{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:54:34Z","timestamp":1769853274125,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mar Biotechnol"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1007\/s10126-008-9100-2","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T13:53:00Z","timestamp":1209563580000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Nutrient Limitation is the Main Regulatory Factor for Carotenoid Accumulation and for Psy and Pds Steady State Transcript Levels in Dunaliella salina (Chlorophyta) Exposed to High Light and Salt Stress"],"prefix":"10.1007","volume":"10","author":[{"given":"Sacha Nicole","family":"Coesel","sequence":"first","affiliation":[]},{"given":"Alexandra Cordeiro","family":"Baumgartner","sequence":"additional","affiliation":[]},{"given":"Licia Marlene","family":"Teles","sequence":"additional","affiliation":[]},{"given":"Ana Alexandra","family":"Ramos","sequence":"additional","affiliation":[]},{"given":"Nuno Miguel","family":"Henriques","sequence":"additional","affiliation":[]},{"given":"Leonor","family":"Cancela","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Carlos Serafim","family":"Varela","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"9100_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1104\/pp.72.3.593","volume":"72","author":"A Ben-Amotz","year":"1983","unstructured":"Ben-Amotz A, Avron M (1983) On the factors which determine massive \u03b2-carotene accumulation in the halotolerant alga Dunaliella bardawil. Plant Physiol 72:593\u2013597","journal-title":"Plant Physiol"},{"key":"9100_CR2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1529-8817.1982.tb03219.x","volume":"18","author":"A Ben-Amotz","year":"1982","unstructured":"Ben-Amotz A, Katz A, Avron M (1982) Accumulation of \u03b2-carotene in halotolerant algae: purification and characterization of beta-carotene-rich globules from Dunaliella bardawil (Chlorophyceae). J Phycol 18:529\u2013537","journal-title":"J Phycol"},{"key":"9100_CR3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1529-8817.1987.tb04441.x","volume":"23","author":"A Ben-Amotz","year":"1987","unstructured":"Ben-Amotz A, Gressel J, Avron A (1987) Massive accumulation of phytoene induced by norflurazon in Dunaliella bardawil (Chlorophyceae) prevents recovery from photoinhibition. J Phycol 23:176\u2013181","journal-title":"J Phycol"},{"key":"9100_CR4","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1104\/pp.91.3.1040","volume":"91","author":"A Ben-Amotz","year":"1989","unstructured":"Ben-Amotz A, Shaish A, Avron M (1989) Mode of action of the massively accumulated beta-carotene of Dunaliella bardawil in protecting the alga against damage by excess irradiation. Plant Physiol 91:1040\u20131043","journal-title":"Plant Physiol"},{"key":"9100_CR5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0167-4781(02)00500-6","volume":"1579","author":"F Bohne","year":"2002","unstructured":"Bohne F, Linden H (2002) Regulation of carotenoid biosynthesis genes in response to light in Chlamydomonas reinhardtii. Biochim Biophys Acta 1579:26\u201334","journal-title":"Biochim Biophys Acta"},{"key":"9100_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF00023372","volume":"2","author":"MA Borowitzka","year":"1990","unstructured":"Borowitzka MA, Borowitzka LJ, Kessly D (1990) Effects of salinity increase on carotenoid accumulation in the green alga Dunaliella salina. J Appl Phycol 2:111\u2013119","journal-title":"J Appl Phycol"},{"key":"9100_CR7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10725-005-4831-9","volume":"48","author":"L Campisi","year":"2006","unstructured":"Campisi L, Fambrini M, Michelotti V, Salvini M, Giuntini D, Pugliesi C (2006) Phytoene accumulation in sunflower decreases the transcript levels of the phytoene synthase gene. Plant Growth Regul 48:79\u201387","journal-title":"Plant Growth Regul"},{"key":"9100_CR8","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1093\/jxb\/43.12.1535","volume":"43","author":"AK Cowan","year":"1992","unstructured":"Cowan AK, Rose PD, Horne LG (1992) Dunaliella salina: a model system for studying the response of plant cells to stress. J Exp Bot 43:1535\u20131547","journal-title":"J Exp Bot"},{"key":"9100_CR9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1146\/annurev.arplant.49.1.557","volume":"49","author":"FX Cunningham","year":"1998","unstructured":"Cunningham FX, Gantt E (1998) Genes and enzymes of carotenoid biosynthesis in plants. Annu Rev Plant Phys 49:557\u2013583","journal-title":"Annu Rev Plant Phys"},{"key":"9100_CR10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1096\/fasebj.10.4.8647339","volume":"10","author":"B Demmig-Adams","year":"1996","unstructured":"Demmig-Adams B, Gilmore AM, Adams WW 3rd (1996) Carotenoids 3: in vivo function of carotenoids in higher plants. FASEB J 10:403\u2013412","journal-title":"FASEB J"},{"key":"9100_CR11","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-009-5860-9","volume-title":"The biochemistry of the carotenoids","author":"TW Goodwin","year":"1980","unstructured":"Goodwin TW (1980) The biochemistry of the carotenoids. London, Chapham and Hall"},{"key":"9100_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev.genet.38.072902.092328","volume":"38","author":"AR Grossman","year":"2004","unstructured":"Grossman AR, Lohr M, Im CS (2004) Chlamydomonas reinhardtii in the landscape of pigments. Annu Rev Genet 38:119\u2013173","journal-title":"Annu Rev Genet"},{"key":"9100_CR13","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1104\/pp.122.4.1261","volume":"122","author":"K Grunewald","year":"2000","unstructured":"Grunewald K, Eckert M, Hirschberg J, Hagen C (2000) Phytoene desaturase is localized exclusively in the chloroplast and up-regulated at the mRNA level during accumulation of secondary carotenoids in Haematococcus pluvialis (Volvocales, Chlorophyceae). Plant Physiol 122:1261\u20131268","journal-title":"Plant Physiol"},{"key":"9100_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.0022-3646.1994.00241.x","volume":"30","author":"C Hagen","year":"1994","unstructured":"Hagen C, Braune W, Bjorn LO (1994) Functional aspects of secondary carotenoids in Haematococcus lacustris (Volvocales). III. Action as a \u201csunshade\u201d. J Phycol 30:241\u2013248","journal-title":"J Phycol"},{"key":"9100_CR15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1104\/pp.93.2.389","volume":"93","author":"A Lers","year":"1990","unstructured":"Lers A, Biener Y, Zamir A (1990) Photoinduction of massive beta-carotene accumulation by the alga Dunaliella bardawil: kinetics and dependence on gene activation. Plant Physiol 93:389\u2013395","journal-title":"Plant Physiol"},{"key":"9100_CR16","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1104\/pp.104.056069","volume":"138","author":"M Lohr","year":"2005","unstructured":"Lohr M, Im CS, Grossman AR (2005) Genome-based examination of chlorophyll and carotenoid biosynthesis in Chlamydomonas reinhardtii. Plant Physiol 138:490\u2013515","journal-title":"Plant Physiol"},{"key":"9100_CR17","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1023\/A:1008017928651","volume":"10","author":"N Marin","year":"1998","unstructured":"Marin N, Morales F, Lodeiros C, Tamigneaux E (1998) Effect of nitrate concentration on growth and pigment synthesis of Dunaliella salina cultivated under low illumination and preadapted to different salinities. J Appl Phycol 10:405\u2013411","journal-title":"J Appl Phycol"},{"key":"9100_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1104\/pp.128.2.603","volume":"128","author":"T Masuda","year":"2002","unstructured":"Masuda T, Polle JE, Melis A (2002) Biosynthesis and distribution of chlorophyll among the photosystems during recovery of the green alga Dunaliella salina from irradiance stress. Plant Physiol 128:603\u2013614","journal-title":"Plant Physiol"},{"key":"9100_CR19","unstructured":"Navalho J (1997) Biotechnology of Dunaliella salina for beta-carotene production. MSc thesis, University of Algarve, Faro, Portugal"},{"key":"9100_CR20","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1104\/pp.116.4.1239","volume":"116","author":"S Rabbani","year":"1998","unstructured":"Rabbani S, Beyer P, Von Lintig J, Hugueney P, Kleinig H (1998) Induced beta-carotene synthesis driven by triacylglycerol deposition in the unicellular alga Dunaliella bardawil. Plant Physiol 116:1239\u20131248","journal-title":"Plant Physiol"},{"key":"9100_CR21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S1389-0344(03)00065-0","volume":"20","author":"A Salguero","year":"2003","unstructured":"Salguero A, De La Morena B, Vigara J, Vega JM, Vilchez C, Leon R (2003) Carotenoids as protective response against oxidative damage in Dunaliella bardawil. Biomol Eng 20:249\u2013253","journal-title":"Biomol Eng"},{"key":"9100_CR22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.jplph.2004.04.011","volume":"162","author":"M Salvini","year":"2005","unstructured":"Salvini M, Bernini A, Fambrini M, Pugliesi C (2005) cDNA cloning and expression of the phytoene synthase gene in sunflower. J Plant Physiol 162:479\u2013484","journal-title":"J Plant Physiol"},{"key":"9100_CR23","unstructured":"Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY"},{"key":"9100_CR24","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s10529-006-9001-2","volume":"28","author":"L S\u00e1nchez-Estudillo","year":"2006","unstructured":"S\u00e1nchez-Estudillo L, Freile-Pelegrin Y, Rivera-Madrid R, Robledo D, Narvaez-Zapata JA (2006) Regulation of two photosynthetic pigment-related genes during stress-induced pigment formation in the green alga, Dunaliella salina. Biotechnol Lett 28:787\u2013791","journal-title":"Biotechnol Lett"},{"key":"9100_CR25","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/j.1365-3040.2006.01515.x","volume":"29","author":"L Schaeffer","year":"2006","unstructured":"Schaeffer L, Sandmann M, Woitsch S, Sandmann G (2006) Coordinate up-regulation of carotenoid biosynthesis as a response to light stress in Synechococcus PCC7942. Plant Cell Environ 29:1349\u20131356","journal-title":"Plant Cell Environ"},{"key":"9100_CR26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1515\/znc-2003-5-615","volume":"58","author":"AJ Simkin","year":"2003","unstructured":"Simkin AJ, Laboure AM, Kuntz M, Sandmann G (2003a) Comparison of carotenoid content, gene expression and enzyme levels in tomato (Lycopersicon esculentum) leaves. Z Naturforsch [C] 58:371\u2013380","journal-title":"Z Naturforsch [C]"},{"key":"9100_CR27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1078\/0176-1617-00871","volume":"160","author":"AJ Simkin","year":"2003","unstructured":"Simkin AJ, Zhu C, Kuntz M, Sandmann G (2003b) Light-dark regulation of carotenoid biosynthesis in pepper (Capsicum annuum) leaves. J Plant Physiol 160:439\u2013443","journal-title":"J Plant Physiol"},{"key":"9100_CR28","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1104\/pp.125.2.810","volume":"125","author":"J Steinbrenner","year":"2001","unstructured":"Steinbrenner J, Linden H (2001) Regulation of two carotenoid biosynthesis genes coding for phytoene synthase and carotenoid hydroxylase during stress-induced astaxanthin formation in the green alga Haematococcus pluvialis. Plant Physiol 125:810\u2013817","journal-title":"Plant Physiol"},{"key":"9100_CR29","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1023\/A:1023948929665","volume":"52","author":"J Steinbrenner","year":"2003","unstructured":"Steinbrenner J, Linden H (2003) Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Mol Biol 52:343\u2013356","journal-title":"Plant Mol Biol"},{"key":"9100_CR30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1046\/j.1365-313X.1997.00625.x","volume":"12","author":"J Von Lintig","year":"1997","unstructured":"Von Lintig J, Welsch R, Bonk M, Giuliano G, Batschauer A, Kleinig H (1997) Light-dependent regulation of carotenoid biosynthesis occurs at the level of phytoene synthase expression and is mediated by phytochrome in Sinapis alba and Arabidopsis thaliana seedlings. Plant J 12:625\u2013634","journal-title":"Plant J"},{"key":"9100_CR31","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/j.0022-3646.2003.03-043.x","volume":"39","author":"B Wang","year":"2003","unstructured":"Wang B, Zarka A, Trebst A, Boussiba S (2003) Astaxanthin accumulation in Haematococcus pluvialis (Chlorophyceae) as an active photoprotective process under high irradiance. J Phycol 39:1116\u20131124","journal-title":"J Phycol"},{"key":"9100_CR32","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1093\/pcp\/pcf105","volume":"43","author":"AL White","year":"2002","unstructured":"White AL, Jahnke LS (2002) Contrasting effects of UV-A and UV-B on photosynthesis and photoprotection of beta-carotene in two Dunaliella spp. Plant Cell Physiol 43:877\u2013884","journal-title":"Plant Cell Physiol"}],"container-title":["Marine Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-008-9100-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10126-008-9100-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-008-9100-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10126-008-9100-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T01:10:02Z","timestamp":1652663402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10126-008-9100-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["9100"],"URL":"https:\/\/doi.org\/10.1007\/s10126-008-9100-2","relation":{},"ISSN":["1436-2228","1436-2236"],"issn-type":[{"value":"1436-2228","type":"print"},{"value":"1436-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,1]]},"assertion":[{"value":"18 December 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"602"}}