{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T18:43:28Z","timestamp":1763923408741},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s10534-012-9590-2","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T16:38:23Z","timestamp":1351096703000},"page":"13-21","source":"Crossref","is-referenced-by-count":32,"title":["Nickel induces apoptosis in human neutrophils"],"prefix":"10.1007","volume":"26","author":[{"given":"Marisa","family":"Freitas","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Barcellos-de-Souza","sequence":"additional","affiliation":[]},{"given":"Christina","family":"Barja-Fidalgo","sequence":"additional","affiliation":[]},{"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"9590_CR1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","volume":"30","author":"B Amulic","year":"2012","unstructured":"Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A (2012) Neutrophil function: from mechanisms to disease. Annu Rev Immunol 30:459\u2013489","journal-title":"Annu Rev Immunol"},{"key":"9590_CR2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jbm.a.30811","volume":"79","author":"A Au","year":"2006","unstructured":"Au A, Ha J, Hernandez M, Polotsky A, Hungerford DS, Frondoza CG (2006) Nickel and vanadium metal ions induce apoptosis of T lymphocyte Jurkat cells. J Biomed Mater Res A 79:512\u2013521","journal-title":"J Biomed Mater Res A"},{"key":"9590_CR3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0002-9343(00)00481-2","volume":"109","author":"BM Babior","year":"2000","unstructured":"Babior BM (2000) Phagocytes and oxidative stress. Am J Med 109:33\u201344","journal-title":"Am J Med"},{"key":"9590_CR4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1081\/CLT-100102423","volume":"37","author":"DG Barceloux","year":"1999","unstructured":"Barceloux DG (1999) Nickel. J Toxicol Clin Toxicol 37:239\u2013258","journal-title":"J Toxicol Clin Toxicol"},{"key":"9590_CR5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"9590_CR6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1023\/A:1017962113235","volume":"222","author":"F Chen","year":"2001","unstructured":"Chen F, Ding M, Castranova V, Shi X (2001) Carcinogenic metals and NF-kappaB activation. Mol Cell Biochem 222:159\u2013171","journal-title":"Mol Cell Biochem"},{"key":"9590_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0041-008X(03)00086-3","volume":"189","author":"CY Chen","year":"2003","unstructured":"Chen CY, Wang YF, Huang WR, Huang YT (2003) Nickel induces oxidative stress and genotoxicity in human lymphocytes. Toxicol Appl Pharmacol 189:153\u2013159","journal-title":"Toxicol Appl Pharmacol"},{"key":"9590_CR8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/15287390903421250","volume":"73","author":"CY Chen","year":"2010","unstructured":"Chen CY, Lin TK, Chang YC, Wang YF, Shyu HW, Lin KH, Chou MC (2010) Nickel(II)-induced oxidative stress, apoptosis, G2\/M arrest, and genotoxicity in normal rat kidney cells. J Toxicol Environ Health A 73:529\u2013539","journal-title":"J Toxicol Environ Health A"},{"key":"9590_CR9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbpb.2008.05.010","volume":"151","author":"I Chowdhury","year":"2008","unstructured":"Chowdhury I, Tharakan B, Bhat GK (2008) Caspases\u2014an update. Comp Biochem Physiol B 151:10\u201327","journal-title":"Comp Biochem Physiol B"},{"key":"9590_CR10","first-page":"591","volume":"10","author":"DC Dooley","year":"1982","unstructured":"Dooley DC, Simpson JF, Meryman HT (1982) Isolation of large numbers of fully viable human neutrophils: a preparative technique using percoll density gradient centrifugation. Exp Hematol 10:591\u2013599","journal-title":"Exp Hematol"},{"key":"9590_CR11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495\u2013516","journal-title":"Toxicol Pathol"},{"key":"9590_CR12","unstructured":"EMEA (2008) Guideline on the specification limits for residues of metal catalysts or metal reagents. European Medicines Agency"},{"key":"9590_CR13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2006.09.030","volume":"42","author":"L Fialkow","year":"2007","unstructured":"Fialkow L, Wang Y, Downey GP (2007) Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 42:153\u2013164","journal-title":"Free Radic Biol Med"},{"key":"9590_CR14","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.4049\/jimmunol.170.4.1964","volume":"170","author":"G Fossati","year":"2003","unstructured":"Fossati G, Moulding DA, Spiller DG, Moots RJ, White MR, Edwards SW (2003) The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J Immunol 170:1964\u20131972","journal-title":"J Immunol"},{"key":"9590_CR15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1039\/c1mt00050k","volume":"3","author":"M Freitas","year":"2011","unstructured":"Freitas M, Fernandes E (2011) Zinc, cadmium and nickel increase the activation of NF-kappaB and the release of cytokines from THP-1 monocytic cells. Metallomics 3:1238\u20131243","journal-title":"Metallomics"},{"key":"9590_CR16","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00775-010-0685-3","volume":"15","author":"M Freitas","year":"2010","unstructured":"Freitas M, Gomes A, Porto G, Fernandes E (2010) Nickel induces oxidative burst, NF-kappaB activation and interleukin-8 production in human neutrophils. J Biol Inorg Chem 15:1275\u20131283","journal-title":"J Biol Inorg Chem"},{"key":"9590_CR17","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/cdd.2011.75","volume":"18","author":"B Geering","year":"2011","unstructured":"Geering B, Simon HU (2011) Peculiarities of cell death mechanisms in neutrophils. Cell Death Differ 18:1457\u20131469","journal-title":"Cell Death Differ"},{"key":"9590_CR18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc776","volume":"2","author":"FH Igney","year":"2002","unstructured":"Igney FH, Krammer PH (2002) Death and anti-death: tumor resistance to apoptosis. Nat Rev Cancer 2:277\u2013288","journal-title":"Nat Rev Cancer"},{"key":"9590_CR19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mrfmmm.2003.08.021","volume":"533","author":"KS Kasprzak","year":"2003","unstructured":"Kasprzak KS, Sunderman FW Jr, Salnikow K (2003) Nickel carcinogenesis. Mutat Res 533:67\u201397","journal-title":"Mutat Res"},{"key":"9590_CR20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jtemb.2010.11.003","volume":"25","author":"JZ Krockova","year":"2011","unstructured":"Krockova JZ, Massanyi P, Sirotkin AV, Pivko J, Makarevich AV, Lukac N, Capcarova M, Toman R, Polakova Z (2011) Nickel induced structural and functional alterations in mouse Leydig cells in vitro. J Trace Elem Med Biol 25:14\u201318","journal-title":"J Trace Elem Med Biol"},{"key":"9590_CR21","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jbm.b.31063","volume":"88","author":"JB Lewis","year":"2009","unstructured":"Lewis JB, Messer RL, Pitts L, Hsu SD, Hansen JM, Wataha JC (2009) Ni(II) ions dysregulate cytokine secretion from human monocytes. J Biomed Mater Res B Appl Biomater 88:358\u2013365","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"9590_CR22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1600-0536.2008.01363.x","volume":"59","author":"C Liden","year":"2008","unstructured":"Liden C, Skare L, Vahter M (2008) Release of nickel from coins and deposition onto skin from coin handling\u2013comparing euro coins and SEK. Contact Dermatitis 59:31\u201337","journal-title":"Contact Dermatitis"},{"key":"9590_CR23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-005-8215-2","volume":"279","author":"H Lu","year":"2005","unstructured":"Lu H, Shi X, Costa M, Huang C (2005) Carcinogenic effect of nickel compounds. Mol Cell Biochem 279:45\u201367","journal-title":"Mol Cell Biochem"},{"key":"9590_CR24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cbi.2005.07.004","volume":"156","author":"P M\u2019Bemba-Meka","year":"2005","unstructured":"M\u2019Bemba-Meka P, Lemieux N, Chakrabarti SK (2005) Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro. Chem Biol Interact 156:69\u201380","journal-title":"Chem Biol Interact"},{"key":"9590_CR25","doi-asserted-by":"crossref","unstructured":"Nielsen F (2007) Trace mineral deficiencies. In: Handbook of Nutrition and Food. Carolyn D. Berdanier, Johanna T. Dwyer, Elaine B. Feldman CRC Press: 159-176","DOI":"10.1201\/9781420008890.ch8"},{"key":"9590_CR26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/tx9003193","volume":"23","author":"J Pan","year":"2010","unstructured":"Pan J, Chang Q, Wang X, Son Y, Zhang Z, Chen G, Luo J, Bi Y, Chen F, Shi X (2010) Reactive oxygen species-activated Akt\/ASK1\/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem Res Toxicol 23:568\u2013577","journal-title":"Chem Res Toxicol"},{"key":"9590_CR27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1006873518427","volume":"174","author":"S Papa","year":"1997","unstructured":"Papa S, Skulachev VP (1997) Reactive oxygen species, mitochondria, apoptosis and aging. Mol Cell Biochem 174:305\u2013319","journal-title":"Mol Cell Biochem"},{"key":"9590_CR28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mrfmmm.2003.07.015","volume":"533","author":"MD Pulido","year":"2003","unstructured":"Pulido MD, Parrish AR (2003) Metal-induced apoptosis: mechanisms. Mutat Res 533:227\u2013241","journal-title":"Mutat Res"},{"key":"9590_CR29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jtemb.2008.08.002","volume":"22","author":"SVS Rana","year":"2008","unstructured":"Rana SVS (2008) Metals and apoptosis: recent developments. J Trace Elem Med Biol 22:262\u2013284","journal-title":"J Trace Elem Med Biol"},{"key":"9590_CR30","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/carcin\/19.7.1203","volume":"19","author":"YH Shiao","year":"1998","unstructured":"Shiao YH, Lee SH, Kasprzak KS (1998) Cell cycle arrest, apoptosis and p53 expression in nickel(II) acetate-treated Chinese hamster ovary cells. Carcinogenesis 19:1203\u20131207","journal-title":"Carcinogenesis"},{"key":"9590_CR31","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.4049\/jimmunol.174.7.4279","volume":"174","author":"S Sim","year":"2005","unstructured":"Sim S, Yong TS, Park SJ, Im KI, Kong Y, Ryu JS, Min DY, Shin MH (2005) NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1\/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica. J Immunol 174:4279\u20134288","journal-title":"J Immunol"},{"key":"9590_CR32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","volume":"5","author":"HU Simon","year":"2000","unstructured":"Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5:415\u2013418","journal-title":"Apoptosis"},{"key":"9590_CR33","first-page":"39","volume":"2","author":"F Torres","year":"2009","unstructured":"Torres F, das Gracas M, Melo M, Tosti A (2009) Management of contact dermatitis due to nickel allergy: an update. Clin Cosmet Investig Dermatol 2:39\u201348","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"9590_CR34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2005.05.019","volume":"159","author":"D Trombetta","year":"2005","unstructured":"Trombetta D, Mondello MR, Cimino F, Cristani M, Pergolizzi S, Saija A (2005) Toxic effect of nickel in an in vitro model of human oral epithelium. Toxicol Lett 159:219\u2013225","journal-title":"Toxicol Lett"},{"key":"9590_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R","volume":"31","author":"M Engeland van","year":"1998","unstructured":"van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP (1998) Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31:1\u20139","journal-title":"Cytometry"},{"key":"9590_CR36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1354\/vp.40-5-481","volume":"40","author":"CJ Zeiss","year":"2003","unstructured":"Zeiss CJ (2003) The apoptosis-necrosis continuum: insights from genetically altered mice. Vet Pathol 40:481\u2013495","journal-title":"Vet Pathol"},{"key":"9590_CR37","doi-asserted-by":"crossref","first-page":"28443","DOI":"10.1074\/jbc.M210727200","volume":"278","author":"B Zhang","year":"2003","unstructured":"Zhang B, Hirahashi J, Cullere X, Mayadas TN (2003) Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK\/ERK activation. J Biol Chem 278:28443\u201328454","journal-title":"J Biol Chem"}],"container-title":["BioMetals"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-012-9590-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10534-012-9590-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10534-012-9590-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T23:43:54Z","timestamp":1562283834000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10534-012-9590-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["9590"],"URL":"https:\/\/doi.org\/10.1007\/s10534-012-9590-2","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,25]]}}}