet Radiol Ultrasound 45(3):255\u2013260","journal-title":"Vet Radiol Ultrasound"},{"issue":"3","key":"4059_CR10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2460\/javma.229.3.401","volume":"229","author":"KM Rassnick","year":"2006","unstructured":"Rassnick KM, Goldkamp CE, Erb HN et al (2006) Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 cases (1993\u20132003). J Am Vet Med Assoc 229(3):401\u2013406","journal-title":"J Am Vet Med Assoc"},{"issue":"9","key":"4059_CR11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/vr.151.9.253","volume":"151","author":"RJ Mellanby","year":"2002","unstructured":"Mellanby RJ, Stevenon RK, Herrtage ME et al (2002) Long-term outcome of 56 dogs with nasal tumours treated with four doses of radiation at intervals of seven days. Vet Rec 151(9):253\u2013257","journal-title":"Vet Rec"},{"issue":"1","key":"4059_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-5827.1996.tb01924.x","volume":"37","author":"JS Morris","year":"1996","unstructured":"Morris JS, Dunn KJ, Dobson JM et al (1996) Radiological assessment of severity of canine nasal tumours and relationship with survival. J Small Anim Pract 37(1):1\u20136","journal-title":"J Small Anim Pract"},{"key":"4059_CR13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1748-5827.2007.00512.x","volume":"49","author":"A Avner","year":"2008","unstructured":"Avner A, Dobson JM, Sales JI et al (2008) Retrospective review of 50 canine nasal tumours evaluated by low-field magnetic resonance imaging. J Small Anim Pract 49:233\u2013239","journal-title":"J Small Anim Pract"},{"issue":"5","key":"4059_CR14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/oxfordjournals.aje.a009475","volume":"147","author":"JS Reif","year":"1998","unstructured":"Reif JS, Bruns C, Lower KS (1998) Cancer of the nasal cavity and paranasal sinuses and exposure to environmental tobacco smoke in pet dogs. Am J Epidemiol 147(5):488\u2013492","journal-title":"Am J Epidemiol"},{"issue":"10","key":"4059_CR15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1748-5827.1999.tb02998.x","volume":"40","author":"S Tasker","year":"1999","unstructured":"Tasker S, Knottenbelt CM, Munro EA et al (1999) Aetiology and diagnosis of persistent nasal disease in the dog: a retrospective study of 42 cases. J Small Anim Pract 40(10):473\u2013478","journal-title":"J Small Anim Pract"},{"issue":"7","key":"4059_CR16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/009841098158719","volume":"54","author":"JA Bukowski","year":"1998","unstructured":"Bukowski JA, Wartenberg D, Goldschmidt M (1998) Environmental causes for sinonasal cancers in pet dogs, and their usefulness as sentinels of indoor cancer risk. J Toxicol Environ Health A 54(7):579\u2013591","journal-title":"J Toxicol Environ Health A"},{"issue":"10","key":"4059_CR17","first-page":"809","volume":"29","author":"EJ Laing","year":"1988","unstructured":"Laing EJ, Binnington AG (1988) Surgical therapy of canine nasal tumors: a retrospective study (1982\u20131986). Can Vet J 29(10):809\u2013813","journal-title":"Can Vet J"},{"issue":"6","key":"4059_CR18","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1532-950X.1990.tb01123.x","volume":"18","author":"DL Holmberg","year":"1989","unstructured":"Holmberg DL, Fries C, Cockshutt J et al (1989) Ventral rhinotomy in the dog and cat. Vet Surg 18(6):446\u2013449","journal-title":"Vet Surg"},{"issue":"3","key":"4059_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.20431\/2455-9792.0103001","volume":"1","author":"CL Miguel","year":"2016","unstructured":"Miguel CL, Azevedo P (2016) Comparison of the Influence of CO2-LASER and Scalpel Skin Incisions on the Surgical Wound Healing Process. ARC J Anesthesiol 1(3):1\u20138. https:\/\/doi.org\/10.20431\/2455-9792.0103001","journal-title":"ARC J Anesthesiol"},{"issue":"9","key":"4059_CR20","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.2460\/javma.1992.201.09.1425","volume":"201","author":"SE Lent","year":"1992","unstructured":"Lent SE, Hawkins EC (1992) Evaluation of rhinoscopy and rhinoscopy-assisted mucosal biopsy in diagnosis of nasal disease in dogs: 119 cases (1985\u20131989). J Am Vet Med Assoc 201(9):1425\u20131429","journal-title":"J Am Vet Med Assoc"},{"issue":"8","key":"4059_CR21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2460\/ajvr.1997.58.08.857","volume":"58","author":"RM Gamblin","year":"1997","unstructured":"Gamblin RM, Sagartz JE, Couto CG (1997) Overexpression of p53 tumor suppressor protein in spontaneously arising neoplasms of dogs. Am J Vet Res 58(8):857\u2013863","journal-title":"Am J Vet Res"},{"issue":"1","key":"4059_CR22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jcpa.2004.01.006","volume":"131","author":"G Borzacchiello","year":"2004","unstructured":"Borzacchiello G, Paciello O, Papparella S (2004) Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas. J Comp Pathol 131(1):70\u201376","journal-title":"J Comp Pathol"},{"issue":"3","key":"4059_CR23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tvjl.2007.03.022","volume":"176","author":"JA Impellizeri","year":"2008","unstructured":"Impellizeri JA, Esplin DG (2008) Expression of cyclooxygenase-2 in canine nasal carcinomas. Vet J 176(3):408\u2013410","journal-title":"Vet J"},{"issue":"6","key":"4059_CR24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1748-5827.2005.tb00321.x","volume":"46","author":"J Lefebvre","year":"2005","unstructured":"Lefebvre J, Kuehn NF, Wortinger A (2005) Computed tomography as an aid in the diagnosis of chronic nasal disease in dogs. J Small Anim Pract 46(6):280\u2013285","journal-title":"J Small Anim Pract"},{"issue":"4","key":"4059_CR25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1740-8261.2003.tb00477.x","volume":"44","author":"JH Saunders","year":"2003","unstructured":"Saunders JH, van Bree H, Gielen I et al (2003) Diagnostic value of computed tomography in dogs with chronic nasal disease. Vet Radiol Ultrasound 44(4):409\u2013413","journal-title":"Vet Radiol Ultrasound"},{"issue":"3","key":"4059_CR26","first-page":"201","volume":"2","author":"RS Dhaliwal","year":"2004","unstructured":"Dhaliwal RS, Kitchell BE, Losonsky JM et al (2004) Subjective evaluation of computed tomography and magnetic resonance imaging for detecting intracalvarial changes in canine nasal neoplasia. Intern J Appl Res Vet Med 2(3):201\u2013208","journal-title":"Intern J Appl Res Vet Med"},{"issue":"7","key":"4059_CR27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1748-5827.2009.00729.x","volume":"50","author":"R Drees","year":"2009","unstructured":"Drees R, Forrest LJ, Chappell R (2009) Comparison of computed tomography and magnetic resonance imaging for the evaluation of canine intranasal neoplasia. J Small Anim Pract 50(7):334\u2013340","journal-title":"J Small Anim Pract"},{"issue":"12","key":"4059_CR28","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.2460\/javma.2004.224.1952","volume":"224","author":"RC Windsor","year":"2004","unstructured":"Windsor RC, Johnson LR, Herrgesell EJ et al (2004) Idiopathic lymphoplasmacytic rhinitis in dogs: 37 cases (1997\u20132002). J Am Vet Med Assoc 224(12):1952\u20131957","journal-title":"J Am Vet Med Assoc"},{"issue":"3","key":"4059_CR29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5326\/0410179","volume":"41","author":"JL Strasser","year":"2005","unstructured":"Strasser JL, Hawkins EC (2005) Clinical features of epistaxis in dogs: a retrospective study of 35 cases (1999\u20132002). J Am Anim Hosp Assoc 41(3):179\u2013184","journal-title":"J Am Anim Hosp Assoc"},{"issue":"3","key":"4059_CR30","first-page":"293","volume":"51","author":"DW Hunley","year":"2010","unstructured":"Hunley DW, Mauldin GN, Shiomitsu K et al (2010) Clinical outcome in dogs with nasal tumors treated with intensity-modulated radiation therapy. Can Vet J 51(3):293\u2013300","journal-title":"Can Vet J"},{"issue":"3","key":"4059_CR31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1939-1676.2001.tb02309.x","volume":"15","author":"NC Northrup","year":"2001","unstructured":"Northrup NC, Etuw SM, Ruslander DM et al (2001) Retrospective study of orthovoltage radiation therapy for nasal tumors in 42 dogs. J Vet Intern Med 15(3):183\u2013189","journal-title":"J Vet Intern Med"},{"issue":"6","key":"4059_CR32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1740-8261.2007.00304.x","volume":"48","author":"AN Gutierrez","year":"2007","unstructured":"Gutierrez AN, Deveau M, Forrest LJ et al (2007) Radiobiological and treatment planning study of a simultaneously integrated boost for canine nasal tumors using helical tomotherapy. Vet Radiol Ultrasound 48(6):594\u2013602","journal-title":"Vet Radiol Ultrasound"},{"issue":"3","key":"4059_CR33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1740-8261.1991.tb00096.x","volume":"32","author":"MC McEntee","year":"1991","unstructured":"McEntee MC, Page RL, Heidner GL et al (1991) A retrospective study of 27 dogs with intranasal neoplasms treated with cobalt radiation. Vet Radiol 32(3):135\u2013139","journal-title":"Vet Radiol"},{"issue":"6","key":"4059_CR34","doi-asserted-by":"crossref","first-page":"936","DOI":"10.2460\/javma.2005.227.936","volume":"227","author":"WM Adams","year":"2005","unstructured":"Adams WM, Bjorling DE, McAnulty JE et al (2005) Outcome of accelerated radiotherapy alone or accelerated radiotherapy followed by exenteration of the nasal cavity in dogs with intranasal neoplasia: 53 cases (1990\u20132002). J Am Vet Med Assoc 227(6):936\u2013941","journal-title":"J Am Vet Med Assoc"},{"issue":"6","key":"4059_CR35","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1740-8261.2004.04100.x","volume":"45","author":"SE Lana","year":"2004","unstructured":"Lana SE, Dernell WS, Lafferty MH et al (2004) Use of radiation and a slow-release cisplatin formulation for treatment of canine nasal tumors. Vet Radiol Ultrasound 45(6):577\u2013581","journal-title":"Vet Radiol Ultrasound"},{"issue":"3","key":"4059_CR36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5326\/0440116","volume":"44","author":"T Gieger","year":"2008","unstructured":"Gieger T, Rassnick K, Siegel S et al (2008) Palliation of clinical signs in 48 dogs with nasal carcinomas treated with coarse-fraction radiation therapy. J Am Anim Hosp Assoc 44(3):116\u2013123","journal-title":"J Am Anim Hosp Assoc"},{"key":"4059_CR37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1748-5827.1994.tb03821.x","volume":"35","author":"JS Morris","year":"1994","unstructured":"Morris JS, Dunn KJ, Dobson JM et al (1994) Effects of radiotherapy alone and surgery and radiotherapy on survival of dogs with nasal tumours. J Small Anim Pract 35:573\u2013576","journal-title":"J Small Anim Pract"},{"issue":"1","key":"4059_CR38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5326\/0390086","volume":"39","author":"SS Correa","year":"2003","unstructured":"Correa SS, Mauldin GN, Mauldin GE et al (2003) Efficacy of cobalt-60 radiation therapy for the treatment of nasal cavity nonkeratinizing squamous cell carcinoma in the dog. J Am Anim Hosp Assoc 39(1):86\u201389","journal-title":"J Am Anim Hosp Assoc"},{"issue":"3","key":"4059_CR39","first-page":"311","volume":"191","author":"WM Adams","year":"1987","unstructured":"Adams WM, Withrow SJ, Walshaw R et al (1987) Radiotherapy of malignant nasal tumors in 67 dogs. J Am Vet Med Assoc 191(3):311\u2013315","journal-title":"J Am Vet Med Assoc"},{"issue":"6","key":"4059_CR40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1740-8261.1997.tb00875.x","volume":"38","author":"SE Lana","year":"1997","unstructured":"Lana SE, Dernell WS, LaRue SM et al (1997) Slow release cisplatin combined with radiation for the treatment of canine nasal tumors. Vet Radiol Ultrasound 38(6):474\u2013478","journal-title":"Vet Radiol Ultrasound"},{"issue":"6","key":"4059_CR41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1740-8261.2009.01603.x","volume":"50","author":"J Buchholz","year":"2009","unstructured":"Buchholz J, Hagen R, Leo C et al (2009) 3D conformal radiation therapy for palliative treatment of canine nasal tumors. Vet Radiol Ultrasound 50(6):679\u2013683","journal-title":"Vet Radiol Ultrasound"},{"issue":"4","key":"4059_CR42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1740-8261.2007.00262.x","volume":"48","author":"G Sfiligoi","year":"2007","unstructured":"Sfiligoi G, Theon AP, Kent MS (2007) Response of nineteen cats with nasal lymphoma to radiation therapy and chemotherapy. Vet Radiol Ultrasound 48(4):388\u2013393","journal-title":"Vet Radiol Ultrasound"},{"issue":"10","key":"4059_CR43","first-page":"1460","volume":"194","author":"SM Evans","year":"1989","unstructured":"Evans SM, Goldschmidt M, McKee LJ et al (1989) Prognostic factors and survival after radiotherapy for intranasal neoplasms in dogs: 70 cases (1974\u20131985). J Am Vet Med Assoc 194(10):1460\u20131463","journal-title":"J Am Vet Med Assoc"},{"issue":"1","key":"4059_CR44","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1515\/med-2015-0089","volume":"10","author":"D Testa","year":"2015","unstructured":"Testa D, Motta S, Massimilla EA, Tafuri D, Russo D, Russo A, Landolfo PG, Mesolella M, Motta G (2015) Cavernous hemangioma of rhinopharynx: our experience and review of literature. Open Med 10(1):523\u2013528. https:\/\/doi.org\/10.1515\/med-2015-0089","journal-title":"Open Med"},{"issue":"1","key":"4059_CR45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mla.2007.02.002","volume":"22","author":"H Deppe","year":"2007","unstructured":"Deppe H, Horch HH (2007) Current Status of LASER Application in Oral and Cranio-Maxillofacial Surgery. Med Laser Appl 22(1):39\u201342","journal-title":"Med Laser Appl"},{"key":"4059_CR46","unstructured":"Strauss R (1997) Laser management of discrete lesions. In: Catone G, Alling C (eds) Laser applications in oral and maxillofacial surgery (Chapter 14, pp 257). WB Saunders,\u00a0Philadelphia"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-04059-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-024-04059-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-04059-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:44:24Z","timestamp":1738338264000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-024-04059-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,25]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4059"],"URL":"https:\/\/doi.org\/10.1007\/s10103-024-04059-2","relation":{},"ISSN":["1435-604X"],"issn-type":[{"type":"electronic","value":"1435-604X"}],"subject":[],"published":{"date-parts":[[2024,4,25]]},"assertion":[{"value":"28 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors disclose financial or non-financial interests that are directly or indirectly related to the work submitted for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"Project approval registration number by the Research and Teaching Ethics Committee (CEIE),Faculty of Veterinary Medicine\u2014University of Lisbon (FMV_ULisboa), Lisboa\u2014Portugal, N\/Ref\u00aa 015\/2022.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Trial registration number and date of registration for prospectively registered trials"}}],"article-number":"114"}}