{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:30:54Z","timestamp":1773023454898,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s10534-009-9264-x","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T07:07:46Z","timestamp":1253084866000},"page":"31-41","source":"Crossref","is-referenced-by-count":22,"title":["Zinc activates neutrophils\u2019 oxidative burst"],"prefix":"10.1007","volume":"23","author":[{"given":"Marisa","family":"Freitas","sequence":"first","affiliation":[]},{"given":"Gra\u00e7a","family":"Porto","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 L. F. C.","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"9264_CR1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature02356","volume":"427","author":"J Ahluwalia","year":"2004","unstructured":"Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW (2004) The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature 427:853\u2013858","journal-title":"Nature"},{"key":"9264_CR2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V93.5.1464","volume":"93","author":"BM Babior","year":"1999","unstructured":"Babior BM (1999) NADPH oxidase: an update. Blood 93:1464\u20131476","journal-title":"Blood"},{"key":"9264_CR3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1022388022947","volume":"22","author":"G Benoni","year":"1998","unstructured":"Benoni G, Cuzzolin L, Marrella M, Crivellente F, Adami A, Bertaso C, Velo G, Milanino R (1998) Neutrophil behavior following exposure to in vivo or in vitro zinc in normal and acutely-inflamed rats: studies on lysozyme secretion, superoxide anion release and platelet adhesion. Inflammation 22:175\u2013189","journal-title":"Inflammation"},{"key":"9264_CR4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/A:1012905406548","volume":"14","author":"D Beyersmann","year":"2001","unstructured":"Beyersmann D, Haase H (2001) Functions of zinc in signalling, proliferation and differentiation of mammalian cells. Biometals 14:331\u2013341","journal-title":"Biometals"},{"key":"9264_CR5","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1681\/ASN.2007020143","volume":"18","author":"SM Brunelli","year":"2007","unstructured":"Brunelli SM, Goldfarb S (2007) Hypophosphatemia: clinical consequences and management. J Am Soc Nephrol 18:1999\u20132003","journal-title":"J Am Soc Nephrol"},{"key":"9264_CR6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/clinchem\/25.3.495a","volume":"25","author":"HB Collier","year":"1979","unstructured":"Collier HB (1979) Binding of Zn2+ by buffers. Clin Chem 25:495\u2013496","journal-title":"Clin Chem"},{"key":"9264_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1179\/135100008X308876","volume":"13","author":"D Costa","year":"2008","unstructured":"Costa D, Gomes A, Lima JL, Fernandes E (2008) Singlet oxygen scavenging activity of non-steroidal anti-inflammatory drugs. Redox Rep 13:153\u2013160","journal-title":"Redox Rep"},{"key":"9264_CR8","first-page":"1","volume":"1657","author":"AR Cross","year":"2004","unstructured":"Cross AR, Segal AW (2004) The NADPH oxidase of professional phagocytes\u2013prototype of the NOX electron transport chain systems. Biochem Biophys Acta 1657:1\u201322","journal-title":"Biochem Biophys Acta"},{"key":"9264_CR9","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1016\/S0021-9258(18)68668-5","volume":"263","author":"P Csermely","year":"1988","unstructured":"Csermely P, Szamel M, Resch K, Somogyi J (1988) Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes. J Biol Chem 263:6487\u20136490","journal-title":"J Biol Chem"},{"key":"9264_CR10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/BTER:74:2:97","volume":"74","author":"EB Dawson","year":"2000","unstructured":"Dawson EB, Evans DR, Harris WA, Powell LC (2000) Seminal plasma trace metal levels in industrial workers. Biol Trace Elem Res 74:97\u2013105","journal-title":"Biol Trace Elem Res"},{"key":"9264_CR11","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nature01523","volume":"422","author":"TE DeCoursey","year":"2003","unstructured":"DeCoursey TE, Morgan D, Cherny VV (2003) The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels. Nature 422:531\u2013534","journal-title":"Nature"},{"key":"9264_CR12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj3470285","volume":"347","author":"LV Dekker","year":"2000","unstructured":"Dekker LV, Leitges M, Altschuler G, Mistry N, McDermott A, Roes J, Segal AW (2000) Protein kinase C-beta contributes to NADPH oxidase activation in neutrophils. Biochem J 347:285\u2013289","journal-title":"Biochem J"},{"key":"9264_CR13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.tox.2004.11.023","volume":"208","author":"A Denicola","year":"2005","unstructured":"Denicola A, Radi R (2005) Peroxynitrite and drug-dependent toxicity. Toxicology 208:273\u2013288","journal-title":"Toxicology"},{"key":"9264_CR14","doi-asserted-by":"crossref","first-page":"C45","DOI":"10.1152\/ajpcell.00450.2006","volume":"293","author":"K Essin","year":"2007","unstructured":"Essin K, Salanova B, Kettritz R, Sausbier M, Luft FC, Kraus D, Bohn E, Autenrieth IB, Peschel A, Ruth P, Gollasch M (2007) Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity. Am J Physiol Cell Physiol 293:C45\u2013C54","journal-title":"Am J Physiol Cell Physiol"},{"key":"9264_CR15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1085\/jgp.200609504","volume":"127","author":"JK Femling","year":"2006","unstructured":"Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirjak G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE (2006) The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. J Gen Physiol 127:659\u2013672","journal-title":"J Gen Physiol"},{"key":"9264_CR16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ajcn\/51.2.225","volume":"51","author":"GJ Fosmire","year":"1990","unstructured":"Fosmire GJ (1990) Zinc toxicity. Am J Clin Nutr 51:225\u2013227","journal-title":"Am J Clin Nutr"},{"key":"9264_CR17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/13547500500264660","volume":"10","author":"MF Frasco","year":"2005","unstructured":"Frasco MF, Fournier D, Carvalho F, Guilhermino L (2005) Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity. Biomarkers 10:360\u2013375","journal-title":"Biomarkers"},{"key":"9264_CR18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.clinbiochem.2007.12.021","volume":"41","author":"M Freitas","year":"2008","unstructured":"Freitas M, Porto G, Lima JL, Fernandes E (2008) Isolation and activation of human neutrophils in vitro. The importance of the anticoagulant used during blood collection. Clin Biochem 41:570\u2013575","journal-title":"Clin Biochem"},{"key":"9264_CR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.aca.2009.06.063","volume":"649","author":"M Freitas","year":"2009","unstructured":"Freitas M, Lima JL, Fernandes E (2009a) Optical probes for detection and quantification of neutrophils\u2019 oxidative burst. A review. Anal Chim Acta 649:8\u201323","journal-title":"Anal Chim Acta"},{"key":"9264_CR20","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.talanta.2009.02.050","volume":"78","author":"M Freitas","year":"2009","unstructured":"Freitas M, Porto G, Lima JL, Fernandes E (2009b) Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro. Talanta 78:1476\u20131483","journal-title":"Talanta"},{"key":"9264_CR21","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V92.9.3007","volume":"92","author":"MB Hampton","year":"1998","unstructured":"Hampton MB, Kettle AJ, Winterbourn CC (1998) Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 92:3007\u20133017","journal-title":"Blood"},{"key":"9264_CR22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/1522-7243(200009\/10)15:5<321::AID-BIO605>3.0.CO;2-O","volume":"15","author":"H Hasegawa","year":"2000","unstructured":"Hasegawa H, Suzuki K, Nakaji S, Sugawara K (2000) Effects of zinc on the reactive oxygen species generating capacity of human neutrophils and on the serum opsonic activity in vitro. Luminescence 15:321\u2013327","journal-title":"Luminescence"},{"key":"9264_CR23","first-page":"285","volume":"255","author":"LM Henderson","year":"1988","unstructured":"Henderson LM, Chappell JB, Jones OT (1988) Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge. Biochem J 255:285\u2013290","journal-title":"Biochem J"},{"key":"9264_CR24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cbi.2005.06.005","volume":"155","author":"P Irato","year":"2005","unstructured":"Irato P, Albergoni V (2005) Interaction between copper and zinc in metal accumulation in rats with particular reference to the synthesis of induced-metallothionein. Chem Biol Interact 155:155\u2013164","journal-title":"Chem Biol Interact"},{"key":"9264_CR25","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1523\/JNEUROSCI.1236-08.2008","volume":"28","author":"TM Kauppinen","year":"2008","unstructured":"Kauppinen TM, Higashi Y, Suh SW, Escartin C, Nagasawa K, Swanson RA (2008) Zinc triggers microglial activation. J Neurosci 28:5827\u20135835","journal-title":"J Neurosci"},{"key":"9264_CR26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/096032719801700205","volume":"17","author":"M Lindahl","year":"1998","unstructured":"Lindahl M, Leanderson P, Tagesson C (1998) Novel aspect on metal fume fever: zinc stimulates oxygen radical formation in human neutrophils. Hum Exp Toxicol 17:105\u2013110","journal-title":"Hum Exp Toxicol"},{"key":"9264_CR27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2006.01.006","volume":"20","author":"W Maret","year":"2006","unstructured":"Maret W, Sandstead HH (2006) Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol 20:3\u201318","journal-title":"J Trace Elem Med Biol"},{"key":"9264_CR28","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/15216540701242508","volume":"59","author":"S Miyamoto","year":"2007","unstructured":"Miyamoto S, Ronsein GE, Prado FM, Uemi M, Correa TC, Toma IN, Bertolucci A, Oliveira MC, Motta FD, Medeiros MH, Mascio PD (2007) Biological hydroperoxides and singlet molecular oxygen generation. IUBMB Life 59:322\u2013331","journal-title":"IUBMB Life"},{"key":"9264_CR29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/10715760500511484","volume":"40","author":"P Mladenka","year":"2006","unstructured":"Mladenka P, Simunek T, Hubl M, Hrdina R (2006) The role of reactive oxygen and nitrogen species in cellular iron metabolism. Free Rad Res 40:263\u2013272","journal-title":"Free Rad Res"},{"key":"9264_CR30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0048-9697(01)00964-0","volume":"286","author":"V Muzyka","year":"2002","unstructured":"Muzyka V, Bogovski S, Viitak A, Veidebaum T (2002) Alterations of heme metabolism in lymphocytes and metal content in blood plasma as markers of diesel fuels effects on human organism. Sci Total Environ 286:73\u201381","journal-title":"Sci Total Environ"},{"key":"9264_CR31","doi-asserted-by":"crossref","first-page":"RC111","DOI":"10.1523\/JNEUROSCI.20-23-j0001.2000","volume":"20","author":"KM Noh","year":"2000","unstructured":"Noh KM, Koh JY (2000) Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J Neurosci 20:RC111","journal-title":"J Neurosci"},{"key":"9264_CR32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/cr0206263","volume":"104","author":"G Parkin","year":"2004","unstructured":"Parkin G (2004) Synthetic analogues relevant to the structure and function of zinc enzymes. Chem Rev 104:699\u2013767","journal-title":"Chem Rev"},{"key":"9264_CR33","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1016\/j.febslet.2006.10.024","volume":"580","author":"QF Remijsen","year":"2006","unstructured":"Remijsen QF, Fontayne A, Verdonck F, Clynen E, Schoofs L, Willems J (2006) The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophils. FEBS Lett 580:6206\u20136210","journal-title":"FEBS Lett"},{"key":"9264_CR34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1023\/A:1012986225203","volume":"14","author":"L Rink","year":"2001","unstructured":"Rink L, Gabriel P (2001) Extracellular and immunological actions of zinc. Biometals 14:367\u2013383","journal-title":"Biometals"},{"key":"9264_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-005-0009-5","volume":"80","author":"M Stefanidou","year":"2006","unstructured":"Stefanidou M, Maravelias C, Dona A, Spiliopoulou C (2006) Zinc: a multipurpose trace element. Arch Toxicol 80:1\u20139","journal-title":"Arch Toxicol"},{"key":"9264_CR36","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/jcbfm.2008.61","volume":"28","author":"SW Suh","year":"2008","unstructured":"Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, Chan PH, Swanson RA (2008) Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. J Cereb Blood Flow Metab 28:1697\u20131706","journal-title":"J Cereb Blood Flow Metab"},{"key":"9264_CR37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0773.1995.tb00102.x","volume":"76","author":"Y Takeyama","year":"1995","unstructured":"Takeyama Y, Ogino K, Segawa H, Kobayashi H, Uda T, Houbara T (1995) Effects of zinc on production of active oxygen species by rat neutrophils. Pharmacol Toxicol 76:50\u201355","journal-title":"Pharmacol Toxicol"},{"key":"9264_CR38","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/labinvest.3780067","volume":"80","author":"V Witko-Sarsat","year":"2000","unstructured":"Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L (2000) Neutrophils: molecules, functions and pathophysiological aspects. Lab Invest 80:617\u2013653","journal-title":"Lab Invest"},{"key":"9264_CR39","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-9877-7","volume-title":"Corrosion and electrochemistry of zinc","author":"XG Zhang","year":"1996","unstructured":"Zhang XG (1996) Corrosion and electrochemistry of zinc. Plenum Press, New York"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-009-9264-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-009-9264-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-009-9264-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T20:06:42Z","timestamp":1633896402000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-009-9264-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,17]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["9264"],"URL":"https:\/\/doi.org\/10.1007\/s10534-009-9264-x","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,17]]}}}