{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:32:47Z","timestamp":1774524767523,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00678\/2022"],"award-info":[{"award-number":["UIDB\/00678\/2022"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/FER-HFC\/30665\/2017"],"award-info":[{"award-number":["PTDC\/FER-HFC\/30665\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005765","name":"Universidade de Lisboa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005765","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Biotheor"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this article we analyse the issue of what accounts for developmental potential, i.e., the possible phenotypes a developing organism can manifest during ontogeny. We shall argue in favour of two theses. First, although the developing organism is the unit of development, the complete causal basis for its potential to develop does neither lie entirely in itself as a whole nor in any specific part of itself (such as its genome). Thus, the extra-organismal environment must be counted as one of the three necessary, partial and complementary causal bases for development potential. Secondly, we shall defend a constructivist view of the developmental process. If the genome, the developing organism and the extra-organismal environment are to be counted as proper elements of the causal basis for an organism\u2019s developmental potential, the latter is not a given. Rather, it is the result of an interaction-based construction, a process sometimes generating genuine developmental novelty. We will thus argue for an interactionist multi-causal basis view of developmental potential construction. We contend that our view provides a biologically tenable and metaphysically coherent account of developmental dynamics.<\/jats:p>","DOI":"10.1007\/s10441-023-09456-8","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T13:05:23Z","timestamp":1675083923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Multi-Causal Basis of Developmental Potential Construction"],"prefix":"10.1007","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-7370","authenticated-orcid":false,"given":"Davide","family":"Vecchi","sequence":"first","affiliation":[]},{"given":"Gil","family":"Santos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"9456_CR1","volume-title":"Introduction to psychology","author":"RL Atkinson","year":"1987","unstructured":"Atkinson RL et al (1987) Introduction to psychology, 9th edn. Harcourt Brace Jovanovich, New York","edition":"9"},{"key":"9456_CR2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10539-014-9454-y","volume":"30","author":"CJ Austin","year":"2015","unstructured":"Austin CJ (2015) The dispositional genome: primus inter pares. Biol Philos 30:227\u2013246","journal-title":"Biol Philos"},{"key":"9456_CR3","volume-title":"Evolutionary Developmental Biology: A Reference Guide","author":"CJ Austin","year":"2021","unstructured":"Austin CJ, Nu\u00f1o de la Rosa L (2021) Dispositional properties in Evo-Devo. In: Nu\u00f1o de la Rosa L, M\u00fcller G (eds) Evolutionary Developmental Biology: A Reference Guide. Springer, Cambridge"},{"key":"9456_CR4","volume-title":"Evolvability A Unifying Concept in Evolutionary Biology","author":"I Brigandt","year":"2023","unstructured":"Brigandt I et al (2023) Evolvability as a Disposition: Philosophical Distinctions, Scientific Implications. In: Hansen Thomas F, Houle David, Pavli\u010dev Mihaela, P\u00e9labon Christophe (eds) Evolvability A Unifying Concept in Evolutionary Biology. MIT Press, Cambridge"},{"key":"9456_CR6","volume-title":"Evolution, Genetics, and Man","author":"T Dobzhansky","year":"1955","unstructured":"Dobzhansky T (1955) Evolution, Genetics, and Man. Wiley, New York"},{"issue":"45","key":"9456_CR7","doi-asserted-by":"publisher","first-page":"15857","DOI":"10.1073\/pnas.0407197101","volume":"101","author":"JP Dumbacher","year":"2004","unstructured":"Dumbacher JP et al (2004) Melyrid beetles (Choresine): a putative source for the Batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds. PNAS 101(45):15857\u201315860","journal-title":"PNAS"},{"issue":"1","key":"9456_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1073\/pnas.91.1.11","volume":"91","author":"E Epstein","year":"1994","unstructured":"Epstein E (1994) The anomaly of silicon in plant biology. PNAS 91(1):11\u201317","journal-title":"PNAS"},{"key":"9456_CR9","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.2141","volume-title":"Philosophie anatomique: Des organes respiratoires sous le rapport de la d\u00e9termination et de l'identit\u00e9 de leurs pi\u00e8ces osseuses","author":"\u00c9 Geoffroy Saint-Hilaire","year":"1818","unstructured":"Geoffroy Saint-Hilaire \u00c9 (1818) Philosophie anatomique: Des organes respiratoires sous le rapport de la d\u00e9termination et de l\u2019identit\u00e9 de leurs pi\u00e8ces osseuses, vol 1. M\u00e9quignon-Marvis, Paris"},{"key":"9456_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/BF02426835","volume":"6","author":"SF Gilbert","year":"1991","unstructured":"Gilbert SF (1991) Epigenetic landscaping: Waddington\u2019s use of cell fate bifurcation diagrams. Biol Philos 6:135\u2013154","journal-title":"Biol Philos"},{"key":"9456_CR11","volume-title":"Ecological Developmental Biology: Integrating Epigenetics, Medicine, and Evolution","author":"SF Gilbert","year":"2009","unstructured":"Gilbert SF, Epel D (2009) Ecological Developmental Biology: Integrating Epigenetics, Medicine, and Evolution. Sinauer Associates Inc., Sunderland"},{"key":"9456_CR12","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1089\/scd.2011.0630","volume":"21","author":"N Hong","year":"2012","unstructured":"Hong N et al (2012) Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation. Stem Cells Dev 21:2333\u20132341","journal-title":"Stem Cells Dev"},{"key":"9456_CR13","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/978-94-024-1287-1_16","volume-title":"Handbook of Potentiality","author":"A H\u00fcttemann","year":"2018","unstructured":"H\u00fcttemann A, Kaiser MI (2018) Potentiality in Biology. In: Engelhard K, Quante M (eds) Handbook of Potentiality. Springer, Dordrecht, pp 401\u2013428"},{"key":"9456_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1126\/science.164.3881.788","volume":"164","author":"JL King","year":"1969","unstructured":"King JL, Jukes TH (1969) Non-darwinian evolution: most evolutionary change in proteins may be due to neutral mutations and genetic drift. Science 164:88\u201398","journal-title":"Science"},{"key":"9456_CR15","first-page":"1","volume-title":"Dispositions and causal powers","author":"M Kistler","year":"2007","unstructured":"Kistler M, Gnassounou B (2007) Introduction. In: Kistler M, Gnassounou B (eds) Dispositions and causal powers. Ashgate, Hampshire, pp 1\u201340"},{"issue":"4","key":"9456_CR16","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1093\/nar\/gkp089","volume":"37","author":"EV Koonin","year":"2009","unstructured":"Koonin EV (2009) Darwinian evolution in the light of genomics. Nucleic Acids Res 37(4):1011\u20131034","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"9456_CR17","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1086\/377385","volume":"70","author":"AC Love","year":"2003","unstructured":"Love AC (2003) Evolvability, dispositions, and intrinsicality. Philosophy of Science 70(5):1015\u20131027","journal-title":"Philosophy of Science"},{"key":"9456_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-03368-5","volume-title":"Foundations of Biophilosophy","author":"M Mahner","year":"1997","unstructured":"Mahner M, Bunge MA (1997) Foundations of Biophilosophy. Springer, Berlin"},{"key":"9456_CR19","unstructured":"Marshall, Dan and Brian Weatherson 2018 Intrinsic vs. Extrinsic Properties, The Stanford Encyclopedia of Philosophy (Spring 2018 Edition), Edward N. Zalta (ed.), URL = https:\/\/plato.stanford.edu\/archives\/spr2018\/entries\/intrinsic-extrinsic\/"},{"key":"9456_CR20","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1098\/rstb.2006.1881","volume":"362","author":"W Martin","year":"2007","unstructured":"Martin W, Russell MJ (2007) On the origin of biochemistry at an alkaline hydrothermal vent. Phil Trans R Soc B 362:1887\u20131925","journal-title":"Phil Trans R Soc B"},{"issue":"11","key":"9456_CR21","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nrmicro1991","volume":"6","author":"Martin","year":"2008","unstructured":"Martin et al (2008) Hydrothermal vents and the origin of life. Nat Rev Microbiol 6(11):805\u2013814","journal-title":"Nat Rev Microbiol"},{"key":"9456_CR22","volume-title":"Autopoiesis and cognition: the realization of the living","author":"HR Maturana","year":"1991","unstructured":"Maturana HR, Varela FJ (1991) Autopoiesis and cognition: the realization of the living. Springer, Dordrect"},{"key":"9456_CR23","first-page":"49","volume-title":"Potentiality: metaphysical and bioethical dimensions","author":"J McKitrick","year":"2014","unstructured":"McKitrick J (2014) Dispositions and Potentialities. In: Lizza JP (ed) Potentiality: metaphysical and bioethical dimensions. Johns Hopkins University Press, Baltimore, pp 49\u201368"},{"issue":"4","key":"9456_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s11692-013-9227-6","volume":"40","author":"DW McShea","year":"2013","unstructured":"McShea DW, Hordijk W (2013) Complexity by subtraction. Evol Biol 40(4):504\u2013520","journal-title":"Evol Biol"},{"key":"9456_CR25","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511541476","volume-title":"The development of animal form: ontogeny, morphology, and evolution","author":"A Minelli","year":"2003","unstructured":"Minelli A (2003) The development of animal form: ontogeny, morphology, and evolution. Cambridge University Press, Cambridge"},{"key":"9456_CR26","volume-title":"Evolutionary Developmental Biology: a Reference Guide","author":"SA Newman","year":"2021","unstructured":"Newman SA (2021) Inherency. In: Nu\u00f1o de la Rosa L, M\u00fcller G (eds) Evolutionary Developmental Biology: a Reference Guide. Springer, New York"},{"issue":"2\u20133","key":"9456_CR27","first-page":"289","volume":"32","author":"L Nu\u00f1o de la Rosa","year":"2010","unstructured":"Nu\u00f1o de la Rosa L (2010) Becoming organisms: the organisation of development and the development of organisation. Hist Philos Life Sci 32(2\u20133):289\u2013315","journal-title":"Hist Philos Life Sci"},{"key":"9456_CR28","doi-asserted-by":"publisher","first-page":"572106","DOI":"10.3389\/fpsyg.2020.572106","volume":"11","author":"L Nu\u00f1o de la Rosa","year":"2021","unstructured":"Nu\u00f1o de la Rosa L et al (2021) Pregnant Females as Historical Individuals: An Insight From the Philosophy of Evo-Devo. Front. Psychol. 11:572106. https:\/\/doi.org\/10.3389\/fpsyg.2020.572106","journal-title":"Front. Psychol."},{"issue":"3","key":"9456_CR29","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1037\/0735-7036.102.3.254","volume":"102","author":"A Platt","year":"1988","unstructured":"Platt A et al (1988) Norm-of-Reaction: Definition and Misinterpretation of Animal Research. J Comp Psychol 102(3):254\u2013261","journal-title":"J Comp Psychol"},{"key":"9456_CR30","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1023\/A:1006574719901","volume":"12","author":"A Rosenberg","year":"1997","unstructured":"Rosenberg A (1997) Reductionism redux: computing the embryo. Biol Philos 12:445\u2013470","journal-title":"Biol Philos"},{"key":"9456_CR31","doi-asserted-by":"publisher","first-page":"17867","DOI":"10.1073\/pnas.0804968105","volume":"105","author":"ME Rumpho","year":"2008","unstructured":"Rumpho ME et al (2008) Horizontal gene transfer of the algal nuclear gene psb O to the photosynthetic sea slug Elysia chlorotica. PNAS 105:17867\u201317871","journal-title":"PNAS"},{"key":"9456_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1242\/jeb.046540","volume":"214","author":"ME Rumpho","year":"2011","unstructured":"Rumpho ME et al (2011) The making of a photosynthetic animal. J Exp Biol 214:303\u2013311","journal-title":"J Exp Biol"},{"key":"9456_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s10698-020-09373-5","volume":"22","author":"G Santos","year":"2020","unstructured":"Santos G et al (2020) A relational-constructionist account of protein macrostructure and function. Found Chem 22:363\u2013382","journal-title":"Found Chem"},{"key":"9456_CR34","volume-title":"Molecular models of life","author":"S Sarkar","year":"2005","unstructured":"Sarkar S (2005) Molecular models of life. MIT Press, Cambridge"},{"key":"9456_CR35","volume-title":"Evolution: A View from the 21st Century","author":"JA Shapiro","year":"2011","unstructured":"Shapiro JA (2011) Evolution: A View from the 21st Century. FT Press Science, Upper Saddle River"},{"issue":"3","key":"9456_CR36","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1086\/288942","volume":"47","author":"E Sober","year":"1980","unstructured":"Sober E (1980) Evolution, population thinking, and essentialism. Philos Sci 47(3):350\u2013383","journal-title":"Philos Sci"},{"key":"9456_CR37","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1525-142X.2006.00101.x","volume":"8","author":"A Stoltzfus","year":"2006","unstructured":"Stoltzfus A (2006) Mutationism and the Dual Causation of Evolutionary Change. Evol Dev 8:304\u2013317","journal-title":"Evol Dev"},{"key":"9456_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.shpsc.2019.101245","author":"D Vecchi","year":"2020","unstructured":"Vecchi D (2020) DNA is not an ontologically distinctive developmental cause. Stud Hist Philos Biol Biomed Sci. https:\/\/doi.org\/10.1016\/j.shpsc.2019.101245","journal-title":"Stud Hist Philos Biol Biomed Sci"},{"key":"9456_CR39","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.7217","volume-title":"Principles of Embryology","author":"CH Waddington","year":"1956","unstructured":"Waddington CH (1956) Principles of Embryology. Macmillan, New York"},{"key":"9456_CR40","volume-title":"The Strategy of the Genes","author":"CH Waddington","year":"1957","unstructured":"Waddington CH (1957) The Strategy of the Genes. Allen and Unwin, London"},{"key":"9456_CR41","first-page":"163","volume-title":"(1997), Intelligence, Heredity and Environment","author":"D Wahlsten","year":"1997","unstructured":"Wahlsten D, Gottlieb G (1997) The invalid separation of effects of nature and nurture: Lessons from animal experimentation. In: Sternberg RJ, Grigorenko E (eds) (1997), Intelligence, Heredity and Environment. Cambridge University Press, Cambridge, pp 163\u2013192"},{"key":"9456_CR42","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3389\/fpls.2017.00701","volume":"8","author":"M Wang","year":"2017","unstructured":"Wang M et al (2017) Role of Silicon on Plant-Pathogen Interactions. Front Plant Sci 8:701","journal-title":"Front Plant Sci"},{"key":"9456_CR43","volume-title":"Behaviorism","author":"JB Watson","year":"2009","unstructured":"Watson JB (2009) Behaviorism. Routledge, London ([orig.: 1925])"},{"key":"9456_CR44","volume-title":"The Germ Plasm","author":"A Weismann","year":"1893","unstructured":"Weismann A (1893) The Germ Plasm. Charles Scribners, New York"},{"key":"9456_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195122343.001.0001","volume-title":"Developmental plasticity and evolution","author":"MJ West-Eberhard","year":"2003","unstructured":"West-Eberhard MJ (2003) Developmental plasticity and evolution. Oxford University Press, New York"},{"key":"9456_CR46","first-page":"14","volume":"34","author":"L Wolpert","year":"1975","unstructured":"Wolpert L, Lewis LJ (1975) Towards a theory of development. Fed Proc 34:14\u201320","journal-title":"Fed Proc"}],"container-title":["Acta Biotheoretica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10441-023-09456-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10441-023-09456-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10441-023-09456-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T07:54:46Z","timestamp":1728806086000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10441-023-09456-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["9456"],"URL":"https:\/\/doi.org\/10.1007\/s10441-023-09456-8","relation":{},"ISSN":["0001-5342","1572-8358"],"issn-type":[{"value":"0001-5342","type":"print"},{"value":"1572-8358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"assertion":[{"value":"21 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"6"}}